کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9823192 1520034 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Neutral buoyancy and sleep-deprived serum factors alter expression of cytokines regulating osteogenesis
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی هوافضا
پیش نمایش صفحه اول مقاله
Neutral buoyancy and sleep-deprived serum factors alter expression of cytokines regulating osteogenesis
چکیده انگلیسی
We examined expression of genes associated with cytokine production, and genes implicated in regulating bone metabolism, in bone stromal and osteoblast cells incubated under standard ground conditions and under conditions of neutral buoyancy, and in the presence/absence of serum from normal or sleep-deprived mice. We observed a clear interaction between these two conditions (exposure to neutral buoyancy and serum stimulation) in promoting enhanced osteoclastogenesis. Both conditions independently altered expression of a number of cytokines implicated in the regulation of bone metabolism. However, using stromal cells from IL-1 and TNFα cytokiner KO mice, we concluded that the increased bone loss under microgravity conditions was not primarily cytokine mediated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Astronautica - Volume 56, Issues 9–12, May–June 2005, Pages 890-899
نویسندگان
, , , , , , ,