Novel imaging agents for β-amyloid plaque based on the N-benzoylindole core
Keywords: بیماری آلزایمر; Alzheimer's disease; β-Amyloid; Binding affinity; Imaging agent;
مقالات ISI بیماری آلزایمر (ترجمه نشده)
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Endoplasmic reticulum stress enhances γ-secretase activity
Keywords: بیماری آلزایمر; ER; endoplasmic reticulum; UPR; unfolded protein response; PS; presenilin; ATF4; activating transcription factor 4; GCN2; general control non-derepressible 2; PKR; protein kinase RNA; PERK; PKR-like ER kinase; HRI; heme-regulated inhibitor; eIF2α; eukary
Altered dopamine modulation of LTD-like plasticity in Alzheimer's disease patients
Keywords: بیماری آلزایمر; Transcranial magnetic stimulation; Cortical plasticity; Alzheimer's disease; LTD; Dopamine; rTMS;
Use of strong opioids among community-dwelling persons with and without Alzheimer's disease in Finland
Keywords: بیماری آلزایمر; Pain; Analgesics; Alzheimer's disease; Drug utilization; Finland;
Featured ArticleFrequency of Alzheimer's disease pathology at autopsy in patients with clinical normal pressure hydrocephalus
Keywords: بیماری آلزایمر; Normal pressure hydrocephalus; Alzheimer's disease; Cerebrospinal fluid shunt; Autopsy study; Dementia;
T-817MA, a neuroprotective agent, attenuates the motor and cognitive impairments associated with neuronal degeneration in P301L tau transgenic mice
Keywords: بیماری آلزایمر; AD; Alzheimer's disease; FTDP-17; frontotemporal dementia and parkinsonism linked to chromosome 17; P301L mice; transgenic mice expressing FTDP-17 mutation P301L of human tau; T-817MA; 1-{3-[2-(1-benzothiophen-5-yl)ethoxy]propyl} azetidin-3-ol maleate;
Prospects for designating Alzheimer's disease research a national priority
Keywords: بیماری آلزایمر; Alzheimer's disease; Research; Funding; Public policies; Strategic plan; Congress; Legislation; National Alzheimer's Project Act; PAD2020; Alzheimer's Association; Prevention; Treatment;
The first synthesis of [11C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3)
Keywords: بیماری آلزایمر; [11C]SB-216763; Glycogen synthase kinase-3 (GSK-3); Radiosynthesis; Positron emission tomography (PET); Cancer; Alzheimer's disease;
Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist
Keywords: بیماری آلزایمر; PPARγ; Peroxisome proliferator-activated receptor; Alzheimer's disease; Benzimidazoles;
Crocetin inhibits beta-amyloid fibrillization and stabilizes beta-amyloid oligomers
Keywords: بیماری آلزایمر; Aβ; beta-amyloid; AD; Alzheimer's disease; HSA; human serum albumin; BBB; blood-brain barrier; HPLC; high-performance liquid chromatography; MALDI-TOF; matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; HFIP; hexafluoroisop
Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line
Keywords: بیماری آلزایمر; 5-aza-dC; 5-aza-2â²-deoxycytidine; Aβ; beta amyloid; AD; Alzheimer's disease; APP; amyloid precursor protein; APP-sw; Swedish mutation of amyloid precursor protein; DMS; differentially methylated CpG site; MSP; methylation-specific PCR; qRT-PCR; quant
White matter changes in dementia with Lewy bodies and Alzheimer's disease: A tractography-based study
Keywords: بیماری آلزایمر; Alzheimer's disease; Diffusion tensor imaging; Dementia with Lewy bodies; Tractography; Tract-based method; White matter;
DNA methylation in repetitive elements and Alzheimer disease
Keywords: بیماری آلزایمر; Alzheimer's disease; Epigenetics; DNA methylation; Repetitive elements; Peripheral blood leukocytes;
Cytokine expression and microglial activation in progressive supranuclear palsy
Keywords: بیماری آلزایمر; Alzheimer's disease; Brain; Cytokines; Inflammation; Microglia; Progressive supranuclear palsy;
Regional white matter hyperintensities in normal aging, single domain amnestic mild cognitive impairment, and mild Alzheimer's disease
Keywords: بیماری آلزایمر; Alzheimer's disease; Cognitive continuum; Deep and periventricular white matter hyperintensities; Single domain amnestic mild cognitive impairment;
Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice
Keywords: بیماری آلزایمر; Insulin resistance; Hyperinsulinemia; Insulin signaling; Alzheimer's disease; Amyloid β; Senile plaque;
Attenuation of neurodegenerative phenotypes in Alzheimer-like presenilin 1/presenilin 2 conditional double knockout mice by EUK1001, a promising derivative of xanomeline
