Role of the p21-activated kinases (PAKs) in influenza A virus replication
Keywords: Influenza virus; PAK1; ERK; Protein activation; Virus replication;
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Inhibitory effects of flavonoid glycosides isolated from the peel of Japanese persimmon (Diospyros kaki Fuyu) on antigen-stimulated degranulation in rat basophilic leukaemia RBL-2H3 cells
Keywords: Ag; antigen; BSA; bovine serum albumin; CM-H2DCF-DA; 5-(and-6-)-carboxy-2â²,7â²-dichlorodihydrofluorescein diacetat; DNP; dinitrophenol; DPPH; 1,1-diphenyl-2-picrylhydrazyl; DPI; diphenyleneiodonium chloride; EGCG; (â)-epigallocatechin gallate; ERK; e
Andrographolide attenuates tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes
Keywords: ERK; extracellular signal-regulated kinase; GSK3β; glycogen synthase kinase-3β; I-κB-α; inhibitor of kappaB-alpha; IKKβ; IκB kinase β; iNOS; inducible nitric oxide synthase; IR; insulin receptor; IRS-1; insulin receptor substrate-1; JNK; c-Jun N-te
The transcription factor FOXM1c is activated by protein kinase CK2, protein kinase A (PKA), c-Src and Raf-1
Keywords: cAMP; cyclic adenosine 3â²,5â²-monophosphate; Cdk; cyclin-dependent kinase; CK2, protein kinase CK2; casein kinase II; DBD; DNA binding domain; dn; dominant-negative; ERK; extracellular signal-regulated kinase; FOXM1c; Forkhead box M1, splice variant c;
Phospholipase D2 activation by p38 MAP kinase is involved in neurite outgrowth
Keywords: PLD; phospholipase D; PC; phosphatidylcholine; PA; phosphatidic acid; PI(4,5)P2; phosphatidylinositol 4,5-bisphosphate; NGF; nerve growth factor; PEt; phosphatidylethanol; MAP kinase; mitogen-activated protein kinase; ERK; extracellular signal-regulated k
Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1
Keywords: Arsenic; Transformation; ROS; AKT; ERK; p70S6K;
Testin, a novel binding partner of the calcium-sensing receptor, enhances receptor-mediated Rho-kinase signalling
Keywords: CaR; calcium-sensing receptor; ERK; extracellular-signal-regulated kinase; LIM; Lin-11, Isl-1, Mec-3; PET; prickle, espinas, testin; SRE; serum response element; Calcium-sensing receptor; Testin; ERK signalling; Rho signalling; LIM domain; Yeast two-hybri
Syntrophin isoforms play specific functional roles in the α1D-adrenergic receptor/DAPC signalosome
Keywords: AR; adrenergic receptor; DAPC; dystrophin-associated protein complex; ERK; extracellular signal regulated kinase; GPCR; G-protein coupled receptor; HEK; human embryonic kidney; KO; knock-out; PDZ; PSD95/DlgA/Zo-1; G-protein coupled receptor; α1-adrenergi
Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells
Keywords: EGF-R; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; nAChR; nicotinic acetylcholine receptor; NO; nitric oxide; nNOS; neuronal nitric oxide synthase; PKC; protein kinase C; PKG; prote
Research reportInvolvement of spinal cord BDNF in the generation and maintenance of chronic neuropathic pain in rats
Keywords: AUC; area under the time-course curve; BDNF; brain-derived neurotrophic factor; CREB; cyclic AMP response element binding protein; DRG; dorsal root ganglia; ERK; extracellular signal-regulated kinase; GABA; γ-aminobutyric acid; MAPK; mitogen-activated pr
Mitochondrial density contributes to the immune response of macrophages to lipopolysaccharide via the MAPK pathway
Keywords: ERK; extracellular signal-regulated kinase; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinase; MEK; MAPK-ERK kinase; NOx; nitric oxide metabolite; TNF-α; tumor necrosis factor-alpha; ROS; reactive oxygen species; TLR; Toll-like receptor; Ï
The hydrophobic amino acids in putative helix 8 in carboxy-terminus of histamine H3 receptor are involved in receptor-G-protein coupling
Keywords: GPCR; G-protein coupled receptor; H3R; histamine H3 receptor; HEK; human embryonic kidney; CLIC4; chloride intracellular channel 4; DMEM; Dulbecco's modified Eagle's medium; PBS; phosphate buffered saline; PAGE; polyacrylamide gel electrophoresis; RAMH; R
Tetrandrine down-regulates ERK/NF-κB signaling and inhibits activation of mesangial cells
Keywords: Tetrandrine; ERK; NF-κB; NO; MMP-9; Mesangial cell;
Changes in phosphorylation of CREB, ERK, and c-fos induction in rat ventral tegmental area, hippocampus and prefrontal cortex after conditioned place preference induced by chemical stimulation of lateral hypothalamus
Keywords: Conditioned place preference (CPP); CREB; ERK; c-fos; Lateral hypothalamus; Ventral tegmental area; Hippocampus; Prefrontal cortex
Tick saliva regulates migration, phagocytosis, and gene expression in the macrophage-like cell line, IC-21
Keywords: ERK; extracellular signal-regulated kinase; IRAK; interleukin-1 receptor associated kinase; TGF-β; transforming growth factor-beta; SGx; salivary gland extract; PDGF; platelet-derived growth factor; PACE; phosphoantibody cell-based ELISA; EDTA; ethylened
Inhibitory effect of Sanguisorba officinalis ethanol extract on NO and PGE2 production is mediated by suppression of NF-κB and AP-1 activation signaling cascade
Keywords: PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumor necrosis factor; ERK; extracellular signal-related kinase; TLR; toll-like receptors; MAPK; mitogen activated protein kinase; NF-κB; nuclear factor-κB;
Carmustine induces ERK- and JNK-dependent cell death of neuronally-differentiated PC12 cells via generation of reactive oxygen species
Keywords: Carmustine; Reactive oxygen species; ERK; JNK;
Endocrine disruption via estrogen receptors that participate in nongenomic signaling pathways
Keywords: Ab; antibody; DAT; dopamine transporter; DES; diethylstilbestrol; E2; estradiol; E3; estriol; E1; estrone; ERK; extracellular-regulated kinase; ERR; estrogen receptor-related receptor; ER; estrogen receptor; GPER; G protein-coupled estrogen receptor; MAPK
Signalling pathway of goldfish melanin-concentrating hormone receptors 1 and 2
Keywords: cAMP; cyclic AMP; ERK1/2; extracellular signal-related kinase 1/2; gfMCHR; goldfish melanin-concentrating hormone receptor; HEK293; human embryonic kidney 293; MCH; melanin-concentrating hormone; MCHR1; MCH-1 receptor; MCHR2; MCH-2 receptor; PTX; pertussi
Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells
Keywords: LPC; lysophosphatidylcholine; EL; endothelial lipase; 16:0 LPC; palmitoyl-lysophosphatidylcholine; 18:2 LPC; linoleoyl-LPC; 20:4 LPC; arachidonoyl-LPC; 18:1 LPC; oleoyl-LPC; HAEC; human aortic endothelial cells; AA; arachidonic acid; NEFA; nonesterified f
The PDE10A inhibitor, papaverine, differentially activates ERK in male and female rat striatal slices
Keywords: Striatum; PDE10A; ERK; Dopamine; Estrogen; Gender; cAMP; 3â²,5â²-cyclic adenosine monophosphate; cGMP; Guanosine 3â²,5â²-cyclic mononucleotide; MSNs; medium spiny neurons; PDE10A; phosphodiesterase 10A; p-ERK; phosphorylated extracellular-signal-regul
Open-label riluzole in fragile X syndrome
Keywords: Fragile X syndrome; ERK; Riluzole
MicroRNA-126 inhibits ischemia-induced retinal neovascularization via regulating angiogenic growth factors
Keywords: MicroRNA; Retinal neovascularization; Oxygen-induced retinopathy; VEGF; IGF-2; HIF-1α; p38; ERK
Norcantharidin induces cell cycle arrest and inhibits progression of human leukemic Jurkat T cells through mitogen-activated protein kinase-mediated regulation of interleukin-2 production
Keywords: AP-1; activating protein-1; CaN; calcineurin; CsA; Cyclosporine A; CyP; cyclophilin; ERK; extracellular signal-regulated protein kinase; FCS; fetal calf serum; FK506; Tacrolimus; IP3; inositol triphosphate; JNK; c-Jun NH2-terminal kinases; MAPK; mitogen-a
Cytotrienin A, a translation inhibitor that induces ectodomain shedding of TNF receptor 1 via activation of ERK and p38 MAP kinase
Keywords: Cytotrienin A; ERK; p38 MAP kinase; TNF receptor 1; TNF-α-converting enzyme; Triene-ansamycin
Aurora-C interacts with and phosphorylates the transforming acidic coiled-coil 1 protein
Keywords: TACC1; transforming acidic coiled-coil 1; LSM7; Sm-like protein; SmG; Sm protein G; FHK; four and Half LIM-only; snRNPs; small nuclear ribonucleoproteins; ERK; extracellular signal-regulated kinases; GAS41/Nu11; glioma amplified sequence 41/NuMa binding p
Dual role of NO donors in the reversal of tumor cell resistance and EMT: Downregulation of the NF-κB/Snail/YY1/RKIP circuitry
Keywords: Bcl-xL; B-cell leukemia-xL; CDDP; cis-diammine-dichloro-platinum; DETANONOate; (Z)-1-[2-(2-aminoethyl)-N-(2-ammonio-ethyl) amino] diazen-1-ium-1, 2-diolate; DHMEQ; dehydroxymethylepoxyquinomicin; DR; death receptor; ERK; extracellular signal-regulated kin
Urotensin II inhibits the proliferation but not the differentiation of cardiac side population cells
Keywords: Urotensin II; Cardiac side population cell; JNK; ERK; Proliferation; Differentiation
MiR-146a inhibits oxidized low-density lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4
Keywords: miRNAs; microRNAs; oxLDL; oxidized low-density lipoprotein; TLR2; toll-like receptor 2; TLR3; toll-like receptor 3; TLR4; toll-like receptor 4; TLRs; toll-like receptors; IL-6; interleukin 6; IL-8; interleukin 8; MCP-1; chemokine (C-C motif) ligand 2; M
Bisphenol-A rapidly enhanced passive avoidance memory and phosphorylation of NMDA receptor subunits in hippocampus of young rats
Keywords: BPA; Bisphenol-A; BSA; bovine serum albumin; CaMKII; calcium/calmodulin kinase II; CNS; central nervous system; CREB; cAMP response element binding protein; E2; estradiol; ECL; enhanced chemiluminescence; EB; estradiol benzoate; ER; estrogen receptor; ERK
ReviewContributions of ERK signaling in the striatum to instrumental learning and performance
Keywords: ERK; extracellular signal regulated kinase; LTP; long-term potentiation; LTD; long-term depression; PIT; Pavlovian-instrumental transfer; pDMS; posterior dorsomedial striatum; DLS; dorsolateral striatum; NAc; nucleus accumbens; Nucleus accumbens; Dorsomed
DcR3 induces cell proliferation through MAPK signaling in chondrocytes of osteoarthritis
Keywords: Decoy receptor 3; Chondrocyte; Apoptosis; ERK; Fas-ligand; Proliferation
Cyclic AMP-mediated immune regulation - Overview of mechanisms of action in T cells
Keywords: AC; Adenylyl cyclase; AKAP; A-kinase anchoring protein; AKAP-KL; AKAP-kidney lung; AKB; A-kinase binding domain; AP-1; Activator protein 1; ATF; Activation transcription factor; C; Catalytic (subunit of PKA); CBP; CREB-binding protein; CNG; Cyclic nucleot
Akt isoform-specific inhibition of MDA-MB-231 cell proliferation
Keywords: Akt isoforms; Breast cancer; CDK2; ERK; p27
Differential effects of growth factors on oligodendrocyte progenitor migration
Keywords: Oligodendrocyte progenitor; Migration; PDGF-A; FGF2; ERK
Transport of animals between rooms: A little-noted aspect of laboratory procedure that may interfere with memory
Keywords: Social recognition; Memory disruption; Social recognition memory; Rats transfer; Principal Component Analysis; PCA; AGR; mild aggression; ANO; sniffing the anogenital region; BOD; sniffing the body; CREB; cyclic AMP responsible element binding protein; DO
Stimulation of IFN-γ production by garlic lectin in mouse spleen cells: Involvement of IL-12 via activation of p38 MAPK and ERK in macrophages
Keywords: Garlic lectin; IL-12; IFN-γ; Macrophages; Spleen cells; p38 MAPK; ERK
Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts
Keywords: AITC; allyl isothiocyanate; ARE; antioxidant response element; BITC; butyl isothiocyanate; CpG; cytosine-phospho-guanine; ERK; extracellular signal-regulated kinase; FCS; fetal calf serum; γGCS; γ-glutamyl cysteine synthetase; HO-1; heme oxygenase-1; IT
Arsenic-induced alteration in intracellular calcium homeostasis induces head kidney macrophage apoptosis involving the activation of calpain-2 and ERK in Clarias batrachus
Keywords: MS222; Methanesulfonate salt; RPMI-1640; Roswell Park Memorial Institute culture medium-1640; FBS; Fetal bovine serum; ROS; Reactive oxygen species; MAPK; Mitogen activated protein kinase; ERK; Extracellular signal-regulated kinase; JNK; c-Jun NH2-termina
Bisphenol-A suppresses neurite extension due to inhibition of phosphorylation of mitogen-activated protein kinase in PC12 cells
Keywords: Bisphenol-A; PC12 cell; MAPK; ERK; Neurite; Nerve growth factor;
Induction of cardiac fibroblast lysyl oxidase by TGF-β1 requires PI3K/Akt, Smad3, and MAPK signaling
Keywords: Fibrosis; Collagen; BMP-1; ERK; JNK
Research ArticleHepatitis B virus X protein stimulates IL-6 expression in hepatocytes via a MyD88-dependent pathway
Keywords: HCC; hepatocellular carcinoma; HBV; hepatitis B virus; IL-6; interleukin-6; MyD88; myeloid differentiation factor 88; TGF-β; transforming growth factor β; ERK; extracellular signal-stimulated kinase; TLR; Toll-like receptor; PI3K; phosphatidylinositol-3
The mood stabilizer valproic acid induces proliferation and myelination of rat Schwann cells
Keywords: Valproic acid; Schwann cell; GAP-43; Myelination; ERK
CommentaryUnderstanding SOS (Son of Sevenless)
Keywords: AhR; aryl hydrocarbon receptor; Cdc 25; cell division cycle 25; CFC; cardio-facio-cutaneous syndrome; DH; Dbl homology; E3b1; Eps8 SH3 domain binding protein 1; Eps8; EGFR pathway substrate 8; ERK; extracellular signal-regulated protein kinase; Grb2; grow
Endosomal signalling of epidermal growth factor receptors contributes to EGF-stimulated cell cycle progression in primary hepatocytes
Keywords: Endosomal signalling; Cell proliferation; EGF receptors; Akt; ERK; Hepatocytes;
The selective p38 mitogen-activated protein kinase inhibitor, SB203580, improves renal disease in MRL/lpr mouse model of systemic lupus
Keywords: MAPK; Mitogen-activated protein kinase; BUN; blood urea nitrogen; Ig; immunoglobulin; MCP; monocyte chemoattractant protein; ERK; extracellular signal-regulated kinase; JNK; c-Jun NH2-terminal protein kinase; IBD; inflammatory bowel disease; ALT; alanine
Partially purified components of Nardostachys chinensis suppress melanin synthesis through ERK and Akt signaling pathway with cAMP down-regulation in B16F10 cells
Keywords: CREB; cAMP response element-binding protein; Dct; dopachrome tautomerase; ERK; extracellular signal-related kinase; MAPK; mitogen-activated protein kinase; MC1; melanocortin 1; MEK; mitogen-activated protein kinase kinase; MITF; microphthalmia-associated
Non-antibiotic properties of tetracyclines as anti-allergy and asthma drugs
Keywords: MAPK; mitogen-activated protein kinase; PBMC; peripheral blood mononuclear cells; BPO-KLH; benzylpenicilloyl-keyhole limpet hemocyanin; CMT; chemically modified tetracyclines; ELISA; enzyme-linked immunosorbent assay; ELISPOT; enzyme-linked immunosorbant
Piceatannol enhances TRAIL-induced apoptosis in human leukemia THP-1 cells through Sp1- and ERK-dependent DR5 up-regulation
Keywords: Piceatannol; TRAIL; Death receptor; Sp1; ERK;
Blockade of the Ras/MEK/ERK and Ras/PI3K/Akt pathways by statins reduces the expression of bFGF, HGF, and TGF-β as angiogenic factors in mouse osteosarcoma
Keywords: Statin; Ras; ERK; Akt; Angiogenic factor;