دانلود مقالات ISI درباره Jak2 + ترجمه فارسی

An unusual long-term outcome of a child with primary myelofibrosis harboring a JAK2 mutation

Keywords: BM; bone marrow; MPN; myeloproliferative neoplasm; CMD; chronic myeloproliferative disease; DIPSS; dynamic-IPSS; EC; endothelial cells; HSCT; hematopoietic stem cell transplantation; INCA; Instituto Nacional de Câncer; IPSS; International Prognostic Scor

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Acute promyelocytic leukemia with JAK2 V617F and severe differentiation syndrome

Keywords: Acute promyelocytic leukemia (APL); Myeloproliferative neoplasm (MPN); Essential thrombocythemia (ET); JAK2; Differentiation syndrome

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

In silico identification of natural product inhibitors of JAK2

Keywords: JAK2; Natural product; Emodic acid; 6-Chloroemodic acid; Virtual screening

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

The clinical and laboratory evaluation of the patient with erythrocytosis

Keywords: Erythrocytosis; Polycythemia; Hypoxia; Myeloproliferative neoplasm; JAK2; Erythropoietin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

SOHO Supplement 2015New Therapeutic Approaches in Polycythemia Vera

Keywords: Hydroxyurea; Interferon; JAK2; Polycythemia vera; Ruxolitinib;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Granulocyte-colony stimulating factor activates JAK2/PI3K/PDE3B pathway to inhibit corticosterone synthesis in a neonatal hypoxic-ischemic brain injury rat model

Keywords: Hypoxia-ischemia; Granulocyte colony stimulating factor; Y1; Corticosterone; JAK2; PDE; Cholera toxin; Adrenal cortical cells; Hypothalamic-pituitary-adrenal axis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Prolactin and the dietary protein/carbohydrate ratio regulate the expression of SNAT2 amino acid transporter in the mammary gland during lactation

Keywords: BSA; bovine serum albumin; cAMP; cyclic adenosine monophosphate; CRE; cAMP response element; DAB; diaminobenzidine; ECL; enhanced chemiluminescence; HPRT1; hypoxanthine phosphoribosyl transferase 1; HPR; horseradish peroxidase; JaK2; janus kinase 2; MAPK;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice

Keywords: JAK2; M1/M2; TG101209; Microglia; APP/PS1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Recombinant Human Erythropoietin Protects Myocardial Cells from Apoptosis via the Janus-Activated Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway in Rats with Epilepsy

Keywords: apoptosis; epilepsy; erythropoietin; JAK2; STAT5

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

PRDX6 promotes tumor development via the JAK2/STAT3 pathway in a urethane-induced lung tumor model

Keywords: PRDX6; JAK2; STAT3; Lung cancer; GPx; iPLA2; Free radicals;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Anti-inflammatory role of microglial alpha7 nAChRs and its role in neuroprotection

Keywords: Alpha7 nAChR; Inflammation; Neuroprotection; Jak2; HO-1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Essential Thrombocythemia and Polycythemia Vera: Focus on Clinical Practice

Keywords: BM; bone marrow; CALR; calreticulin; CV; cardiovascular; Epo; erythropoietin; ET; essential thrombocythemia; JAK2; Janus kinase 2; MDS; myelodysplastic syndrome; MF; myelofibrosis; MPL; myeloproliferative leukemia virus oncogene; MPN; myeloproliferative

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Cigarette smoke–induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway

Keywords: Abdominal aortic aneurysm; Matrix metalloproteinase; Cigarette smoke; Jak2; Stat3

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Deregulated JAK/STAT signalling in lymphomagenesis, and its implications for the development of new targeted therapies

Keywords: JAK2; STAT signalling; Lymphoma; JAK inhibitors

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Macrocyclic compounds as anti-cancer agents: Design and synthesis of multi-acting inhibitors against HDAC, FLT3 and JAK2

Keywords: Histone deacetylase; FLT3; JAK2; Macrocyclic; Multi-target inhibitor;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders

Keywords: JAK2; Myeloproliferative disorders; Protein kinase inhibitor; Tumour cell proliferation inhibition; Anti-cancer agents;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2015 سفارش ترجمه

Protein flexibility oriented virtual screening strategy for JAK2 inhibitors

Keywords: JAK2; Binding site flexibility; Ensemble docking; Virtual screening; Bayesian categorization;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2015 سفارش ترجمه

A novel del(8)(q23.2q24.11) contributing to disease progression in a case of JAK2/TET2 double mutated chronic myelomonocytic leukemia

Keywords: del(8q); CMML; TET2; JAK2; Transformation

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: Lead optimization

Keywords: JAK2; Kinases; Water interaction; Kinase selectivity; Ligand binding affinity; Kinase partition index; Molecular modeling;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

NS-018, a selective JAK2 inhibitor, preferentially inhibits CFU-GM colony formation by bone marrow mononuclear cells from high-risk myelodysplastic syndrome patients

Keywords: JAK2; CFU-GM; Myelodysplastic syndrome; NS-018; STAT

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Phase I evaluation of XL019, an oral, potent, and selective JAK2 inhibitor

Keywords: Myelofibrosis; JAK2; XL019; Mutation; Inhibitor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

It is time to change thrombosis risk assessment for PV and ET?

