دانلود مقالات ISI درباره 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine + ترجمه فارسی

Preclinical development of gene therapy for Parkinson's disease

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; 6-OHDA; 6-hydroxydopamine; AADC; aromatic l-amino acid decarboxylase; AAV; adeno-associated virus; AdV; adenovirus; BH4; tetrahydrobiopterin; CNS; central nervous system; D2; dopamine D2 receptor; GABA; γ-aminobutyric acid; GAD; glutamic acid decarboxyla

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Environmental enrichment during adolescence regulates gene expression in the striatum of mice

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; EE; Enriched environments; SE; Standard Environment; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; BDNF; Brain-derived neurotrophic factor; cDNA; complementary DNA; MAPK; mitogen-activated protein kinase; GAPDH; Glyceraldehyde-3-phosphate dehydrogen

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

A cell-permeable peptide inhibitor TAT-JBD reduces the MPP+-induced caspase-9 activation but does not prevent the dopaminergic degeneration in substantia nigra of rats

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Akt/PKB; protein kinase B; Apaf-1; apoptotic protease activating factor-1; JNK; c-Jun N-terminal kinase; LEHD; Leu-Glu-His-Asp acid; MAPK; mitogen-activated protein kinase; MPP+; 1-methyl-4-phenylpyridinium ion; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydrop

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

2,3-Benzodiazepine-type AMPA receptor antagonists and their neuroprotective effects

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; ABP; AMPA receptor-binding protein; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CAMK-II and IV; Ca2+-calmodulin kinase II and IV; EAE; experimental autoimmune encephalomyelitis; EGIS-8332; (±)-1-(4-aminophenyl)-3-acetyl-4-cyano-4-meth

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2008 سفارش ترجمه

Low doses of apomorphine transiently reduce locomotor activity in MPTP-treated mice

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Parkinson disease; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Apomorphine; Levodopa; Locomotion;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

N-Methyltetrahydro-β-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic β-carbolinium cations by heme peroxidases

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPTP; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-Methyl-4-phenylpyridinium; β-Carbolinium; N-Methyltetrahydro-β-carbolines; Myeloperoxidase; Lactoperoxidase; Horseradish peroxidase; Cytochrome P450; CYP2D6; Monoamine oxidase (MAO); Parkinson’s

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Calorie restriction in nonhuman primates: assessing effects on brain and behavioral aging

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; locomotor activity; MRI; PET; basal ganglia; neuroprotection; DNA; AL; ad libitum fed; BDNF; brain derived neurotrophic factor; CR; calorie restriction; DA; dopamine; D2R; D2 dopamine receptor; MAP; motor assessment panel; MCI; mild cognitive impairment;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson’s disease

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Parkinson’s disease; Diffusion tensor imaging; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPTP; Substantia nigra; Striatum; Dopaminergic neurons

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Research ReportLipid-lowering drugs in the MPTP mouse model of Parkinson's disease: Fenofibrate has a neuroprotective effect, whereas bezafibrate and HMG-CoA reductase inhibitors do not

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; HMG-CoA; 3-hydroxy 3-methyl glutaryl co-enzyme A; MAO; monoamine oxidase; MPP+; 1-methyl-4-phenyl pyridinium; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD; Parkinson's disease; PPAR; peroxisome proliferator-activated receptor; ROS; reactive oxyg

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Acupuncture inhibits microglial activation and inflammatory events in the MPTP-induced mouse model

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Acupuncture; Parkinson’s disease; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Microglial activation; Cyclooxygenase-2; Inducible nitric oxide synthase

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Imidaprilat, an angiotensin-converting enzyme inhibitor exerts neuroprotective effect via decreasing dopamine efflux and hydroxyl radical generation induced by bisphenol A and MPP+ in rat striatum

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpyridinium ion; ACE; angiotensin-converting enzyme; HPLC; high-performance liquid chromatography; OH; hydroxyl free radical; 2,3-DHBA; 2,3-dihydroxybenzoic acid; DA; Dopamine; Angi

