کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9891595 | 1540771 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Modulation effect of tea polyphenol toward N-methyl-Nâ²-nitro-N-nitrosoguanidine-induced precancerous gastric lesion in rats
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
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چکیده انگلیسی
The chemopreventive effect of tea polyphenol (TP) on precancerous gastric lesion was examined. A rat model was established by gavage of N-methyl-Nâ²-nitro-N-nitrosoguanidine (MNNG), and different concentrations of TP were given to Wistar rats in drinking water during the 16 weeks of the experiment. The histopathological data showed an effect of TP to lighten the lesions induced by MNNG. By flow cytometry, we demonstrated that TP treatment decreased the proliferation and apoptosis index (AI) induced by MNNG. The arrest in the G0-G1 phase of the cell cycle was also obtained. The results suggested that TP had preventive effect against gastric carcinogenesis at the preinitiation stage and such prevention may be related to the modulation of the balance of cell death and cell proliferation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Nutritional Biochemistry - Volume 16, Issue 3, March 2005, Pages 172-177
Journal: The Journal of Nutritional Biochemistry - Volume 16, Issue 3, March 2005, Pages 172-177
نویسندگان
Yuying Mei, Dongzhi Wei, Jianwen Liu,