Heme controls the regulation of protein tyrosine kinases Jak2 and Src
Keywords: Jak2; Src; Heme; Tyrosine kinase; Phosphorylation; Heme regulation;
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Prolactin-induced Jak2 phosphorylation of RUSH: A key element in Jak/RUSH signaling
Keywords: Jak2; Prolactin; HLTF; Nucleolin; Actin; HRE-H9 cells (rabbit endometrium)
Autocrine IL-6 regulates GRO-α production in thymic epithelial cells
Keywords: Thymic epithelial cells; IL-6; GRO-α; Jak2
Angiotensin II activates JAK2/STAT3 pathway and induces interleukin-6 production in cultured rat brainstem astrocytes
Keywords: Angiotensin II; Interleukin-6; JAK2; STAT3; Astrocytes; Proliferation
ISG15 over-expression inhibits replication of the Japanese encephalitis virus in human medulloblastoma cells
Keywords: IFN-stimulated gene 15; Japanese encephalitis virus; IRF-3; JAK2; STAT1
Significance of JAK2 and TET2 mutations in myelodysplastic syndromes
Keywords: Myelodysplasia; Ringsideroblasts; Apoptosis; JAK2; TET2
Research ArticleFerroportin disease: A systematic meta-analysis of clinical and molecular findings
Keywords: AUROC; area under the receiver operator curve; ER; endoplasmic reticulum; HIC; hepatic iron concentration; JAK2; Janus Kinase 2; MRI; magnetic resonance imaging; PolyPhen; polymorphism phenotyping; ROC; receiver operator curve; SIFT; sorting intolerant fr
Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1
Keywords: MPD; Jak2; V617F mutation; Triptolide; Apoptosis
Expression, purification, characterization and crystallization of non- and phosphorylated states of JAK2 and JAK3 kinase domain
Keywords: JAK2; JAK3; Non-receptor protein tyrosine kinase; Phosphorylation states; Protein purification; Assay development
Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells
Keywords: STAT3, signal transducer and activator of transcription 3; HCC, hepatocellular carcinoma; FBS, fetal bovine serum; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromideSTAT3; JAK2; Diosgenin; Hepatocellular carcinoma; Apoptosis
Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells
Keywords: Akt; Cobra venom; Cardiotoxin; JAK2; MDA-MB-231 cells; PI3K; STAT3
A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling
Keywords: Prolactin; Src family kinases; Src scaffold functions; Jak2; Stat5; Akt; Erk1/2; Cell proliferation;
Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury
Keywords: Akt/PKB; a serine/threonine protein kinase B; BBB; Blood Brain Barrier; BrdU; Bromodeoxyuridine; BDNF; Brain-derived neurotrophic factor; CCI; Controlled cortical impact; CREB; CyclicAMP responsive element binding protein; CNS; Central nervous system; eNO
Anemia, Ineffective Erythropoiesis, and Hepcidin: Interacting Factors in Abnormal Iron Metabolism Leading to Iron Overload in β-Thalassemia
Keywords: β-Thalassemia; Ineffective erythropoiesis; Iron overload; Splenomegaly; Hepcidin; Jak2;
Thrombopoietin in normal and neoplastic stem cell development
Keywords: thrombopoietin; stem cell; myeloproliferative disorders; c-MPL; JAK2; HOX;
Inhibiton of RET and JAK2 Signals and Upregulation of VEGFR3 Phosphorylation in Vitro by Galectin-1 in Trophoblast Tumor Cells BeWo
Keywords: Galectin; BeWo; RET; JAK2; VEGFR3
Discovery of pyrazol-3-ylamino pyrazines as novel JAK2 inhibitors
Keywords: JAK2; JAK2 V617F; Non-receptor tyrosine kinase; STATs; MPN; Pyrazol-3-ylamino pyrazines
2-Aminopyrazolo[1,5-a]pyrimidines as potent and selective inhibitors of JAK2
Keywords: Janus kinase 2; JAK2; Structure based design; 2-Amino-pyrazolo[1,5-a]pyrimidines; Polycythemia vera; Kinase inhibitor
Role of Janus kinase-2 in IgE receptor-mediated leukotriene C4 production by mast cells
Keywords: Mast cells; JAK2; LTC4; FcεRI
A Jak2 inhibitor, AG490, reverses lipin-1 suppression by TNF-α in 3T3-L1 adipocytes
Keywords: Lipin; Obesity; TNF-α; Jak2; Adipocytes;
JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV)
Keywords: ET; PV; JAK2; Colony formation; Diagnostic tool