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Decreased susceptibility to oxidative stress underlies the resistance of specific dopaminergic cell populations to paraquat-induced degeneration

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; paraquat; substantia nigra; ventral tegmental area; calbindin; Parkinson's disease; lipid peroxidation; ANOVA; analysis of variance; CB; calbindin-D28k; DAB; 3,3′-diaminobenzidine; IACUC; Institutional Animal Care and Use Committee; MOM; Mouse-on-Mous

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Early signs of neuronal apoptosis in the substantia nigra pars compacta of the progressive neurodegenerative mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of Parkinson's disease

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; chronic parkinsonian mouse; dopaminergic neurodegeneration; microglial activation; neuroapoptosis; TUNEL; tyrosine hydroxylase; DA; dopamine; DCSP; digital chemospectrophotography; DMSO; dimethyl sulfoxide; HRLM; high resolution light microscope; IL-B4; i

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

Acute intranigral homocysteine administration produces stereotypic behavioral changes and striatal dopamine depletion in Sprague-Dawley rats

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; AD; Alzheimer's disease; COMT; catechol-O-methyl transferase; DA; dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; 5-HIAA; 5-hydroxyindolecaetic acid; 5-HT; 5-hydroxytryptamine; HVA; homovanillic acid; l-DOPA; levodopa; MPP+; 1-methyl-4-phenylpyridinium;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Alterations of the expression and activity of midbrain nitric oxide synthase and soluble guanylyl cyclase in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; neuronal nitric oxide synthase; guanylyl cyclase; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Parkinson’s disease; substantia nigra pars compactacGMP, guanosine 3′,5′-cyclic monophosphate; DA-ergic, dopaminergic; GC, guanylyl cyclase; GCβ1, guanylyl cyc

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2006 سفارش ترجمه

Sulfiredoxin: a potential therapeutic agent?

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Glutathione; Glutathionylation; Sulfiredoxin; Reactive oxygen/nitrogen species; Oxidative stress; GST; ALS; amylotrophic lateral sclerosis; ER; endoplasmic reticulum; FRDA; Friedrich's ataxia; Grx; glutaredoxin; GSH; glutathione; GSSG; glutathione disul

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Simvastatin prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion and protein tyrosine nitration in mice

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Disorders of the nervous system; Degenerative disease: Parkinson's; Simvastatin; Parkinson's disease; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Dopamine; 3-Nitrotyrosine;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Role of oxidative metabolites of cocaine in toxicity and addiction: oxidative stress and electron transfer

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; CNS; central nervous system; ET; electron transfer; OS; oxidative stress; ROS; reactive oxygen species; SO; superoxide; PCP; phencyclidine; CYP450; cytochrome P450; NO; nitric oxide; GSH; glutathione; AO; antioxidant; MDA; malondialdehyde; RNS; reactive n

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

In mice, production of plasma IL-1 and IL-6 in response to MPTP is related to behavioral lateralization

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Endocrine and autonomic regulation; Neural-immune interactions; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Interleukin-1β; Interleukin-6; Brain asymmetry; Blood; Mouse;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Behavioral responses to injections of muscimol into the subthalamic nucleus: Temporal changes after nigrostriatal lesions

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; globus pallidus; GABA; GABAA receptor; Parkinson's disease; 6-hydroxydopamine; basal ganglia; ANOVA; analysis of variance; BTCP; 3H-N-[1-92-benzo(b)thiophenylcyclohexyl]-piperidine; GAD67; glutamic acid decarboxylase (Mr 67,000); MPTP; 1-methyl-4-phenyl

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Enhanced susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in high-fat diet-induced obesity

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPP+; 1-methyl-4-phenylpuridinium; HF; high fat; DIO; diet-induced obesity; MAP-2; microtubule-associated protein 2; TH; tyrosine hydroxylase; Mn-SOD; manganese superoxide dismutase; Cu-Zn-SOD; copper-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Formation of stacking complexes between caffeine (1,2,3-trimethylxanthine) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine may attenuate biological effects of this neurotoxin

