کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9918762 | 1557557 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Release behavior of diethylhexyl phthalate from the polyvinyl-chloride tubing used for intravenous administration and the plasticized PVC membrane
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The release behavior of diethylhexyl phthalate (DEHP) from polyvinyl-chloride (PVC) tubing, which composes materials in an intravenous administration set, was investigated using polysorbate 80 (Tween 80) aqueous solutions. When Tween 80 solution was circulated in PVC tubing, the amount of DEHP released increased with increasing circulation velocity and temperature. In order to clarify the effect of temperature on the release behavior of DEHP, PVC films containing varying amounts of DEHP were mounted on a cylindrical shaft and rotated at 5 and 40 °C. The cumulative amount of DEHP released increased with an increase in temperature, the diffusion coefficients [D Ã 10â10 cm2 minâ1] at 5 and 40 °C were 9.1 and 156.0, respectively. The glass transition temperature (Tg) of PVC films decreased with an increase in DEHP in the PVC film, as measured by differential scanning calorimeter (DSC) and release of DEHP occurred at temperatures above Tg. These results indicate that the release of DEHP from PVC tubing is closely associated with the state of the PVC and is related to diffusion of DEHP throughout the PVC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 297, Issues 1â2, 13 June 2005, Pages 30-37
Journal: International Journal of Pharmaceutics - Volume 297, Issues 1â2, 13 June 2005, Pages 30-37
نویسندگان
Hanawa Takehisa, Endoh Naoko, Suzuki Masahiko, Terada Katsuhide, Ohkuma Moriyuki, Sakuta Keizoh, Tanaka Mutsuko, Kawano Kenji, Nakajima Shin'ichiro, Oguchi Toshio,