Keywords: بیماری آلزایمر; Xanomeline; EUK1001; Muscarinic M1 agonist; Presenilins; Neurodegeneration; Alzheimer's disease;
Secretases as therapeutic targets for Alzheimer's disease
Keywords: بیماری آلزایمر; Alzheimer's disease; γ-Secretase; β-Secretase; Aβ;
Nitrosative stress-induced Parkinsonian Lewy-like aggregates prevented through polyphenolic phytochemical analog intervention
Keywords: بیماری آلزایمر; AD; Alzheimer's disease; PD; Parkinson's disease; PDI; protein disulfide isomerase; EF-24; 3,5-bis(2-flurobenzylidene) piperidin-4-one; Protein-disulfide isomerase; Nitrosative stress; Neurodegenerative disorders; Synphilin-1; EF-24; Lewy body;
Splicing factor SC35 promotes tau expression through stabilization of its mRNA
Keywords: بیماری آلزایمر; Tau; Alzheimer's disease; SC35; mRNA stabilization;
Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells
Keywords: بیماری آلزایمر; Mammalian target of rapamycin (mTOR); p70S6K; Phosphatidic acid; Tau protein; Oxidative stress; Alzheimer's disease;
Synuclein modulation of monoamine transporters
Keywords: بیماری آلزایمر; α-Syn; α-synuclein; β-Syn; β-synuclein; γ-Syn; γ-synuclein; AD; Alzheimer's disease; CNS; central nervous system; DA; dopamine; DAT; dopamine transporter; DMI; desipramine; MAT; presynaptic plasma membrane monoamine transporters; NAC; non-Aβ comp
Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease
Keywords: بیماری آلزایمر; γ-Secretase inhibitor; Alzheimer's disease; β-Amyloid; Notch; Amino-caprolactam;
Severe Alzheimer's Disease: Treatment Effects on Function and Care Requirements
Keywords: بیماری آلزایمر; Alzheimer's disease; cholinesterase inhibitors; function; memantine;
Featured ArticleSources of variability in estimates of the prevalence of Alzheimer's disease in the United States
Keywords: بیماری آلزایمر; Epidemiologic studies; Dementia; Alzheimer's disease; Vascular dementia; Mild cognitive impairment; Cognitive impairment no dementia;
Prevalence of asymptomatic vasogenic edema in pretreatment Alzheimer's disease study cohorts from phase 3 trials of semagacestat and solanezumab
Keywords: بیماری آلزایمر; Alzheimer's disease; Clinical trials; Magnetic resonance imaging; Vasogenic edema; Cerebral microhemorrhage;
Genetic association of complement receptor 1 polymorphism rs3818361 in Alzheimer's disease
Keywords: بیماری آلزایمر; Alzheimer's disease; Association; CR1; Genotype; Meta-analysis; Molecular genetics; Polymorphism;
Isoflurane induces hippocampal cell injury and cognitive impairments in adult rats
Keywords: بیماری آلزایمر; Cell injury; Cognitive functions; Cytokines; Isoflurane; Rats; Aβ; β-amyloid peptide; AD; Alzheimer's disease; IL-1β; interleukin-1β; MAC; minimum alveolar concentrations; POCD; post-operative cognitive dysfunction; SpO2; pulse oximeter oxygen satur
Featured ArticleIntroduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Keywords: بیماری آلزایمر; Alzheimer's disease; Diagnostic criteria; Biomarkers; Imaging; Cerebrospinal fluid;
Carotenoids and Alzheimer's Disease: An insight into therapeutic role of retinoids in animal models
Keywords: بیماری آلزایمر; Alzheimer's Disease; Carotenoids; Retinoic acid; All trans retinoic acid; Neuroprotection; Animal model;
Loss of emotional insight in behavioral variant frontotemporal dementia or “frontal anosodiaphoria”
Keywords: بیماری آلزایمر; Insight; Anosognosia; Anosodiaphoria; Dementia; Frontotemporal dementia; Alzheimer's disease;
A simple approach for human recombinant apolipoprotein E4 expression and purification
Keywords: بیماری آلزایمر; Apolipoprotein E; Recombinant protein expression; ApoE structure; ApoE function; Alzheimer's disease; Cardiovascular disease;
Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging
Keywords: بیماری آلزایمر; Alzheimer; Tau; Plaque; Multiphoton; In vivo imaging; AD; Alzheimer's disease; Aβ; amyloid beta; NFT; neurofibrillary tangle; APP; amyloid precursor protein;
PerspectiveA European perspective on population studies of dementia
Keywords: بیماری آلزایمر; Alzheimer's disease; Dementia; Mild cognitive impairment; Diagnostic criteria; Prevalence; Incidence; Population-based;
Protective effect of the phosphodiesterase III inhibitor cilostazol on amyloid β-induced cognitive deficits associated with decreased amyloid β accumulation
Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; amyloid β; N2aSwe; N2a cells stably expressing human amyloid precursor protein Swedish mutation; Alzheimer's disease; Amyloid β; Phosphorylated tau; ApoE; Microglia;
AMSH is required to degrade ubiquitinated proteins in the central nervous system
Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMSH; associated molecule with the SH3 domain of STAM; AMPAR; α-amino-3-hydroxy-5-methyl-isoxazolepropionic acid receptor; CHMP; chromatin modifying protein; ESCRT; endosomal sorting complexe
CXCL8 protects human neurons from amyloid-β-induced neurotoxicity: Relevance to Alzheimer's disease
Keywords: بیماری آلزایمر; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; DAPI; 4â²,6-diamidino-2-phenylindole; AD; Alzheimer's disease; Aβ; amyloid-β; BDNF; brain-derived neurotrophic factor; CNND; Center for Neurovirology and Neurodegenerative Disorders;
Ethanol protects cultured neurons against amyloid-β and α-synuclein-induced synapse damage
Keywords: بیماری آلزایمر; Alzheimer's disease; Dementia; Ethanol; Phospholipase A2; Synapses; Synaptophysin;
Novel insights for the treatment of Alzheimer's disease
Keywords: بیماری آلزایمر; 5-HT; 5-hydroxytryptamine (serotonin); Aβ; beta amyloid peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; BDNF; brain-derived neurotrophic factor; cDNA; complementary deoxyribonucleic acid; CoQ10; coenzyme Q10 (ubiquinone); GSK3; glycog
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2â² region
Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; β-amyloid peptide; APP; β-amyloid precursor protein; BACE; β-site APP cleaving enzyme; FRET; fluorescence resonance energy transfer; ELISA; enzyme-linked immune sandwich assay; CHO; Chinese hamster ovary; Alzheimer's d
NSAID-derived γ-secretase modulation requires an acidic moiety on the carbazole scaffold
Keywords: بیماری آلزایمر; Alzheimer's disease; γ-Secretase modulation; Carboxylic acid isosteres; Carprofen;
Public financial support receipt and non-medical resource utilization in Alzheimer's disease results from the PLASA study
Keywords: بیماری آلزایمر; France; Alzheimer's disease; Informal care; Dementia; Health policy; Resource use; Substitution effect; Older people;
Antioxidant activity, acetylcholinesterase inhibition, iridoid content and mutagenic evaluation of Leucosidea sericea
Keywords: بیماری آلزایمر; 2-AA; 2-aminoanthracene; 4NQO; 4-nitroquinoline-1-oxide; AA; antioxidant activity; AChE; acetylcholinesterase; AChEIs; acetylcholinesterase inhibitors; AD; Alzheimer's disease; ANOVA; analysis of variance; ANT; average antioxidant activity; ATCI; acetyl
Increased biomagnetic activity in healthy elderly with subjective memory complaints
Keywords: بیماری آلزایمر; Subjective memory complaints; Mild cognitive impairment; Magnetoencephalography; Alzheimer's disease;
ReviewThe legacy of nanotechnology: Revolution and prospects in neurosurgery
Keywords: بیماری آلزایمر; Nanotechnology; Neurosurgery; Alzheimer's disease; HIV; Glioblastoma multiforme; Encephalopathy; Nanoparticles; Brain; Brain implants; Fullerenes; Nanowires; Thermotherapy; Photodynamic therapy; Quantum dots;
Butanol extract of Ecklonia cava prevents production and aggregation of beta-amyloid, and reduces beta-amyloid mediated neuronal death
Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; beta-amyloid; APP; amyloid-precursor protein; CTF; C-terminal fragment of APP; sAPP; soluble APP; BACE; beta-site of APP cleaving enzyme; DHA; docosahezaenoic acid; PUFA; polyunsaturated fatty acid; ELISA; enzyme linked imm
Insights into cholinesterase inhibitory and antioxidant activities of five Juniperus species
Keywords: بیماری آلزایمر; Juniperus; Cupressaceae; Cholinesterase inhibition; Antioxidant activity; Alzheimer's disease;
Magnetic resonance imaging-measured atrophy and its relationship to cognitive functioning in vascular dementia and Alzheimer's disease patients
Keywords: بیماری آلزایمر; Alzheimer's disease; MRI; Dementia; Vascular; Hippocampus; Atrophy;
Simultaneous Arterial Spin Labeling Cerebral Blood Flow and Morphological Assessments for Detection of Alzheimer's Disease
Keywords: بیماری آلزایمر; Alzheimer's disease; voxel-based morphometry; cerebral blood flow; magnetic resonance imaging; diagnosis;
Are anaesthetics toxic to the brain?
Keywords: بیماری آلزایمر; anaesthesia, general; Alzheimer's disease; neurobehavioural manifestations; postoperative complications;