دانلود مقالات ISI درباره Grna + ترجمه فارسی

درمان های عملکردی برای بهبود زخم های پوستی در اپیدرمولیز بلوز

Functional therapies for cutaneous wound repair in epidermolysis bullosa

Keywords: EB; epidermolysis bullosa; BMZ; basement membrane zone; EBS; epidermolysis bullosa simplex; JEB; junctional epidermolysis bullosa; DEB; dystrophic epidermolysis bullosa; KS; kindler syndrome; DEJ; dermal-epidermal junction; PTC; premature termination codo

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

محاسبه مقیاس و حافظه در سلول های زنده

Scaling computation and memory in living cells

Keywords: Recombinase-based gene circuits; CRISPR-based gene circuits; Cellular computing; ADC; analog-to-digital converter; att; attachment sites; BLADE; Boolean logic and arithmetic through DNA excision; Cas; CRISPR-associated nuclease; CRISPR; clustered regularl

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

دستکاری ژنتیکی در محصولات: چالش ها و فرصت ها

Genetic manipulations in crops: Challenges and opportunities

Keywords: Bt; Bacillus thuringiensis; CRISPR/Cas9; Clustered Regularly Interspaced Short Palindromic Repeat; DSB; Double stranded breaks; GM; Genetically modified; gRNA; Guide RNA; GURTs; Gene Use Restriction Technologies; HR; Homologous recombination; NHEJ; Non-ho

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

ترجمه ژنتیک فیبروز کیستیک به پزشکی شخصی

Translating the genetics of cystic fibrosis to personalized medicine

Keywords: AAV; Adeno associated virus; ABC; ATP-binding cassette; ACMG; American College Medical Genetics; AH; Ancestral Haplotype; ASL; airway surface liquid; ATP; Adenosine triphosphate; cas; CRISPR associated; CF; Cystic fibrosis; CFTR; Cystic Fibrosis Transmemb

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

زیست شناسی مصنوعی و ژنتیک مولکولی در مخمرهای غیر متعارف: ابزارهای فعلی و پیشرفت های آینده

Synthetic biology and molecular genetics in non-conventional yeasts: Current tools and future advances

Keywords: ARS; autonomously replicating sequence; CEN; centromere; CRISPR; Clustered, Regularly Interspaced, Short Palindromic Repeats; DSB; double strand break; GFP; green fluorescent protein; GRAS; Generally Regarded As Safe; gRNA; guide RNA (for CRISPR); HR; hom

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

بررسی استفاده از ویرایش ژنوم در مطالعه کاهش شنوایی

ReviewThe application of genome editing in studying hearing loss

Keywords: AAV; Adeno-associated virus; ARHL; age-related hearing loss; Cas9; CRISPR-associated nuclease 9; CRISPR; clustered, regularly interspaced, short palindromic repeat; crRNA; CRISPR RNA; dCas9; defective Cas9; DSBs; double-strand breaks; gRNA; guide RNA; HDR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

In vivo gene correction with targeted sequence substitution through microhomology-mediated end joining

Keywords: In vivo gene correction; Microhomology-mediated end-joining (MMEJ); Targeted sequence substitution (TSS); Hereditary tyrosinemia; Homology-directed repair (HDR); HDR; Homology-directed repair; NHEJ; Non-homologous end-joining; MMEJ; Microhomology-mediate

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Moringa oleifera and their phytonanoparticles: Potential antiproliferative agents against cancer

Keywords: ARE; antioxidant response element; CPT1; carnitine palmitoyltransferase I; CPTII; carnitine palmitoyltransferase II; associated 9 (Cas9); clustered regulatory interspaced short palindromic repeat (CRISPR); DEN; diethyl nitrosamine; DMBA; 7, 12 dimethylben

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Clustered Regularly Interspaced Short Palindromic Repeats-Based Genome Surgery for the Treatment of Autosomal Dominant Retinitis Pigmentosa

Keywords: AAV; adeno-associated virus; adRP; autosomal dominant retinitis pigmentosa; bp; base pair; CRISPR; clustered regularly interspaced short palindromic repeat; CRISPRd; clustered regularly interspaced short palindromic repeats using Cas9 and double guide RNA

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Strategies for controlling CRISPR/Cas9 off-target effects and biological variations in mammalian genome editing experiments

Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; gRNA; guide RNA; OTE; off-target effects; KO; knock out; NHEJ; non-homologous end joining; KI; knock in; HDR; homology directed repair; GOI; gene of interest; LOI; locus of interest; iPSC;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

CRMP2-Neurofibromin Interface Drives NF1-related Pain

Keywords: ANOVA; analysis of variance; AP; action potential; Cas9; CRISPR-associated protein-9 nuclease; CaV2.2; N-type voltage-gated calcium channel; CGRP; calcitonin gene-related peptide; CNRP1; CRMP2-neurofibromin regulating peptide 1; CRISPR; clustered regula

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

In vivo methods for acute modulation of gene expression in the central nervous system

Keywords: AAV; adeno-associated viruses; ADV; adenoviruses; ApoE; apolypoprotein E; BBB; blood brain barrier; cap; encapsulation; Cas9; CRISPR associated protein 9; cDNA; coding DNA; CMV; cytomegalovirus; CNS; central nervous system; CNT; carbon nanotubes; CRISPR;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2018 سفارش ترجمه

Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages

Keywords: Blau syndrome; nucleotide-binding oligomerization domain 2; nuclear factor κB; IFN-γ; disease-specific induced pluripotent stem cells; ChIP; Chromatin immunoprecipitation; DAPI; 4′-6-Diamidino-2-phenylindole dihydrochloride; gRNA; Guide RNA; GSEA; Gen

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

Highly efficient genome editing by homology-directed repair using Cas9 protein in Ceratitis capitata

Keywords: ssODN-mediated homology-directed repair; CRISPR-Cas9 ribonucleoprotein complexes; Mediterranean fruit fly; Tephritids; Sterile insect technique; BFP; blue fluorescent protein; bp; base pair(s); Cas; CRISPR associated; CRISPR; Clustered Regularly Interspac

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Efficient transgene insertion in a pseudorabies virus vector by CRISPR/Cas9 and marker rescue-enforced recombination

Keywords: ASFV; African swine fever virus; BAC; bacterial artificial chromosome; Cas9; CRISPR associated protein 9; CRISPR; clustered regularly interspaced short palindromic repeats; DSB; double strand break; EGFP; enhanced green fluorescent protein; FBS; fetal bov

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

The potential and challenges of CRISPR-Cas in eradication of hepatitis B virus covalently closed circular DNA

Keywords: CHB; chronic hepatitis B; HBV; hepatitis B virus; NA; nucleos(t)ide analogue; cccDNA; covalently closed circular DNA; guide RNA; gRNA; NTCP; sodium taurocholate cotransporting polypeptide; RC-DNA; relaxed circular DNA; pgRNA; pregenomic RNAs; HBsAg; HBV s

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

CD163 knockout pigs are fully resistant to highly pathogenic porcine reproductive and respiratory syndrome virus

Keywords: Gene-knockout pigs; CD163; Highly pathogenic PRRSV; CRISPR/Cas9; SCNT; Antiviral breeding; AF; Alexa Fluor; DPI; day post inoculation; gRNA; guide RNA; Hb; Hemoglobin; Hp; haptoglobin; HP-PRRSV; highly pathogenic porcine reproductive and respiratory syndr

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Evaluating different DNA binding domains to modulate L1 ORF2p-driven site-specific retrotransposition events in human cells

Keywords: AAV; Adeno-Associated Virus; CRISPR; clusters of regularly interspaced short palindromic repeats; DBDs; DNA binding domains; gRNA; guide RNA; HAC; homology Arm Cassette; HRP; Horse Radish Peroxidase; PAM; Protospacer Adjacent Motif; TAL; Transcription act

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

A two-plasmid inducible CRISPR/Cas9 genome editing tool for Clostridium acetobutylicum

Keywords: aTc; anhydrotetracycline; CRISPR; Clustered regularly interspaced short palindromic repeats; Cas; CRISPR-associated proteins; Cas9n; Cas9 nickase; DSB; Double-strand break; gDNA; genomic DNA; gRNA; guide RNA; HR; Homologous recombination; NHEJ; Non-homolo

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting

Keywords: Islet; α-cell; Enteroendocrine L-cell; Glucagon; GLP1; CRISPR; Cre; Cre recombinase; CreERT2; tamoxifen-inducible Cre recombinase-estrogen receptor fusion protein; CRISPR; clustered regularly interspaced short palindromic repeat; DAPI; 4′,6-diamidino-2

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA

Keywords: CRISPR; clustered regularly interspaced short palindromic repeats; CAS9; CRISPR associated protein; gRNA; guide RNA; PAM; protospacer adjacent motif; RNP; ribonucleoprotein; HDR; homology directed repair; hESCs; human embryonic stem cells; NHEJ; non-homol

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Optimization of CRISPR/Cas9 genome editing for loss-of-function in the early chick embryo

Keywords: CRISPR/Cas9; Chick embryos; gRNA; Neural crest; Knockout;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

An analysis of possible off target effects following CAS9/CRISPR targeted deletions of neuropeptide gene enhancers from the mouse genome

Keywords: Neuropeptide, enhancer; CAS9/CRISPR; Off-target effects; Transgenic mouse; CAS9 mRNA; gRNA; 1-cell mouse embryo; Cytoplasmic microinjection; CRISPR design tool; UCSC browser BLAT; PCR; Sanger sequencing;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

CRISPR/Cas9 Engineering of Adult Mouse Liver Demonstrates That the Dnajb1-Prkaca Gene Fusion Is Sufficient to Induce Tumors Resembling Fibrolamellar Hepatocellular Carcinoma

Keywords: Liver Cancer; Protein Kinase A; PKA; Genomic Engineering; Mouse Model; CEA; carcinoembryonic antigen; CRISPR/Cas9; clustered regularly interspaced short palindromic repeats/CRISPR-associated 9; FACS; fluorescence-activated cell sorting; FL-HCC; fibrolamel

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Distinct roles of neuronal and microglial CB2 cannabinoid receptors in the mouse hippocampus

Keywords: AAV; adeno-associate virus; AP; anterior posterior; CaMKII; calcium/calmodulin-dependent protein kinase II; Cas9; CRISPR-associated protein 9; CB1R; type-1 cannabinoid receptor; CB2R; type-2 cannabinoid receptor; CNS; central nervous system; CRISPR; clust

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Correction of Hirschsprung-Associated Mutations in Human Induced Pluripotent Stem Cells Via Clustered Regularly Interspaced Short Palindromic Repeats/Cas9, Restores Neural Crest Cell Function

Keywords: PSC-Based Model; Neural Development; Enteric Nervous System; Congenital; CD; coding; CNS; central nervous system; CRISPR; clustered regularly interspaced short palindromic repeats; ENCC; enteric neural crest cell; FA; focal adhesion; GDNF; glial cell-deri

دانلود رایگان متن کامل مقاله ISI 70 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleThe A2b adenosine receptor antagonist PSB-603 promotes oxidative phosphorylation and ROS production in colorectal cancer cells via adenosine receptor-independent mechanism

Keywords: PSB603; Off-target effect; Cellular redox state; Reactive oxygen species; Chemotherapy; MTT; 5-FU; Fluorouracil; AR(s); Adenosine receptor(s); CRC; Colorectal cancer; ECAR; extracellular acidification rate; gRNA; guide RNA; HBSS; Hank's Balanced Saline So

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Structure and intrinsic disorder of the proteins of the Trypanosoma brucei editosome

Keywords: gRNA; guide RNAs; RECC; RNA editing core complex; MQAPs; Model Quality Assessment Programs; GDT_TS; global distance test total score; PROQ; Protein Quality Predictor; RMSD; root-mean-square deviation; IDRs; intrinsically disordered regions; NTD; N-termina

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Metabolic engineering of Escherichia coli using CRISPR-Cas9 meditated genome editing

Keywords: CRISPR; clustered regularly interspaced short palindromic repeat; PAM; protospacer adjacent motif; gRNA; guide RNA; DSB; double strand break; ORF; open reading frame; MMR; mismatch repair; MEP; methylerythritol-phosphate; ssDNA; single-strand DNA; dsDNA;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2015 سفارش ترجمه

Multiplex metabolic pathway engineering using CRISPR/Cas9 in Saccharomyces cerevisiae

Keywords: CRISPR; clustered regularly interspaced short palindromic repeat; PAM; protospacer adjacent motif; BTS1; Geranylgeranyl pyrophosphate synthase; ROX1; Heme-dependent repressor of hypoxic genes; TALEN; transcription activator-like effector nuclease; gRNA; g

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2015 سفارش ترجمه

U-insertion/deletion RNA editing multiprotein complexes and mitochondrial ribosomes in Leishmania tarentolae are located in antipodal nodes adjacent to the kinetoplast DNA

Keywords: gRNA; guide RNA; kDNA; kinetoplast DNA; RECC; RNA editing core complex; RET1; RNA editing TUTase 1; REH1; RNA editing helicase 1; REMC; RNA editing mediator complex; TAC; tripartite attachment complex; RESC; RNA editing substrate binding complex; GRBC; gR

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2015 سفارش ترجمه

Improving the specificity and efficacy of CRISPR/CAS9 and gRNA through target specific DNA reporter

Keywords: CRISPR; CAS9; gRNA; EGFP reporter; SpecificityCRISPR, clustered regularly interspaced short palindromic repeats; CAS9, CRISPR associated protein; gRNA, guide RNA; NHEJ, none homologous end joining; DSB, double strand DNA break; NGS, next generation sequen

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Retrospective on the all-in-one retroviral nucleocapsid protein

Keywords: RV; retroviruses; CA; capsid; MA; matrix; NC; nucleocapsid; RT; reverse transcriptase; IN; integrase; PBS; primer binding site; gRNA; genomic RNA; DLS; dimer linkage structure; DIS; dimer initiation sequence; MuLV; murine leukemia virus; MoMuLV; Moloney M

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Efficient isolation of specific genomic regions and identification of associated proteins by engineered DNA-binding molecule-mediated chromatin immunoprecipitation (enChIP) using CRISPR

Keywords: enChIP; CRISPR; dCas9; gRNA; Mass spectrometry; Locus-specific biochemical epigenetics/chromatin biochemistry;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Translation initiation is driven by different mechanisms on the HIV-1 and HIV-2 genomic RNAs

Keywords: 4E-BP; eIF4E-binding protein; BMH; branched multiple hairpins; CrPV; cricket paralysis virus; CSFV; Classical Swine Fever Virus; DIS; dimerization site; eIF; eukaryotic initiation factor; EMCV; encephalomyocarditis virus; FMDV; foot-and-mouth-disease viru

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies

Keywords: CDR; complementarity determining region; gRNA; guide RNA; KREL; kinetoplastid RNA-editing ligase; KREPA6; kinetoplastid RNA-editing interaction protein A6; KRET2; kinetoplastid RNA-editing TUTase 2; KREX2; kinetoplastid RNA-editing 3′ → 5′-exonucl

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

Complete set of mitochondrial pan-edited mRNAs in Leishmania mexicana amazonensis LV78

Keywords: aa; amino acid; CO; cytochrome c oxidase; Cyb; apocytochrome b; gRNA; guide RNA; kDNA; kinetoplast DNA; mRNA; messenger RNA; MURF; maxicircle unassigned reading frame; ORF; open reading frame; RPS12; ribosomal protein S12; rRNA; ribosomal RNA; tRNA; trans

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Mapping of nucleocapsid residues important for HIV-1 genomic RNA dimerization and packaging

Keywords: C; cysteine, except in “C-terminal”, where it means “carboxyl-terminal”; CA; capsid; DIS; dimerization initiation site; Gag; group specific antigen; gRNA; genomic RNA; HIV-1; human immunodeficiency virus type 1; MoMuLV; Moloney murine leukemia vir

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2008 سفارش ترجمه

Evolutionary patterns of non-coding RNAs

Keywords: Evolution; Non-coding RNA; mRNA; rRNA; snRNA; snoRNA; miRNA; Y-RNA; Vault RNA; gRNA; RNA editing; UTR;

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2005 سفارش ترجمه