Keywords: polycythemia; thrombocythemia; prognosis; thrombosis; JAK2; CALR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model

Keywords: Lung cancer; Oncogene addiction; EGFR; JAK2; STAT3; Transgenic mice;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Leptin enhances the secretion of interleukin (IL)-18, but not IL-1β, from human monocytes via activation of caspase-1

Keywords: E. coli; Escherichia coli; G-CSF; granulocyte-colony stimulating factor; JAK2; janus kinase 2; LPS; lipopolysaccharide; MAPK; mitogen-activated protein kinases; MDDC; monocyte-derived dendritic cells; NLRP3; NLR-family, pyrin containing 3; PAMPs; pathogen

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Increased STAT5 signaling in the ring dove brain in response to prolactin administration and spontaneous elevations in prolactin during the breeding cycle

Keywords: JAK2; Janus Kinase 2; STAT5; Signal Transducer and Activator of Transcription 5; pSTAT5; phosphorylated STAT5; ir; immunoreactivity; POA; preoptic area; SCN; suprachiasmatic nucleus of the hypothalamus; PVN; paraventricular nucleus of the hypothalamus; VM

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

GSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation

Keywords: Ang II; angiotensin II; VSMCs; vascular smooth muscle cells; GSTpi; glutathione S-transferase pi; STAT3; signal transducer and activator of transcription 3; GSH; glutathione; TNF-α; tumor necrosis factor alpha; JNK; c-Jun NH2-terminal kinases; TRAF2; tum

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Modulators of Erythropoiesis

Keywords: Steady state; Stress and ineffective erythropoiesis; Hemoglobinopathies; JAK2; Transforming growth factor β; ACE-011; ACE-536; LY-2157299;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Hereditary erythrocytosis, thrombocytosis and neutrophilia

Keywords: hereditary erythrocytosis; familial; polycythaemia; thrombocytosis; neutrophilia; JAK2; MPL; TPO

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function

Keywords: ABC; ATP-binding cassette; ABCC1; multidrug resistance-associated protein 1; ABCG2; breast cancer resistance protein; CSCs; Cancer stem cell; DOX; doxorubicin; FTC; fumitremorgin C; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Rho123; Rhodamine 123; M

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Aspirin-triggered Lipoxin A4 attenuates mechanical allodynia in association with inhibiting spinal JAK2/STAT3 signaling in neuropathic pain in rats

Keywords: ALX; LXA4 receptor; ATL; aspirin-triggered Lipoxin A4; CCI; chronic constriction injury; COX-2; cycloxygenase-2; CSF; cerebral spinal fluid; CT; threshold cycle; DMSO; dimethyl sulfoxide; FITC; fluorescein isothiocyanate; JAK2; Janus Kinase 2; LO; lipoxyg

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Pyrrole-3-carboxamides as potent and selective JAK2 inhibitors

Keywords: JAK2; Myeloproliferative disorders; Protein kinase inhibitor; Tumour cell proliferation inhibition; Anti-cancer agents

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

The association of the JAK2 46/1 haplotype with non-splanchnic venous thrombosis

Keywords: JAK2; Janus kinase 2; SVT; splanchnic venous thrombosis; non-SVT; non-splanchnic venous thrombosis; MPNs; myeloproliferative neoplasms; SNP; single nucleotide polymorphism; HWE; Hardy-Weinberg equilibrium; AS-PCR; allele-specific polymerase chain reaction

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Lymphoid malignancies: Another face to the Janus kinases

Keywords: JAK2; Acute lymphoblastic leukemia; JAK inhibitors;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

STAT3 interacts with Skp2/p27/p21 pathway to regulate the motility and invasion of gastric cancer cells

Keywords: Ace-tubulin; Acetylated-tubulin; ANOVA; analysis of variance; DAPI; 4′,6-diamidino-2-phenylindole; E-cad; E-cadherin; ELISA; enzyme-linked immunosorbent assay; FAK; focal adhesion kinase; FITC; fluorescein isothiocyanate; GAPDH; glyceraldehyde-3-phospha

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

2-Amino-[1,2,4]triazolo[1,5-a]pyridines as JAK2 inhibitors

Keywords: JAK2; Janus kinase; Triazolopyridine;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

