Inhibitors of hepatitis C virus NS3·4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics Fulltext Access 6 Pages 2007
Heterocyclic substituted cantharidin and norcantharidin analogues—synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity Fulltext Access 6 Pages 2007
Potent and selective isophthalamide S2 hydroxyethylamine inhibitors of BACE1 Fulltext Access 6 Pages 2007
Structure–activity relationships of novel, highly potent, selective, and orally active CCR1 antagonists Fulltext Access 6 Pages 2007
(Arylpiperazinyl)cyclohexylsufonamides: Discovery of α1a/1d-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Urinary Tract Symptoms (BPH/LUTS) Fulltext Access 6 Pages 2007
Rational design of inhibitors of VirA–VirG two-component signal transduction Fulltext Access 6 Pages 2007
Discovery of potent and orally bioavailable heterocycle-based β3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity Fulltext Access 6 Pages 2007
Synthesis and structure–activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists Fulltext Access 6 Pages 2007
Synthesis and in vitro antibacterial activity of novel methylamino piperidinyl oxazolidinones Fulltext Access 6 Pages 2007
Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant—taxoid conjugates as novel cytotoxic agents Fulltext Access 6 Pages 2007
Pyrrolidines as potent functional agonists of the human melanocortin-4 receptor Fulltext Access 6 Pages 2007
Structure-based organic synthesis of unnatural aeruginosin hybrids as potent inhibitors of thrombin Fulltext Access 6 Pages 2007
Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment Fulltext Access 6 Pages 2007
Identification of Sansalvamide a analog potent against pancreatic cancer cell lines Fulltext Access 6 Pages 2007
Synthesis and SAR of p38α MAP kinase inhibitors based on heterobicyclic scaffolds Fulltext Access 6 Pages 2007
Synthesis and antibacterial activity of C11, C12-cyclic urea analogues of ketolides Fulltext Access 6 Pages 2007
Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors Fulltext Access 6 Pages 2007
Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. Fulltext Access 6 Pages 2007
Design and synthesis of 6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid derivatives as PPARγ activators Fulltext Access 6 Pages 2007
Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups—new classes of PPAR γ/δ and PPAR α/γ/δ agonists Fulltext Access 6 Pages 2007
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions Fulltext Access 6 Pages 2007
Inhibition of membrane-associated carbonic anhydrase isozymes IX, XII and XIV with a library of glycoconjugate benzenesulfonamides Fulltext Access 6 Pages 2007
Constrained 7-fluorocarboxychromone-4-aminopiperidine based Melanin-concentrating hormone receptor 1 antagonists: The effects of chirality on substituted indan-1-ylamines Fulltext Access 6 Pages 2007
Pyrazole-based factor Xa inhibitors containing N-arylpiperidinyl P4 residues Fulltext Access 6 Pages 2007
Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening Fulltext Access 6 Pages 2007
Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA Fulltext Access 6 Pages 2007
3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa) Fulltext Access 6 Pages 2007
Amino acid-based enantiomerically pure 3-substituted 1,4-benzodiazepin-2-ones: A new class of anti-ischemic agents Fulltext Access 6 Pages 2007
N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3 Fulltext Access 6 Pages 2007
3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes Fulltext Access 6 Pages 2007
In-silico fragment-based identification of novel angiogenesis inhibitors Fulltext Access 6 Pages 2007
Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists Fulltext Access 6 Pages 2007
Synthesis of O-prenylated and O-geranylated derivatives of 5-benzylidene2,4-thiazolidinediones and evaluation of their free radical scavenging activity as well as effect on some phase II antioxidant/detoxifying enzymes Fulltext Access 6 Pages 2007
Study on synthesis, structure, and DNA-binding of lanthanide complexes with 2-carboxylbenzaldehyde thiosemicarbazone Fulltext Access 6 Pages 2007
Identification, synthesis, and biological evaluation of novel pyrazoles as low molecular weight luteinizing hormone receptor agonists Fulltext Access 6 Pages 2007
Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists Fulltext Access 6 Pages 2007
Modifications of the GSK3β substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics Fulltext Access 6 Pages 2007
Synthesis and antibacterial activity of 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine quinolones Fulltext Access 6 Pages 2007
RETRACTED: Synthesis, kinetic studies and pharmacological evaluation of mutual azo prodrug of 5-aminosalicylic acid with d-phenylalanine for colon specific drug delivery in inflammatory bowel disease Fulltext Access 6 Pages 2007
A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1′ group for the β-amino hydroxamic acid derived TACE inhibitors Fulltext Access 6 Pages 2007
Transformation of the amyloidogenic peptide amylin(20–29) into its corresponding peptoid and retropeptoid: Access to both an amyloid inhibitor and template for self-assembled supramolecular tapes Fulltext Access 6 Pages 2007
Dihydro-[1H]-quinolin-2-ones as retinoid X receptor (RXR) agonists for potential treatment of dyslipidemia Fulltext Access 6 Pages 2007
