Keywords: Idiopathic normal pressure hydrocephalus; Alzheimer's disease; Amyloid-beta; Total tau protein; Lumbo-peritoneal shunt surgery; Treatment; NPH; normal pressure hydrocephalus; iNPH; idiopathic NPH; AD; Alzheimer's disease; iNPH/ADÂ +; Â iNPH patients with
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Keywords: Inclusion-body myositis; Review; Pathogenesis; Classification; Therapeutic management; Aβ42; amyloid-β42; AβPP; amyloid-β precursor protein; BACE-1; β-secretase 1; cN1A; cytosolic 5â²-nucleotidase 1A; COX; cytochrome c oxidase; HMGB1; high-mobility
Keywords: CR; cerebellum; VC; visual cortex; DLPFC; dorsolateral prefrontal cortex; EC; Brodmann's areas; BA; entorhinal cortex; SFG; superior frontal gyrus; HIP; hippocampus; MTG; middle temporal gyrus; PCG; posterior cingulate cortex; MeV; MultiExperiment Viewer;
Keywords: Aβ; β-Amyloid peptide; Aβ40; 40-amino acid isoform of β-Amyloid peptide; Aβ42; 42-amino acid isoform of β-Amyloid peptide; Aβ42/Aβ40; ratio of measured steady-state levels of Aβ42 and Aβ40; AD; Alzheimer's Disease; AICD; APP intracellular domain
Keywords: Aβ40; beta-amyloid, amino acids 1-40; Aβ42; beta-amyloid, amino acids 1-42; AD; Alzheimer's disease; ADNI; Alzheimer's Disease Neuroimaging Initiative; ADRDA; Alzheimer's Disease and Related Disorders Association; CREB; cAMP response element-binding
Keywords: Aβ42; 42 residue-length amyloid β peptide; AD; Alzheimer's disease; ATG1; autophagy-specific gene 1; cfu; colony-forming units; CHC; central hydrophobic cluster; DMSO; dimethyl sulfoxide; EtOH; ethanol; GFP; green fluorescent protein; HD; Huntington's d
Keywords: AD; Alzheimer's disease; Aβ; beta-amyloid; Aβ42; amyloid-β peptide fragment 1-42; ACh; acetylcholine; AChE; acetylcholinesterase; AChI; acetylcholine iodide; BTA; benzothiazole; CAS; catalytic active site; DPPH; 2,2-diphenyl-1-picrylhydrazyl radica
A new purified Lawsoniaside remodels amyloid-β42 fibrillation into a less toxic and non-amyloidogenic pathway
Keywords: Aβ42; β-amyloid peptide42; AD; Alzheimer's disease; BSA; bovine serum albumin; CD; circular dichroism; CTX-B; cholera toxin subunit B; DLS; dynamic light scattering; DMSO; dimethyl sulfoxide; FRET; fluorescence resonance energy transfer; GM1; monosialot
Early striatal amyloid deposition distinguishes Down syndrome and autosomal dominant Alzheimer's disease from late-onset amyloid deposition
Keywords: Down syndrome; Autosomal dominant Alzheimer dementia; Pittsburgh compound B; Striatum; Diffuse plaque; Aβ42;
Plasma pharmacokinetics and cerebral nuclei distribution of major constituents of Psoraleae fructus in rats after oral administration
Keywords: Psoraleae fructus; Pharmacokinetics; Cerebral nuclei distribution; Coumarins; Prenylflavonoids; LC-MS/MS; ACN; acetonitrile; AUC; area under curve; Aβ42; β-amyloid 42; CE; collision energy; Cmax; maximum drug concentration; CMC-Na; carboxymethyl cellulo
Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse
Keywords: Alzheimer's disease; Posiphen; APP; Aβ42; CTFα; CTFβ; APP/PS1; Cognition; Long-term potentiation;
A pectin from fruits of Lycium barbarum L. decreases β-amyloid peptide production through modulating APP processing
Keywords: Lycium barbarum L.; Pectin; Aβ42; Alzheimer's disease; Amyloid precursor protein processing;
Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-β(1-42)
Keywords: Amyloid; Aβ42; Aggregation; 1,4-naphthoquinone; Menadione sodium bisulfite; Caenorhabditis elegans;
Screening for amyloid-β aggregation inhibitor and neuronal toxicity of eight Tunisian medicinal plants