TIS21/BTG2/PC3 inhibits interleukin-6 expression via downregulation of STAT3 pathway

Keywords: TIS21/BTG2/PC3; Interleukin-6; STAT3; ROS; JAK2;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Combined inhibition of PI3K and activation of MAPK p38 signaling pathways trigger erythroid alternative splicing switch of 4.1R pre-mRNA in DMSO-induced erythroleukemia cells

Keywords: BFU-E; burst forming unit-erythroid; DMSO; dimethylsulfoxide; EPO; erythropoietin; EPO-R; erythropoietin receptor; ERK; extracellular signal-regulated kinase; JAK2; Janus kinase-2; MAPK; mitogen-activated protein kinase; MEK; mitogen-activated protein kin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Research ReportInfluence of the core circadian gene “Clock” on obesity and leptin resistance in mice

Keywords: JAK2; Janus-activating kinase 2; STAT3; signal transducer and activators of transcription 3; NPY; neuropeptide Y; AgRP; agouti-related protein; CNS; central nervous system; POMC; proopiomelanocortin; SOCS-3; suppressor of cytokine signaling-3; ARC; arcuat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Peroxiredoxin V selectively regulates IL-6 production by modulating the Jak2-Stat5 pathway

Keywords: PrdxV; peroxiredoxin V; LPS; lipopolysaccaride; IL-6; interleukin 6; Jak2; janus kinase 2; Stat5; signal transducer and activator of transcription 5; SOCS1; suppressor of cytokine signaling 1; TNF-α; tumor necrosis factor α; IFN-β; interferon β; RANTE

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Critical role of FANCC in JAK2 V617F mutant-induced resistance to DNA cross-linking drugs

Keywords: ATM; ataxia-telangiectasia mutated; Epo; erythropoietin; EpoR; erythropoietin receptor; ET; essential thrombocythemia; FA; Fanconi anemia; JAK2; Janus kinase 2; MPNs; myeloproliferative neoplasms; PMF; primary myelofibrosis; PV; polycythemia vera; RT-PCR;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Transcriptomic profiling of progesterone in the male fathead minnow (Pimephales promelas) testis

Keywords: 11-KT; 11-ketotestosterone; AKT1; RAC-α serine/threonine-protein kinase; APOE; apolipoprotein E; APP; amyloid β (A4) precursor protein; AR; androgen receptor; BCL2L1; BCL2-like 1; BCL6; B-cell CLL/lymphoma 6; BMP2; bone morphogenetic protein 2; BMP4; bo

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Polyphenol tri-vanillic ester 13c inhibits P-JAK2V617F and Bcr-Abl oncokinase expression in correlation with STAT3/STAT5 inactivation and apoptosis induction in human leukemia cells

Keywords: Kinase; JAK2; Bcr-Abl; 13c; Polyphenol; STAT;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Gene expression profiling for analysis acquired oxaliplatin resistant factors in human gastric carcinoma TSGH-S3 cells: The role of IL-6 signaling and Nrf2/AKR1C axis identification

Keywords: AKR1Cs; aldo-keto reductase family members (e.g. AKR1C1, AKR1C2, or AKR1C3); ARE; antioxidant response element; cisplatin; cis-diamminedichloroplatinum(II) (CDDP); ERCC-1; excision repair cross-complementing-1; ERK; extracellular signal-related kinase; FF

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2013 سفارش ترجمه

JAK2 V617F Mutation in Adult Taiwanese Patients with Essential Thrombocythemia: More Prevalent in Old Patients and Correlated with Higher Hemoglobin Level and Higher Leukocyte Count

Keywords: essential thrombocythemia; JAK2; mutation; prevalence

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Long term molecular responses in a cohort of Danish patients with essential thrombocythemia, polycythemia vera and myelofibrosis treated with recombinant interferon alpha

Keywords: Myeloproliferative; Interferon; Molecular; JAK2

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells

Keywords: OPB-31121; Gastric cancer; STAT3; JAK2; IL-6

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Analysis of steady-state Förster resonance energy transfer data by avoiding pitfalls: Interaction of JAK2 tyrosine kinase with N-methylanthraniloyl nucleotides

Keywords: MANT nucleotide; FRET; JAK2; Primary inner filter effect; Secondary inner filter effect; Ligand binding

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Therapy with the histone deacetylase inhibitor pracinostat for patients with myelofibrosis

Keywords: Myelofibrosis; Pracinostat; SB939; Histone deacetylase inhibitor; JAK2

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Optimization of a novel kinase inhibitor scaffold for the dual inhibition of JAK2 and FAK kinases

Keywords: Kinase; JAK2; FAK; Inhibitors;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells

Keywords: Withaferin A; STAT3; JAK2; Apoptosis

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه