دانلود مقالات ISI درباره Jak2 + ترجمه فارسی

Leptin-induced basal Akt phosphorylation and its implication in exercise-mediated improvement of insulin sensitivity

Keywords: Leptin; Insulin resistance; Akt; JAK2; Acute exercise; Chronic exercise;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2018 سفارش ترجمه

Ilex asprella aqueous extracts exert in vivo anti-inflammatory effects by regulating the NF-κB, JAK2/STAT3, and MAPK signaling pathways

Keywords: ASA; Acetylsalicylic acid; DAB; tetrahydrochloride dehydrate; Dex; dexamethasone; ELISA; enzyme-linked immunosorbent assay; ERK 1/2; extracellular regulated protein kinases; HE; hematoxylin-eosin; IA; Ilex asprella; IL-6; interleukin-6; IL-1β; interleuki

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

A Placebo-Controlled Phase II Study of Ruxolitinib in Combination With Pemetrexed and Cisplatin for First-Line Treatment of Patients With Advanced Nonsquamous Non-Small-Cell Lung Cancer and Systemic Inflammation

Keywords: Janus kinase (JAK); JAK1; JAK2; Modified Glasgow prognostic score; Signal transducers and activators of transcription (STAT);

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Mucuna pruriens (L.) DC chemo sensitize human breast cancer cells via downregulation of prolactin-mediated JAK2/STAT5A signaling

Keywords: ANOVA; Analysis of variance; PRL; prolactin; PRLR; prolactin receptor; JAK2; janus kinase 2; STAT5A; signal transducer and activator of transcription 5A; LD; levodopa; MP; Mucuna pruriens (L.) DC; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

The roles of JAK2 in DNA damage and repair in the myeloproliferative neoplasms: Opportunities for targeted therapy

Keywords: JAK2; DNA damage; Myeloproliferative neoplasms;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Heat shock protein B1 is required for the prolactin-induced cytoprotective effects on pancreatic islets

Keywords: Apoptosis; Diabetes; Human islets; Islet transplantation; Prolactin; Survival; Mouse islets; AG490; Tyrphostin AG490; BAX; BCL2-associated X protein; BCL2; B cell CLL/lymphoma 2; BCLxL; BCL extra large; DM1; Type 1 diabetes mellitus; FCS; Fetal calf serun

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

The IL-6/STAT3 pathway regulates adhesion molecules and cytoskeleton of endothelial cells in thromboangiitis obliterans

Keywords: Ace-tubulin; acetylated-tubulin; ANOVA; analysis of variance; DAPI; 4′,6-diamidino-2-phenylindole; C3; C3 transferase (RhoA inhibitor); ELISA; enzyme-linked immunosorbent assay; eNOS; endothelial nitric oxide synthase; FAK; focal adhesion kinase; FITC;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Vibrational (FT-IR and FT-Raman), electronic (UV-Vis), NMR (1H and 13C) spectra and molecular docking analyses of anticancer molecule 4-hydroxy-3-methoxycinnamaldehyde

Keywords: 4-Hydroxy-3-methoxycinnamaldehyde; JAK2; DFT; FT-IR; FT-Raman; NMR;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation

Keywords: ABL; Abelson murine leukemia viral oncogene homolog 1; ALIS; aggresome-like induced structure; ALL; acute lymphoblastic leukemia; BCR; breakpoint cluster region; CML; chronic myeloid leukemia; DCFH-DA; 2′, 7′-dichlorodihydrofluorescein diacetate; DCPI

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2018 سفارش ترجمه

Pyrrolidine dithiocarbamate alleviates the anti-tuberculosis drug-induced liver injury through JAK2/STAT3 signaling pathway: An experimental study

Keywords: Drug-induced liver injury; Anti-tuberculosis drug; Pyrrolidine dithiocarbamate; JAK2; STAT3;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Haptoglobin is frequently low in patients with myelofibrosis: Clinical relevance

Keywords: Myelofibrosis; Haptoglobin; JAK2; JAK inhibitors;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2017 سفارش ترجمه

Short CommunicationA novel somatic JAK2 kinase-domain mutation in pediatric acute lymphoblastic leukemia with rapid on-treatment development of LOH

Keywords: JAK2; kinase-domain; lymphoblastic leukemia;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Markers of iron deficiency in patients with polycythemia vera receiving ruxolitinib or best available therapy

Keywords: BAT; best available therapy; EORTC QLQ-C30; European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire−Core 30; JAK2; Janus kinase 2; LLN; lower limit of normal; MCHC; mean corpuscular hemoglobin concentration; MCV; mean co

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Gln223Arg polymorphism in the Caucasian population and Pro1019Pro polymorphism in the Chinese population are risk factors for OSAS: An updated meta-analysis of 1159 subjects

Keywords: ACC; acetyl-CoA carboxylase; AMPK; 5′ adenosine monophosphate-activated protein kinase; CI; confidence intervals; CNKI; Chinese National Knowledge Infrastructure; Grb2; growth factor receptor-bound protein 2; HWE; Hardy-Weinberg equilibrium; IRS; insu

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Distinct roles of prolactin, epidermal growth factor, and glucocorticoids in β-casein secretion pathway in lactating mammary epithelial cells

Keywords: Prolactin; Epidermal growth factor; Glucocorticoid; Dexamethasone; β-casein; Mammary epithelial cell; DEX; dexamethasone; EGF; epidermal growth factor; EGFr; EGF receptor; FBS; fetal bovine serum; GR; glucocorticoid receptor; JAK2; Janus kinase 2; MEC; m

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleAnti-myeloma effects of ruxolitinib combined with bortezomib and lenalidomide: A rationale for JAK/STAT pathway inhibition in myeloma patients

Keywords: Multiple myeloma; JAK/STAT; Ruxolitinib; JAK1; JAK2; Small molecule inhibitor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleDifferential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions

Keywords: Lymphoblastic leukemia; JAK2; Genomics;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Multiple pathways of SIRT6 at the crossroads in the control of longevity, cancer, and cardiovascular diseases

Keywords: ALP; alkaline phosphatase; AMPK; AMP-activated protein kinase; Ang II; angiotensin II; BER; base excision repair; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CHIP; carboxyl terminus of Hsp70-interacting protein; CLL; chronic lympho

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewModeling myeloproliferative neoplasms: From mutations to mouse models and back again

Keywords: Mouse modeling; Myeloproliferative neoplasms; JAK2; MPL; Calreticulin;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

ETS transcription factor ELF5 induces lumen formation in a 3D model of mammary morphogenesis and its expression is inhibited by Jak2 inhibitor TG101348

Keywords: CEACAM1; ELF5; JAK2; Breast cancer; Mammary morphogenesis; RNAi;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Mechanisms of Resistance to JAK2 Inhibitors in Myeloproliferative Neoplasms

Keywords: JAK2; Myeloproliferative neoplasms; JAK2 inhibition; Resistance;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewAfter 10 years of JAK2V617F: Disease biology and current management strategies in polycythaemia vera

Keywords: Polycythaemia vera; Erythrocytosis; Myeloproliferative; JAK2;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor

Keywords: BRD4 inhibitor; Kinase; BI-2536; Dihydroquinoxalin-2(1H)-one; PLK1; Polo-like Kinase 1; JAK2; Janus kinase 2; PTMs; post-translational modifications; KAc; acetylated lysine; BET; Bromodomain and Extra-Terminal; P-TEFb; positive transcription elongation fa

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

The JAK2V617F mutation in normal individuals takes place in differentiating cells

Keywords: AS-PCR; allele specific PCR; AS-RQ-PCR; allele-specific real-time PCR; ddPCR; digital PCR techniques; ARMS; amplification refractory mutation system;  ∆ Ct; delta threshold cycle; Ct; threshold cycle; EPO; erythropoietin; HSC; hematopoietic stem cell;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine

Keywords: JAK2; NVP-BSK805; CEP-33779; Cancer; P-gp; Drug-resistance; CEP-33779; CEP; NVP-BSK805; NVP; vincristine; VIC; Verapamil; VER; Dimethylsulfoxide; DMSO; p-glycoprotein; P-gp; Cleaved ploy ADP ribose polymerase; C-PARP; Fluorescence-activated cell sorting;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Fractalkine/CX3CR1 axis modulated the development of pancreatic ductal adenocarcinoma via JAK/STAT signaling pathway

Keywords: Pancreatic ductal adenocarcinoma; Fractalkine; CX3CR1; JAK2; STAT3;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Intraventricular administration of Tenebrio molitor larvae extract regulates food intake and body weight in mice with high-fat diet-induced obesity

Keywords: Appetite; Diet-induced obesity; Hypothalamus; Neuropeptide; Tenebrio molitor larvae; AgRP; agouti-related peptide; ATF4; activating transcription factor 4; CHOP; c/EBP-homologous protein; eIF2α; α subunit of eukaryotic translation initiation factor 2; E

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Peptide nucleic acid probe-based fluorescence melting curve analysis for rapid screening of common JAK2, MPL, and CALR mutations

Keywords: Peptide nucleic acid; FMCA; Mutation screening; JAK2; MPL; CALR;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Icariin induces apoptosis in acute promyelocytic leukemia by targeting PIM1

Keywords: APL; Icariin; JAK2; PIM1; STAT3; STAT5;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Protein tyrosine phosphatase 1B inhibitors as antidiabetic agents - A brief review

Keywords: CD45; cluster of differentiation 45; CDC25; cell division cycle 25; DFMP; difluoromethylene phosphonates; IDDM; insulin-dependent diabetes mellitus; IGT; impaired glucose tolerance; JAK2; Janus Kinase 2; IBA; imbricatolic acid; MA; maslinic acid; MAP; mit

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

The roles of subcellularly located EGFR in autophagy

Keywords: AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells

Keywords: ATF6; activating transcription factor 6; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; HNF4α; hepatocyte nuclear factor 4α; GAP; GTPase-activating protein; HFD; high fat diet; IL-4; interleukin-4; IRE1α; inositol-requiring enzyme 1

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

CALR mutation profile in Irish patients with myeloproliferative neoplasms

Keywords: CALR; Essential thrombocythemia; JAK2; Myeloproliferative neoplasm; Primary myelofibrosis;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Massive upper gastrointestinal bleeding due to splenoportal axis thrombosis in a patient with a tested JAK2 mutation: A case report and review literature

Keywords: Portal hypertension; Thrombosis portal; JAK2; Upper bleeding; Primary myeloproliferative disorders; Case report

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance

Keywords: platelet clearance; glycans; Ashwell Morell Receptor; thrombopoietin; JAK2; STAT3

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

cAMP/PKA enhances interleukin-1β-induced interleukin-6 synthesis through STAT3 in glial cells

Keywords: 8-bromo cAMP; adenosine-3′,5′-cyclic monophosphate, 8-bromo-, sodium salt; CMI; 4-cyano-3-methylisoquinoline; CNS; central nervous system; DMEM; Dulbecco's modified Eagle's medium; EPAC; exchange proteins directly activated by cAMP; ELISA; enzyme-link

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Leptin receptor overlapping transcript (LepROT) gene participates in insulin pathway through FoxO

Keywords: 20E; 20-Hydroxyecdysone; S; Dimethyl sulfoxide; FBS; Fetal bovine serum; H. armigera; Helicoverpa armigera; HaEpi; H. armigera epidermal cell line; IGF; Insulin/insulin-like growth factor; IR; Insulin receptor; IRS; Insulin receptor substrate; JAK2; Janus

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

BCR–JAK2 fusion in a myeloproliferative neoplasm with associated eosinophilia

Keywords: JAK2; BCR–JAK2 fusion; myeloproliferative neoplasm; B-lymphoblastic leukemia/lymphoma; eosinophilia

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Leptin activates chicken growth hormone promoter without chicken STAT3 in vitro

Keywords: CK2; Growth hormone; JAK2; Leptin; Pit-1α

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Unbiased pro-thrombotic features at diagnosis in 977 thrombocythemic patients with Philadelphia-negative chronic myeloproliferative neoplasms

Keywords: Thrombocythemia; Thrombosis; Platelets; Leukocytes; Hematocrit; JAK2;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Scutellarin protects cardiomyocyte ischemia–reperfusion injury by reducing apoptosis and oxidative stress

Keywords: Ischemia; JAK2; Scutellarin; Cardiomyocyte; Apoptosis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Cullin 5-RING E3 ubiquitin ligases, new therapeutic targets?

Keywords: E3 ubiquitin ligase; Cullin RING ligase; Ubiquitin-proteasome system; Therapeutic targets; ASB; ankyrin repeat-containing proteins with a SOCS box; β-Trcp; β-transducin repeat-containing protein; BTB; bric-a-brac; CIS1; cytokine-inducible Src homology

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Expression and prognostic roles of PIK3CA, JAK2, PD-L1, and PD-L2 in Epstein-Barr virus–associated gastric carcinoma

Keywords: EBVaGC; PIK3CA; JAK2; PD-L1; PD-L2

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non–Small Cell Lung Cancer

Keywords: Non–small cell lung cancer; Gene amplification; PD-L1; JAK2; Inhibitor

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression

Keywords: Cervical cancer; JAK2; Quercetin nanoparticles; Cell death; Proliferation

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Myeloproliferative neoplasms: Current molecular biology and genetics

Keywords: Myeloproliferative neoplasms; Polycythemia vera; JAK2; CALR;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

The dipeptide Pro-Asp promotes IGF-1 secretion and expression in hepatocytes by enhancing JAK2/STAT5 signaling pathway

Keywords: Dipeptide; Pro-Asp; IGF-1; Hepatocytes; JAK2/STAT5; Akt; protein kinase B; Asp; aspartic acid; ERK; extracellular signal-regulated kinase; GH; growth hormone; IGF-1; insulin-like growth factor 1; JAK2; Janus kinase 2; PepT1; peptide transporter 1; PepT2;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2016 سفارش ترجمه

Integrative proteomics and transcriptomics revealed that activation of the IL-6R/JAK2/STAT3/MMP9 signaling pathway is correlated with invasion of pituitary null cell adenomas

Keywords: Pituitary adenomas; Null cell adenomas; Invasion; IL-6R; JAK2; STAT3;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

The discovery of 2,5-isomers of triazole-pyrrolopyrimidine as selective Janus kinase 2 (JAK2) inhibitors versus JAK1 and JAK3

Keywords: JAK2; JAK2V617F; JAK2 inhibitor; STAT (signal transducer and activator of transcription); 4-(2,5-Triazole)-pyrrolopyrimidine;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2016 سفارش ترجمه

Acute promyelocytic leukemia with JAK2 V617F and severe differentiation syndrome

Keywords: Acute promyelocytic leukemia (APL); Myeloproliferative neoplasm (MPN); Essential thrombocythemia (ET); JAK2; Differentiation syndrome

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه