کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9823192 | 1520034 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neutral buoyancy and sleep-deprived serum factors alter expression of cytokines regulating osteogenesis
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موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی هوافضا
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چکیده انگلیسی
We examined expression of genes associated with cytokine production, and genes implicated in regulating bone metabolism, in bone stromal and osteoblast cells incubated under standard ground conditions and under conditions of neutral buoyancy, and in the presence/absence of serum from normal or sleep-deprived mice. We observed a clear interaction between these two conditions (exposure to neutral buoyancy and serum stimulation) in promoting enhanced osteoclastogenesis. Both conditions independently altered expression of a number of cytokines implicated in the regulation of bone metabolism. However, using stromal cells from IL-1 and TNFα cytokiner KO mice, we concluded that the increased bone loss under microgravity conditions was not primarily cytokine mediated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Astronautica - Volume 56, Issues 9â12, MayâJune 2005, Pages 890-899
Journal: Acta Astronautica - Volume 56, Issues 9â12, MayâJune 2005, Pages 890-899
نویسندگان
Reginald M. Gorczynski, Christopher P. Gorczynski, Laura Y. Gorczynski, Jiang Hu, Jin Lu, Justin Manuel, Lydia Lee,