Keywords: Aβ42; β-Amyloid peptide 42; ABTS; 2â²-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid; AD; Alzheimer disease; BSA; bovine serum albumin; CD; Circular Dichroism; CM-H2 DCFDA; 2,7-dichlorofluorescin diacetate acetyl ester; CTX-B; cholera toxin subunit
Longitudinal structural cerebral changes related to core CSF biomarkers in preclinical Alzheimer's disease: A study of two independent datasets
Keywords: AD; Alzheimer's disease; Aβ42; amyloid beta; p-tau; phosphorylated tau; t-tau; total tau; Ctrl; control; preAD; preclinical Alzheimer's disease; HCB; Hospital Clinic Barcelona; ADNI; Alzheimer's Disease Neuroimaging Initiative; MMSE; Mini Mental State ex
MFG-E8 inhibits Aβ-induced microglial production of cathelicidin-related antimicrobial peptide: A suitable target against Alzheimer's disease
Keywords: Aβ42; MFG-E8; Microglia; CRAMP; Alzheimer's disease;
An arabinogalactan from fruits of Lycium barbarum L. inhibits production and aggregation of Aβ42
Keywords: Lycium barbarum; Polysaccharide; Aβ42; Alzheimer's disease;
Competitive homo- and hetero- self-assembly of amyloid-β 1-42 and 1-40 in the early stage of fibrillation
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β peptide; Aβ40; amyloid-β peptide (1-40); Aβ42; amyloid β peptide (1-42); APP; amyloid precursor protein; Ala; alanine; ATD; arrival time distribution; CCS; collision cross section; DTIMS; drift tube ion m
Correlations between CSF proteins and spontaneous neuronal activity in Parkinson's disease
Keywords: BJLO; Benton Judgment of Line Orientation; fALFF; fractional amplitude of low-frequency fluctuation; HVLT-R; Hopkins Verbal Learning Test-Revised; HVLT-R_Dis_Rec; Hopkins Verbal Learning Test-Revised recognition discrimination index; LNS; Letter Number Se
Amelioration by nitric oxide (NO) mimetics on neurobehavioral and biochemical changes in experimental model of Alzheimer's disease in rats
Keywords: Alzheimer's disease; Icv streptozotocin; Aβ40; Aβ42; BDNF; GSNO;
CSF biomarkers β-amyloid, tau proteins and a-synuclein in the differential diagnosis of Parkinson-plus syndromes
Keywords: Aβ42; beta-amyloid; AD; Alzheimer's disease; ANCOVA; analysis of covariance; ANOVA; analysis of variance; a-syn; a-synuclein; CBD; Corticobasal degeneration; CBS; corticobasal syndrome; CBS-AD; corticobasal syndrome with underlying AD pathology; CBS-non-
Expression of MEGF10 in cholinergic and glutamatergic neurons
Keywords: MEGF10; multiple-EGF like domains 10; ABCA1; ATP binding cassette transporter 1; Aβ42; amyloid-β protein 42; AD; Alzheimer's disease; EMEM; Eagle's minimum essential medium; FBS; fetal bovine serum; GM-CSF; granulocyte macrophage colony stimulating fact
Amyloid β concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis
Keywords: Amyloid β; Aβ42; Turnover; Kinetics; Human; Plasma;
Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid
Keywords: Alzheimer's; Aβ42; Synaptic vesicles; Neuronal activation; Synapsin; VPA;
Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils
Keywords: AD; Alzheimer's disease; GAGs; glycosaminoglycans; Aβ40; A-beta 40-residue peptide; Aβ42; A-beta 42-residue peptide; SSNMR; solid-state NMR; LMWH; low-molecular-weight heparin; HS; heparan sulfate; WT; wild-type; NS; N-sulfate; 6-OS; 6-O-sulfate; 2-OS;
Modulating amyloid-β aggregation: The effects of peptoid side chain placement and chirality
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β protein; Aβ40; amyloid-β 1-40; Aβ42; amyloid-β 1-42; HD; Huntington's disease; ThT; thioflavin T; DMF; dimethylformamide; TFA; trifluoroacetic acid; HPLC; high performance liquid chromatography; TEM; tr
