Ras/MAP Kinase pathways are involved in Ras specific apoptosis induced by sodium butyrate
Keywords: Sodium butyrate; Apoptosis; Ras; MAP kinase; ERK;
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The novel angiotensin II type 1 receptor (AT1R)-associated protein ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy
Keywords: Ang II; angiotensin II; ACE; angiotensin-converting enzyme; AT1R; angiotensin II type 1 receptor; C-terminal; carboxy-terminal; ATRAP; angiotensin II type 1 receptor-associated protein; hemagglutinin epitope-tagged ATRAP; HA-ATRAP; FLAG-tagged mouse AT1R;
Suppression of MEK/ERK signalling by Myc: role of Bin-1
Keywords: MEK; ERK; Signalling; Bin-1; Myc; Apoptosis;
Anisomycin induces COX-2 mRNA expression through p38MAPK and CREB independent of small GTPases in intestinal epithelial cells
Keywords: PG; prostaglandin; COX; cyclooxygenase; EGF; epidermal growth factor; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; JNK; c-Jun N-terminal kinase; GPCR; G-protein coupled receptor; GAPDH; glyceraldehyde 3-phosphate deh
AP-1 mediates β-amyloid-induced iNOS expression in PC12 cells via the ERK2 and p38 MAPK signaling pathways
Keywords: AP-1; β-Amyloid; ERK; iNOS; Nitrosative stress; p38 MAPK; PC12 cells;
Brevetoxin augments NMDA receptor signaling in murine neocortical neurons
Keywords: VGSC; voltage-gated sodium channel; PbTx-2; brevetoxin-2; ERK1/2; extracellular signal-regulated kinases; CGC; cerebellar granule cells; [Ca2+]i; intracellular [Ca2+]; [Na+]i; intracellular [Na+]; PP2; 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]
Endothelins stimulate the expression of neurotrophin-3 in rat brain and rat cultured astrocytes
Keywords: endothelin-1; growth factor; gene transcription; neurotrophin; glial cell; BDNF; brain-derived neurotrophic factor; CREB; cAMP-responsing element binding protein; ERK; extracellular signal regulated kinase; ET; endothelin; GFAP; glial fibrillary acidic pr
Food restriction increases NMDA receptor-mediated calcium-calmodulin kinase II and NMDA receptor/extracellular signal-regulated kinase 1/2-mediated cyclic amp response element-binding protein phosphorylation in nucleus accumbens upon D-1 dopamine receptor
Keywords: food restriction; NMDA receptor; MAP kinase; nucleus accumbens; D1 receptor; AL; ad libitum fed; ANOVA; analysis of variance; CaMK II; calcium-calmodulin kinase II; CREB; cyclic AMP response element-binding protein; DA; dopamine; ECL; enhanced chemilumi
Role of MEK-ERK pathway in sphingosylphosphorylcholine-induced cell death in human adipose tissue-derived mesenchymal stem cells
Keywords: MSCs; mesenchymal stem cells; SPC; sphingosylphosphorylcholine; MAPKs; mitogen-activated protein kinases; ERK; extracellular signal-regulated kinase; JNK; c-Jun NH2-terminal protein kinase; GPCRs; G protein-coupled receptors; hATSCs; human adipose tissue-
Microdermabrasion: A molecular analysis following a single treatment
Keywords: AP; activator protein; ATF; activating transcription factor; ERK; extracellular signal-regulated kinase; HMG CoA; 3-hydroxy-3-methylglutaryl coenzyme A; IL; interleukin; JNK; C-jun NH terminal kinase; MAB; monoclonal antibody; MAP; mitogen activated prote
Inhibition of ERK phosphorylation decreases nociceptive behaviour in monoarthritic rats
Keywords: ERK; Monoarthritis; Spinal cord; CFA; MAPK;
Catalase potentiates interleukin-1β-induced expression of nitric oxide synthase in rat vascular smooth muscle cells
Keywords: iNOS; inducible nitric oxide synthase; NO; nitric oxide; VSMC; vascular smooth muscle cells; IL-1β; interleukin-1β; MAPK; mitogen-activated protein kinases; ERK; extracellular signal-regulated kinases; NF-κB; nuclear factor-κB; ROS; reactive oxygen
TG1019/OXE, a Gαi/o-protein-coupled receptor, mediates 5-oxo-eicosatetraenoic acid-induced chemotaxis
