کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9894372 | 1542455 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats
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کلمات کلیدی
NSTDMNDVCtrh - بازارAutonomic nervous system - دستگاه عصبی خودمختار یا خودگردان یا اتونومcentral nervous system - سیستم عصبی مرکزیdorsal vagal complex - مجتمع وگال پشتیNeuropeptide - نوروپپتیدnucleus of the solitary tract - هسته دستگاه انفرادیdorsal motor nucleus of the vagus - هسته موتور پشتی وحشیthyrotropin-releasing hormone - هورمون آزاد کننده تیروتروپین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats](/preview/png/9894372.png)
چکیده انگلیسی
Central administration of thyrotropin-releasing hormone (TRH) enhanced pancreatic blood flow in animal models. TRH nerve fibers and receptors are localized in the dorsal vagal complex (DVC), and retrograde tracing techniques have shown that pancreatic vagal nerves arise from the DVC. However, nothing is known about the central sites of action for TRH to elicit the stimulation of pancreatic blood flow. Effect of microinjection of a TRH analog into the DVC on pancreatic blood flow was investigated in urethane-anesthetized rats. After measuring basal flow, a stable TRH analog (RX-77368) was microinjected into the DVC and pancreatic blood flow response was observed for 120 min by laser Doppler flowmetry. Vagotomy of the several portions, or pretreatment with atoropine methyl nitrate or NG-nitro-l-arginine-methyl ester was performed. Microinjection of RX-77368 (0.1-10 ng) into the left or right DVC dose-dependently increased pancreatic blood flow. The stimulation of pancreatic blood flow by RX-77368 microinjection was eliminated by the same side of cervical vagotomy as the microinjection site or subdiaphragmatic vagotomy, but not by the other side of cervical vagotomy. The TRH-induced stimulation of pancreatic blood flow was abolished by atropine or NG-nitro-l-arginine-methyl ester. These results suggest that TRH acts in the DVC to stimulate pancreatic blood flow through vagal-cholinergic and nitric oxide dependent pathways, indicating that neuropeptides may act in the specific brain nuclei to regulate pancreatic function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Peptides - Volume 131, Issues 1â3, 15 November 2005, Pages 74-81
Journal: Regulatory Peptides - Volume 131, Issues 1â3, 15 November 2005, Pages 74-81
نویسندگان
Masashi Yoneda, Manabu Goto, Kimihide Nakamura, Shiro Yokohama, Toru Kono, Masaya Tanamo, Tadahito Shimada, Hideyuki Hiraishi,