کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9667530 863757 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Analysis of DNA-chip and antigen-chip data: studies of cancer, stem cells and autoimmune diseases
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی تئوریک و عملی
پیش نمایش صفحه اول مقاله
Analysis of DNA-chip and antigen-chip data: studies of cancer, stem cells and autoimmune diseases
چکیده انگلیسی
Biology has undergone a revolution during the past decade. Deciphering the human genome has opened new horizons, among which the advent of DNA microarrays has been perhaps the most significant. These miniature measuring devices report the levels at which tens of thousands of genes are expressed in a collection of cells of interest (such as tissue from a tumor). I describe here briefly this technology and present an example of how analysis of data obtained from such high throughput experiments provides insights of possible clinical and therapeutic relevance for Acute Lymphoblastic Leukemia. Next, I describe how gene expression data is used to deduce a new design principle, “Just In Case”, used by stem cells. Finally I briefly review a different novel technology, of antigen chips, which provide a fingerprint of a subject's immune system and may become a predictive clinical tool. The work reviewed here was done in collaboration with numerous colleagues and students.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Computer Physics Communications - Volume 169, Issues 1–3, 1 July 2005, Pages 183-187
نویسندگان
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