Keywords: 5-Oxo-ETE; TG1019; OXE; Chemotaxis; PI3K; Phospholipase C; ERK; Calcium mobilization; U73122; LY294002; GPCR; Lipid mediator;
Differential functions of PKC-δ and PKC-ζ in cisplatin response of normal and transformed thyroid cells
Keywords: PC Cl3; Cisplatin; ERK; PKC-ζ; PKC-δ;
Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells
Keywords: Caveolin-2; Insulin; ERK; Cell cycle;
CCL3 (MIP-1α) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2
Keywords: ERK; Extracellular signal-regulated kinase; MAPK; Mitogen-activated protein kinase; ELR; Glutamic acid-leucine-arginine; HBSS; Hanks balanced salt solution; PBS; Dulbecco's phosphate-buffered saline; Neutrophil; Chemotaxis; GM-CSF; Chemokines; Signal
Exposure to toxic concentrations of aluminum activates a MAPK-like protein in cell suspension cultures of Coffea arabica
Keywords: Aluminum toxicity; Coffee cell suspension cultures; MAP kinase-like activity; BSA; bovine serum albumin; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol-bis(aminoethylether)-N,N,Nâ²,Nâ²-tetraacetic acid; ERK; extracellular signal-regulated
ETV6-NTRK3: a chimeric protein tyrosine kinase with transformation activity in multiple cell lineages
Keywords: EN; ETV6-NTRK3; ETV6; ETS variant gene 6; NTRK3; neurotrophic tyrosine kinase, receptor, type 3; PTK; protein tyrosine kinase; ERK; extracellular signal-regulated kinase; IGFIR; insulin-like growth factor-I receptor; IRS-1; insulin receptor substrate-1;
Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control
Keywords: Cortactin; Src; Erk; Kinase; Phosphorylation; Actin cytoskeleton;
Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK
Keywords: ERK; extracellular signal-regulated kinase; JNK; c-jun NH2 terminal kinase; GST; glutathione S-transferase; HIF-1; hypoxia-inducible factor-1; HRE; hypoxia responsive element; MAPK; mitogen-activated protein kinase; MKP; mitogen-activated protein kinase p
Control of density-dependent, cell state-specific signal transduction by the cell adhesion molecule CEACAM1, and its influence on cell cycle regulation
Keywords: Cell adhesion; Cell signaling; Cell proliferation; Contact inhibition; CEACAM1; Erk; p27;
Stretch-induced cell proliferation is mediated by FAK-MAPK pathway
Keywords: Uni-axial cyclic stretch; Cell morphology; Cell proliferation; ERK; p38 MAPK
Secretory IgA induces antigen-independent eosinophil survival and cytokine production without inducing effector functions
Keywords: Human; eosinophils; mucosa; secretory IgA; innate immunity; immunomodulation; αCS; α-Calf serum; CCL; CC chemokine ligand; CXCL; CXC chemokine ligand; EDN; Eosinophil-derived neurotoxin; ERK; Extracellular signal-regulated kinase; FPLC; Fast performan
Increased expression of soluble decoy receptor 3 in acutely inflamed intestinal epithelia
Keywords: DcR3; decoy receptor 3; TNF; tumor necrosis factor; TNFR; TNF receptor; TLR; Toll-like receptor; IEC; intestinal epithelial cell; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; JNK; c-Jun NH2-terminal protein kinase; L
Chemokine IL-8 induction by particulate wear debris in osteoblasts is mediated by NF-κB
Keywords: ERK; extracellular signal-regulated kinase; IL-1; interleukin 1; JNK; c-Jun-NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MCP-1; monocyte chemoattractant protein-1; TGF-β; transforming growth factor-β; TNFα; tumor necrosis factor-α; NF-
Amphiregulin: An early trigger of liver regeneration in mice
Keywords: AR; amphiregulin; BrdU; 5-bromo-2â²-deoxyuridine; CRE; cyclic adenosine monophosphate-responsive element; EGF; epidermal growth factor; EGF-R; epidermal growth factor receptor; ERK; extracellular regulated kinase; FCS; fetal calf serum; HB-EGF; heparin-b
The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis
Keywords: IGF1; insulin-like growth factor 1; GH; growth hormone; IRS; insulin receptor substrates; BDL; bile duct ligation; PCNA; proliferating cellular nuclear antigen; IGFBP; IGF binding protein; ERK; extracellular regulated kinases; PI3-kinase; phosphatidylinos
IL-1β induces IL-8 in bronchial cells via NF-κB and NF-IL6 transcription factors and can be suppressed by glucocorticoids
Keywords: IL-8; NF-κB; Fluticasone propionate; Lung; IL; Interleukin; Th; T helper; RANTES; regulated upon activation, normal T cell expressed and secreted; GM-CSF; granulocyte-macrophage colony stimulating factor; IRAK; IL-1 receptor associated kinase; NF; nuclea
Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes
Keywords: AP-1; activator protein-1; EMSA; electrophoresis mobility shift assay; ERK; extracellular signal-regulated protein kinase; 4-HPR; N-(4-hydroxyphenyl)retinamide; IκBα; I kappa B alpha; IL; interleukin; JNK; c-jun N-terminal kinase; mAb; monoclonal antibo
Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by phenolic (3E)-4-(2-hydroxyphenyl)but-3-en-2-one in RAW 264.7 macrophages
Keywords: DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; EMSA; electrophoretic mobility shift assay; ERK; extracellular signal-regulated kinase; HPB; (3E)-4-(2-hydroxyphenyl)but-3-en-2-one; IκB; inhibitory factor-κB; IKK; IκB kinase; iNOS; inducible NO syntha
Double blockade of cell cycle progression by coptisine in vascular smooth muscle cells
Keywords: bFGF; basic fibroblast growth factor; CDK; cyclin dependent kinase; DEPC; diethyl pyrocarbonate; DMEM; Dulbecco's modified Eagle's medium; ERK; extracellular signal-regulated kinase; FCS; fetal calf serum; GAPDH; glyceraldehyde-3-phosphate dehydrogenase;
MEK inhibitor, U0126, attenuates cisplatin-induced renal injury by decreasing inflammation and apoptosis
Keywords: cisplatin; ERK; TNF-α; inflammation; caspase; apoptosis;
Ursolic acid promotes the release of macrophage migration inhibitory factor via ERK2 activation in resting mouse macrophages
Keywords: COX; cyclooxygenase; DMEM; dulbecco's modified eagle medium; DMSO; dimethylsulfoxide; ELISA; Enzyme-linked immunosorbent assay; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; GAPDH; glyceraldehyde phosphate dehydrogenase; ICE; IL-1β
Acetoxycycloheximide (E-73) rapidly induces apoptosis mediated by the release of cytochrome c via activation of c-Jun N-terminal kinase
Keywords: CHX; cycloheximide; ERK; extracellular signal-regulated kinase; FasL; Fas ligand; JNK; c-Jun N-terminal kinase; MCA; 4-methyl-coumaryl-7-amide; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; zVAD-fmk; benzyloxycarbonyl-Val-Ala-Asp(OMe)
Chemical complementation: A definitive phenotypic strategy for identifying small molecule inhibitors of elusive cellular targets
Keywords: Chemical complementation; Forward Pharmacology; Reverse Pharmacology; High-content screening; Cell-based assay; Drug discovery; Erk; extracellular signal-regulated kinase; GFP; green fluorescent protein; HTS; high-throughput screening; MAPK; mitogen-activ
Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways
Keywords: ECM; extracellular matrix; ERK; extracellular signal-regulated kinase; MAPK; mitogen activator protein kinase; MMPs; matrix mtealloproteinases; MMP-2; matrix metalloproteinase-2; MMP-9; matrix metalloproteinase-9; u-PA; urokinase-plasminogen activator; Si
Signalling pathways regulating the invasive differentiation of human trophoblasts: a review
Keywords: Human trophoblast; Signal transduction; Differentiation; Cell invasion; ALKs; activin-receptor-like kinases; bHLH; basic helix-loop-helix; CaMKII; Ca/calmodulin-dependent kinase II; CTB; cytotrophoblast; eCTB; endovascular cytotrophoblast; ECM; extracellu
15d-PGJ2: The anti-inflammatory prostaglandin?
