کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9720419 | 1472950 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanisms
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanisms Breakthrough pain in malignant and non-malignant diseases: a review of prevalence, characteristics and mechanisms](/preview/png/9720419.png)
چکیده انگلیسی
Breakthrough pain or transient worsening of pain in patients with an ongoing steady pain is a well known feature in cancer pain patients, but it is also seen in non-malignant pain conditions with involvement of nerves, muscles, bones or viscera. Continuous and intermittent pain seems to be a general feature of these different pain conditions, and this raises the possibility of one or several common mechanisms underlying breakthrough pain in malignant and non-malignant disorders. Although the mechanisms of spontaneous ongoing pain and intermittent flares of pain (BTP) may be difficult to separate, we suggest that peripheral and/or central sensitization (hyperexcitability) may play a major role in many causes of BTP. Mechanical stimuli (e.g. micro-fractures) changes in chemical environments and release of tumour growth factors may initiate sensitization both peripherally and centrally. It is suggested that sensitization could be the common denominator of BTP in malignant and non-malignant pain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pain - Volume 9, Issue 2, April 2005, Pages 195-206
Journal: European Journal of Pain - Volume 9, Issue 2, April 2005, Pages 195-206
نویسندگان
Kristina B. Svendsen, Steen Andersen, Sigurdur Arnason, Staffan Arnér, Harald Breivik, Tarja Heiskanen, Eija Kalso, Ulf E. Kongsgaard, Per Sjogren, Peter Strang, Flemming W. Bach, Troels S. Jensen,