دانلود مقالات ISI درباره Erk + ترجمه فارسی

Targeting ERK signaling pathway by polyphenols as novel therapeutic strategy for neurodegeneration

Keywords: Neurodegenerative diseases; Flavonoids; Natural products; MAPK; ERK; MEK/ERK;

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease

Keywords: mGlu; Metabotropic glutamate receptor; PD; Parkinson's disease; T10; Triptolide; LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; TNF; tumor necrosis factor; IL; interleukin; SN; substantia nigra; COX; cyclooxygenase; JN

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses

Keywords: AngII; Angiotensin II; AT1R; angiotensin type 1 receptor; βarr; β-Arrestin; DMR; dynamic mass redistribution; ERK; extracellular signal-regulated kinase; GPCR; G protein coupled receptor; PTX; pertussis toxin; PI3K; phosphoinoside 3-kinase; rVSMC; rat v

دانلود رایگان متن کامل مقاله ISI 52 صفحه سال انتشار : 2018 سفارش ترجمه

Redox control of cancer cell destruction

Keywords: ABC transporters; ATP-binding cassette transporters; ADCC; antibody-dependent cell-mediated cytotoxicity; ADCP; antibody-dependent cancer cell phagocytosis; AML; acute myeloid leukemia; APE1; apurinic/apyrimidinic endonuclease 1; ASK-1; apoptosis signal-r

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

On the G protein-coupling selectivity of the native A2B adenosine receptor

Keywords: BAY60-6583; 2-[[6-amino-3,5-dicyano-4-[4-(cyclopropylmethoxy)phenyl]-2-pyridinyl]thio]-acetamide; cAMP; 3′,5′-cyclic adenosine monophosphate; CE3F4; 5,7-dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde; CGS21680; 2-[p-(2-carboxyethy

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

Impairment of learning and memory performances induced by BPA: Evidences from the literature of a MoA mediated through an ED

Keywords: Bisphenol A; Endocrine disruption; Learning and memory; Nervous system; 5α-R; 5 α-reductase; AChE; acetylcholinesterase; Akt; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANSES; Agence Nationale de Sécurité Sanitaire

دانلود رایگان متن کامل مقاله ISI 54 صفحه سال انتشار : 2018 سفارش ترجمه

Atorvastatin impaired glucose metabolism in C2C12 cells partly via inhibiting cholesterol-dependent glucose transporter 4 translocation

Keywords: ABC; ATP-binding cassette; Akt; Protein kinase B; AUC; area under the concentrationtime curve; BW; body weight; CMC; carboxyl methyl cellulose; ERK; extracellular-regulated protein kinase; GCK; glucokinase; GLUT2; glucose transporter 2; GLUT4; glucose tra

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

Uveal melanocytes express high constitutive levels of MMP-8 which can be upregulated by TNF-α via the MAPK pathway

Keywords: Uveal melanocyte; MMP-8; TNF-α; JNK; ERK; Uveal melanoma; DMEM; Dulbecco's modified Eagle's medium; ECM; extracellur matrix; ERK; extracellular signal-regulated kinases; FBS; fetal bovine serum; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated prote

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2018 سفارش ترجمه

Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents

Keywords: MAPK; RAF inhibitors; Anti-cancer agents; Abl; Abelson murine leukemia viral oncogene; ATP; Adenine triphosphate; Bcl-2; B-cell lymphoma; CNS; Central nervous system; COX-2; Cyclo-oxygenase enzyme-2; CR; Conserved region; CRD; Cysteine-rich domain; DFG; A

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2018 سفارش ترجمه

The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review

Keywords: AM; Atractylodes macrocephala Koidz.; TCM; traditional Chinese medicine; UPLC; ultra-performance liquid chromatography; PDA; photo-diode array; IR; infrared spectroscopy; HS-LP-LPE; headspace liquid phase-liquid-phase extraction; GC-MS; gas chromatography

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2018 سفارش ترجمه

Memantine ameliorates depressive-like behaviors by regulating hippocampal cell proliferation and neuroprotection in olfactory bulbectomized mice

Keywords: Apoptosis; Cell proliferation; Depression; Emotional behavior; Olfactory bulbectomy; Neuroinflammation; ANOVA; analysis of variance; Bax; Bcl-2-associated protein X; Bcl-2; B cell lymphoma/leukemia gene 2; BDNF; brain-derived neurotrophic factor; BrdU; 5-

دانلود رایگان متن کامل مقاله ISI 58 صفحه سال انتشار : 2018 سفارش ترجمه

Trichosanthis Fructus: botany, traditional uses, phytochemistry and pharmacology

Keywords: T. kirilowii; Trichosanthes kirilowii Maxim.; T. rosthornii; Trichosanthes rosthornii Harms; TF; Trichosanthis Fructus; TP; Trichosanthis Pericarpium; TS; Trichosanthis Semen; TR; Trichosanthis Radix; MI; myocardial infarction; AMI; acute myocardial infar

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2018 سفارش ترجمه

Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells

Keywords: Human mast cells; IgE receptor; Lyn activation; DJ-1; signaling; reactive oxygen species; spleen tyrosine kinase; Csk; C-terminal Src kinase; ERK; Extracellular signal-regulated kinase; HuMC; CD34+-derived human mast cell; JNK; c-Jun N-terminal kinase; LA

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2018 سفارش ترجمه

ERK regulates mitochondrial membrane potential in fission deficient Drosophila follicle cells during differentiation

Keywords: PFC; Posterior Follicle Cells; EGFR; Epidermal Growth Factor Receptor; NICD; Notch Intra-Cellular Domain; ROS; Reactive Oxygen Species; ETC; Electron Transport Chain; Ψm; Mitochondrial Membrane Potential; Mitochondria; Signaling; Drosophila; ERK; Notch;

دانلود رایگان متن کامل مقاله ISI 63 صفحه سال انتشار : 2018 سفارش ترجمه

ERK1/2 activated PHLPP1 induces skeletal muscle ER stress through the inhibition of a novel substrate AMPK

Keywords: 2-NBDG; 2-(N-[7-nitrobenz-2-oxa-1,3-diazol-4-yl]amino)-2-deoxyglucose; AICAR; 5-aminoimidazole-4-carboxamide-1-b-d-ribofuranoside; AMPK; AMP-activated protein kinase; AS160; Akt Substrate of 160 kDa; ATF4; Activating Transcription Factor 4; AUC; area un

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2018 سفارش ترجمه

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

Keywords: Akt; oncogene in the transforming retrovirus, AKT8; AP-1; activator protein 1; ARAF; v-raf murine sarcoma 3611 viral oncogene homologue; ASK1; apoptosis signal-regulating kinase 1; BCL2; B-cell lymphoma 2; BCL-XL; B-cell lymphoma extra large; BRAF; v-raf

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

Impact of microRNAs on ischemic stroke: From pre- to post-disease

Keywords: AAV; adeno-associated virus; ABCA1; ATP-binding cassette transporter 1; AGO; argonaute; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionate; AT1R; angiotensin II type 1 receptor; AQPs; aquaporins; BBB; blood-brain barrier; Bcl-6; B-cell lymphoma-6;

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2018 سفارش ترجمه

Serum proteome mapping of EGF transgenic mice reveal mechanistic biomarkers of lung cancer precursor lesions with clinical significance for human adenocarcinomas

Keywords: 2-DE; two-dimensional gel-electrophoresis; AC; adenocarcinoma; A2M; α-2-macroglobulin; AAH; atypical adenomatous hyperplasia; AAT; α-1-antitrypsin; ApoA1; apolipoprotein A-I; ApoA4; apolipoprotein A-IV; ApoC3; apolipoprotein C-III; ApoE; apolipoprotein

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2018 سفارش ترجمه

Autophagy as a pharmacological target in hematopoiesis and hematological disorders

Keywords: 3-MA; 3-methyladenine; ALL; acute lymphoblastic leukemia; AMKL; acute megakaryoblastic leukemia; AML; acute myeloid leukemia; AMPK; 5′-adenosine monophosphate-activated protein kinase; APL; acute promyelocytic leukemia; Atg; autophagy-related proteins;

دانلود رایگان متن کامل مقاله ISI 80 صفحه سال انتشار : 2018 سفارش ترجمه

Regulation of vascular tone homeostasis by NO and H2S: Implications in hypertension

Keywords: ADRF; adipocyte-derived relaxing factor; AE; anion exchanger; ATP; adenosine triphosphate; BH4; tetrahydrobiopterin; BKCa; big conductance Ca2+-sensitive K+ channel; CaM; calmodulin; cAMP; cyclic adenosine monophosphate; CAT; cysteine aminotransferase; CB

دانلود رایگان متن کامل مقاله ISI 88 صفحه سال انتشار : 2018 سفارش ترجمه

Activation of Nrf2 signaling by natural products-can it alleviate diabetes?

Keywords: Nrf2; type 2 diabetes; natural products; hyperglycemia; cellular stress; insulin sensitivity; β-cell function; vascular complications; AGE; advanced glycation end products; AhR; arylhydrocarbon receptor; AMPK; AMP-activated kinase; ARE; antioxidant respo

دانلود رایگان متن کامل مقاله ISI 89 صفحه سال انتشار : 2018 سفارش ترجمه

Clinical benefits and pharmacology of scutellarin: A comprehensive review

Keywords: Aβ; β-amyloid peptide; ACE; angiotensin-converting enzyme; AD; Alzheimer's disease; ADE; adverse drug effect; ADR; adverse drug reaction; AIF; apoptosis-inducing factor; Akt; protein kinase B or PKB; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activat

دانلود رایگان متن کامل مقاله ISI 116 صفحه سال انتشار : 2018 سفارش ترجمه

The histology, physiology, neurochemistry and circuitry of the substantia gelatinosa Rolandi (lamina II) in mammalian spinal cord

Keywords: [Ca2+]i; intracellular Ca2+ concentration; 5-HT; serotonin; Ach; acetylcholine; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptor; BDNF; brain-derived neurotrophic factor; CCK; cholecystokinin;

دانلود رایگان متن کامل مقاله ISI 175 صفحه سال انتشار : 2018 سفارش ترجمه

A review of the mechanism of action and clinical applications of sorafenib in advanced osteosarcoma

Keywords: Sorafenib; Advanced osteosarcoma; Denosumab; Everolimus; Novel therapy; Second line; RANKL; Tyrosine kinase; Nexavar; MTORC; Italian Sarcoma Group; Primary bone cancer; MAPK; ERK; Temsirolimus; Bevacizumab;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Contrary influence of clinically applied sorafenib concentrations among hepatocellular carcinoma patients

Keywords: HCC; hepatocellular carcinoma; MAPK; mitogen-activated protein kinase; ERK; extracellular signal regulated kinase; MEK; MAPK (ERK) kinase; RT-PCR; reverse transcriptase-polymerase chain reaction; Angiogenesis; Hepatocellular carcinoma; KDR; PDGFRB; Prolif

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Exchange proteins directly activated by cAMP induce the proliferation of rat anterior pituitary GH3 cells via the activation of extracellular signal-regulated kinase

Keywords: Epac; B-Raf; ERK; Proliferation; Pituitary cells;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibitory effect of 5-iodotubercidin on pigmentation

Keywords: 5-Iodotubercidin; Pigmentation; CREB; AKT; ERK; Zebrafish;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Prevention of oxytosis-induced c-Raf down-regulation by (arylthio)cyclopentenone prostaglandins is neuroprotective

Keywords: DMEM; Dulbecco's modified Eagle medium; ERK; extracellular-regulated protein kinase; Glu; glutamate; LDH; lactate dehydrogenase; Keap1; Kelch-like ECH-associated protein 1; MAPK; mitogen-activated protein kinase; MEK; mitogen-activated protein kinase kina

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Preclinical Evaluation of MET Inhibitor INC-280 With or Without the Epidermal Growth Factor Receptor Inhibitor Erlotinib in Non-Small-Cell Lung Cancer

Keywords: Acquired resistance; AKT; Combination therapy; EGFR mutant; ERK;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

TGF-β1 promotes Staphylococcus aureus adhesion to and invasion into bovine mammary fibroblasts via the ERK pathway

Keywords: TGF-β1; Bovine mammary fibroblast; Staphylococcus aureus; ERK;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Isolation and lipolytic activity of eurycomanone and its epoxy derivative from Eurycoma longifolia

Keywords: Ac; acetyl; βAR; beta adrenergic receptor; DEX; dexamethasone; DMEM; Dulbecco's Modified Eagle's medium; EC50; half maximal effective concentration; ERK; extracellular signal-regulated kinase; ESI; electrospray ionization; FBS; fetal bovine serum; HMBC;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Docosahexaenoic acid induces glial cell-line derived neurotrophic factor release in C6 glioma cells: Implications of antidepressant effects for docosahexaenoic acid

Keywords: DHA; GDNF; ERK; PKC; FGFR; Antidepressant;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Patterns of constitutively phosphorylated kinases in B cells are associated with disease severity in common variable immunodeficiency

Keywords: BCR; B-cell receptor; Btk; Bruton's tyrosine kinase; CD40L; CD40 ligand; CVID; Common variable immunodeficiency; Erk; extracellular signal-related kinase; IκBα; NFκB inhibitor α; Ig; immunoglobulin; IVIG; intravenous immunoglobulin; PCA; principle com

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

The tubulin deacetylase sirtuin-2 regulates neuronal differentiation through the ERK/CREB signaling pathway

Keywords: Alpha-tubulin; CREB; ERK; Histone deacetylase 6; Mesenchymal stem cells; Sirtuin 2;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Dual hypopigmentary effects of punicalagin via the ERK and Akt pathways

Keywords: α-MSH; α-melanocyte-stimulating hormone; ERK; extracellular signal-regulated kinase; GSK3β; glycogen synthase kinase3β; MITF; microphthalmia-associated transcription factor; Akt; ERK; Melanogenesis; MITF; Punicalagin; Tyrosinase;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

The interaction of auraptene and other oxyprenylated phenylpropanoids with glucose transporter type 4

Keywords: Auraptene; Glucose transporter type 4; Metabolism; Oxyprenylated secondary metabolites; Propolis; BSA; bovine serum albumin; CREB; cAMP response element-binding protein; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; GLUT4; glucose t

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Research paperProfiling of cytosolic and mitochondrial H2O2 production using the H2O2-sensitive protein HyPer in LPS-induced microglia cells

Keywords: DPI; diphenyleneiodonium; ERK; extracellular signal-regulated kinases; JNK; c-Jun N-terminal kinases; LPS; lipopolysaccharide; NAC; N-acetyl-l-cysteine; NADPH oxidase; nicotinamide adenine dinucleotide phosphate oxidase; p38 MAPK; p38 mitogen-activated pr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Research ArticleChlorogenic acid inhibits hepatocellular carcinoma in vitro and in vivo

Keywords: Chlorogenic acid (PubChem CID: 1794427); Chlorogenic acid; Chemoprevention; Hepatocellular carcinoma; ERK; MMP;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Protein kinase C-eta regulates Mcl-1 level via ERK1

Keywords: DAG; diacylglycerol; ERK; extracellular signal-regulated kinase; GSK3; glycogen synthase kinase-3; MAPK; mitogen-activated protein kinase; Mcl-1; myeloid cell leukemia-1; Mule; Mcl-1 ubiquitin ligase; PI3K; phosphatidylinositol 3-kinase; PKC; protein kina

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Potent osteogenic activity of a novel imidazobenzimidazole derivative, IBIP

Keywords: IBIP; Osteoblast differentiation; BMP2; SMAD; ERK;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Expression of ERK and Akt proteins in women with unexplained first-trimester recurrent miscarriage

Keywords: Recurrent miscarriage; Pregnancy loss; ERK protein; Akt protein; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; MCL-1; myeloid leukemia cell-1; MMP; matrix metalloproteinase; PI3K; phospha

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Breadfruit flavonoid derivatives attenuate advanced glycation end products (AGEs)-enhanced colon malignancy in HCT116 cancer cells

Keywords: AC-a; 2′,4,4′-trihydroxy-3′-[6-hydroxy-3,7-dimethyl-2(E),7-octadienyl]chalcone; AC-b; 6-geranyl-4′,7-dihydroxyflavanone; AC-c; 5′-geranyl-2′,4,4′-trihydroxydihydrochalcone; AC-d; 6-geranyl-4′,5,7-trihydroxyflavanone; AGEs; advanced glycati

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

LXR agonists promote the proliferation of neural progenitor cells through MEK-ERK pathway

Keywords: Neural progenitor cells; Proliferation; LXR agonists; GW3965; LXR623; ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1; ABCG1; ATP-binding cassette, sub-family G (WHITE), member 1; AD; Alzheimer diseases; CNS; central nervous system; DMEM; Dulbe

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Gab3 is required for human colorectal cancer cell proliferation

Keywords: Colorectal cancer; Gab3; Akt; Erk; Oncogene;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

PAQR3 overexpression suppresses the aggressive phenotype of esophageal squamous cell carcinoma cells via inhibition of ERK signaling

Keywords: Aggressiveness; ERK; Growth; Hypermethylation; Invasion; PAQR3;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Emodin targets mitochondrial cyclophilin D to induce apoptosis in HepG2 cells

Keywords: CyPD; cyclophilin D; mPTP; mitochondrial permeability transition pore; CsA; cyclosporin A; Cyto-C; cytochrome c; NAC; N-acetyl-l-cysteine; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; MMP; mitochondrial membrane potential; MTD

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways

Keywords: Protein tyrosine phosphatase non-receptor type 22; siRNA; Jurkat; Apoptosis; AKT; ERK; T-cell leukemia;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

LL-37-induced human mast cell activation through G protein-coupled receptor MrgX2

Keywords: Akt; protein kinase B; AMPs; antimicrobial peptides; BAC; benzalkonium chloride; DAG; diacylglycerol; ERK; extracellular signal-regulated kinase; FPR-2 or FPRL1; formyl peptide receptor 2; G protein; guanine nucleotide-binding protein; GPCRs; G protein-co

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

An inhibitory mechanism of action of a novel syringic-acid derivative on α-melanocyte-stimulating hormone (α-MSH)-induced melanogenesis

Keywords: Melanogenesis; Tyrosinase; MITF; ERK; Syringic-acid derivative;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Research articleNGF protects against oxygen and glucose deprivation-induced oxidative stress and apoptosis by up-regulation of HO-1 through MEK/ERK pathway

Keywords: NGF; HO-1; OGD; ERK; Neuroprotection; ROS; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه