کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10904772 | 1086693 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK
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کلمات کلیدی
Jnkshort interfering RNAsC-Jun NH2 terminal kinaseMKP-1MKPTransactivationHREERKGSTHIF-1MAPK - MAPKsiRNA - siRNATAD - بلهHypoxia responsive element - عنصر پاسخگو هیپوکسیhypoxia-inducible factor-1 - فاکتور القای هیپوکسی -1Vascular endothelial growth factor - فاکتور رشد اندوتلیال عروقیVascular Endothelial Growth Factor (VEGF) - فاکتور رشد اندوتلیال عروقی (VEGF)Phosphorylation - فسفریلاسیونHypoxia - هیپوکسیmitogen-activated protein kinase - پروتئین کیناز فعال با mitogenmitogen-activated protein kinase Phosphatase - پروتئین کیناز پروتئین فعال Mitogen فسفاتازextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولیglutathione S-transferase - گلوتاتیون S-ترانسفراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK Dual-specificity phosphatase DUSP1 protects overactivation of hypoxia-inducible factor 1 through inactivating ERK MAPK](/preview/png/10904772.png)
چکیده انگلیسی
Hypoxia-inducible factor 1 (HIF-1) plays a critical role in controlling oxygen delivery and metabolic adaptation to hypoxic conditions in hypoxic tumor cells. HIF-1 activation is initiated by several factors including mitogen-activated protein kinase (MAPK) superfamily. We have previously reported that mitogen-activated protein kinase phosphatase DUSP1 (MKP-1) was implicated in the negative regulation of HIF-1α subunit phosphorylation and HIF-1 activity. However, the molecular basis by which MKP-1 influences HIF-1 activity is not clarified. In this paper, we show that hypoxia transcriptionally induces MKP-1 expression in a time-dependent manner. Meanwhile, hypoxia also activates extracellular signal-regulated kinase (ERK) whose activity is enhanced or reduced by MKP-1 suppression or MKP-1 overexpression, respectively. We also show that suppression of MKP-1 expression facilitates the interaction between HIF-1α subunit and p300, a co-activator of HIF-1. Moreover, MKP-1 suppression leads to enhanced HIF-1 activity, which can be counteracted by PD98059, an ERK kinase inhibitor. Taken together, the results presented here suggest that hypoxia-induced MKP-1 protects overactivation of HIF-1 activation through inhibiting ERK kinase activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Cell Research - Volume 309, Issue 2, 1 October 2005, Pages 410-418
Journal: Experimental Cell Research - Volume 309, Issue 2, 1 October 2005, Pages 410-418
نویسندگان
Changjiang Liu, Yongquan Shi, Yulei Du, Xiaoxuan Ning, Na Liu, Dawei Huang, Jie Liang, Yan Xue, Daiming Fan,