کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9721011 1473269 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Nerve growth factor mediates hyperalgesia and cachexia in auto-immune arthritis
چکیده انگلیسی
Pain and cachexia are two of the most debilitating aspects of rheumatoid arthritis. Despite that, the mechanisms by which they are mediated are not well understood. We provide evidence that nerve growth factor (NGF), a secreted regulatory protein that controls neuronal survival during development, is a key mediator of pain and weight loss in auto-immune arthritis. Function blocking antibodies to NGF completely reverse established pain in rats with fully developed arthritis despite continuing joint destruction and inflammation. Likewise, these antibodies reverse weight loss while not having any effect on levels of the pro-cachectic agent tumor necrosis factor (TNF). Taken together, these findings argue that pathological joint pain and joint destruction are mechanistically independent processes and that NGF regulates an alternative cachexia pathway that is independent or downstream of TNF.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pain - Volume 116, Issues 1–2, July 2005, Pages 8-16
نویسندگان
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