Design, synthesis and biological evaluation of potent FAAH inhibitors
Keywords: FAAH inhibitor; AEA; PEA; Cannabinoid receptors; PPAR-α;
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A Refractory Celiac Patient Successfully Treated With Mesenchymal Stem Cell Infusions
Keywords: AEA; antienterocyte antibody; ATA; anti-tissue transglutaminase antibody; B; basophils; CD; celiac disease; Cl; serum chloride; E; eosinophils; EMA; antiendomysial antibody; HC; healthy control; IEL; intraepithelial lymphocyte; Ig; immunoglobulin; IL; i
Docosahexaenoic acid attenuates in endocannabinoid synthesis in RAW 264.7 macrophages activated with benzo(a)pyrene and lipopolysaccharide
Keywords: AA; arachidonic acid; AEA; N-arachidonoyl ethanolamine anandamide; BaP; benzo(a)pyrene; CB; cannabinoid receptor; DHEA; N-docosahexaneoyl ethanolamide DHA docosahexaenoic acid; ECBs; endocannabinoids; EAE; eicosapentaenoyl ethanolamide; EPA; eicosapentaen
Bisphenol A induces hypothalamic down-regulation of the the cannabinoid receptor 1 and anorexigenic effects in male mice
Keywords: 2-AG; 2-arachidonoylglycerol; AT; adipose tissue; AgRP; agouti-related protein; AEA; anandamide; ARC; arcuate nucleus; ArKO; aromatase knock-out; BPA; bisphenol A; BAT; brown adipose tissues; CB1; cannabinoid receptor 1; CART; cocaine and amphetamine-regu
Parabens inhibit fatty acid amide hydrolase: A potential role in paraben-enhanced 3T3-L1 adipocyte differentiation
Keywords: AADAC; arylacetamide deacetylase; AEA; arachidonoyl ethanolamide; BnP; benzylparaben; BuP; butylparaben; CB1R; cannabinoid receptor 1; CB2R; cannabinoid receptor 2; CMNA; cyano(6-methoxynaphthalen-2-yl)methyl acetate; EC; endocannabinoid; FAAH; fatty acid
Salivary concentration of N-acylethanolamines upon food mastication and after meal consumption: Influence of food dietary fiber
Keywords: βGB; β-glucan biscuits; WWBB; whole-wheat bran biscuits; CB; control biscuits; NAEs; N-acylethanolamines; OEA; oleoylethanolamide; LEA; linoleoylethanolamide; PEA; palmitoylethanolamide; ECs; endocannabinoids; 2-AG; 2-acylglycerol; AEA; arachidonylethan
CB1 cannabinoid receptor-mediated anandamide signaling mechanisms of the inferior colliculus modulate the haloperidol-induced catalepsy
Keywords: AEA; anandamide; DMSO; dimethyl sulfoxide; IC; inferior colliculus; PAG; periaqueductal gray matter; TRPV1; transient receptor potential vanilloid type-1; haloperidol catalepsy; endocannabinoids; anandamide; AM251; CB1 cannabinoid receptor; inferior colli
Cannabinoid receptor agonists modulate calcium channels in rat retinal müller cells
Keywords: 2-AG; 2-arachidonoyl glycerol; AEA; anandamide; [Ca2+]i; intracellular calcium concentration; CB1R; cannabinoid CB1 receptor; CB2R; cannabinoid CB2 receptor; DMSO; dimethyl sulfoxide; eCB; endocannabinoid; GS; glutamine synthetase; PBS; phosphate-buffered
Protective role of cannabinoid CB1 receptors and vascular effects of chronic administration of FAAH inhibitor URB597 in DOCA-salt hypertensive rats
Keywords: Ach; acetylcholine; AEA; anandamide; BP; blood pressure; CRCs; concentration-response curves; DMF; N,N-Dimethylformamide; DMSO; dimethyl sulfoxide; DOCA; deoxycorticosterone acetate; FAAH; fatty acid amide hydrolase; HÂ +Â E; hematoxylin and eosin; i.p.;
Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists
Keywords: G protein-coupled receptor 55; Molecular modeling; Structure-activity relationships; ABHD6/12; α/β-hydrolase domain containing 6/12; 2-AG; 2-arachidonoylglycerol; AEA; N-arachidonoylethanolamine; ARA-LPI; 1-arachidonoyl-2-hydroxy-sn-glycero-3-phosphoi
Spatio-temporal common pattern: A companion method for ERP analysis in the time domain
Keywords: AEA; arithmetic ensemble average; CSTP; Common Spatio-Temporam Pattern; ACSTP; adaptive CSTP; Event-related potential (ERP); Ensemble average; Multivariate; Adaptive; Overlapping; Artifact;
Microglia activation states and cannabinoid system: Therapeutic implications
Keywords: 2-AG; 2-arachidonoylglycerol; Aβ; amyloid β; ABDH; α/β-hydrolase; AD; Alzheimer's disease; AEA; anandamide; Arg-1; arginase-1; BBB; blood brain barrier; BDNF; brain derived nerve factor; CB; cannabinoid; CB1; cannabinoid receptor 1; CB2; cannabinoid r
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties
Keywords: FAAH; fatty acid amide hydrolase; AEA; arachidonyl ethanolamide; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CP; cytoplasmic port; ABP; acyl binding pocket; MAC; membrane access channel; D-AMC; decanoyl 7-amino-4-methyl coumarin; A
Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain
Keywords: 2-AG; 2-arachidonyl glycerol; 2-LG; 2-linoleoyl glycerol; ABHD4; α/β-hydrolase domain 4; AEA; N-arachidonoyl ethanolamine (anandamide); A-Taur; N-arachidonoyl taurine; CER; cerebellum; COX; cyclooxygenase; CTX; cortex; DEA; N-docosahexaenoyl ethanolamin
Platinum anti-cancer drugs: Free radical mechanism of Pt-DNA adduct formation and anti-neoplastic effect
Keywords: G=Guan; guanine, guanosine; HOMO; highest occupied molecular orbital; LUMO; lowest occupied molecular orbital; AIE; adiabatic ionisation energy; AEA; adiabatic electron affinity; TS; transition state; ÎEâ¡; TS activation energy; ÎG; change in free ener
Oxylipins, endocannabinoids, and related compounds in human milk: Levels and effects of storage conditions
Keywords: DHET; dihydroxy-eicosatrienoic acid; HETE; hydroxy-eicosatetraenoic acid; LTB4; leukotriene B4; EpOME; epoxy-octadecenoic acid; EET; epoxy-eicosatrienoic acid; TXB2; thromboxane B2; PGD2; prostaglandin D2; HODE; hydroxy-octadecadienoic acid; DiHOME; dihyd
Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23-IL-17 signaling in macrophages
Keywords: AA-5-HT; arachidonoyl serotonin; AEA; arachidonoyl ethanolamide (anandamide); COX-2; cyclooxygenase 2; DHA; docosahexaenoic acid (22:6n-3); DHA-5-HT; docosahexaenoyl serotonin; DHEA; docosahexaenoyl ethanolamine; EPA-5-HT; eicosapentaenoyl serotonin; FAA;
Anterior and Posterior Ethmoidal Artery Ligation in Anterior Skull Base Meningiomas: AÂ Review on Microsurgical Approaches
Keywords: Anterior skull base meningioma; Arterial ligation; Meningioma; Olfactory groove meningioma; AEA; Anterior ethmoidal artery; ECA; External carotid artery; ICA; Internal carotid artery; MMA; Middle meningeal artery; PEA; Posterior ethmoidal artery;
Efficacy of a new intravenous β2-adrenergic agonist (bedoradrine, MN-221) for patients with an acute exacerbation of asthma
Keywords: Asthma; Beta agonists; Emergency medicine; Pharmacotherapy; AEA; acute exacerbation of asthma; ICU; intensive care unit; FEV; forced expiratory volume; AUC; area under the curve; SAE; serious adverse event; TEAE; treatment-emergent adverse event; ITT; int
Intra-visceral insular cortex 2-arachidonoylglycerol, but not N-arachidonoylethanolamide, suppresses acute nausea-induced conditioned gaping in rats
Keywords: 2-AG; 2-arachidonoylglycerol; 5-HT; 5-hydroxytryptamine; AA; arachidonic acid; AEA; N-arachidonoylethanolamide; ANOVA; analysis of variance; CB1; cannabinoid receptor type 1; COX; cyclooxygenase; eCBs; endogenous cannabinoids; FAAH; fatty acid amide hydro
Simultaneous determination of endocannabinoids in murine plasma and brain substructures by surrogate-based LC–MS/MS: Application in tumor-bearing mice
Keywords: AEA; 2-AG; Surrogate analyte; LC–MS/MS; Tumor-bearing miceeCBs, endocannabinoids; AEA, N-arachidonoylethanolamine; AEA-d4, isotope-deuterated N-arachidonoylethanolamine; 2-AG, 2-ararchidonyl glycerol; 1-AG, 1-ararchidonyl glycerol; 2-AG-d5, isotope-deuter
Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence
Keywords: ECBS; Endocannabinoids; AEA; Anandamide; FAAH; fatty acid amide hydrolase; CB1; Cannabinoid type 1 receptor; CB2; Cannabinoid type 2 receptor; TRPV1; Transient potential vanilloid type 1 receptor; CBD; cannabidiol; PFC; Prefrontal cortex; MPFC; Medial pr
The CCDC55 couples cannabinoid receptor CNR1 to a putative DISC1 schizophrenia pathway
Keywords: 5-HTT; serotonin transporter; 5-HTTLPR; serotonin-transporter-linked polymorphic region; AEA; N-arachidonoyl-ethanolamine; CCDC55; coiled coil domain-containing 55; CNR1; cannabinoid receptor 1; CNRIP1a; cannabinoid receptor-interacting protein 1a; CSLM;
Lipopolysaccharide-induced murine embryonic resorption involves changes in endocannabinoid profiling and alters progesterone secretion and inflammatory response by a CB1-mediated fashion
Keywords: Endocannabinoid system; CB1 knockout; Decidua; Embryotoxicity; 2-AG; 2-arachidonoylglycerol; 2-LG; 2-linoleoyl-sn-glycerol; 2-OG; 2-oleoyl-sn-glycerol; AEA; anandamide; AGly; N-arachidonoylglycine; CB1; cannabinoid receptor type 1; CB1-KO; CB1 receptor kn
Interaction between the protective effects of cannabidiol and palmitoylethanolamide in experimental model of multiple sclerosis in C57BL/6 mice
Keywords: Î9-THC; delta-9-tetrahydrocannabinol; AEA; anandamide; ALS; amyotrophic lateral sclerosis; AMT; anandamide membrane transporter; ANOVA; analysis of variance; CBD; cannabidiol; CBs; Cannabinoids; CFA; complete Freund's adjuvant; CNS; central nervous sys
Anandamide rescues retinal barrier properties in Müller glia through nitric oxide regulation
Keywords: AEA; N-arachidonoyl ethanolamide; AM-251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3 carboxamide; AM-630; 6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone); BRB; blood retinal barri
Gαi/o-dependent Ca2+ mobilization and Gαq-dependent PKCα regulation of Ca2+-sensing receptor-mediated responses in N18TG2 neuroblastoma cells
Keywords: N18TG2 cells; Neuronal CaS; Gαq antisense knock-down; Gαi/o; Ca2+ mobilization; CaS responses; Protein kinase C; AEA; anandamide; 2-APB; 2-aminoethyldiphenyl borate; DRG; dorsal root ganglion; EGFP; enhanced green fluorescent protein; GPCR; G protein-co
ReviewReceptome: Interactions between three pain-related receptors or the “Triumvirate” of cannabinoid, opioid and TRPV1 receptors
Keywords: 2-AG; 2-arachidonoylglycerol; 2-AGE; 2-arachidonyl glyceryl ether; AEA; anandamide; AM251; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CNS; ce
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy
Keywords: Neuropathic pain; HIV neuropathy; Allodynia; Antinociception; Endocannabinoid; Gabapentin; HIV; human immunodeficiency virus; HIV-SN; HIV sensory neuropathy; CB; cannabinoidF; AA; fatty acid amide; FAAH; fatty acid amide hydrolase; AEA; anandamide; 2-AG;
Optimization of Panax notoginseng extraction process using a design space approach
