کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918598 | 1557550 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Solid state characteristics of ternary solid dispersions composed of PVP VA64, Myrj 52 and itraconazole
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The purpose of the present study was to characterize the solid state properties of ternary solid dispersions made up of PVP VA64, Myrj 52 and itraconazole. The solid dispersions were prepared by dissolving the materials in methylene chloride, followed by evaporation under reduced pressure of the solvent at 55 °C in a rotovapor. Binary and ternary solid dispersions were characterized by standard and modulated temperature differential scanning calorimetry and X-ray powder diffraction. Although PVP VA64 and itraconazole were found to be completely miscible in the solid state, addition of a small amount of Myrj 52 to the drug-polymer system leads to separation of itraconazole thus demonstrating that Myrj 52 expels the drug from the polymer phase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 303, Issues 1â2, 13 October 2005, Pages 54-61
Journal: International Journal of Pharmaceutics - Volume 303, Issues 1â2, 13 October 2005, Pages 54-61
نویسندگان
Xin Wang, Armand Michoel, Guy Van den Mooter,