Carbamate-appended N-alkylsulfonamides as inhibitors of γ-secretase
Keywords: بیماری آلزایمر; Alzheimer's disease; Secretase; Amyloid-β; Sulfonamides;
مقالات ISI بیماری آلزایمر (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Verification of the C-terminal intramolecular β-sheet in Aβ42 aggregates using solid-state NMR: Implications for potent neurotoxicity through the formation of radicals
Keywords: بیماری آلزایمر; Aβ42; Alzheimer's disease; Amyloid; β-Sheet; Rotational resonance; Solid-state NMR;
Mapping of phosphorylation-dependent anti-tau monoclonal antibodies in immunoblots using human tau-constructs synthesized by native chemical ligation
Keywords: بیماری آلزایمر; Alzheimer's disease; mAb; Peptide synthesis; Phosphopeptide; Western blot;
Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells
Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid precursor protein (APP); Low density lipoprotein receptor-related protein (LRP); Fluorescence resonance energy transfer (FRET); Fluorescence lifetime imaging microscopy (FLIM);
Reduced brain volumes in mice expressing APP-Austrian mutation but not in mice expressing APP-Swedish-Austrian mutations
Keywords: بیماری آلزایمر; Alzheimer's disease; Transgenic mouse; Amyloid precursor protein; Austrian APP mutation; Swedish APP mutation; Intraneuronal amyloid; Magnetic resonance imaging;
Macelignan attenuates LPS-induced inflammation and reduces LPS-induced spatial learning impairments in rats
Keywords: بیماری آلزایمر; Alzheimer's disease; Neuroinflammation; Microglia; Memory; Macelignan;
PerspectiveWe should not distinguish between symptomatic and disease-modifying treatments in Alzheimer's disease drug development
Keywords: بیماری آلزایمر; Alzheimer's disease; Clinical trials; Symptomatic treatment; Disease-modifying treatment;
Synthesis of fluorescent probes based on stilbenes and diphenylacetylenes targeting β-amyloid plaques
Keywords: بیماری آلزایمر; BODIPY; 4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene; PEG; poly ethylene glycol; Fluorescent probes; Alzheimer's disease; BODIPY; Near-IR imaging;
PerspectiveMemory health clinics-a first step to prevention
Keywords: بیماری آلزایمر; Alzheimer's disease; Preventive trials; Multi-domain approach; Memory health clinics;
Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain
Keywords: بیماری آلزایمر; AD; Alzheimer's disease; CD; circular dichroism; Cy; cyanidin; His; histidine; EM; electron microscopy; MAP; microtubule-associated protein; MB; methylene blue; MBD; microtubule-binding domain; 3RMBD; three-repeated MBD; 4RMBD; four-repeated MBD; MT; mi
PerspectiveMore than a decade of estrogen neuroprotection
Keywords: بیماری آلزایمر; Estrogens; Estradiol; Neuroprotection; Alzheimer's disease; Stroke; Mitochondria; Cell signaling;
PerspectiveOptimizing phase II of drug development for disease-modifying compounds
Keywords: بیماری آلزایمر; Drug development; Alzheimer's disease; Phase II; Phase III; Adaptive design; Neuropsychological test battery;
Oxidative damage in brain from human mutant APP/PS-1 double knock-in mice as a function of age
Keywords: بیماری آلزایمر; Aβ; amyloid β-peptide; BSA; bovine serum albumin; AD; Alzheimer's disease; APP; amyloid precursor protein; HNE; 4-hydroxy-2-trans-nonenal; 3-NT; 3-nitrotyrosine; PBS; phosphate-buffered saline; PS; presenilin; SDS; sodium dodecyl sulfate; Alzheimer's
In vitro production of huperzine A, a promising drug candidate for Alzheimer's disease
Keywords: بیماری آلزایمر; Huperzine A; Phlegmariurus squarrosus; Huperzia serrata; In vitro propagation; Alzheimer's disease; Lycopodium alkaloid; LC-MS;
Glial expression of cannabinoid CB2 receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome
Keywords: بیماری آلزایمر; cannabinoids; inflammation; amyloid; immunohistochemistry; AA; arachidonic acid; Aβ; β-amyloid; AD; Alzheimer's disease; AEA; arachidonoylethanolamide (anandamide); DS; Down's syndrome; ECS; endocannabinoid system; FAAH; fatty acid amide hydrolase;
Adaptación y validez convergente de una versión telefónica del Mini-Mental State Examination
Keywords: بیماری آلزایمر; MMSE; Trastorno cognoscitivo; Demencia; Enfermedad de Alzheimer; Telemedicina; MMSE; Cognitive impairment; Dementia; Alzheimer's disease; Telemedicine;
PerspectiveElectroencephalography and event-related potentials as biomarkers of mild cognitive impairment and mild Alzheimer's disease
Keywords: بیماری آلزایمر; Mild cognitive impairment; Alzheimer's disease; EEG; ERP; Biomarker;
Transthyretin binding to A-Beta peptide - Impact on A-Beta fibrillogenesis and toxicity
Keywords: بیماری آلزایمر; AD; Alzheimer's disease; WT TTR; wild-type transthyretin; V30M TTR; transthyretin with a valine substitute by a methionine at position 30; L55P TTR; transthyretin with a leucine substitute by a praline at position 55; Y78F TTR; transthyretin with a tyro
Cortical Damage in Alzheimer's Disease
Keywords: بیماری آلزایمر; Brain; diffusion; neurodegeneration; Alzheimer's disease;
PerspectiveRealizing the potential of positron emission tomography with 18F-fluorodeoxyglucose to improve the treatment of Alzheimer's disease
Keywords: بیماری آلزایمر; Clinical trial design; Alzheimer's disease; Brain imaging; Positron emission tomography; Image analysis;
Featured articleOne-week dose titration of extended release galantamine in patients with Alzheimer's disease
Keywords: بیماری آلزایمر; Alzheimer's disease; Acetylcholinesterase inhibitors; Galantamine; Extended release; Dose titration;
Featured articlePrognosis of Alzheimer's disease today: A two-year prospective study in 686 patients from the REAL-FR Study
Keywords: بیماری آلزایمر; Alzheimer's disease; Evolution; Prospective study; Specific management; Specific treatments;
Featured articleThe Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): Design and baseline characteristicsâ
Keywords: بیماری آلزایمر; Alzheimer's disease; Randomized clinical trial; Drug treatment; Atorvastatin; Donepezil;
Neuroimaging of individuals with Down's syndrome at-risk for dementia: Evidence for possible compensatory events
Keywords: بیماری آلزایمر; Down's syndrome; Alzheimer's disease; Dementia; Pre-clinical AD; MRI; PET; Voxel-based morphometry; Brain imaging;
PerspectivePartnership between academia and industry for drug discovery in Alzheimer's disease
Keywords: بیماری آلزایمر; Alzheimer's disease; Drug development; Drug discovery; Collaboration; Pharmaceutical industry; Academia;
Structure and dynamics of the full-length M1 muscarinic acetylcholine receptor studied by molecular dynamics simulations
Keywords: بیماری آلزایمر; Muscarinic M1 receptor; G-protein coupled proteins; Molecular dynamics simulations; Acetylcholine receptor; Alzheimer's disease;
Effectiveness and Safety of Donepezil in Hispanic Patients with Alzheimer's Disease: A 12-Week Open-Label Study
Keywords: بیماری آلزایمر; Alzheimer's disease; drugs; Latinos;
PerspectivePrevention therapeutics of dementia
Keywords: بیماری آلزایمر; Alzheimer's disease; Dementia; Clinical trials; Prevention; Drug development; Cholinesterase inhibitors; Memantine;
Aging-From molecules to populations
Keywords: بیماری آلزایمر; AD; Alzheimer's disease; SNP; single nucleotide polymorphism; Lifespan; Life course; Proteosome; Cognitive decline; Elite aging; Alzheimer's disease;
PerspectiveDifferentiating Alzheimer's disease from dementia with Lewy bodies and Parkinson's disease with (+)-[11C]dihydrotetrabenazine positron emission tomography
Keywords: بیماری آلزایمر; Dementia with Lewy bodies; Alzheimer's disease; Parkinson's disease; Nigrostriatal projection; Vesicular monoamine transporter type-2; Positron emission tomography; Dihydrotetrabenazine;
The pre-mild cognitive impairment, subjective cognitive impairment stage of Alzheimer's disease
Keywords: بیماری آلزایمر; Subjective cognitive impairment; Cognitive complaints; Brain aging; Mild cognitive impairment; Dementia; Alzheimer's disease;
PerspectiveEyes on the prize: Federal Alzheimer's research effort aims to facilitate interventions
Keywords: بیماری آلزایمر; Alzheimer's disease; National Institute on Aging; Dementia;
Automated Method for Identification of Patients With Alzheimer's Disease Based on Three-dimensional MR Images
Keywords: بیماری آلزایمر; Alzheimerâs disease; computer-aided diagnosis (CAD); magnetic resonance (MR) image; level set method;
Phosphorylation of tau and α-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related α-synucleinopathies
Keywords: بیماری آلزایمر; α-synuclein; tau; Parkinson's disease; dementia with Lewy bodies; Alzheimer's disease; A53T transgenic mouse; AD; Alzheimer's disease; BS; buffered sucrose; DLB; dementia with Lewy bodies; DLBc; common form of Dementia with Lewy bodies; DLBp; pure
