A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction
Keywords: GLP-1; Exendin-4; Glucagon; GPCR; Receptor activation
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Vanilloid receptors—do they have a role in whole body metabolism? Evidence from TRPV1
Keywords: TRPV1; Glucose; Insulin; GLP-1; Hypothalamus
Potential of incretin-based therapies for non-alcoholic fatty liver disease
Keywords: Glucagon like peptide-1; GLP-1; Exenatide; DPP4; Hepatic steatosis; NAFLD; Fatty liver; AMP kinase; GLP-1 receptor; Gliptin; Obesity
Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: Recommendations from PancreasFest 2012
Keywords: Diabetes mellitus; Chronic pancreatitis; Incretin; Pancreatogenic diabetes; Insulin; Glucose tolerance test; Pancreatic polypeptide; GLP-1
Incretin dysfunction in type 2 diabetes: Clinical impact and future perspectives
Keywords: Incretin; GIP; GLP-1; Type 2 diabetes; InsulinIncrétine; GIP; GLP-1; Diabète de type 2; Insuline
GLP-1 agonists in type 1 diabetes
Keywords: GLP-1; Glucagon-like peptide 1; Type 1 diabetes
Glucagon-like peptide 1 and appetite
Keywords: GLP-1; appetite; gastrointestinal motility; food intake
Effect of surface chemistry of porous silicon microparticles on glucagon-like peptide-1 (GLP-1) loading, release and biological activity
Keywords: In vivo; Mesoporous silicon; Peptide delivery; GLP-1; Blood glucose levels
Nutrients related to GLP1 secretory responses
Keywords: GLP-1; Glucagon-like peptide1; Type 2 diabetes; Fatty acids; Protein; Carbohydrate
Characterization of the use of liraglutide for glycemic control in healthy and Type 1 diabetes mellitus suffering dogs
Keywords: Dogs; GLP-1; Glucose; Insulin; Liraglutide
Concomitant use of miglitol and mitiglinide as initial combination therapy in type 2 diabetes mellitus
Keywords: Miglitol; Mitiglinide; Initial combination; GLP-1; GIP
Changes in gut hormone profile and glucose homeostasis after laparoscopic sleeve gastrectomy
Keywords: Laparoscopic sleeve gastrectomy; Bariatric surgery; Glucagon-like peptide-1; GLP-1; Peptide YY; PYY; Gut hormones; Insulin; Glucose;
Evaluating insulin secretagogues in a humanized mouse model with functional human islets
Keywords: GLP-1; glucagon-like peptide-1; GPR40; G protein-coupled receptor 40; STZ; streptozotocin; OGTT; oral glucose tolerance test; Islet; Diabetes; Human islet grafts; Mice; Insulin;
Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1 diabetic mice
Keywords: GLP-1; exendin-4; omeprazole; type 1 diabetes; insulin sensitivity; Nrf-2; IRS-1
Oxyntomodulin attenuates exendin-4-induced hypoglycemia in cattle
Keywords: Exendin-4; GLP-1; Oxyntomodulin; Glucagon; Glucose; Cattle
Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1
Keywords: FFA1; GLP-1; Allosterism; Type 2 diabetes
Hormone changes and diabetes resolution after biliopancreatic diversion and laparoscopic sleeve gastrectomy: a comparative prospective study
Keywords: Biliopancreatic diversion; Sleeve gastrectomy; Weight loss; Diabetes mellitus; Hypertension; Dyslipidemia; Ghrelin; PYY; GLP-1; Insulin; Glucagon;
Identification of novel cis-regulatory regions from the Notch receptor genes lin-12 and glp-1 of Caenorhabditis elegans
Keywords: Notch signaling; lin-12; glp-1; Caenorhabditis elegans; Neuronal expression; cis-Regulatory region
Effects of LX4211, a Dual SGLT1/SGLT2 Inhibitor, Plus Sitagliptin on Postprandial Active GLP-1 and Glycemic Control in Type 2 Diabetes
Keywords: adult; diabetes; dipeptidyl peptidase-4; GIP; GLP-1; glucose; glycemic control; human; insulin; PYY; SGLT1; SGLT2; sitagliptin; urinary glucose excretion;
Effects of LX4211, a Dual Sodium-Dependent Glucose Cotransporters 1 and 2 Inhibitor, on Postprandial Glucose, Insulin, Glucagon-like Peptide 1, and Peptide Tyrosine Tyrosine in a Dose-Timing Study in Healthy Subjects
Keywords: Diabetes; GLP-1; SGLT1; SGLT2; PYY; urinary glucose excretion;
Neuronal and intracellular signaling pathways mediating GLP-1 energy balance and glycemic effects
Keywords: Leptin; GLP-1; NTS; Hypothalamus; Pancreas; Insulin; PKA; AMPK; MAPK; ERK; CREB; Food intake; Obesity;
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Keywords: DPP-4; GLP-1; Type II diabetes; Pyridopyrimidinedione;
Glucagon-like peptide 1 (GLP-1) in the gastrointestinal tract of the pheasant (Phasianus colchicus)
Keywords: GLP-1; Gastrointestinal tract; Duodenum; Pheasant
Postconditioning with curaglutide, a novel GLP-1 analog, protects against heart ischemia-reperfusion injury in an isolated rat heart
Keywords: GLP-1; GLP-1(7-36)amide glucagon-like peptide-1; IR; ischemia-reperfusion; IRI; ischemia-reperfusion injury; LVS; left ventricle systolic pressure; LVD; left ventricle diastolic pressure; LVDEV; left ventricle developed pressure; BPM; beats per minute;
Early intervention with liraglutide improves glucose tolerance without affecting islet microcirculation in young Goto-Kakizaki rats
Keywords: ABF; adrenal blood flow; fIBF; fraction IBF out of PBF; GK; Goto-Kakizaki; GLP-1; glucagon-like peptide-1; IBF; islet blood flow; KBF; kidney blood flow; MABP; mean arterial blood pressure; PBF; pancreatic blood flow; Diabetes; Islet; Insulin; Glucagon-
Effect of exendin (exenatide)-GLP 1 receptor agonist on the thyroid and parathyroid gland in a rat model
Keywords: Exendin-4; GLP-1; Thyroid; Parathyroid; Rat;
Dipeptidyl peptidase-4 inhibitor with β-amino amide scaffold: Synthesis, SAR and biological evaluation
Keywords: Diabetes; DPP4; GLP-1; β-Amino amide;
Reduced levels of active GLP-1 in patients with cystic fibrosis with and without diabetes mellitus
Keywords: Cystic fibrosis related diabetes (CFRD); GLP-1; Intestinal hormones; Endocrinology
Exendin-4 restores glucolipotoxicity-induced gene expression in human coronary artery endothelial cells
Keywords: Exendin-4; GLP-1; Endothelial cell; Diabetes; Vascular disease; Endothelial function;
Optogenetic Therapeutic Cell Implants
Keywords: GLP-1; glucagon-like peptide 1; ipRGCs; intrinsically photosensitive retinal ganglion cells; T2DM; type 2 diabetes mellitus;
Exenatide and feeding: Possible peripheral neuronal pathways
Keywords: GLP-1; Meal size; Intermeal interval; Sympathetic; Vagus
Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran
Keywords: DPP-IV; dipeptidyl peptidase IV; GLP-1; glucagon-like peptide-1; HPLC; high-performance liquid chromatography; IC50; half-maximal inhibitory concentration; LAP; leucine aminopeptidase; LC-MS; HPLC-mass spectrometry; pNA; p-nitroanilide; RB; rice bran;
β-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic β INS832/13 cells
Keywords: β-Cell mass; Incretin; GLP-1; c-Src; β-Arrestin; Proliferation;
Gastric Bypass Surgery Attenuates Ethanol Consumption in Ethanol-Preferring Rats
Keywords: Alcohol; aversion; ghrelin; GLP-1; reward; Roux-en-Y gastric bypass
DPP-IV inhibitory potential of naringin: An in silico, in vitro and in vivo study
Keywords: DPP-IV; GLP-1; In silico; In vitro; In vivo; Naringin;
Increased secretion of insulin and proliferation of islet β-cells in rats with mesenteric lymph duct ligation
Keywords: GIP; glucose-dependent insulinotropic polypeptide; GLP-1; glucagon-like peptide-1; OGTT; oral glucose tolerance test; Insulin secretion; Glucose metabolism; Lymph duct ligation; Incretin;
Synergism by individual macronutrients explains the marked early GLP-1 and islet hormone responses to mixed meal challenge in mice
Keywords: GPCR; G-Protein coupled receptors; GLP-1; Glucagon-like peptide 1; sAUC; Suprabasal area under the curve; tAUC; Total area under the curve; QUICKI; Quantitative insulin sensitivity check index; OGIS; Oral glucose insulin sensitivity index; Macronutrients;
GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress
Keywords: GLP-1; Liraglutide; ER stress; HUVEC;
Exogenous and endogenous ghrelin counteracts GLP-1 action to stimulate cAMP signaling and insulin secretion in islet β-cells
Keywords: Ghrelin; GLP-1; Insulin release; Cytosolic Ca2+; cAMP; Islet β-cell;
Enzymatic mono-pegylation of glucagon-like peptide 1 towards long lasting treatment of type 2 diabetes
Keywords: GLP-1; Pegylated GLP-1; Enzymatic pegylation; Transglutaminase; Type 2 diabetes
The development of Byetta (exenatide) from the venom of the Gila monster as an anti-diabetic agent
Keywords: Exendin-4; Insulin secretion; GLP-1
Research ArticleIntestinal GATA4 deficiency protects from diet-induced hepatic steatosis
Keywords: DNL; de novo lipogenesis; TG; triglycerides; NAFLD; non-alcoholic fatty liver disease; WTD; Western-type diet; ACC; acetyl-CoA carboxylase alpha; MCDD; methionine and choline-deficient diet; GLP-1; glucagon-like peptide-1; IIS; ileal interposition surgery
Degradation, insulin secretion, glucose-lowering and GIP additive actions of a palmitate-derivatised analogue of xenin-25
Keywords: ESI; electrospray ionisation; FASTA; FAST-All; GIP; glucose-dependent insulinotropic polypeptide; GLP-1; glucagon-like peptide-1; HPLC; high performance liquid chromatography; Lys; lysine; MALDI-TOF; matrix-assisted laser desorption ionisation-time of fli
Glucagon-like peptide-1 of brainstem origin activates dorsomedial hypothalamic neurons in satiated rats
Keywords: Amy; amygdala; Arc; arcuate nucleus; cc; central canal; CCK; cholecystokinin; cp; cerebral peduncle; Cx; cerebral cortex; DAB; 3,3â²-diaminobenzidine; DMH; hypothalamic dorsomedial nucleus; DMHc; pars compacta of the DMH; DMHv; ventral subdivision of the
Dysbiosis of Gut Microbiota (DOGMA) - A novel theory for the development of Polycystic Ovarian Syndrome
Keywords: PCOS; Polycystic Ovarian Syndrome; LH; Lutenizing Hormone; FSH; Follicle Stimulating Hormone; SHBG; Sex Hormone Binding Globulin; DOGMA; Dysbiosis of Gut Microbiota; LPS; lipopolysaccaride; CFU; colony forming units; SCFA; short chain fatty acids; IBS; Ir
Mitochondrial signals drive insulin secretion in the pancreatic β-cell
Keywords: AGC; aspartate-glutamate carrier; BCATm; branched chain amino transferase; cICD; cytosolic isocitrate dehydrogenase; GDH; glutamate dehydrogenase; GLP-1; glucagon-like peptide-1; LDH; lactate dehydrogenase; mtDNA; mitochondrial DNA; PC; pyruvate carboxy
Glucagon-like peptide-1 inhibits insulinotropic effects of oxyntomodulin and glucagon in cattle
Keywords: Oxyntomodulin; Glucagon; GLP-1; Insulin; Glucose; Cattle
Enteroendocrine cells in terminal ileal Crohn's disease
Keywords: AR; Antigen retrieval; BSA; Bovine serum albumin; CgA; Chromogranin A; CCK; Cholecystokinin; CD; Crohn's disease; CDAI; CD activity index; Cy5; Cyanine 5; DAPI; 4â²,6-diamidino-2-phenylindole; EDTA; Ethylenediaminetetraacetic acid; EEC; Enteroendocrine c
Harnessing the incretin system beyond glucose control: Potential cardiovascular benefits of GLP-1 receptor agonists in type 2 diabetes
Keywords: Cardiovascular disease; Incretin therapy; Type 2 diabetes; GLP-1; Endothelial function; Hypertension; Myocardial function; ReviewDiabète de type 2; Incrétines; GLP-1; Hypertension artérielle; Fonction myocardique; Insuffisance cardiaque; Revue générale
Role of phospholipase Cε in physiological phosphoinositide signaling networks
Keywords: PLC; phosphoinositide-specific phospholipase C; PKC; protein kinase C; LPA; lysophosphatidic acid; S1P; sphingosine-1 phosphate; Epac; Exchange protein directly activated by cAMP; GPCR; G protein-coupled receptor; GEF; guanine nucleotide exchange factor;