Keywords: AEA; amount of ethanol added (mL/g); ANOVA; analysis of variance; ARD; average relative deviation (%); C; saponin concentration; Cal; calculated values; CPP; critical process parameter; CQA; critical quality attribute; DM; the dry matter content of an ext
Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro venomous pit viper
Keywords: 2-AG; 2-arachidonylglycerol; AEA; anandamide; CB1RS; CB1 cannabinoid receptors; CBRs; cannabinoid receptors; dPAG; dorsal periaqueductal gray; eCBs; endocannabinoids; GABA; γ-aminobutyric acid; MT; mesencephalic tectum; SC; superior colliculus; SNpr; sub
Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling
Keywords: AD; Alzheimer's disease; AEA; anandamide; Bax; Bcl-2-associated X protein; BCCAo; bilateral common carotid artery occlusion; Bcl; B cell lymphoma; CCH; chronic cerebral hypoperfusion; DAPI; 4â²,6-diamidino-2-phenylindole; DMSO; dimethyl sulfoxide; ECS;
Endocannabinoids drive the acquisition of an alternative phenotype in microglia
Keywords: ABDH6; α,β-hydrolase-6; ABDH12; α,β-hydrolase-12; AEA; anandamide; 2-AG; 2-arachidonoylglycerol; Arg-1; Arginase-1; CB1R; cannabinoid receptor 1; CB2R; cannabinoid receptor 2; DAGLs; diacylglycerol lipases; eCBs; endocannabinoids; eCBSS; endocannabino
Effects of CB1 receptor agonism and antagonism on behavioral fear and physiological stress responses in adult intact, ovariectomized, and estradiol-replaced female rats
Keywords: 2-AG; 2-arachidonyl glycerol; ACEA; arachidonyl 2â²-chlorethylamide; AEA; arachidonylethanolamine; ANOVA; analysis of variance; CB1; cannabinoid receptor type 1; DMSO; dimethyl sulfoxide; dPAG; dorsal periaqueductal gray area; E2; 17β-Estradiol; ECS; en
Pyrazole phenylcyclohexylcarbamates as inhibitors of human fatty acid amide hydrolases (FAAH)
Keywords: FAAH inhibitors; Pyrazole phenylcyclohexylcarbamate; Molecular modeling; Reversibility; FAAH; fatty acid amide hydrolase; hrFAAH; human recombinant fatty acid amide hydrolase; MAGL; monoacylglycerol lipase; NAEs; N-acyl-ethanolamines; MAGs; monoacylglycer
Modulatory effects by CB1 receptors on rat spinal locomotor networks after sustained application of agonists or antagonists
Keywords: 2 AG; 2-arachidonoylglycerol; 5-HT; 5-hydroxytryptamine or serotonin; AEA; N-arachidonoylethanolamine or anandamide; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; cAMP; cyclic adenosine monophosphate; CB1R; cannabinoid receptor-1; DMSO; dim
The disease-modifying effects of a Sativex-like combination of phytocannabinoids in mice with experimental autoimmune encephalomyelitis are preferentially due to Î9-tetrahydrocannabinol acting through CB1 receptors
Keywords: AEA; anandamide; BBB; blood-brain barrier; CB1 receptor; cannabinoid type-1 receptor; CB2 receptor; cannabinoid type-2 receptor; CBD-BDS; cannabidiol botanical drug substance; CFA; complete Freund's adjuvant; CNS; central nervous system; CSF; cerebros
Airfield self-consolidating concrete pavements (ASCCP): Mechanical and durability properties
Keywords: ASCCP; Self-consolidating concrete; Freeze/thaw; Mechanical properties; Mineral admixtures; AEA;
Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
Keywords: 2-AG; 2-arachidonoylglcerol; AEA; anandamide; ANOVA; analysis of variance; CB1; cannabinoid receptor one; CB2; cannabinoid receptor two; COX-1; cyclooxygenase one; COX-2; cyclooxygenase two; ECS; endocannabinoid system; FAAH; fatty acid amide hydrolase; K
Cannabinoid receptor-dependent metabolism of 2-arachidonoylglycerol during aging
Keywords: ABHD6; serine hydrolase alpha/beta-hydrolase domain-containing 6; 2-AG; 2-Arachidonoylglycerol; AEA; anandamide; BSA; bovine serum albumin; CBRs; CB1 and CB2 receptors; CC; cerebral cortex; CNS; central nervous system; DAG; diacylglycerol; DAGL; diacylgly
A new constraint handling method based on the modified Alopex-based evolutionary algorithm
Keywords: AEA; EDA; Constrained optimization problems; Adaptive penalty function;
Changes in endocannabinoid and N-acylethanolamine levels in rat brain structures following cocaine self-administration and extinction training
Keywords: AEA; anandamide; 2-AG; 2-arachidonoylglycerol; eCBs; endocannabinoids; LC-MS/MS; liquid chromatography tandem mass spectrometry; NAEs; N-acylethanolamines; OEA; oleoylethanolamide; PEA; palmitoylethanolamide; “Yoked” procedure; Cocaine self-administra
Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH)
Keywords: 2-AG; 2-arachidonyloglicerol; 2-OG; 2-oleoylglycerol; AA; arachidonic acid; AEA; anandamide; COX; cyclooxygenase; DMSO; dimethyl sulfoxide; DSS; dextran sulfate sodium; FAAH; fatty acid amide hydrolase; HPRT; hypoxanthine-guanine phosphoribosyltransferase
The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury
Keywords: TBI; FAAH inhibition; AEA; Inflammation; Neuroprotection;
Hypoximimetic activity of N-acyl-dopamines. N-arachidonoyl-dopamine stabilizes HIF-1α protein through a SIAH2-dependent pathway
Keywords: AEA; N-arachidonoyl-ethanolamide; BNIP3; Bcl-2/E1B-nineteen kiloDalton interacting protein; CB1; cannabinoid receptor-1; EPO; erythropoietin; HBMECs; human brain microvascular endothelial cells; HUVECs; human umbilical vein endothelial cells; HIF; hypoxia
2-AG into the lateral hypothalamus increases REM sleep and cFos expression in melanin concentrating hormone neurons in rats
Keywords: OX; Orexins/hypocretins; MCH; melanin-concentrating hormone; CB1R; cannabinoid receptor 1; CB2R; cannabinoid receptor 2; SWC; sleep-wake cycle; W; wakefulness; SWS; slow wave sleep; REMS; rapid eye movement sleep; eCBs; endocannabinoids; 2-AG; 2-araquidon
Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase
Keywords: DDGNGFVNTZJMMZ-UHFFFAOYSA-N; RAOOQXZPVIXTHJ-UHFFFAOYSA-N; BQCJLJCOFLBHAZ-UHFFFAOYSA-N; KOLZZKRWBHRCBJ-UHFFFAOYSA-N; DOAANJRARCETMX-UHFFFAOYSA-N; YHUSQEUMDTXFFE-UHFFFAOYSA-N; FAAH; fatty acid amide hydrolase; PET; positron emission tomography; CB1; cannabi
Interleukin-1β alters the sensitivity of cannabinoid CB1 receptors controlling glutamate transmission in the striatum
Keywords: 2AG; 2-arachidonoylglycerol; ACSF; artificial cerebrospinal fluid; AEA; anadamide; BDNF; brain-derived neurotrophic factor; CB1Rs(GABA); cannabinoid CB1 receptors controlling GABA transmission; CB1Rs(glu); CB1Rs controlling glutamate transmission; CNQX; 6
Progesterone reverts LPS-reduced FAAH activity in murine peripheral blood mononuclear cells by a receptor-mediated fashion
Keywords: AEA; anandamide; 2-AG; 2-arachidonoylglycerol; CB; cannabinoid receptor EmRe: embryonic resorption FAAH: fatty acid amide hydrolase; LPS; lipopolysacharide; LONA; Lonaprisan; NAPE-PLD; N-arachidonoyl phosphatidylethanolamine; MAGL; monoacylglycerol lipase
Modulation of low-voltage-activated T-type Ca2Â + channels
Keywords: LVA; low-voltage-activated; HVA; high-voltage-activated; T-type channels; T-type Ca2Â + channels; cAMP; cyclic adenosine monophosphate; PKA; protein kinase A; PKC; protein kinase C; PKG; protein kinase G; PTK; protein tyrosine kinase; HEK293; human embryo