Relaxant effect of sildenafil in the rabbit basilar artery
Keywords: Cerebral arteries; cGMP; PDE-5; PDE inhibitors; Sildenafil; Vasodilation
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Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta
Keywords: Lepechinia caulescens; Ursolic acid; Oleanolic acid; Relaxation; Aortic smooth muscle; Nitric oxide; cGMP;
VEGF-E activates endothelial nitric oxide synthase to induce angiogenesis via cGMP and PKG-independent pathways
Keywords: VEGFR-2 (KDR); VEGF; cGMP; PKG; Nitric oxide; Angiogenesis
The impact of cGMP compliance on consumer confidence in dietary supplement products
Keywords: Current Good Manufacturing Practices (GMP); cGMP; Dietary supplements; Regulations; Quality control; Purity; Testing requirements
Heme oxygenase–carbon monoxide (HO–CO) system in rat uterus: Effect of sexual steroids and prostaglandins
Keywords: Heme oxygenase; Carbon monoxide; Uterus; Pregnancy; Prostaglandins; cGMP; Steroids; Oxidative stress
Developmental regulation of nerve and receptor mediated contractions of mammalian urinary bladder smooth muscle
Keywords: Development; Cholinergic; Purinergic; Rho-kinase; cGMP
Cyclic nucleotide kinases and tachyzoite–bradyzoite transition in Toxoplasma gondii
Keywords: Differentiation; Bradyzoite; Kinase; Toxoplasma; Reporter parasite; Cyclic nucleotide; cAMP; cGMP
Characterization of a novel cyclic nucleotide-gated channel from zebrafish brain
Keywords: Cyclic nucleotide-gated channel; CNG channel; Brain; cGMP; cAMP; Rundown; Zebrafish
Signalisation cellulaire et physiopathologie de l'hypertension artérielle pulmonaire
Keywords: Monoxyde d'azote; NO synthase; GMPc; Guanylate cyclase soluble; Phosphodiestérase-5; Endothéline-1; Récepteurs ET-A et ET-B de l'endothéline; Biologie; Hypertension artérielle pulmonaire; Nitric oxide; NO synthase; cGMP; Soluble guanyl cyclase; P
Analysis of PDE6 function using chimeric PDE5/6 catalytic domains
Keywords: Phototransduction; Phosphodiesterase; PDE5; PDE6; cGMP
An anti-tumor role for cGMP-dependent protein kinase
Keywords: Protein kinase; Gene expression; Colon cancer; cGMP; Nude mouse; Tumor
Nitric oxide stimulates PC12 cell proliferation via cGMP and inhibits at higher concentrations mainly via energy depletion
Keywords: PC12; cGMP; Nitrogen monoxide; Mitochondria; Cytostasis; Glycolysis
C-type natriuretic peptide modulates glutamate receptors on cultured rat retinal amacrine cells
Keywords: C-type natriuretic peptide; glutamate receptor; cGMP; amacrine cells; retinaANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; CNP, C-type natriuretic peptide; DMEM, Dulbecco’s modified Eagle’s medium; DMSO, dimethyl sulfoxide; GC, guanylyl
Intracellular cGMP may promote Ca2+-dependent and Ca2+-independent release of catecholamines from sympathetic nerve terminals
Keywords: Sympathetic nerves; Norepinephrine release; β-Adrenergic receptors; cGMP; Nitric oxide (NO); Propranolol; Rat;
Distribution and expression pattern of the nitrergic system in the cerebellum of the sheep
Keywords: neuronal nitric oxide synthase; inducible nitric oxide synthase; nitrotyrosine; sheep; cerebellum; cGMP; cyclic guanosine-5â²-monophosphate; iNOS; inducible nitric oxide synthase; NADPH; nicotinamide adenine dinucleotide phosphate; nNOS; neuronal nitric
Role of epithelial nitric oxide in airway viral infection
Keywords: BALF; bronchoalveolar lavage fluid; CF; cystic fibrosis; cGMP; guanosine 3â²,5â²-cyclic monophosphate; CMV; cytomegalovirus; dsRNA; double-stranded RNA; EPO; eosinophil peroxidase; GAS; γ-activated site; GSH; reduced glutathione; HIV; human immunodefic
The regulation of myosin II in Dictyostelium
Keywords: Dictyostelium, myosin; Cortical tension; Signal transduction; cGMP
Differential expression of genes involved in cGMP-dependent nitric oxide signaling in murine embryonic stem (ES) cells and ES cell-derived cardiomyocytes
Keywords: Embryonic stem cells; Cardiomyocyte; Differentiation; Nitric oxide; cGMP
Phosphorylation: A molecular switch in opioid tolerance
Keywords: Phosphorylation; Protein kinase; Phosphatase; PKC; CaMKII; PKA; PKG; GRK; CREB; NO; cAMP; cGMP; Calmodulin; Calcium; NMDA
The nitric oxide–guanosine 3′,5′-cyclic monophosphate pathway regulates dopamine efflux in the medial preoptic area and copulation in male rats
Keywords: male sexual behavior; nitric oxide; dopamine; cGMP; sGC; MPOAaCSF, artificial cerebrospinal fluid; BL, baseline sample; cAMP, cyclic AMP; cGMP, guanosine 3′,5′-cyclic monophosphate; COP, copulation testing sample; DA, dopamine; DOPAC, 3, 4-dihydroxyphenyl
Cortical feedback to the thalamus is selectively enhanced by nitric oxide
Keywords: nitric oxide; vision; LGN; thalamus; parabrachial brainstem; NMDA; ACSF; artificial cerebrospinal fluid; APV; dl-2-amino-5-phosphonovaleric acid; cGMP; cyclic guanosine 3â²,5â²-monophosphate; DNQX; 6,7-dinitroquinoxaline-2,3(1H,4H)-dione; EPSC; excitato
ANP-mediated cGMP signaling and phosphodiesterase inhibition in the rat cervical spinal cord
Keywords: Natriuretic peptides; Phosphodiesterase; cGMP; Spinal cord; Intersegmental connections;
Signalling via cGMP: Lessons from Drosophila
Keywords: cGMP; Drosophila; Renal tubules; cGMP-dependent protein kinase; Phosphodiesterase;
Therapeutic potential of nitric oxide in cancer
Keywords: Nitric oxide sensitization; cGMP; NO donors; S-nitrosation; S-nitrosylation; NO-based therapy; Cancer therapy; Apoptosis
Cellular neuroscienceA novel role for cyclic guanosine 3â²,5â²monophosphate signaling in synaptic plasticity: A selective suppressor of protein kinase A-dependent forms of long-term potentiation
Keywords: hippocampus; cyclic nucleotides; phosphodiesterase; protein phosphatase; ACSF; artificial cerebrospinal fluid; cAMP; cyclic AMP; cGMP; cyclic guanosine 3â²,5â²monophosphate; DMSO; dimethyl-sulfoxide; DPCPX; 1,3-dipropyl-8-cyclopentyl xanthine; fEPSP; fi
Novel isoforms of NADPH-oxidase in cerebral vascular control
Keywords: Aβ; amyloid-β peptide; ACE; angiotensin-converting enzyme; ACh; acetylcholine; AD; Alzheimer's disease; AEBSF; aminoethylbenzenesulfono fluoride; APP; amyloid precursor protein; CBF; cerebral blood flow; cGMP; guanosine monophosphate; DETCA; diethyldith
The role of phosphodiesterase isoforms 2, 5, and 9 in the regulation of NO-dependent and NO-independent cGMP production in the rat cervical spinal cord
Keywords: Nitric oxide; cGMP; Phosphodiesterase; Spinal cord; Micropharmacology; Nociception;
Sildenafil potentiates nitric oxide mediated inhibition of human platelet aggregation
Keywords: Nitric oxide; cGMP; Phosphodiesterase inhibitors; Platelet aggregation;
Effects of acute and chronic restraint stress on nitroglycerin-induced hyperalgesia in rats
Keywords: cGMP; Hyperalgesia; Immobilization; Migraine; Pain; Nitric oxide; Nitroglycerin; Stress; Tail-flick test;
The effect of a nitric oxide donor, sodium nitroprusside, on the release of acetylcholine from the in vitro cat carotid body
Keywords: Carotid body; Acetylcholine; Nitric oxide; Sodium nitroprusside; Cgmp; Nitrosylation; Calcium channels; Hypoxia;
Vaccines based on Nef and on Nef/ÎV2 Env
Keywords: HIV Env; MVA vaccine vector; HIV Nef; cGMP; current good manufacturing practices; HAART; highly active anti-retroviral therapy; HLA; human leucocyte antigens; HIV; human immunodeficiency virus; ICS; intracellular cytokine staining; IFNγ; interferon-gamma
Effects of MK-801 on nitrite and cGMP levels during focal cerebral ischemia in rats
Keywords: Focal cerebral ischemia; Stroke; Nitric oxide; Nitrite; cGMP; MK-801;
Effect of IPs, cAMP, and cGMP on the hPL and hCG secretion from human term placenta
Keywords: Human placenta; Human chorionic gonadotrophin; Human placental lactogen; IPs; cAMP; cGMP;
Distribution of cGMP-dependent protein kinase type I and its isoforms in the mouse brain and retina
Keywords: brain; cGMP; immunohistochemistry; nitric oxide; protein kinase; retina; am; amygdala; cGK; cyclic guanosine-3â²,5â²-monophosphate-dependent protein kinase; cGKI; cyclic guanosine-3â²,5â²-monophosphate-dependent protein kinase type I; cGMP; cyclic gua
Natriuretic peptide interaction with [3H]isatin binding sites in rat brain
Keywords: Neurotransmitters, modulators, transporters, and receptors; Other neurotransmitters; Brain; Isatin; Isatin binding sites; Natriuretic peptide receptors; cGMP; cAMP; Signalling;
Induced Nitric Oxide Impairs Relaxation but Not Contraction in Endotoxin-Exposed Rat Pulmonary Arteries
Keywords: sepsis; pulmonary artery; lung injury; nitric oxide; inducible nitric oxide synthase; cGMP; pulmonary hypertension;
Activation of α2-adrenoceptors is necessary to induce nitric oxide release in isoprenaline-induced relaxation
Keywords: Isoprenaline; Forskolin; cAMP; cGMP; Vasodilatation; Vascular endothelium; α2-Adrenoceptors;
Endothelium-dependent and direct relaxation induced by ethyl acetate extract from Flos Chrysanthemi in rat thoracic aorta
Keywords: 4-AP; 4-aminopyridine; cGMP; cyclic guanosine monophosphate; EDHF; endothelium-derived hyperpolarizing; EGTA; ethylene glycol-bis-[β-aminoethyl]-N,N,Nâ²,Nâ²-tetraacetic acid; FC; Flos Chrysanthemi; FCE; Flos Chrysanthemi extract; 5-HD; 5-hydroxydecanoa
cGMP (guanosine 3â²,5â²-cyclic monophosphate) transport across human erythrocyte membranes
Keywords: OSV; one-step inside-out membrane vesicles prepared by the spontaneous vesiculation method; SKNV; inside-out membrane vesicles prepared by the modified Steck and Kant; Nycodenz method; Erythrocyte; cGMP; ABC transporter; Multidrug-resistance associated pr
Hemodynamic Effects of Sildenafil in Patients With Congestive Heart Failure and Pulmonary Hypertension
Keywords: heart failure, congestive; hypertension, pulmonary; nitric oxide; type 5 phosphodiesterase; vasodilator agents; cGMP; cyclic guanosine monophosphate; CI; cardiac index; +dP/dtmax; maximal rate of rise in LV pressure; +dP/dtmax/DT; maximal rate of rise in
Restoration of learning ability in hyperammonemic rats by increasing extracellular cGMP in brain
Keywords: Neural bases of behavior; Learning and memory: physiology; Hepatic encephalopathy; Nitric oxide; Soluble guanylate cyclase; Learning; Hyperammonemia; cGMP;
Calcium/calmodulin-dependent nitric oxide synthase activity in the CNS of Aplysia californica: Biochemical characterization and link to cGMP pathways
Keywords: Aplysia californica; Nitric oxide synthase; cGMP; Molluscs; Invertebrates;
Soluble guanylyl cyclase: more secrets revealed
Keywords: cGMP; Nitric oxide; Guanylyl cyclase;
Serotonin transporter mutations associated with obsessive-compulsive disorder and phosphorylation alter binding affinity for inhibitors
Keywords: Serotonin; Transporter; Antidepressant; cGMP; Regulation; Mutation;
Relationship between urinary cGMP excretion and serum total cholesterol levels in a general population
Keywords: cGMP; Nitric oxide; Total cholesterol; Cross-sectional studies;
Peroxynitrite-induced relaxation in isolated rat aortic rings and mechanisms of action
Keywords: Peroxynitrite; Rat aorta; Relaxation; Oxidants; Reactive oxygen species; cGMP; Hyperpolarization;
Inducible nitric oxide synthase-dependent stimulation of PKGI and phosphorylation of VASP in human embryonic kidney cells
Keywords: cAMP; cyclic adenosine 3â²-5â²-monophosphate; cGMP; cyclic guanosine 3â²-5â²-monophosphate; DEA/NO; 2,2-diethyl-1-nitroso-oxyhydrasine; DETA/NO; (Z)-1-[(2-aminoethyl)-N-(2-ammonioethyl) amino] diazen-1-ium-1,2-diolate; GC; guanylyl cyclase; HEK ce
Vibration induced hearing loss in guinea pig cochlea: expression of TNF-α and VEGF
Keywords: CAP; compound action potential; TNF-α; tumour necrosis factor alpha; TNFR; TNF receptor; VEGF; vascular endothelium growth factor; VEGFR; VEGF receptor; SSRE; shear stress response element; NF-κB; nuclear factor-κB; PDGF-B; platelet-derived growth fact
Activation of protein kinase A by atrial natriuretic peptide in neonatal rat cardiac fibroblasts: Role in regulation of the local renin-angiotensin system
Keywords: Cardiac fibroblasts; Renin; Angiotensinogen; Angiotensin II; cAMP; cGMP; Cardiac development;
Inhibitory effects on human eosinophil chemotaxis in vitro by BAY 41-2272, an activator of nitric oxide-independent site of soluble guanylate cyclase
Keywords: BAY 41-2272; 5-cyclopropyl-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidin-4-ylamine; cAMP; cyclic adenosine-3â²,5â²-monophosphate; cGMP; cyclic guanosine-3â²,5â²-monophosphate; fMLP; formyl-methionyl-leucyl-phenylalanine; IBMX; 3-iso