Monitoring of whole body cryotherapy effects by thermal imaging: preliminary report Fulltext Access 6 Pages 2006
Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase-1 Fulltext Access 6 Pages 2006
The ribosomal protein L32-2 (RPL32-2) of S. pombe exhibits a novel extraribosomal function by acting as a potential transcriptional regulator Fulltext Access 6 Pages 2006
Normal specification of the extraembryonic lineage after somatic nuclear transfer Fulltext Access 6 Pages 2006
Silencing of filamin A gene expression inhibits Ca2+-sensing receptor signaling Fulltext Access 6 Pages 2006
Identification of multiple actin-binding sites in cofilin-phosphatase Slingshot-1L Fulltext Access 6 Pages 2006
Differential gene expression in egg cells and zygotes suggests that the transcriptome is restructed before the first zygotic division in tobacco Fulltext Access 6 Pages 2006
The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis Fulltext Access 6 Pages 2006
Chemical glycosylation: New insights on the interrelation between protein structural mobility, thermodynamic stability, and catalysis Fulltext Access 6 Pages 2006
Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein Fulltext Access 6 Pages 2006
Use of GAFCHROMIC XR type R films for skin-dose measurements in interventional radiology: Validation of a dosimetric procedure on a sample of patients undergone interventional cardiology Fulltext Access 6 Pages 2006
Highly efficient protein trans-splicing by a naturally split DnaE intein from Nostoc punctiforme Fulltext Access 6 Pages 2006
Development and in vitro efficacy of novel MMP2 and MMP9 specific doxorubicin albumin conjugates Fulltext Access 6 Pages 2006
6-Acylamino-2-amino-4-methylquinolines as potent melanin-concentrating hormone 1 receptor antagonists: Structure–activity exploration of eastern and western parts Fulltext Access 6 Pages 2006
Synthesis and antibacterial activity of 3-O-acyl-6-O-carbamoyl erythromycin A derivatives Fulltext Access 6 Pages 2006
Microwave-assisted synthesis of N-alkylated benzotriazole derivatives: Antimicrobial studies Fulltext Access 6 Pages 2006
Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists Fulltext Access 6 Pages 2006
Semicarbazone-based inhibitors of cathepsin K, are they prodrugs for aldehyde inhibitors? Fulltext Access 6 Pages 2006
Pyridobenzodiazepines: A novel class of orally active, vasopressin V2 receptor selective agonists Fulltext Access 6 Pages 2006
Novel fluorescent labelled affinity probes for diadenosine-5′,5‴-P1,P4-tetraphosphate (Ap4A)-binding studies Fulltext Access 6 Pages 2006
Highly potent and selective zwitterionic agonists of the δ-opioid receptor. Part 1 Fulltext Access 6 Pages 2006
Novel non-nucleobase inhibitors of Staphylococcus aureus DNA polymerase IIIC Fulltext Access 6 Pages 2006
Characterization of severe acute respiratory syndrome coronavirus membrane protein Fulltext Access 6 Pages 2006
Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents Fulltext Access 6 Pages 2006
The plant-specific VIMAG domain of Glutamine Dumper1 is necessary for the function of the protein in arabidopsis Fulltext Access 6 Pages 2006
Alternative splicing of human and mouse NPFF2 receptor genes: Implications to receptor expression Fulltext Access 6 Pages 2006
On the interplay of gene positioning and the role of rho-independent terminators in Escherichia coli Fulltext Access 6 Pages 2006
Solution structure and NMR characterization of the binding to methylated histone tails of the plant homeodomain finger of the tumour suppressor ING4 Fulltext Access 6 Pages 2006
Haem carrier protein 1 (HCP1): Expression and functional studies in cultured cells Fulltext Access 6 Pages 2006
A major role of PKC θ and NFκB in the regulation of hTERT in human T lymphocytes Fulltext Access 6 Pages 2006
Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae Fulltext Access 6 Pages 2006
The polyamine spermine protects against high salt stress in Arabidopsis thaliana Fulltext Access 6 Pages 2006
New measures of insecticidal efficacy and safety obtained with the 39K promoter of a recombinant baculovirus Fulltext Access 6 Pages 2006
The intrachain disulfide bridge is responsible of the unusual stability properties of novel acylphosphatase from Escherichia coli Fulltext Access 6 Pages 2006
Binding of different monosaccharides by lectin PA-IIL from Pseudomonas aeruginosa: Thermodynamics data correlated with X-ray structures Fulltext Access 6 Pages 2006
Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists Fulltext Access 6 Pages 2006
The role of Glu196 in the environment around the substrate binding site of leucine aminopeptidase from Streptomyces griseus Fulltext Access 6 Pages 2006
High phosphorylation of HBV core protein by two α-type CK2-activated cAMP-dependent protein kinases in vitro Fulltext Access 6 Pages 2006
A chloroplastic inner envelope membrane protease is essential for plant development Fulltext Access 6 Pages 2006
RETRACTED: The effect of 2′,4′,7-trihydroxyisoflavone on ultraviolet-induced matrix metalloproteinases-1 expression in human skin fibroblasts Fulltext Access 6 Pages 2006
Construction of a fully active truncated alternansucrase partially deleted of its carboxy-terminal domain Fulltext Access 6 Pages 2006
Catechin derivatives: Specific inhibitor for caspases-3, 7 and 2, and the prevention of apoptosis at the cell and animal levels Fulltext Access 6 Pages 2006
Mutational analysis of the oxidoreductase ERp57 reveals the importance of the two central residues in the redox motif Fulltext Access 6 Pages 2006
Faster and more accurate global protein function assignment from protein interaction networks using the MFGO algorithm Fulltext Access 6 Pages 2006
Activation of ErbB2 by 2-methyl-1,4-naphthoquinone (menadione) in human keratinocytes: Role of EGFR and protein tyrosine phosphatases Fulltext Access 6 Pages 2006
Synthesis of gallic acid based naphthophenone fatty acid amides as cathepsin D inhibitors Fulltext Access 6 Pages 2006
Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring Fulltext Access 6 Pages 2006
Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa Fulltext Access 6 Pages 2006
DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides Fulltext Access 6 Pages 2006
Synthesis and structure–activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists Fulltext Access 6 Pages 2006
Structure–activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists Fulltext Access 6 Pages 2006
Nε-Thioacetyl-lysine: A multi-facet functional probe for enzymatic protein lysine Nε-deacetylation Fulltext Access 6 Pages 2006
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors Fulltext Access 6 Pages 2006
Synthesis of the PPARβ/δ-selective agonist GW501516 and C4-thiazole-substituted analogs Fulltext Access 6 Pages 2006
Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2) Fulltext Access 6 Pages 2006
Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series Fulltext Access 6 Pages 2006
Design and synthesis of potent and selective 1,3,4-trisubstituted-2-oxopiperazine based melanocortin-4 receptor agonists Fulltext Access 6 Pages 2006
Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: Synthesis and SAR studies Fulltext Access 6 Pages 2006
Two novel immunosuppressive pregnane glycosides from the roots of Stephanotis mucronata Fulltext Access 6 Pages 2006
Tubeimoside V (1), a new cyclic bisdesmoside from tubers of Bolbostemma paniculatum, functions by inducing apoptosis in human glioblastoma U87MG cells Fulltext Access 6 Pages 2006
Antibacterial activity of pyrrolopyridine-substituted oxazolidinones: synthesis and in vitro SAR of various C-5 acetamide replacements Fulltext Access 6 Pages 2006
Tri-substituted triazoles as potent non-nucleoside inhibitors of the HIV-1 reverse transcriptase Fulltext Access 6 Pages 2006
Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors Fulltext Access 6 Pages 2006
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II ‘selective’ inhibitor celecoxib Fulltext Access 6 Pages 2006
Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors Fulltext Access 6 Pages 2006
Synthesis and biological activity of the first cyclic biphalin analogues Fulltext Access 6 Pages 2006
Design, synthesis and structure–activity relationships of new phosphinate inhibitors of MurD Fulltext Access 6 Pages 2006
Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors Fulltext Access 6 Pages 2006
Synthesis and anthelmintic activity of substituted (R)-phenyllactic acid containing cyclohexadepsipeptides Fulltext Access 6 Pages 2006
Synthesis and antiprotozoal activity of some new synthetic substituted quinoxalines Fulltext Access 6 Pages 2006
Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2 Fulltext Access 6 Pages 2006
Anticancer activity of a series of platinum complexes integrating demethylcantharidin with isomers of 1,2-diaminocyclohexane Fulltext Access 6 Pages 2006
Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase Fulltext Access 6 Pages 2006
The water-soluble fullerene derivative ‘Radical Sponge®’ exerts cytoprotective action against UVA irradiation but not visible-light-catalyzed cytotoxicity in human skin keratinocytes Fulltext Access 6 Pages 2006
Synthesis of (2E)-3-{2-[(substituted benzyl)oxy]phenyl}acrylaldehydes as novel anti-inflammatory agents Fulltext Access 6 Pages 2006
Synthesis and structure–activity relationship of a novel, achiral series of TNF-α converting enzyme inhibitors Fulltext Access 6 Pages 2006
Discovery of bitriazolyl compounds as novel antiviral candidates for combating the tobacco mosaic virus Fulltext Access 6 Pages 2006
Orally active thrombin inhibitors. Part 2: Optimization of the P2-moiety Fulltext Access 6 Pages 2006
Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability Fulltext Access 6 Pages 2006
Specific volume and compressibility of human serum albumin–polyanion complexes Fulltext Access 6 Pages 2006
Modeling and synthesis of non-cyclic derivatives of GPI-1046 as potential FKBP ligands with neurotrophic properties Fulltext Access 6 Pages 2006
The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production Fulltext Access 6 Pages 2006
β-Secretase inhibitors: Modification at the P4 position and improvement of inhibitory activity in cultured cells Fulltext Access 6 Pages 2006
Structure–activity relationships of triazolopyridine oxazole p38 inhibitors: Identification of candidates for clinical development Fulltext Access 6 Pages 2006
Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: Achieving selectivity against the μ opioid and nociceptin/orphanin FQ peptide (NOP) receptors Fulltext Access 6 Pages 2006
1,4-Dihydroindeno[1,2-c]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors Fulltext Access 6 Pages 2006
Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors Fulltext Access 6 Pages 2006
Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists Fulltext Access 6 Pages 2006
Dithiocarbamic acid esters as anticancer agent. Part 1: 4-Substituted-piperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl esters Fulltext Access 6 Pages 2006
Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors Fulltext Access 6 Pages 2006
Identification of a lead pharmacophore for the development of potent nuclear receptor modulators as anticancer and X syndrome disease therapeutic agents Fulltext Access 6 Pages 2006