Keywords: WHC-17; Woodchuck; Mitochondria; Cinnamic; Sinapic; Ferullic; CA; caffeic acid; FA; ferulic acid; HCC; hepatocellular carcinoma; ECAR; extra cellular acidification rate; TAE; transarterial embolization; FBS; fetal bovine serum; DMSO; dimethylsulfoxide; PB
مقالات ISI (ترجمه نشده)
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Keywords: RA; rheumatoid arthritis; RF; rheumatoid factor; ACPA; anti-citrullinated protein antibodies; AA; arachidonic acid; PG; prostaglandins; LT; leukotrienes; TX; thromboxanes; LX; lipoxins; NSAID; non steroidal anti-inflammatory drugs; COXIB; COX-2 selective
Keywords: Allergy; Eosinophils; Interleukin-18; iNKT cells; Mast cells; 5-LO; 5-lipooxygenase; APC; antigen-presenting cell; ASC; apoptosis-associated speck-like protein; CTMC; connective-tissue mast cell; DC; dendritic cell; ECP; eosinophil cationic protein; EoE;
Keywords: 5-Lipoxygenase inhibitor; Inflammation; Triazole; Polyphenol; Caffeic acid; Zileuton; 5-LO; 5-Lipoxygenase; LT; Leukotriene; AA; Arachidonic Acid; SAR; Structure-Activity Relationship; CuAAC; Copper(I)-catalysed Azide Alkyne Cycloaddition; DCC; Dicyclohex
Keywords: Diversity-oriented synthesis; Imidazoheterocyclic; Groebke-Blackburn-Bienayme reaction; Fused imidazole; Lewis acid; Ugi type; Ac; acetyl; Aq; aqueous; Ar; aryl; Bn; benzyl; Boc; tert-butoxycarbonyl; BDMS; bromodimethylsulfonium bromide; CDK; cyclin-d
Keywords: Mouse paw edema; Chemotaxis; Inhibition of apoptosis; Pro-inflammatory eicosanoids; Reactive oxygen species; Urease inhibitor; rHPU; recombinant Helicobacter pylori urease; LTB4; leukotriene B4; ROS; reactive oxygen species; PMA; phorbol 12-myristate 13-a
Keywords: AA; arachidonic acid; COX; cyclooxygenase; EDTA; ethylenediaminetetraacetate; ESI; electrospray ionization; fMLP; formyl-methionyl-leucyl-phenylalanine; 12-HHT; 12(S)-hydroxy-5-cis-8,10-trans-heptadecatrienoic acid; 5-H(P)ETE; 5(S)-hydro(pero)xy-6-trans-8
Keywords: Mast cell; Atherosclerosis; Restenosis; Aneurysm; Vein graft; Vascular remodeling; 5-LO; 5-lipoxygenase; AAA; abdominal aortic aneurisma; ABCA1; ATP-binding cassette transporter A1; ACE; angiotensin converting enzyme; ACEI; angiotensin converting enzyme i
Treatment targets for M2 microglia polarization in ischemic stroke
Keywords: PACAP; pituitary adenylate cyclase-activating polypeptide; OGA; beta-N-acetylglucosaminidase; FAM19A3; TAFA3, TAFA family (TAFA1-5); TPA; tissue plasminogen activator; GSH; glutathione-SH; NGF; nerve growth factor; BCL-2/BCL-X1; B cell leukemia/lymphoma
Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys
Keywords: 5-HETE; 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid; 5-oxo-ETE; 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; 5-LO; 5-lipoxygenase; DMP; Dess-Martin periodinane; PTSA; p-toluenesulfonic acid; DHP; 3,4-dihydro-2H-pyran; LT; leukotriene; TBDPS-Cl; tert-buty
The role of T cells in the pathogenesis of Parkinson's disease
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APC; antigen-presenting cell; AQP4; Aquaporin-4; BBB; blood-brain barrier; BCL6; B cell lymphoma 6; BCR; B cell receptor; BEC; brain endothelial cells; CCL20; C-C motif ligand 20; CCR2; C-C