Synthesis of fluorescent molecular probes specific for the receptor of blepharismone, a mating-inducing pheromone of the ciliate Blepharisma japonicum Fulltext Access 6 Pages 2007
Design and synthesis of novel and potent amide linked PPARγ/δ dual agonists Fulltext Access 6 Pages 2007
Discovery of orally bioavailable and novel urea agonists of the high affinity niacin receptor GPR109A Fulltext Access 6 Pages 2007
Synthesis and antibacterial activity of potent heterocyclic oxazolidinones and the identification of RBx 8700 Fulltext Access 6 Pages 2007
tris-Azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release Fulltext Access 6 Pages 2007
Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route Fulltext Access 6 Pages 2007
Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity Fulltext Access 6 Pages 2007
Unified QSAR approach to antimicrobials. Part 2: Predicting activity against more than 90 different species in order to halt antibacterial resistance Fulltext Access 6 Pages 2007
Chiral multinuclear macrocyclic polyamine complexes: Synthesis, characterization and their interaction with plasmid DNA Fulltext Access 6 Pages 2007
Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase Fulltext Access 6 Pages 2007
Synthesis and antitumor activity of indolylpyrimidines: Marine natural product meridianin D analogues Fulltext Access 6 Pages 2007
Synthesis and in vivo evaluation of [18F]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide as a PET imaging probe for COX-2 expression Fulltext Access 6 Pages 2007
Antidepressant-like profile of action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the forced swimming test Fulltext Access 6 Pages 2007
Synthesis and antioxidant properties of substituted 3-benzylidene-7-alkoxychroman-4-ones Fulltext Access 6 Pages 2007
Synthesis of hybrid molecules of caffeine and eudistomin D and its effects on adenosine receptors Fulltext Access 6 Pages 2007
Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase λ from a fungus, Nodulisporium sp. Fulltext Access 6 Pages 2007
Syntheses and binding affinities of 6-nitroquipazine analogues for serotonin transporter. Part 5: 2′-Substituted 6-nitroquipazines Fulltext Access 6 Pages 2007
Synthesis and antihypertensive activity of novel 3-benzyl-2-substituted-3H-[1,2,4]triazolo[5,1-b]quinazolin-9-ones Fulltext Access 6 Pages 2007
Design, synthesis, and biological activities of novel Ligustrazine derivatives Fulltext Access 6 Pages 2007
Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus Fulltext Access 6 Pages 2007
Erythrocarpines A–E, new cytotoxic limonoids from Chisocheton erythrocarpus Fulltext Access 6 Pages 2007
QSAR studies for the inhibition of the transmembrane isozymes XII and XIV of human carbonic anhydrase with a series of sulfonamides Fulltext Access 6 Pages 2007
Synthesis, determination of the absolute configuration of tonkinelin, and inhibitory action with bovine heart mitochondrial complex I Fulltext Access 6 Pages 2007
Acridone derivatives: Design, synthesis, and inhibition of breast cancer resistance protein ABCG2 Fulltext Access 6 Pages 2007
A quantitative assessment of hERG liability as a function of lipophilicity Fulltext Access 6 Pages 2007
Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors Fulltext Access 6 Pages 2007
Identification and optimization of novel 1,3,4-oxadiazole EP1 receptor antagonists Fulltext Access 6 Pages 2007
Next-generation spirobenzazepines: Identification of RWJ-676070 as a balanced vasopressin V1a/V2 receptor antagonist for human clinical studies Fulltext Access 6 Pages 2007
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13 Fulltext Access 6 Pages 2007
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists Fulltext Access 6 Pages 2007
Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors Fulltext Access 6 Pages 2007
Cytotoxic and apoptotic activities of novel amino analogues of boswellic acids Fulltext Access 6 Pages 2007
The evaluation and structure-activity relationships of 2-benzoylaminobenzoic esters and their analogues as anti-inflammatory and anti-platelet aggregation agents Fulltext Access 6 Pages 2007
1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors Fulltext Access 6 Pages 2007
Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2 Fulltext Access 6 Pages 2007
Computational approach to the basicity of a series of α1-adrenoceptor ligands in aqueous solution Fulltext Access 6 Pages 2007
Carbonic anhydrase inhibitors: Binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties Fulltext Access 6 Pages 2007
Synthesis, antimycobacterial activity evaluation, and QSAR studies of chalcone derivatives Fulltext Access 6 Pages 2007
Novel 4-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)methylbenzofuran derivatives as selective α2C-adrenergic receptor antagonists Fulltext Access 6 Pages 2007
Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor Fulltext Access 6 Pages 2007
Carbonic anhydrase inhibitors: Inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties Fulltext Access 6 Pages 2007
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions Fulltext Access 6 Pages 2007
Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library Fulltext Access 6 Pages 2007
Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2 Fulltext Access 6 Pages 2007
Structure–activity relationships of adenosines with heterocyclic N6-substituents Fulltext Access 6 Pages 2007
Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARα agonists Fulltext Access 6 Pages 2007