کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9879482 1534760 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Can β-carotene regulate cell growth by a redox mechanism? An answer from cultured cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی سالمندی
پیش نمایش صفحه اول مقاله
Can β-carotene regulate cell growth by a redox mechanism? An answer from cultured cells
چکیده انگلیسی
Many studies suggest a protective role of β-carotene against cancer. However, the ATBC and the CARET trials have shown that β-carotene increases the incidence of lung cancer in heavy smokers and asbestos workers. To explain this paradox, it can be hypothesized that β-carotene modulates intracellular redox status and through this mechanism, it affects redox-sensitive molecular pathways involved in the regulation of cell cycle progression and apoptosis. Studies conducted in cultured cells seem to confirm such a hypothesis. At low concentrations, the carotenoid may serve as an antioxidant, inhibiting free radical production, while at relatively high concentrations and/or in the presence of a chronic oxidative stress (i.e. smoke), it may behave as a prooxidant, propagating free radical-induced reactions, consuming endogenous antioxidants and inducing DNA oxidative damage. In this context, it may regulate cell growth and death by the modulation of redox-sensitive genes and transcription factors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1740, Issue 2, 30 May 2005, Pages 215-221
نویسندگان
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