Transgenic mice overexpressing human acetylcholinesterase and the Swedish amyloid precursor protein mutation: Effect of nicotine treatment
Keywords: بیماری آلزایمر; Aβ; hAChE-Tg//APPswe mice; nAChRs; l(â)-nicotine; d(+)-nicotine; AChE; acetylcholinesterase; AChE-S; synaptic acetylcholinesterase; AD; Alzheimer's disease; APP; amyloid precursor protein; APPswe mice; transgenic mice carrying the Swedish mutation of
Review articleBehavioral effects of current Alzheimer's disease treatments: A descriptive review
Keywords: بیماری آلزایمر; Alzheimer's disease; Cholinesterase inhibitors; Memantine; Behavior; Neuropsychiatric Inventory;
Making Alzheimer's disease matter. Enacting, interfering and doing politics of nature
Keywords: بیماری آلزایمر; Alzheimer's disease; Matters of concern; Enactment; Politics of nature; Ontological multiplicity; Interference;
Featured articleApolipoprotein E4 domain interaction: Synaptic and cognitive deficits in mice
Keywords: بیماری آلزایمر; apolipoprotein E; Alzheimer's disease; apoE4 domain interaction; Arg-61 apoE mouse model; synaptophysin; activity-regulated cytoskeleton-associated protein; neuroligin-1; glutamate transporter;
Consortium to Establish a Registry for Alzheimer's Disease (CERAD): The first twenty years
Keywords: بیماری آلزایمر; Consortium to Establish a Registry for Alzheimer's Disease; CERAD; Alzheimer's disease; Clinical assessment; Neuropsychological assessment; Neuropathological assessment; Norms; Prevalence; Incidence;
PerspectiveDisease-modifying therapies in Alzheimer's diseaseâ
Keywords: بیماری آلزایمر; Alzheimer's disease; Disease modification; Clinical trials; Neuroprotection;
Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses
Keywords: بیماری آلزایمر; Phosphatide; Uridine; Docosahexaenoic acid; Precursor; synaptic membrane; Dendritic spine; Alzheimer's disease;
Featured article2008 Alzheimer's disease facts and figures
Keywords: بیماری آلزایمر; Alzheimer's disease; Incidence; Prevalence; Mortality; Lifetime risks; Caregivers; Health care costs; Direct costs; Indirect costs;
The ubiquitin-proteasome system in spongiform degenerative disorders
Keywords: بیماری آلزایمر; AD; Alzheimer's disease; AgRP; Agouti related protein; AIDS; acquired immune deficiency syndrome; APP; amyloid precursor protein; ASPA; aspartoacylase gene; Atrn; attractin; BSE; bovine spongiform encephalopathy; CD; Canavan's spongiform leukodystroph
Short reportHuman brain myelination and amyloid beta deposition in Alzheimer's disease
Keywords: بیماری آلزایمر; Myelin; Oligodendrocyte; White matter; Amyloid; Iron; Alzheimer's disease; PIB; Degeneration; Dementia; Aging; Medications; Treatment; Prevention;
Greater frequency of subcortical lesions in severely demented patients with early onset Alzheimer's disease
Keywords: بیماری آلزایمر; Subcortical lesions; CT; MRI; Alzheimer's disease;
Short reportA novel PSENEN mutation in a patient with complaints of memory loss and a family history of dementia
Keywords: بیماری آلزایمر; Alzheimer's disease; PSENEN gene; Amyloid beta-protein; Neurogenetics; Skin primary fibroblast;
Serum surfactant protein D is correlated to development of dementia and augmented mortality
Keywords: بیماری آلزایمر; Alzheimer's disease; Cholesterol; Dementia; Inflammation; Mortality; Surfactant protein D;
The binding constant for amyloid Aβ40 peptide interaction with human serum albumin
Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid β40 peptide; Human serum albumin; Circular dichroism; Dissociation constant; α-Helix;
Berberine alters the processing of Alzheimer's amyloid precursor protein to decrease Aβ secretion
Keywords: بیماری آلزایمر; Aβ; amyloid-β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; APPNL-H4 cells; H4 cells stably expressing Swedish-type of human APP695; ELISA; enzyme-linked immunosorbent assay; FL; full-length; LDH; lactate dehydrogenase; LDL; low-de
Baja frecuencia clÃnica de la demencia por cuerpos de Lewy en el Instituto de NeurologÃa de México
Keywords: بیماری آلزایمر; Demencia por cuerpos de Lewy; Enfermedad de Alzheimer; Factores de riesgo vascular; Lewy body dementia; Alzheimer's disease; Vascular risk factors;