Inhibitory effect of curcumin on the Al(III)-induced Aβ42 aggregation and neurotoxicity in vitro

► Al(III) promotes Aβ42 fibrillation, leading to the high neurotoxicity to PC12 cells. ► Curcumin is able to inhibit the formation of Al(III)-induced Aβ42 fibrillation. ► Al(III)-curcumin complexes can remold the Aβ42 fibrils into amorphous aggregates.