دانلود مقالات ISI درباره بیماری آلزایمر + ترجمه فارسی

Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer's disease

Keywords: بیماری آلزایمر; Benzenediol-berberine hybrids; Cholinesterases; Amyloid β; Antioxidant; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Amyloid-β induced toxicity involves ganglioside expression and is sensitive to GM1 neuroprotective action

Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid β-peptide (Aβ); Organotypic culture; Gangliosides; GM1; Neuroprotection; GSK3β;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Opposite effects of P2X7 and P2Y2 nucleotide receptors on α-secretase-dependent APP processing in Neuro-2a cells

Keywords: بیماری آلزایمر; α-CTF; α-cleaved carboxyterminal fragment of APP (also known as C83); Aβ; amyloid-β peptide; AD; Alzheimer's disease; ADAM; a disintegrin and metalloprotease; APP; amyloid precursor protein; BACE; β-secretase; BBG; brilliant blue G; BzATP; 2′(3â€

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibitory effect of Lavandula viridis on Fe2+-induced lipid peroxidation, antioxidant and anti-cholinesterase properties

Keywords: بیماری آلزایمر; ABTS+; 2,2′-Azinobis-(3-ethylbenzothiazoline-6-sulphonic acid radical cation; ACh; Acetylcholine; AChE; Acetylcholinesterase; AD; Alzheimer's disease; ATCI; Acetylthiocholine iodide; Aβ; Amyloid β-protein; BChE; Butyrylcholinesterase; BTCI; Butyrylt

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Postgenomics, uncertain futures, and the familiarization of susceptibility genes

Keywords: بیماری آلزایمر; Genetic testing; Kinship; Family; Alzheimer's disease; Predictive testing; ApoE; Risk; USA; Canada;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Gami-Chunghyuldan ameliorates memory impairment and neurodegeneration induced by intrahippocampal Aβ1-42 oligomer injection

Keywords: بیماری آلزایمر; Gami-Chunghyuldan; Alzheimer's disease; Amyloid beta oligomer; Memory impairment; Neurodegeneration;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Studying synergism of methyl linked cyclohexyl thiophenes with triazole: Synthesis and their cdk5/p25 inhibition activity

Keywords: بیماری آلزایمر; Thiophene; Triazole; cdk5/p25; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Cognitive dysfunctions induced by a cholinergic blockade and Aβ25-35 peptide are attenuated by salvianolic acid B

Keywords: بیماری آلزایمر; Salvianolic acid B; Memory; Alzehimer's disease; GABAA receptor; AD; Alzheimer's disease; SalB; salvianolic acid B; Aβ; amyloid-β; GABA; γ-aminobutyric acid; ACh; acetylcholine; AChE; acetylcholinesterase; BZ; benzodiazepine;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain

Keywords: بیماری آلزایمر; Organophosphate; Dichlorvos; Oxidative stress; Neurodegeneration; MitoQ; ROS; reactive oxygen species; cyt c; cytochrome c; MnSOD; Manganese superoxide dismutase; AD; Alzheimer's disease; PD; Parkinson disease;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Increased activity of Th-17 and Th-9 lymphocytes and a skewing of the post-thymic differentiation pathway are seen in Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Neuroinflammation; T helper lymphocytes; Th-17; Th-9; Memory/naïve lymphocytes;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Featured ArticleIntracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia

Keywords: بیماری آلزایمر; Alzheimer's disease; Vascular dementia; Intracranial atherosclerosis; Circle of Willis; Brain hypoperfusion;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Structure-guided design and synthesis of P1′ position 1-phenylcycloalkylamine-derived pentapeptidic BACE1 inhibitors

Keywords: بیماری آلزایمر; Alzheimer's disease; β-Secretase; Pentapeptides; Bioisosteres; Phenylcycloalkylamines;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Featured ArticleThe measurement of everyday cognition: Development and validation of a short form of the Everyday Cognition scales