Keywords: Prostaglandin; 15d-PGJ2; PPARγ; Inflammation; PGD2; H-PGDS; L-PGDS; NF-κB; Erk;
PAR-2 activation in intestinal epithelial cells potentiates interleukin-1β-induced chemokine secretion via MAP kinase signaling pathways
Keywords: Proteinase-activated receptor-2 (PAR-2); p38; ERK; Interleukin-8; NF-κB;
Prostaglandin E2 release evoked by intrathecal dynorphin is dependent on spinal p38 mitogen activated protein kinase
Keywords: Dialysis; Dynorphin; Dyn2-17; ERK; Intrathecal; Microglia; Pain; p38; Prostaglandin E2; Spinal cord;
Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes
Keywords: DMSO; dimethyl sulfoxide; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; IL-8; interleukin 8; MAP; mitogen-activated protein; MMP; metalloproteinase; NFκB; nuclear factor κ B; PKC; p
Quantitative proteomic analysis of fibroblast nuclear proteins after stimulation with mitogen activated protein kinase inhibiting heparan sulfate
Keywords: Cell growth; Fibroblast; Heparan sulfate; Mitogen-activated protein kinase (MAP kinase); Signal transduction; bFGF; basic fibroblast growth factor; CS; chondroitin sulfate; DS; dermatan sulfate; DexS; dextran sulfate; EGF; epidermal growth factor; EMEM; E
MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits
Keywords: ARE; AU-rich element; ASK; Apoptosis Signal regulating Kinase; ATF-2; Activating Transcription Factor 2; CRE; Cyclic AMP Responsive Element; ERK; Extracellular signal regulated kinase; iNOS; inducible Nitric Oxide Synthase; JNK; c-Jun N-terminal Kinase; L
Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia
Keywords: Capsaicin; Thermal stimuli; Dorsal root ganglion; p38; ERK; TRPV1;
Pathogénie des vascularites systémiques primitives (I) : vascularites ANCA-positives
Keywords: Ac; anticorps; Akt; sérine/thréonine kinase (ou protein kinase B); α1-AT; α 1-antitrypsine; ANCA; Ac anti-cytoplasme de polynucléaire neutrophile; CE; cellule endothéliale; ELAM-1; endothelial-leucocyte adhesion molecule-1; ERK; extracellular signal
Pigment epithelium-derived factor induces pro-survival genes through cyclic AMP-responsive element binding protein and nuclear factor kappa B activation in rat cultured cerebellar granule cells: Implication for its neuroprotective effect
Keywords: pigment epithelium-derived factor; PEDF; pro-survival genes; neuronal apoptosis; transcription factors; signal transduction pathway; ALLN; N-acetyl-Leu-Leu-norleucinal; BSA; bovine serum albumin; CGCs; cerebellar granule cells; CRE; cyclic AMP-response el
17-β Estradiol rapidly enhances extracellular signal-regulated kinase 2 phosphorylation in the rat brain
Keywords: ERK2; rapid signaling; in vivo; diagonal band of Broca; nucleus accumbens; arcuate nucleus; AMPH; amphetamine; AVPV; anteroventral periventricular nucleus; BFCN; basal forebrain cholinergic neurons; BSA; bovine serum albumin; cPOA; caudal preoptic area; C
Extracellular inosine modulates ERK 1/2 and p38 phosphorylation in cultured Sertoli cells: Possible participation in TNF-alpha modulation of ERK 1/2
Keywords: Extracellular inosine; TNF-α; MAPKs; ERK; p38; Sertoli cells;
SIRPα negatively regulates differentiation of PC12 cell
Keywords: BDNF; brain-derived neurotrophic factor; CAMs; Cellular adhesion molecules; CEACAM; carcinoembryonic antigen associated cellular adhesion molecules; ERK; extracellular mitogen regulated kinase; ITIM; immune tyrosine-based inhibitory motif; JNK; c-jun N-te
IGF-I protects cortical neurons against ceramide-induced apoptosis via activation of the PI-3K/Akt and ERK pathways; is this protection independent of CREB and Bcl-2?
Keywords: Development and regeneration; Neuronal death; Ara-C; Cytosine arabinoside; BSA; Bovine serum albumin; CaMKIV; Calcium-calmoduline kinase IV; CAPP; Ceramide activated protein phosphatase; cer: c2-ceramide; CREB; CAMP-response element binding protein; ECLEn