کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918580 | 1557549 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The development and stability assessment of extemporaneous pediatric formulations of Accupril
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The development and stability assessment of extemporaneous pediatric formulations of Accupril The development and stability assessment of extemporaneous pediatric formulations of Accupril](/preview/png/9918580.png)
چکیده انگلیسی
Quinapril, the active ingredient in Accupril® tablets, is an ACE inhibitor used to treat hypertension. Quinapril is unstable in aqueous solution and therefore the development of a liquid formulation is a significant challenge. Previous studies show the rate of degradation of quinapril into its two major degradants to be pH dependent, indicating the parent compound to be most stable in the narrow pH range of 5.5-6.5. Accupril (20 mg) and readily available pharmaceutical components were combined to generate three formulations that are stable for at least 28 days, possess acceptable appearance, and are palatable to pediatric patients. To combat the presence of magnesium carbonate in the Accupril tablets, which increase the pH of the solution above 6.5, several pharmaceutically available buffers were incorporated. Nine prototypes were developed and their characteristics evaluated after 1 week under stressed conditions. The three that most closely matched the stability criteria were chosen for a definitive stability study. A stability-indicating method was developed and validated for these studies. All three formulations met the following specifications when stored at 5 °C for 6 weeks; Quinapril remained â¥90% intact and the two known degradants did not reach values â¥3.0% individually or â¥5.0% combined.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 304, Issues 1â2, 4 November 2005, Pages 135-144
Journal: International Journal of Pharmaceutics - Volume 304, Issues 1â2, 4 November 2005, Pages 135-144
نویسندگان
Anita L. Freed, Steven B. Silbering, Kevin J. Kolodsick, David T. Rossi, Majid Mahjour, Carol A. Kingsmill,