کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8301699 | 1537705 | 2016 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain
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کلمات کلیدی
TRPV1CTXHIPPN-arachidonoyl glycineFAAH2-arachidonyl glyceroleCBN-acyl-phosphatidylethanolamineHYPNAPE-PLDPLA2maglNAE2-AGN-Acyl ethanolaminePPARLEACOXAEADEASTRabhd4PEAGDE1MIDN-Arachidonoyl ethanolamine (anandamide)MRMOEA - OASanandamide - آناندامیدcyclooxygenase - آنزیم سیکلواکسیژنازphospholipase A2 - آنزیم فسفولیپاز A2 Striatum - استریاتومFatty acid amide hydrolase - اسید آمینه هیدرولاز اسید چربThalamus - تالاموسThal - تلهSea - دریاییStem - ساقهBrainstem - ساقه مغزCer - سرCortex - قشرmonoacylglycerol lipase - لیپاز monoacylglycerol لیپازLipidomics - لیپیدومیکسCerebellum - مخچهMidbrain - میانمغز، مزانسفالNAPE - ناپاknockout - ناکاوتNAgly - ناگلیmultiple reactions monitoring - نظارت چند واکنشwild-type - نوع وحشیHypothalamus - هیپوتالاموسHippocampus - هیپوکامپ Transient receptor potential vanilloid 1 - پتانسیل گیرنده گذرا وانیلیوئید 1Endogenous cannabinoid - کانابینوئید آندوژنیکGABA - گاباgamma-amino butyric acid - گاما آمینو اسید بوتیریکperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain](/preview/png/8301699.png)
چکیده انگلیسی
Lipidomics analysis of this third NAPE-PLD KO strain shows a broad range of lipids that were differentially affected by lipid species and brain region. Importantly, all 6 NAEs measured were significantly reduced, though the magnitude of the effect varied by fatty acid saturation length and brain region. 2-AG levels were only impacted in the brainstem, where levels were significantly increased in KO mice. Correspondingly, levels of arachidonic acid were significantly decreased exclusively in brainstem. NAGly levels were significantly increased in 4 brain regions and levels of PGE2 increased in 6 of 8 brain regions in KO mice. These data indicate that deletion of NAPE-PLD has far broader effects on the lipidome than previously recognized. Therefore, behavioral characteristics of suppressing NAPE-PLD activity may be due to a myriad of effects on lipids and not simply due to reduced AEA biosynthesis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1861, Issue 6, June 2016, Pages 491-500
Journal: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids - Volume 1861, Issue 6, June 2016, Pages 491-500
نویسندگان
Emma Leishman, Ken Mackie, Serge Luquet, Heather B. Bradshaw,