کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9754494 | 1494679 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PVC membrane ion-selective electrodes for the determination of Hyoscyamine in pure solution and in pharmaceutical preparations under batch and flow modes
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
New PVC membrane electrodes selective for the determination of hyoscyamine ion (Hy+) based on hyoscyamine tetraphenylborate (Hy-TPB) or hyoscyamine phosphotungstate (Hy-PT) ion-exchangers as electroactive materials are described. The electrodes show a linear response for Hy+ over the concentration range of 1.00 Ã 10â5 to 1.26 Ã 10â2 mol Lâ1 and 1.00 Ã 10â4 to 1.00 Ã 10â2 mol Lâ1 in case of Hy-TPB electrode applying batch and flow injection analysis (FIA), respectively, and 1.00 Ã 10â5 to 4.52 Ã 10â3 mol Lâ1 and 6.31 Ã 10â5 to 1.00 Ã 10â2 mol Lâ1 in case of Hy-PT electrode for batch and FIA, respectively. The lower detection limits are 3.90 Ã 10â6 and 4.51 Ã 10â6 at 25 °C for Hy-TPB and Hy-PT electrodes, respectively. The electrodes posses near Nernstian slopes of 56.5 and 57.8 mV/decade for Hy-TPB and Hy-PT electrodes, respectively, and a fast potential response of â¤20 s which is almost constant over a pH range of 3-10. Selectivity coefficient data for some common inorganic cations, sugars, amino acids and the components, other than hyoscyamine, of the mixed drugs investigated show negligible interference. The electrodes have been applied to the potentiometric determination of hyoscyamine in pure solution and in pharmaceutical preparations under batch and FIA conditions and as end point indicator electrode for the determination of hyoscyanine using potentiometric titration. For the concentrations (1.08 Ã 10â5 mol Lâ1 to 3.16 Ã 10â3 mol Lâ1) an average recovery of 99.95% with relative standard deviation of 0.63% has been achieved. The effect of temperature on the electrodes was also studied.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 39, Issues 1â2, 1 September 2005, Pages 117-124
Journal: Journal of Pharmaceutical and Biomedical Analysis - Volume 39, Issues 1â2, 1 September 2005, Pages 117-124
نویسندگان
Sayed S. Badawy, Yousry M. Issa, Ali A. Mutair,