Pulmonary sarcoidosis is associated with exosomal vitamin D-binding protein and inflammatory molecules
Keywords: Exosomes; extracellular vesicles; sarcoidosis; leukotrienes; vitamin D-binding protein; proteome; biomarkers; complement; BAL; Bronchoalveolar lavage; BALF; Bronchoalveolar lavage fluid; FITC; Fluorescein isothiocyanate; 5-LO; 5-Lipoxygenase; LT; Leukot
5-Lipoxygenase in monocytes emerges as a therapeutic target for intimal hyperplasia in a murine wire-injured femoral artery
Keywords: 5-LO; 5-lipoxygenase; WT; Wild-type; FLAP; 5-lipoxygenase activating protein; LT; leukotriene; ROS; reactive oxygen species; MMP; matrix metalloproteinases; DAMP; damage-associated molecular patterns; HMGB1; high mobility group box 1 protein; VSMC; vascul
The Leukotriene B4 and its Receptor BLT1 Act as Critical Drivers of Neutrophil Recruitment in Murine Bullous Pemphigoid-Like Epidermolysis Bullosa Acquisita
Keywords: 5-LO; 5-lipoxygenase; BP; bullous pemphigoid; EBA; epidermolysis bullous acquisita; LTB4; leukotriene B4; ROS; reactive oxygen species;
Endogenous secreted phospholipase A2 group X regulates cysteinyl leukotrienes synthesis by human eosinophils
Keywords: Eosinophil; leukotriene; phospholipase A2; mitogen-activated kinase; asthma; allergy; 5-LO; 5-Lipoxygenase; cPLA2α; Cytosolic phospholipase A2α; CysLT; Cysteinyl leukotriene; DMSO; Dimethyl sulfoxide; ER; Endoplasmic reticulum; ERK1/2; Extracellular-sig
BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly
Keywords: 5-LO; 5-lipoxygenase; AA; arachidonic acid; COX; cyclooxygenase; cPLA2; cytosolic phospholipase A2; FLAP; 5-lipoxygenase-activating protein; fMLP; N-formyl-methionyl-leucyl-phenylalanine; H(P)ETE; hydro(pero)oxyeicosatetraenoic acid; HHT; hydroxyheptadeca
Bronchipret® syrup containing thyme and ivy extracts suppresses bronchoalveolar inflammation and goblet cell hyperplasia in experimental bronchoalveolitis
Keywords: Acute bronchitis; Thyme; Ivy; Anti-inflammatory; Goblet cells; 5-lipoxygenase; AA; arachidonic acid; AB; acute bronchitis; 5-LO; 5-lipoxygenase; BALF; bronchoalveolar lavage fluid; BLT; LTB4 receptor; BRO; Bronchipret® syrup; LT; leukotriene; COX; cycloo
5-Lipoxygenase is a direct p53 target gene in humans
Keywords: ALOX5; arachidonate 5-lipoxygenase gene; 5-LO; 5-lipoxygenase; PTMs; posttranslational modifications; AA; arachidonic acid; 5-HETE; 5-hydroxyeicosatetraenoic acid; LT; leukotriene; FLAP; 5-lipoxygenase activating protein; HEPES; 4-(2-hydroxyethyl)-1-piper
Recent advances for FLAP inhibitors
Keywords: FLAP; 5-LO; Leukotrienes; Cardiovascular; Inflammatory;
Clostridium difficile-induced colitis in mice is independent of leukotrienes
Keywords: Clostridium difficile; Leukotriene; Eicosanoid; Nosocomial infectionCDI, Clostridium difficile infection; TcdA, Clostridium difficile toxin A; TcdB, Clostridium difficile toxin B; LT, leukotriene; LTB4, leukotriene B4; CysLTs, cysteinyl leukotrienes; 5-LO
