Keywords: Dhfr; ALL; acute lymphoblastic leukemia; AraC; cytosine Arabinoside; BrdU; bromodeoxyuridine; CNS; central nervous system; DG; Dorsal Ganglion; DHFR; dihydrofolate reductase; IP; intraperitoneal; LSD; Fisher's least significant difference; MTX; methotrexate;
مقالات ISI Dhfr (ترجمه نشده)
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Keywords: Dhfr; Flavoenzymes; Folate; Mutagenesis; Enzyme kinetics; Reductase; Glutamine; CH2-H4folate; 5,10-methylenetetrahydrofolate; CH3-H4folate; 5-methyltetrahydrofolate; DHFR; dihydrofolate reductase; E. coli; Escherichia coli; EDTA; ethylenediaminetetraacetic acid
Keywords: Dhfr; 5-FU; 5-Fluorouracil; AI; aromatase inhibitor; BC; breast cancer; CDK; cyclin-dependent kinase; DHF; dihydrofolate; DHFR; dihydrofolate reductase; ER; estrogen receptor; FSH; follicle stimulating hormone; FDA; Food & Drug Administration; GnRH; gonadotroph
Keywords: Dhfr; Folic acid; Folate; Fortification; Supplementation; Neural tube defect; Primary prevention; ASD; autism spectum disorder; BfR; Bundesinstitut für Risikobewertung, Federal Republic of Germany; Cbl; cyanocobalamin; CDC; Centers for Disease Control and Prev
Keywords: Dhfr; Schistosoma mansoni; Nucleotide metabolism; Dihydrofolate reductase (DHFR); Isothermal titration calorimetry (ITC); X-ray crystallography; DHFR; dihydrofolate reductase; rSmDHFR; recombinant Schistosoma mansoni DHFR; NADPH and NADP+; nicotinamide adenine
Keywords: Dhfr; Folate pathway; Trypanosomatids; Structure-based drug design; Selective inhibition; Enzyme inhibitor; Anti-parasitic drug; PTR1; Pteridine reductase 1; DHFR; Dihydrofolate reductase; dUMP; Deoxyuridine monophosphate; dTMP; Deoxythymidine monophosphate; hD
Keywords: Dhfr; Dihydrofolate Reductase; DHFR; Structure-based Alignment; Phylogeny; Evolution; Plasmid evolution; Horizontal Gene Transfer; Network of Coupled Protein Motion;
Keywords: Dhfr; CH2THF; 5,10-methylene tetrahydrofolate; DCD; dCTP deaminase; DCD-DUT; bifunctional dCTP deaminase-dUTPase; DUT; dUTPase; DHF; dihydrofolate; DHFR; dihydrofolate reductase; DHFR-TS; bifunctional dihydrofolate reductase - thymidylate synthase; FAD; f
Keywords: Dhfr; Bone morphogenetic protein-7 (BMP-7); Chinese hamster ovary (CHO) cells; Recombinant protein expression; Stable cell line; Bioreactor process; BMP-7; bone morphogenetic protein-7; CHO; Chinese hamster ovary; DHFR; dihydrofolate reductase; EC50; effective
Keywords: Dhfr; DHFR; dihydrofolate reductase; ecDHFR; Escherichia coli DHFR; NADPH; reduced nicotinamide adenine dinucleotide phosphate; NADP+; oxidized nicotinamide adenine dinucleotide phosphate; DHF; 7,8-dihydrofolate; THF; 5,6,7,8-tetrahydrofolate; Tris; tris(hydrox
Keywords: Dhfr; 2Nal; 3-(2-naphthy)-alanine; AFWK; pheylalanine/tryptophan/lysine triple auxotrophic E. coli; DHB; 2,5-dihydroxybenzoic acid; DHF; dihydrofolate; DHFR; dihydrofolate reductase; Glu; glutamic acid; LB; Lria-Broth; Lys; lysine; MALDI-TOF MS; matrix-assisted
Keywords: Dhfr; Hybrid molecules; Anti-fungal; Anti-tubercular; Anti-malarial; anti-inflammatory; ACTs; artemesinin based combination therapy; CQ; chloroquine; CC50; concentration required to reduce growth by 50%; EC50; half maximal effective concentration; Fqa; ferroqui
Keywords: Dhfr; AdoMet; S-adenosylmethionine; DHF; dihydrofolate; DHFR; DHF reductase; ENU; ethylnitrosourea; ESTR; Expanded Simple Tandem Repeat; FA; folic acid; MTHFR; 5,10-methylenetetrahydrofolate reductase; MN; micronucleus; CD24-; Pig-a mutant phenotype; NCE; normo
Keywords: Dhfr; AS + SP; artesunate + sulfadoxine-pyrimethamine; P. falciparum; Plasmodium falciparum; CQ; chloroquine; dhfr; dihydrofolate reductase; dhps; dihydropteroate synthetase; crt; chloroquine resistance transporter; mdr-1; multi drug resistance 1; SNPs; s
Keywords: Dhfr; ADP; adenosine diphosphate; APH; aminoglycoside phosphotransferase (3â²)-IIIa; BSA; bovine serum albumin; Cc; iso-1-ferricytochrome c; CcP; ferricytochrome c peroxidase; CD; circular dichroism; ConA; concanavalin A; ÎCp; change in heat capacity; ÎG; Gi
Keywords: Dhfr; sGC stimulator BAY 41-8543 (PubChem CID: 9953906); nitroglycerin (PubChem CID: 4510); nitric oxide (PubChem CID: 145068); peroxynitrite (PubChem CID: 104806); superoxide (PubChem CID: 5359597); 3-nitrotyrosine (PubChem CID: 65124); dihydroethidium (PubChe
Keywords: Dhfr; Xenopus; Folate; DHFR; Orofacial development; Retinoic acid and primary palate;
Keywords: Dhfr; ACSS; acetyl-CoA synthetase; ADI; arginine deiminase; AML; acute myeloid leukaemia; AMPK; AMP-activated protein kinase; ALL; acute lymphoblastic leukaemia; ASS; argininosuccinate synthase; BCAAs; branched-chain amino acids; BPTES; bis-2-(5-phenylacetamido
Keywords: Dhfr; Folate intake; Requirements; Pregnancy; DFEs; dietary folate equivalents; DHFR; dihydrofolate reductase; DRI; Dietary Reference Intake; EAR; Estimated Average Requirements; FA; folic acid; MCV; mean corpuscular volume (MCV); MTHFR; methylenetetrahydrofola
Keywords: Dhfr; amino-BH4; 4-amino-(6R)-5,6,7,8-tetrahydro-l-biopterin; BAECs; bovine aortic endothelial cells; BH2; 7,8-dihydro-l-biopterin; BH4; (6R)-5,6,7,8-tetrahydro-l-biopterin; cGMP; 3â²,5â²-cyclic guanosine monophosphate; DAHP; 2,4-diamino-6-hydroxypyrimidine;
Keywords: Dhfr; Antifolate; DHFR; Protein flexibility; X-ray crystallography; Molecular dynamics;
Keywords: Dhfr; Ala; alanine; Amm; ammonium; ATP; adenosine triphosphate; CHO; Chinese hamster ovary cell; DHFR; dihydrofolate reductase; EFM; elementary flux mode; EP; extreme pathway; ETC; electron transfer chain; Glc; glucose; Gln; glutamine; Glu; glutamate; GLY; glyc
Keywords: Dhfr; Epigenetics; Phytochemicals; DNA-methylation; Histone-modification; miRNA; Carcinogenesis; Akt; v-akt murine thymoma viral oncogene homolog 1; AP-1; Activator Protein-1; Bax; BCL2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; Bcl-xL; B-cell lymphoma-
Keywords: Dhfr; ADA-SCID; adenosine deaminase deficiency; cDNA; complementary DNA; CHMP; Committee on Human Medicinal Products; DHFR; dihydrofolate reductase; DNA; deoxyribonucleic acid; E1; adenoviral gene; E1B 55K; adenoviral gene; EMA; European Medicines Agency; FDA;
Plasmodium RON12 localizes to the rhoptry body in sporozoites
Keywords: Dhfr; RON; rhoptry neck protein; PV; parasitophorous vacuole; AMA1; apical membrane antigen 1; DHFR; dihydrofolate reductase; IFA; indirect immunofluorescence assay; IEM; immunoelectron microscopy; Merozoite; Plasmodium; Rhoptry; Rodent malaria; RON12; Sporozoi
Investigation of potential anti-malarial lead candidate 2-(4-fluorobenzylthio)-5-(5-bromothiophen-2-yl)-1,3,4-oxadiazole: Insights from crystal structure, DFT, QTAIM and hybrid QM/MM binding energy analysis
Keywords: Dhfr; Oxadiazole; Thiophene; Hetero-halogen contact; DHFR; Anti-malarial; Hybrid QM/MM;
The application of the HyPer fluorescent sensor in the real-time detection of H2O2 in Babesia bovis merozoites in vitro
Keywords: Dhfr; DHFR; dihydrofolate reductase; GFP; green fluorescent protein; IRBC; infected red blood cell; PCR; polymerase chain reaction; RBC; red blood cell; TPx-1; thioredoxin peroxidase-1; Babesia; Reactive oxygen species; HyPer; Time-lapse imaging;
Single-step purification of recombinant Gaussia luciferase from serum-containing culture medium of mammalian cells
Keywords: Dhfr; CHO-K1/dhfr-; Ni-chelate column; Non-ionic detergent; Coelenterazine; GLase; Gaussia luciferase; GLase-His; histidine-tagged Gaussia luciferase; CHO; Chinese hamster ovary; dhfr; dihydrofolate reductase; Imax; maximum intensity of luminescence; rlu; relat
Visualisation of intracellular production bottlenecks in suspension-adapted CHO cells producing complex biopharmaceuticals using fluorescence microscopy
Keywords: Dhfr; bsAb; bispecific antibody; CHO; chinese hamster ovary; ER; endoplasmic reticulum; IgG; Immunoglobulin G; DTE; difficult-to-express; DHFR; dihydrofolate reductase; MTX; Methotrexate; VCD; viable cell density; qRT-PCR; quantitative real-time polymerase chai
Emerging role of lncRNAs in systemic lupus erythematosus
Keywords: Dhfr; AR5; accessible region 5; C3; complement 3; CNS3; conserved noncoding sequence 3; DBD; DNA-binding domain; DCs; dendritic cells; DDX5; RNA helicase DEAD-box protein 5; DHFR; dihydrofolate reductase; DNMTs; DNA methyltransferases; ERα; estrogen receptor Î
Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics
Keywords: Dhfr; ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy
Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents
Keywords: Dhfr; Pj; Pneumocystis jirovecii; PCP; Pneumocystis pneumonia; ART; antiretroviral therapy; TMP; trimethoprim; SMX; sulfamethoxazole; DHFR; dihydrofolate reductase; DHPS; dihydropteroate synthase; PTX; piritrexim; TMQ; trimetrexate; PC; Pneumocystis carinii; DH
Inhibitors of dihydrofolate reductase as antitumor agents: design, synthesis and biological evaluation of a series of novel nonclassical 6-substituted pyrido[3,2-d]pyrimidines with a three- to five-carbon bridge
Keywords: Dhfr; DHFR; Antitumor; Nonclassical antifolates; Molecular docking study;
1,3,5-triazaspiro[5.5]undeca-2,4-dienes as selective Mycobacterium tuberculosis dihydrofolate reductase inhibitors with potent whole cell activity
Keywords: Dhfr; Dihydrofolate reductase (DHFR); Antimycobacterial agent; Tuberculosis (TB); 1,3,5-triazaspiro[5.5]undeca-2,4-diene; DHFR; dihydrofolate reductase; DMPK; drug metabolism and pharmacokinetics; FRLM; female rat liver microsomes; HBA; hydrogen bond acceptors;
Alpha repeat proteins (αRep) as expression and crystallization helpers
Keywords: Dhfr; PCA; protein complementation assay; DHFR; dihydrofolate reductase; LIC; ligation independant cloning; Artificial repeat proteins; Protein library; Crystallization helper; Protein complementation assay; Fusion protein;
Similar structural stabilities of 3-isopropylmalate dehydrogenases from the obligatory piezophilic bacterium Shewanella benthica strain DB21MT-2 and its atmospheric congener S. oneidensis strain MR-1
Keywords: Dhfr; CD; circular dichroism; CSM; center of fluorescence spectral mass; DHFR; dihydrofolate reductase; IPM; 3-isopropylmalate; IPMDH; 3-isopropylmalate dehydrogenase; NAD; oxidized nicotinamide adenine dinucleotide; PAGE; polyacrylamide gel electrophoresis; pI
Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides
Keywords: Dhfr; Coronary circulation; Endothelium; Nitric oxide; Ischemia; Oxidant stress; 2'-P-(c)ADPR; 2â²-phospho (cyclic) adenosine diphosphate ribose; BH2; Dihydrobiopterin; BH4; Tetrahydrobiopterin; BSA; Bovine serum albumin; CF; Coronary flow; cGMP; Cyclic guan
ReviewMuch more than you expected: The non-DHFR-mediated effects of methotrexate
Keywords: Dhfr; ADA; adenosine deaminase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; ALL; acute lymphoblastic leukemia; ATIC; AICAR transformylase; ATRA; all-trans retinoic acid; DHF; dihydrofolate; DHFR; dihydrofolate reductase; E2F1; E2F transcription factor
The nuclear protein-coding gene ANKRD23 negatively regulates myoblast differentiation
Keywords: Dhfr; MRFS; myogenic regulatory factors; MARP; muscle ankyrin repeat protein; CARP; cardiac ankyrin repeat protein; Ankrd2; Ankyrin repeat domain protein2; ANKRD23; diabetes related ankyrin repeat protein; MyoG; myogenin; LncRNAs; long non-coding RNAs; MLP; mus
H19 mediates methotrexate resistance in colorectal cancer through activating Wnt/β-catenin pathway
Keywords: Dhfr; CRC; colorectal cancer; DHFR; dihydrofolate reductase; DMEM; Dulbecco's modified Eagle's medium; lncRNAs; long or large noncoding RNAs; HT-29-R; MTX-resistant colorectal cell line HT-29; MDR1; multi-drug resistance 1; MTT; 3-(4,5-Dimethylthiazol-2-yl)-2,5
Folate and microRNA: Bidirectional interactions
Keywords: Dhfr; 1CM; One-carbon metabolism; 5-MTHF; methyltetrahydrofolate; Aβ; amyloid-β protein; APP; amyloid precursor protein; DHFR; dihydrofolate reductase; MTHFR; methylenetetrahydrofolate reductase; MTR; methionine synthase; NAFLD; Non-alcoholic fatty liver dise
In silico analysis of glycinamide ribonucleotide transformylase inhibition by PY873, PY899 and DIA
Keywords: Dhfr; GAR; glycinamide ribonucleotide; GART; glycinamide ribonucleotide transformylase; DIA; 5-((4-carboxy-4-(4-(((2,4-diaminopyrido[3,2-d]pyrimidine-6-yl)methyl)amino)benzamido)butyl)carbamoyl)-isophthalic acid; DHFR; dihydrofolate reductase; PY899; 2,4-diamin
Comparison of two methods for transformation of Plasmodium knowlesi: Direct schizont electroporation and spontaneous plasmid uptake from plasmid-loaded red blood cells
Keywords: Dhfr; RBC; red blood cell; pRBC; parasitized red blood cell; hct; hematocrit; dhfr; dihydrofolate reductase gene; hdhfr; human dihydrofolate reductase gene; Malaria; Transfection; Cell electroporation; Luciferase; Genetic modification;
Quinazolinone-benzimidazole conjugates: Synthesis, characterization, dihydrofolate reductase inhibition, DNA and protein binding properties
Keywords: Dhfr; Quinazoline; Benzimidazole; DHFR; Calf thymus DNA; Bovine serum albumin;
Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and antimicrobial activities
Keywords: Dhfr; Benzothiazole; DFT; PM6; Antimicrobial activity; Molecular docking; Antimalarial activity; DHFR;
1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities
Keywords: Dhfr; 1,2,4-Triazole; 1,3,4-Oxadiazole; DFT; PM6; Anti-microbial activity; S. pombe; Molecular docking; Anti-malarial activity; DHFR;
Research review paperImproving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions
Keywords: Dhfr; ATF6c; activating transcription factor 6; CHO; Chinese hamster ovary; DHFR; dihydrofolate reductase; effector gene; a transgene ectopically expressed with the purpose of obtaining a phenotypic change; IE; inducible expression; EPO; erythropoietin; ER; end
Strategies for development of optogenetic systems and their applications
Keywords: Dhfr; AU1; Aureochrome 1; BLUF; blue-light-utilizing FAD; BphP1; bacterial bathy phytochrome 1; BV; biliverdin IXα; COP1; constitutively photomorphogenic 1; CRY2; cryptochrome 2; CIB1; cryptochrome interacting basic-helix-loop-helix protein 1; CPH1; cyanobacte
The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats
Keywords: Dhfr; ACh; acetylcholine; AGE; advanced glycation end products; ALDH-2; mitochondrial aldehyde dehydrogenase; CCL-2; see MCP-1; ChIP; chromatin immunoprecipitation; COX2; cyclooxygenase-2; CRP; C-reactive protein; DHE; dihydroethidine; DHFR; dihydrofolate reduc
Crystal structures of nematode (parasitic T. spiralis and free living C. elegans), compared to mammalian, thymidylate synthases (TS). Molecular docking and molecular dynamics simulations in search for nematode-specific inhibitors of TS
Keywords: Dhfr; TS; thymidylate synthase; Ce; Caenorhabditis elegans; Ec; Escherichia coli; Lc; Lactobacillus casei; Ts; Trichinella spiralis; DHFR; dihydrofolate reductase; Thymidylate synthase (TS); Crystal structures; Molecular docking; Inhibitors of Trichinella spira