Trans-crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients
Keywords: AD; Alzheimer's Disease; Aβ42; amyloid-β (1-42); CatB; cathepsin B; SAD; sporadic form of Alzheimer's Disease; Alzheimer's Disease; Trans-crocetin; Crocus sativus L.; Aβ42 degradation; Cathepsin B; Monocytes;
Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review
Keywords: Aβ42; β-amyloid42; ABCA1; ATP-Binding Cassette Transporter A1; AD; Alzheimers disease; ADAM; AD-related disintegrin and metalloprotease; AICD; APP- intracellular domain; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ApoE; ApolipoproteinE;
β-Amyloid induces nuclear protease-mediated lamin fragmentation independent of caspase activation
Keywords: Aβ; β-Amyloid; Aβ42; 42-amino-acid Aβ; AD; Alzheimer's disease; AMC; aminomethylcoumarin; LA; lamin A; LB; lamin B; LC; lamin C; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NS; nuclear scaffold; STS; staurosporine; β-amyloid; A
Increased albumin CSF/serum ratio in dementia with Lewy bodies
Keywords: Cerebrospinal fluid; Biomarker; Aβ42; Dementia with Lewy bodies; Synucleinopathies; Neurodegenerative diseases; Dementia; Albumin ratio;
An Aβ42 uptake and degradation via Rg3 requires an activation of caveolin, clathrin and Aβ-degrading enzymes in microglia
Keywords: Rg3; Aβ42; Macrophage scavenger receptor class A; Endocytosis; Neprilysin; Insulin degrading enzyme;
Cardioprotective potential of annexin-A1 mimetics in myocardial infarction
Keywords: Ac2-26; Cardioprotection; Cardiomyopathy; Formyl peptide receptors; Inflammation; Ischemia-reperfusion; Aβ42; 42-amino acid beta-amyloid peptide; ABC; ATP-binding cassette; Ac2-26; N-terminal-derived annexin-A1 peptide (acetyl-AMVSEFLKQAWIENEEQEYVVQTVK
The membrane-active amphibian peptide caerin 1.8 inhibits fibril formation of amyloid β1-42
Keywords: Aβ42; Amyloid β1-42 peptide; AD; Alzheimer's disease; APP; Amyloid precursor protein; HPLC; High performance liquid chromatography; IC50; Half maximal inhibitory concentration; MALDI; Mass analysed laser desorption ionization; MD; Molecular dynamics;
Imatinib treatment and Aβ42 in humans
Keywords: Aβ42; Imatinib; Plasma; CML; Alzheimer's disease;
Association of cerebrospinal fluid Aβ42 with A2M gene in cognitively normal subjects
Keywords: Alzheimer's disease; Cerebrospinal fluid; Aβ42; alpha-2-Macroglobulin; A2M; APOE;
Sodium phenylbutyrate reverses lysosomal dysfunction and decreases amyloid-β42 in an in vitro-model of inclusion-body myositis
Keywords: Aβ42; amyloid beta 42; AD; Alzheimer disease; Baf; bafilomycin A1; CHMFs; cultured human muscle fibers; Chl; chloroquine; HDAC; histone deacetylase; iNOS; inducible nitric oxide synthase; NaPB; sodium phenylbutyrate; PD; Parkinson disease; s-IBM; sporadi
Neuroscience Forefront ReviewSensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins
Keywords: AD; Alzheimer's disease; Aβ42; amyloid-β 42; CMAH; cytidine monophosphate-N-acetylneuraminic acid hydroxylase; CNS; central nervous system; Ig; immunoglobulin; IL-1β; interleukin-1β; ITAMs; immunoreceptor tyrosine-based activation motifs; ITIM; immu
Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: Implications for a novel therapeutic strategy for Alzheimer's disease
Keywords: AD; Alzheimer's disease; Aβ40; 40-mer amyloid β-protein; Aβ42; 42-mer amyloid β-protein; DIV; days in vitro; IgG; immunoglobulin G; iPSCs; induced pluripotent stem cells; MTT; 3-(4,5-di-methylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NMR; nucle
Chitosan oligosaccharides protect rat primary hippocampal neurons from oligomeric β-amyloid 1-42-induced neurotoxicity
Keywords: AD; Alzheimer's disease; Aβ; β-amyloid peptide; APP; amyloid precursor protein; SPs; senile plaques; NFTs; neurofibrillary tangles; ROS; reactive oxygen species; COSs; chitosan oligosaccharides; Aβ42; β-amyloid fragments 1-42; HFIP; 1,1,1,3,3,3-hexafl
Pre-analytical factors influencing the stability of cerebrospinal fluid proteins
Keywords: CSF; cerebrospinal fluid; LP; lumbar puncture; Aβ42; amyloid-beta 1-42; P-tau; phosphorylated tau; AD; Alzheimer's disease; SELDI-TOF MS; surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry; RT; room temperature; Cerebrospinal
Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors
Keywords: Alzheimer's disease; γ-Secretase; Aβ42; APP-YAC; In vivo clearance;
Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model
Keywords: Aβ42; amyloid-β-42; AD; Alzheimer's disease; dFOXO; Drosophila forkhead box subgroup O; JNK; Jun-N-terminal kinase; Alzheimer's disease; Apoptosis; dFOXO; Drosophila; Jun-N-terminal kinase;
Differences in brain cholesterol metabolism and insulin in two subgroups of patients with different CSF biomarkers but similar white matter lesions suggest different pathogenic mechanisms
Keywords: Alzheimer disease; Cholesterol; Oxysterols; Hyperintensities; Aβ42; Tau;
A plant cell-based system that predicts aβ42 misfolding: Potential as a drug discovery tool for Alzheimer's disease
Keywords: AD; Alzheimer's disease; Aβ42; amyloid β42; EGCG; epigallocatechin-3-gallate; Hpt II; hygromycin phosphotransferase II; GFP; green fluorescent protein; Alzheimer's disease; Amyloid β (Aβ); Protein misfolding/aggregation; GFP; HptII; Plant cell;
Inhibitory effect of curcumin on the Al(III)-induced Aβ42 aggregation and neurotoxicity in vitro
Keywords: AD; Alzheimer's disease; Aβ42; amyloid-β 42; Al(III); Aluminum ion; CD; circular dichroism; ThT; thioflavin T; AFM; atomic force microscopy; HFIP; hexafluoroisopropanol; CBB; Coomassie Brilliant Blue; A595; absorption at wavelength of 595 nm; Alzheimer
Crosstalk between the ubiquitin-proteasome system and autophagy in a human cellular model of Alzheimer's disease
Keywords: AβPP; amyloid-β precursor protein; Aβ40; amyloid-β (1-40); Aβ42; amyloid-β (1-42); UPS; ubiquitin-proteasome system; HDAC6; histone deacetylase 6; ChT-L; chymotrypsin-like; T-L; trypsin-like; PGPH; peptidylglutamyl-peptide hydrolyzing; AP-N; a
Neurodegeneration the RNA way
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; Aβ42; amyloid β - 42 amino acids; CUGBP1; CUG binding protein 1; DM1; myotonic dystrophy type 1; DM2; myotonic dystrophy type 2; FTD; frontotemporal dementia;
The correlation of plasma Aβ42 levels, depressive symptoms, and cognitive function in the Korean elderly
Keywords: Aβ42; amyloid beta 1-42; AD; Alzheimer's disease; MMSE-KC; Mini-Mental State Examination-Korean version; SGDS-K; Short Form Geriatric Depression Scale-Korean version; Cognitive function; Depressive symptoms; Plasma Aβ42;
Role of Aβ-receptor for advanced glycation endproducts interaction in oxidative stress and cytosolic phospholipase A2 activation in astrocytes and cerebral endothelial cells
Keywords: Aβ42; RAGE; NADPH oxidase; ERK; cPLA2; AbRAGE; anti-RAGE antibody; AD; Alzheimer's disease; Aβ; amyloid-β peptide; Aβ42; amyloid-β oligomers; BBB; blood-brain barrier, CEC, cerebral endothelial cell; cPLA2; cytosolic phospholipase A2; ERK; extracel
CSF biomarker pathology correlates with a medial temporo-parietal network affected by very mild to moderate Alzheimer's disease but not a fronto-striatal network affected by healthy aging
Keywords: Aβ42; Cerebral cortex; Hippocampus; Magnetic resonance imaging; Tau proteins;