Identification of pirinixic acid derivatives bearing a 2-aminothiazole moiety combines dual PPARα/γ activation and dual 5-LO/mPGES-1 inhibition
Keywords: PPARα; PPARγ; Inflammation; 5-LO; mPGES-1; Cancer;
ReviewHelichrysum italicum: From traditional use to scientific data
Keywords: 5-LO; 5-Lipoxygenase; COX; cyclooxygenase; IC; inhibitory concentration; IL; interleukin; TNFα; tumor necrosis factor α; PGE2; prostaglandin E2; LPS; lipopolysaccharides; MIC; minimum inhibitory concentration; HIV; human immunodeficiency virus; LTR; lon
Prostaglandin E2 resistance in granulocytes from patients with aspirin-exacerbated respiratory disease
Keywords: Samter's triad; aspirin-exacerbated respiratory disease; AERD; aspirin triad; nonsteroidal anti-inflammatory drug; asthma; leukotriene; protein kinase A; prostaglandin E2; cyclic AMP; 5-LO; 5-Lipoxygenase; ADPβS; Adenosine diphosphate 5â²-[β-thio]dipho
Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling
Keywords: PGI2; allergy; immune tolerance; BAL; Bronchoalveolar lavage; COX; Cyclooxygenase; IP; PGI2 receptor; KO; Knockout; LTE4; Leukotriene E4; 5-LO; 5-Lipoxygenase; MLN; Mediastinal lymph nodes; OVA; Ovalbumin; PGE2; Prostaglandin E2; PGI2; Prostaglandin I2; T
Molecular targets on mast cells and basophils for novel therapies
Keywords: Mast cell; basophil; mediator; receptor; signaling protein; survival protein; drug; therapy; BCL-2; B-cell lymphoma 2; BH; BCL-2 homology; Bs; Basophils; BTK; Bruton tyrosine kinase; CB; Endocannabinoid receptor; CRAC; Calcium release-activated calcium;
5-Lipoxygenase contributes to PPARγ activation in macrophages in response to apoptotic cells
Keywords: 5-LO; 5-lipoxygenase; AC; apoptotic cell(s); CV; control virus; d/n; dominant negative; F5; fraction 5; FF; firefly; FLAP; 5-LO activating protein; LC; living cell(s); LR; lipid raft(s); Luc; luciferase; M; marker; MΦ; macrophage(s); mÃCDT; methyl-Ã-cy
Yin-Yang regulation of prostaglandins and nitric oxide by PGD2 in human arthritis: Reversal by celecoxib
Keywords: PGD2; prostaglandin D2; PGE2; prostaglandin E2; DP2; prostanoid receptor DP2; L-PGDS; lipocalin-prostaglandin (PG) D synthase; H-PGDS; hematopoietic-prostaglandin (PG) D synthase; NO; nitric oxide; COX-1 or Ptgs1; cyclooxygenase 1; COX-2 or Ptgs2; cycloox
Effect of endocannabinoids on IgE-mediated allergic response in RBL-2H3 cells
Keywords: 2-AG; 2-arachidonoyl glycerol; 5-LO; 5-lipoxygenase; Akt; protein kinase B; CB; cannabinoid; COX-2; cyclooxygenase-2; cPLA2; cytosolic phospholipase A2; ERK1/2; extracellular signal-regulated kinase 1/2; FAAH; fatty acid amide hydrolase; Gab2; GRB2-associ
The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor
Keywords: 12-HHT; 12-hydroxy-5Z,8E,10E-heptadecatrienoic acid; 5,12-diHETE; 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid; 5,15-diHETE; 5S,15S-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid; 5-HEDH; 5-hydroxyeicosanoid dehydrogenase; 5-HEPE; 5S-hydroxy-6E,8Z,
Genetic determinants of 5-lipoxygenase pathway in a Spanish population and their relationship with cardiovascular risk
Keywords: Thrombosis; 5-lipoxygenase; LTA4-hydrolase; LTC4-synthase; FLAP; Leukotrienes; COX; cyclooxygenase; EIA; specific enzyme immunoassay; FLAP; five lipoxygenase activating protein; 5-LO; 5-lipoxygenase; LTA4-H; LTA4-hydrolase; LTC4-S; LTC4-synthase;
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors
Keywords: 5-LO; 5-lipoxygenase; AA; arachidonic acid; CML; chronic myeloid leukemia; cPLA2; cytosolic phospholipase A2; FLAP; 5-LO-activating protein; 5-H(P)ETE; 5(S)-hydro(pero)xy-6-trans-8,11,14-cis-eicosatetraenoic acid; LDH; lactate dehydrogenase; LT; leukotrie
Identification of novel benzimidazole derivatives as inhibitors of leukotriene biosynthesis by virtual screening targeting 5-lipoxygenase-activating protein (FLAP)
Keywords: AA; arachidonic acid; cPLA2; cytosolic phospholipase A2; FLAP; 5-lipoxygenase-activating protein; 5-HpETE; 5-hydroperoxyeicosatetraenoic acid; 5-LO; 5-lipoxygenase; LT; leukotriene; PGC buffer; phosphate-buffered saline pH 7.4 containing 1Â mg/mL glucose
A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold
Keywords: Inflammation; Arachidonic acid cascade; SAR; mPGES-1; 5-LO
5-Oxo-ETE is a major oxidative stress-induced arachidonate metabolite in B lymphocytes
Keywords: BCNU; 1,2-bis(2-chloroethyl)-1-nitrosourea (carmustine); 12-HHT; 12S-hydroxy-6,8,11-heptadecatrienoic acid; 13-HODE; 13S-hydroxy-9Z,11E-octadecadienoic acid; 5-HEDH; 5-hydroxyeicosanoid dehydrogenase; 5-LO; 5-lipoxygenase; 5-oxo-ETE; 5-oxo-6,8,11,14-eicos
Identification of rosmarinic acid as the major active constituent in Cordia americana
Keywords: Cordia americana; Boraginaceae; Rosmarinic acid; Anti-inflammatory; p38α MAPK; TNFα; 5-LO; NF-κB activation; Fibroblast scratch assay
Role of DNA methylation and methyl-DNA binding proteins in the repression of 5-lipoxygenase promoter activity
Keywords: 5â²-AdC; 5â²-aza-2â²-deoxycytidine; 5-LO; 5-lipoxygenase; ChIP; chromatin immunoprecipitation assay; MBDs; methyl-DNA binding protein; MM6; Mono Mac 6 cells; RLU; relative luminescence units; shRNA; small hairpin RNA; 5âlipoxygenase; DNA methylation;
Exosomes from human macrophages and dendritic cells contain enzymes for leukotriene biosynthesis and promote granulocyte migration
Keywords: Antigen-presenting cells; eicosanoids; exosomes; inflammation; leukotrienes; TGF-β1; AA; Arachidonic acid; APC; Antigen-presenting cell; cysLT; Cysteinyl leukotriene; DC; Dendritic cell; FITC; Fluorescein isothiocyanate; FLAP; 5-Lipoxygenase-activating
Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions
Keywords: Peanut allergy; anaphylaxis; mast cells; histamine; PAF; leukotrienes; mathematical modeling; 5-LO; 5-Lipoxygenase; AU; Area under response; cysLT; Cysteinyl leukotriene; MC; Mast cell; PA; Peanut allergy; PAF; Platelet-activating factor; PAF-R; Platelet-
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein
Keywords: 5-LO; FLAP; LT; Asthma; Inflammatory bowel disease; Rheumatoid arthritis; Psoriasis; Atherosclerosis
Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages
Keywords: AA; arachidonic acid; AK; protein kinase A; AM; alveolar macrophages; ANF; atrial naturetic factor; BSA; bovine serum albumin; EIA; enzyme-linked immunoassay; 5-LO; 5-lipoxygenase; FLAP; 5-lipoxygenase activating protein; GC; guanylyl cyclase; GK; protein
Eicosanoid Lipid Mediators in Fibrotic Lung Diseases
Keywords: airway remodeling; leukotrienes; prostaglandins; pulmonary fibrosis; cAMP; cyclic adenosine monophosphate; cysLT; cysteinyl leukotriene; COX; cyclooxygenase; cysLT1; cysteinyl leukotriene receptor 1; EP; E prostanoid receptor; IL; interleukin; IP; I prost
Regulation of the eicosanoid pathway by tumour necrosis factor alpha and leukotriene D4 in intestinal epithelial cells
Keywords: Leukotriene D4; LTD4; CysLT1R; CysLT2R; LTC4S; TNF-α; Intestinal epithelial cells; 5-LO; COX-2
Reactive oxygen species are generated through a BLT2-linked cascade in Ras-transformed cells
Keywords: ROS; reactive oxygen species; cPLA2; cytosolic phospholipase A2; AA; arachidonic acid; LTs; leukotrienes; 5-LO; 5-lipoxygenase; FLAP; 5-lipoxygenase activating protein; COXs; cyclooxygenases; BSA; bovine serum albumin; DPI; diphenylene iodonium; NAC; N-ac
Role of MUC5AC in the pathogenesis of exercise-induced bronchoconstriction
Keywords: Asthma; exercise-induced bronchoconstriction; epithelial cell; goblet cell; mucin; AREG; Amphiregulin; AUC; Area under the FEV1 time curve; cysLT; Cysteinyl leukotriene; DTT; Dithiothreitol; EGF; Epidermal growth factor; EIB; Exercise-induced bronchoconst
Functional characterization of vitamin D responding regions in the human 5-Lipoxygenase gene
Keywords: 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 5-LO; 5-lipoxygenase; ANF; atrial natriuretic factor; ARP0; acidic riboprotein P0; ChIP; chromatin immunoprecipitation; CYP24; 24-hydroxylase; DR; direct repeat; ER; everted repeat; FCS; fetal calf serum; MM6; Mo
Evaluation of the anti-inflammatory and analgesic activity of Me-UCH9, a dual cyclooxygenase-2/5-lipoxygenase inhibitor
Keywords: COX-2; 5-LO; Anti-inflammatory activity; Analgesic activity; Angiogenesis; Chalcone derivatives
Phenylsulphonyl urenyl chalcone derivatives as dual inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase
Keywords: COX-2; 5-LO; Chalcone derivatives
Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site
Keywords: ChIP; chromatin immunoprecipitation; 1,25(OH)2D3; 1,25-dihydroxyvitamin D3; EMSA; electrophoretic mobility shift assay; HDAC; histone deacetlyase; 5-HPETE; 5-hydroperoxyeicosatetraenoic acid; 5-LO; 5-lipoxygenase; rANF; rat atrial natriuretic factor; RLU;
Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae)
Keywords: NSAIDs; non-steroidal anti-inflammatory drugs; COX-1; cyclooxygenase 1; COX-2; cyclooxygenase 2; 5-LO; 5-lipoxygenase; TLC; thin layer chromatography; NP/PEG; natural products-polyethylene glycol; 5-HT; 5-hydroxytryptamine (serotonine); bAP; butanolic Aca
Leukotriene E4-induced persistent eosinophilia and airway obstruction are reversed by zafirlukast in patients with asthma
Keywords: Asthma; airways; biopsies; CysLT1 receptor; LTE4; inflammation; eosinophilia; CysLT; Cysteinyl leukotriene; 5-LO; 5-Lipoxygenase; LT; Leukotriene; Mab; Mouse monoclonal antibodies;