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1,2,3-trimethylxanthine; Parkinson's disease; Stacking complexes; Mutagenicity;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

Role of peroxidases in Parkinson disease: a hypothesis

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; COX-1; cyclooxygenase-1; COX-2; cyclooxygenase-2; IFN-γ; interferon-γ; IL-1β; interleukin-β; LPS; lipopolysaccharide; MAO-B; monoamine oxidase B; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MPDP; 1-methyl-4-phenyl-1,2-dihydropyridine; MPP+; 1-

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه

Sgk1, a cell survival response in neurodegenerative diseases

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ASA; acetylsalicylic acid; C; cytoplasmic fraction; DA; dopamine; DAT; dopamine transporter; DEPD; digital expression pattern display; DEX; dexamethasone; DIC; days in culture; DIG; digoxigenin;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2005 سفارش ترجمه

Somatotopy in the basal ganglia: experimental and clinical evidence for segregated sensorimotor channels

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; CMAc; caudal cingulate motor area; CMA; cingulate motor areas; DBS; deep brain stimulation; PMd; dorsal premotor cortex; GPe; globus pallidus pars externa; GPi; globus pallidus pars interna; PD; Parkinso

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2005 سفارش ترجمه

Neuroprotective properties of cultured neural progenitor cells are associated with the production of sonic hedgehog

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; sonic hedgehog; stem cells; neuroprotection; dopaminergic neurons; apoptosis; Parkinson's disease; AP; anteroposterior; bFGF; basic fibroblast growth factor; BrdU; bromodeoxyuridine; DIV; days in vitro; Dkk-1; Dick-kopf-1; DMEM; Delbeco's minimum esse

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2005 سفارش ترجمه

The role of α-synuclein in neurodegenerative diseases

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; αSp22; O-glycosylated α-synuclein; 6-OHDA; 6-hydroxydopamine; Aβ; β-amyloid; AD; Alzheimer's disease; A; adenine; Ala; alanine; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; AR-JP; autosomal recessive juvenile parkinsonism; BS3;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2005 سفارش ترجمه

The functional role of the subthalamic nucleus in cognitive and limbic circuits

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; AC; anterior commissure; ADL; activities of daily living; CM; centromedian nucleus of the thalamus; CRT; choice reaction time; DLPC; dorsolateral prefrontal cortex; DPC; dorsolateral prefrontal circuit; DRN; dorsal raphe nucleus; EP; entopeduncular nucleu

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2005 سفارش ترجمه

Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; DEP; diesel exhaust particles; PM; particulate matter; PD; Parkinson's disease; AD; Alzheimer's disease; ROS; reactive oxygen species; NO; nitric oxide; TNFα; tumor necrosis factor-alpha; TH; tyrosine hydroxylase; Aβ; beta-amyloid; LPS; lipopolysacharid

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2005 سفارش ترجمه

Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Aβ; β-amyloid; AD; Alzheimer's disease; AIF; apoptosis-inducing factor; ALS; amyotrophic lateral sclerosis; Apaf-1; apoptotic protease-activating factor; APC; adenomatous polyposis coli; APP; amyloid precursor protein; BrdU; bromodeoxyuridine; CARD; cas

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2005 سفارش ترجمه

Therapeutic potential of adenosine A2A receptor antagonists in Parkinson's disease

Keywords: 1-methyl-4-phenyl-1،2،3،6-tetrahydropyridine; Adenosine A2A receptor; Caffeine; Dyskinesia; Neuroprotection; Parkinson's disease; Striatum; 6-OHDA; 6-hydroxydopamine; ACh; acetylcholine; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; APEC; 2-[(2-aminoethylamino)carbonylethyl-phenylethyl

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2005 سفارش ترجمه