Keywords: بیماری آلزایمر; Alzheimer's disease; Mild cognitive impairment; Assessment of cognition; Functional assessment;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Transforming cerebrospinal fluid Aβ42 measures into calculated Pittsburgh compound B units of brain Aβ amyloid

Keywords: بیماری آلزایمر; Alzheimer's disease; Pittsburgh compound B; Amyloid imaging; Aβ amyloid; Cerebrospinal fluid; Alzheimer's disease biomarkers;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Featured ArticleExtended results of the Alzheimer's disease anti-inflammatory prevention trial

Keywords: بیماری آلزایمر; Alzheimer's disease; Randomized controlled trial; Nonsteroidal anti-inflammatory drugs; Follow-up; Biomarkers; Hypothesis;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

An application of two MIFs-based tools (Volsurf+ and Pentacle) to binary QSAR: The case of a palinurin-related data set of non-ATP competitive Glycogen Synthase Kinase 3β (GSK-3β) inhibitors

Keywords: بیماری آلزایمر; Alzheimer's disease; GRIND; MIFs; Palinurin; Binary QSAR; VolSurf descriptors;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists

Keywords: بیماری آلزایمر; Alzheimer's disease; Dihydroquinoline-3-carboxamides; Dihydroquinoline-3-carbohydrazides; hexahydropyrimido[5,4-c]quinoline-2,5-diones; AChE; BuChE; Molecular modeling; Ca channel antagonism;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Featured ArticleThe effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ɛ3/ɛ3 genotype

Keywords: بیماری آلزایمر; Alzheimer's disease; Posterior cingulate; Risk factors; Genetics; APOE; TOMM40;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis and biophysical evaluation of arylhydrazono-1H-2-indolinones as β-amyloid aggregation inhibitors

Keywords: بیماری آلزایمر; Isatin-3-arylhydrazones; Alzheimer's disease; β-Amyloid aggregation inhibitors;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Assessing mutant huntingtin fragment and polyglutamine aggregation by atomic force microscopy

Keywords: بیماری آلزایمر; AD; alzheimer's disease; AFM; atomic force microscopy; EPCG; (2)-epigallocatechin-3-gallate; GST; glutathione S-transferase; htt; huntingtin; HD; huntington disease; N17; the first 17 amino acids at N-terminus of htt; PD; parkinson's disease; PBS; pho

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: Discovery of quinoxaline-based hybrid compounds with AChE, H3R and BACE 1 inhibitory activities

Keywords: بیماری آلزایمر; Alzheimer's disease; BACE 1; AChE; H3R; Multi-Target-Directed Ligands;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Docking studies of benzylidene anabaseine interactions with α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): Application to the design of related α7 selective ligands

Keywords: بیماری آلزایمر; AChBPs; Nicotinic acetylcholine receptor α7; Docking; Benzylidene-anabaseine analogs; Spirodiazepine and spiroimidazoline quinuclidine series; Ac; Aplysia californica; ACHBP; Acetylcholine-binding protein; AD; Alzheimer's disease; ADHD; Attention defic

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Shift in brain metabolism in late onset Alzheimer's disease: Implications for biomarkers and therapeutic interventions

Keywords: بیماری آلزایمر; Mitochondria; Bioenergetics; Alzheimer's disease; Oxidative stress; White matter degeneration; Biomarkers;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Interaction of naproxen amphiphilic derivatives with biomembrane models evaluated by differential scanning calorimetry and Langmuir-Blodgett studies

Keywords: بیماری آلزایمر; Naproxen; Lipoamino acids; Alzheimer's disease; DSC; LB; Amphiphilicity;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus

Keywords: بیماری آلزایمر; Scopolamine; Spontaneous alternation; Exploratory activity; Spatial learning and memory; Arginine metabolism; Dentate gyrus; AD; Alzheimer's disease; Aβ; amyloid beta; Ach; acetylcholine; DG; dentate gyrus; eNOS; endothelial NOS; HPLC; high performance

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

SAR studies of acidic dual γ-secretase/PPARγ modulators

Keywords: بیماری آلزایمر; SAR; Alzheimer's disease; PPARγ agonists; γ-Secretase modulators; Carboxylic acids;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Featured ArticleTranscranial Doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Transcranial Doppler ultrasonography; Cerebral blood flow; Brain hypoperfusion; Mean flow velocity; Pulsatility index;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Magnetic resonance imaging and neuropsychological results from a trial of memantine in Alzheimer's disease

Keywords: بیماری آلزایمر; Memantine; Alzheimer's disease; Magnetic resonance imaging; Neuropsychological testing; Open-label; Multi-center; Clinical trial; Single-arm delayed-start design; Hippocampal volume change; Total brain volume;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Featured ArticleSuitability of the Clinical Dementia Rating-Sum of Boxes as a single primary endpoint for Alzheimer's disease trials

Keywords: بیماری آلزایمر; Alzheimer's disease; Clinical trials; Outcome measures; Responsiveness;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Investigation of α-phenylnorstatine and α-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors

Keywords: بیماری آلزایمر; Alzheimer's disease; BACE-1 inhibitors; tert-Hydroxyl; Transition state mimic; α-Phenylnorstatine; α-Benzylnorstatine;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles

Keywords: بیماری آلزایمر; 2-Aminopyridin-3-carbonitriles; Tacrine analogues; AChE; BuChE; Inhibition mechanism; Neuroprotection; Molecular modelling; Alzheimer's disease; Neuronal cerebrovascular diseases;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Chronic treatment with the α2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP × PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis

Keywords: بیماری آلزایمر; Alzheimer's disease; Noradrenaline; Memory; β-Amyloid; Astrocytosis; Fluparoxan; Alpha2 adrenoceptor antagonist; Aβ; β-amyloid; LC; locus coeruleus; DSP-4; N-(2-chloroethyl)-N-ethyl-bromo-benzylamine; APP; amyloid precursor protein; PS; presenilin; G

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

New potent human acetylcholinesterase inhibitors in the tetracyclic triterpene series with inhibitory potency on amyloid β aggregation

Keywords: بیماری آلزایمر; Acetylcholinesterase inhibitors; N-3-Isobutyrylcycloxobuxidine-F derivatives; Molecular modeling; Alzheimer's disease; β-amyloid aggregation; Butyrylcholinesterase; Synthesis;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Pregnenolone sulfate enhances survival of adult-generated hippocampal granule cells via sustained presynaptic potentiation

Keywords: بیماری آلزایمر; Pregnenolone sulfate (PREGS); Neurogenesis; NMDA receptor (NMDAr); α7 nicotinic acetylcholine receptor (α7nAChR); σ1 receptor (σ1R); AD; Alzheimer's disease; AP5; dl-2-amino-5-phosphonovalericacid; BrdU; bromodeoxyuridine; DMXB; 3-(2,4-dimethoxybenz

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT6 antagonists

Keywords: بیماری آلزایمر; 5-HT; Serotonin; 5-Hydroxytryptamine; 5-HT6; 5-Hydroxytryptamine-6; Alzheimer's disease; Schizophrenia; Cognition; Cognitive impairment; Cognitive dysfunction;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Apolipoprotein E: From lipid transport to neurobiology

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; apo; apolipoprotein; FRET; fluorescence resonance energy transfer; LDL; low-density lipoprotein; NMR; nuclear magnetic resonance; VLDL; very low-density lipoprotein; DMPC; dimyristoylphosphatidylcholine; DPPC; dipalmitoylphospho

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

GMM based SPECT image classification for the diagnosis of Alzheimer's disease

Keywords: بیماری آلزایمر; 87.19.xr; 87.57.nm; 87.57.R−; 87.57.uh; SPECT; Alzheimer's disease; Gaussian mixture model; EM algorithm; Support vector machines (SVMs);

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Featured ArticleLong-term progression of Alzheimer's disease in patients under antidementia drugs

Keywords: بیماری آلزایمر; Alzheimer's disease; Current medical practice; Mortality; Functional incapacity; Behavior disorders; Cognitive decline; Institutionalization; Cohort study; Antidementia drugs; REAL.FR;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease

Keywords: بیماری آلزایمر; Acetylcholinesterase inhibitors; Butyrylcholinesterase inhibitors; Quinolizidine derivatives; Bi- and tricyclic systems derivatives; Single-entity multi-target agents; Aβ; β-amyloid; ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's dise

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β

Keywords: بیماری آلزایمر; NFTs; neurofibrillary tangles; AD; Alzheimer's disease; MAP; microtubule-associated protein; GSK3β; glycogen synthase kinase-3β; PP2A; protein phosphatase-2A; CDK5; cyclin-dependent kinase-5; DYRK1A; dual-specificity tyrosine-phosphorylation regulated

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

PerspectiveSteps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Biomarkers; Magnetic resonance imaging; Hippocampus; Biomarker standards;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Featured ArticleThe Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers

Keywords: بیماری آلزایمر; Alzheimer's disease; Cerebrospinal fluid; Biomarkers; External assurance; External control; Proficiency testing;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Functional and pathological roles of the 12- and 15-lipoxygenases

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; AIF; apoptosis-inducing factor; AA; arachidonic acid; CAM; cellular adhesion molecule; CDC; cinnamyl-3,4-dihydroxy-α-cyanocinnamate; COX; cyclooxygenase; EPA; eicosapentaenoic acid; ESI; electrospray ionization; ELISA; enzyme-l

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Featured ArticleOperationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2

Keywords: بیماری آلزایمر; Alzheimer's disease; Dementia; Mild cognitive impairment; Cognitive impairment not dementia; Diagnostic criteria; Population-based; Prevalence; Incidence;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2011 سفارش ترجمه

Glycerophospholipids and glycerophospholipid-derived lipid mediators: A complex meshwork in Alzheimer's disease pathology

Keywords: بیماری آلزایمر; 2-AG; 2-arachidonoylglycerol; 4-HNE; 4-hydroxynonenals; 4-HHE; 4-hydroxyhexenal; AA; arachidonic acid; Aβ; β-amyloid; ADAM; A Disintegrin And Metalloprotease; ADAPT; Alzheimer's Disease Anti-inflammatory Prevention trial; AD; Alzheimer's disease; AE

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2011 سفارش ترجمه

Alzheimer's Association Report2011 Alzheimer's disease facts and figures

Keywords: بیماری آلزایمر; Alzheimer's disease; Dementia; Prevalence; Incidence; Mortality; Caregivers; Family caregiver; Spouse caregiver; Health care costs; Health expenditures; Long-term care costs; Hospice care costs; Medicare spending; Medicaid spending; Early detection; Ear

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2011 سفارش ترجمه

Tricyclic sulfones as orally active γ-secretase inhibitors: Synthesis and structure-activity relationship studies

Keywords: بیماری آلزایمر; γ-Secretase; Alzheimer's disease; Sulfone;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Tetracyclic sulfones as potent γ-secretase inhibitors: Synthesis and structure-activity relationship studies

Keywords: بیماری آلزایمر; γ-Secretase; Alzheimer's disease; Sulfone;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Nueva mutación en el gen PSEN1 (E120G) asociada a enfermedad de Alzheimer de inicio precoz

Keywords: بیماری آلزایمر; Enfermedad de Alzheimer; Presenilina 1; Demencia de inicio precoz; Mutación; Demencia familiar; Alzheimer's disease; Presenilin 1; Early onset dementia; Mutation; Familial dementia;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate

Keywords: بیماری آلزایمر; Molecular modelling; Ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate; AChE/BuChE inhibition; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه