Identification of short untranslated regions that sufficiently enhance translation in high-quality wheat germ extract Fulltext Access 4 Pages 2014
Identification of novel bivalent mimetics of annonaceous acetogenins via a scaffold-hopping strategy Fulltext Access 4 Pages 2014
Discovery of novel bacterial elongation condensing enzyme inhibitors by virtual screening Fulltext Access 4 Pages 2014
A chiral benzoylthiourea-pyrrolidine catalyst for the highly enantioselective Michael addition of ketones to chalcones Fulltext Access 4 Pages 2014
Design and synthesis of molecular probes for the determination of the target of the anthelmintic drug praziquantel Fulltext Access 4 Pages 2014
Antimalarial chemotherapy: Artemisinin-derived dimer carbonates and thiocarbonates Fulltext Access 4 Pages 2014
Vascular effects of diphenylmethoxypiperidine-derived dopamine uptake inhibitors Fulltext Access 4 Pages 2014
Synthesis of a cluster-forming sialylthio-d-galactose fullerene conjugate and evaluation of its interaction with influenza virus hemagglutinin and neuraminidase Fulltext Access 4 Pages 2014
Synthesis and potent ionophoric activity of a squaramide-linked bis(choloyl) conjugate Fulltext Access 4 Pages 2014
Design, synthesis and antimycobacterial activity evaluation of natural oridonin derivatives Fulltext Access 4 Pages 2014
Synthesis and evaluation of novel dapsone-thalidomide hybrids for the treatment of type 2 leprosy reactions Fulltext Access 4 Pages 2014
Discovery of novel 1,5-benzodiazepine-2,4-dione derivatives as potential anticancer agents Fulltext Access 4 Pages 2014
In silico and pharmacological screenings identify novel serine racemase inhibitors Fulltext Access 4 Pages 2014
Design, synthesis, and antibacterial activity against rice bacterial leaf blight and leaf streak of 2,5-substituted-1,3,4-oxadiazole/thiadiazole sulfone derivative Fulltext Access 4 Pages 2014
Synthesis and characterization of novel 1,2-oxazine-based small molecules that targets acetylcholinesterase Fulltext Access 4 Pages 2014
Selective immunoproteasome inhibitors with non-peptide scaffolds identified from structure-based virtual screening Fulltext Access 4 Pages 2014
Synthesis of new heterocyclic lupeol derivatives as nitric oxide and pro-inflammatory cytokine inhibitors Fulltext Access 4 Pages 2014
Synthesis and biological evaluation of novel trichodermin derivatives as antifungal agents Fulltext Access 4 Pages 2014
Synthesis and biological activity of fluorescent neonicotinoid insecticide thiamethoxam Fulltext Access 4 Pages 2014
Antioxidant effects of the highly-substituted carbazole alkaloids and their related carbazoles Fulltext Access 4 Pages 2014
Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity Fulltext Access 4 Pages 2014
Synthesis and evaluation of novel alkannin and shikonin oxime derivatives as potent antitumor agents Fulltext Access 4 Pages 2014
Synthesis and biological evaluation of novel isoxazoles and triazoles linked 6-hydroxycoumarin as potent cytotoxic agents Fulltext Access 4 Pages 2014
Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase Fulltext Access 4 Pages 2014
Synthesis and biological evaluation of the pirfenidone derivatives as antifibrotic agents Fulltext Access 4 Pages 2014
Synthesis and biological evaluation of novel tricyclic oxazine and oxazepine fused quinazolines. Part 1: Erlotinib analogs Fulltext Access 4 Pages 2014
Sandwiched zinc-finger nucleases demonstrating higher homologous recombination rates than conventional zinc-finger nucleases in mammalian cells Fulltext Access 4 Pages 2014
1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: Synthesis and antimalarial evaluation Fulltext Access 4 Pages 2014
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds Fulltext Access 4 Pages 2014
Dimeric unnatural polyproline-rich peptides with enhanced antibacterial activity Fulltext Access 4 Pages 2014
Colorimetric and fluorometric assays for acetylcholinesterase and its inhibitors screening based on a fluorescein derivate Fulltext Access 4 Pages 2014
Discovery of 2-pyridineformamide thiosemicarbazones as potent antiausterity agents Fulltext Access 4 Pages 2014
Growth inhibitory activity for cancer cell lines of lapachol and its natural and semi-synthetic derivatives Fulltext Access 4 Pages 2014
Inhibition of serine and proline racemases by substrate-product analogues Fulltext Access 4 Pages 2014
Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus Fulltext Access 4 Pages 2014
Synthesis and biological properties of thiazole-analogues of pyochelin, a siderophore of Pseudomonas aeruginosa Fulltext Access 4 Pages 2014
Chemical synthesis and tyrosinase inhibitory activity of rhododendrol glycosides Fulltext Access 4 Pages 2014
Design, synthesis and anti-Alzheimer properties of dimethylaminomethyl-substituted curcumin derivatives Fulltext Access 4 Pages 2014
Design and synthesis of triazolopyrimidine acylsulfonamides as novel anti-mycobacterial leads acting through inhibition of acetohydroxyacid synthase Fulltext Access 4 Pages 2014
Environmentally benign synthesis and antimicrobial study of novel chalcogenophosphates Fulltext Access 4 Pages 2014
Synthesis and fungicidal activities of novel benzothiophene-substituted oxime ether strobilurins Fulltext Access 4 Pages 2014
Discovery of two aminoglycoside antibiotics as inhibitors targeting the menin-mixed lineage leukaemia interface Fulltext Access 4 Pages 2014
Structural requirement and stereospecificity of tetrahydroquinolines as potent ecdysone agonists Fulltext Access 4 Pages 2014
Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum Fulltext Access 4 Pages 2014
Mineralocorticoid receptor antagonists: Identification of heterocyclic amide replacements in the oxazolidinedione series Fulltext Access 4 Pages 2014
Identification of diverse natural products as falcipain-2 inhibitors through structure-based virtual screening Fulltext Access 4 Pages 2014
Evaluation of anticonvulsant activity of novel pyrrolidin-2-one derivatives Fulltext Access 4 Pages 2014
The effect of lipoate on anaerobic cysteine metabolism in erythrocytes of patients treated with peritoneal dialysis Fulltext Access 4 Pages 2014
Vague effects of chronic topiramate administration on maximal electroshock-induced seizures in mice Fulltext Access 4 Pages 2014
Combination therapy of gamma-aminobutyric acid derivative promotes proton pump inhibitor based healing of reflux esophagitis in animal model Fulltext Access 4 Pages 2014
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies Fulltext Access 4 Pages 2014
Centrifugation aided highly sensitive detection of nitrite with a dye–silica conjugate featuring cleavable linkages Fulltext Access 4 Pages 2014
Anti-tumor activity of novel biisoquinoline derivatives against breast cancers Fulltext Access 4 Pages 2014
Synthesis of novel benzimidazole functionalized chiral thioureas and evaluation of their antibacterial and anticancer activities Fulltext Access 4 Pages 2014
Targeted amplification of delivery to cell surface receptors by dendrimer self-assembly Fulltext Access 4 Pages 2014
La prise en charge nutritionnelle d’un adulte atteint de diabète de type 2 Fulltext Access 4 Pages 2014
Phospho-carboxylic anhydride of a homologated nucleoside leads to primer degradation in the presence of a polymerase Fulltext Access 4 Pages 2014
Synthesis and antihyperglycemic evaluation of new 2-hydrazolyl-4-thiazolidinone-5-carboxylic acids having pyrazolyl pharmacophores Fulltext Access 4 Pages 2014
Antiplasmodial activity of synthetic ellipticine derivatives and an isolated analog Fulltext Access 4 Pages 2014
Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors Fulltext Access 4 Pages 2014
Identification of novel IP receptor agonists using historical ligand biased chemical arrays Fulltext Access 4 Pages 2014
The discovery of potent glycine transporter type-2 inhibitors: Design and synthesis of phenoxymethylbenzamide derivatives Fulltext Access 4 Pages 2014
Synthesis and analgesic activity of alkylated, reduced and constrained oligoheterocyclic peptidomimetic analogs of Leu-enkephalin Fulltext Access 4 Pages 2014
A highly sensitive, cell-membrane-permeable fluorescent probe for glutathione Fulltext Access 4 Pages 2014
Identification of combined conjugation of nabumetone phase I metabolites with glucuronic acid and glycine in minipig biotransformation using coupling high-performance liquid chromatography with electrospray ionization mass spectrometry Fulltext Access 4 Pages 2014
Virtual screening reveals allosteric inhibitors of the Toxoplasma gondii thymidylate synthase-dihydrofolate reductase Fulltext Access 4 Pages 2014
Synthesis of halogenated 4-quinolones and evaluation of their antiplasmodial activity Fulltext Access 4 Pages 2014
Undesired versus designed enzymatic cleavage of linkers for liver targeting Fulltext Access 4 Pages 2014
Synthesis and haemolytic activity of novel salts made of nicotine alkaloids and bile acids Fulltext Access 4 Pages 2014
Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model Fulltext Access 4 Pages 2014
A simple and widely applicable hit validation strategy for protein-protein interaction inhibitors based on a quantitative ligand displacement assay Fulltext Access 4 Pages 2014
A highly water soluble benzimidazole derivative useful for the treatment of fasciolosis Fulltext Access 4 Pages 2014
Synthesis and immunoregulatory activities of conjugates of a Toll-like receptor 7 inert ligand Fulltext Access 4 Pages 2014
Dual-stage triterpenoids from an African medicinal plant targeting the malaria parasite Fulltext Access 4 Pages 2014