کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9918982 1557565 2005 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physicochemical studies on Ciclopirox olamine complexes with divalent metal ions
موضوعات مرتبط
علوم پزشکی و سلامت داروسازی، سم شناسی و علوم دارویی علوم دارویی
پیش نمایش صفحه اول مقاله
Physicochemical studies on Ciclopirox olamine complexes with divalent metal ions
چکیده انگلیسی
Ciclopirox olamine (CPO) metal complexes have been prepared and characterized using elemental analysis, infra red (IR), melting point and differential scanning calorimetry (DSC). Spectroscopic titration using molar ratio method indicated the occurrence of 1:1 complexes for CPO with almost all the examined metals. Physicochemical properties were also studied including aqueous solubility and apparent partition coefficient. Results showed that generally complex formation dramatically decreased the solubility and increased apparent partition coefficient. However, some metal complexes exhibited opposite effect. It could be concluded that complex formation can modify the solubility and apparent partition coefficient, which may suggest the use of complexes to manipulate the physicochemical properties of the drug.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 289, Issues 1–2, 31 January 2005, Pages 179-187
نویسندگان
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