Mechanisms of mutations in myeloproliferative neoplasms
Keywords: myeloproliferative neoplasms; MPN; essential thrombocytosis; myelofibrosis; polycythaemia vera; JAK2; TET2; MPL; mutations
Total saponins of Panax ginseng (TSPG) promote erythroid differentiation of human CD34+ cells via EpoR-mediated JAK2/STAT5 signaling pathway
Keywords: Total saponins of Panax ginseng (TSPG); CD34+ cells; Differentiation; JAK2; STAT5
Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs)
Keywords: JAK2; Kinase; Inhibitor; Janus; CYT387; Myeloproliferative
Real-time bioluminescence imaging of polycythemia vera development in mice
Keywords: Polycythemia vera; Mouse model; Jak2; Bioluminescent imaging; Micro-CT
Identification of gene networks associated with erythroid differentiation
Keywords: Erythropoiesis; JAK2; Expression microarrays; Myeloproliferative disorders
The polycythemia vera-associated Jak2 V617F mutant induces tumorigenesis in nude mice
Keywords: Jak2; Polycythemia vera (PV); V617F; Anti-apoptosis; Tumorigenesis
An inhibitor of Janus kinase 2 prevents polycythemia in mice
Keywords: Erythropoietin; Epo; Jak2; Polycythemia vera; Stat5
Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells
Keywords: Akt; Erk; Erythropoietin; Gab1; Jak2; PI3K;
Concomitant downregulation of proliferation/survival pathways dependent on FGF-R3, JAK2 and BCMA in human multiple myeloma cells by multi-kinase targeting
Keywords: aFGF, acidic fibroblast growth factor; BCMA, B-cell maturation antigen; BM, bone marrow; GEP, gene expression profile; HMCL, human multiple myeloma cell line; MM, multiple myeloma; MSC, mesenchymal stromal cellBCMA; FGF-R3; JAK2; Multiple myeloma; RPI-1
Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin
Keywords: Oligonol; Cyclooxygenase-2; Mouse skin; Msk1; JAK2; STAT3; NAD(P)H:quinine oxidoreductase-1; Photoprotection
Red cell and endothelial Lu/BCAM beyond sickle cell disease
Keywords: Lutheran/BCAM; Adhesion; Phosphorylation; JAK2; Polycythemia vera; KO miceLuthéran/BCAM; Adhérence; Phosphorylation; JAK2; Polyglobulie de Vaquez; Inactivation génique
Undiagnosed Myeloproliferative Disease in Cases of Intra-Abdominal Thrombosis: The Utility of the JAK2 617F Mutation
Keywords: BCS; Budd-Chiari syndrome; BMB; bone marrow biopsy; CT; computerized tomography; EHPVT; extrahepatic portal vein thrombosis; ET; essential thrombocythemia; JAK2; Janus kinase 2; MPD; myeloproliferative disorder;
Molecular and neural mediators of leptin action
Keywords: Leptin receptor; STAT3; Hypothalamus; Jak2; Feeding
Fully automated and super-rapid system for the detection of JAK2V617F mutation
Keywords: JAK2; V617F; Chronic myeloproliferative diseases; Guanine quenching probe; Direct sequencing
Expression of the GPI-anchored receptor Prv-1 enhances thrombopoietin and IL-3-induced proliferation in hematopoietic cell lines
Keywords: PRV-1; Thrombopoietin; IL-3; Mpl; Jak2
Potential role of JAK2 in cerebral vasospasm after experimental subarachnoid hemorrhage
Keywords: Cerebral vasospasm; Subarachnoid hemorrhage; JAK2; Apoptosis
G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation
Keywords: Jak2; Gab2; Cytokine signaling; Myeloproliferative disorders; Granulocyte colony-stimulating factor
Leptin regulated calcium channels of neuropeptide Y and proopiomelanocortin neurons by activation of different signal pathways
Keywords: leptin; patch-clamp; calcium current; POMC; NPY; AgRP; agouti-related peptide; ARC; arcuate nucleus; [Ca2+]i; cytosolic Ca2+ concentration; DMEM; modified Dulbecco's Eagle's medium; DMSO; dimethysulfoxide; HVA; high voltage-activated calcium channel; IH
Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through activation of the Jak2 tyrosine kinase pathway in vascular endothelial cells
Keywords: H2O2; Tetrahydrobiopterin; GTP-cyclohydrolase I; Jak2; Vascular endothelial cells;
Signal transducer and activator of transcription 3-A key molecular switch for human mesenchymal stem cell proliferation
Keywords: hBMMSCs; human bone marrow mesenchymal stem cells; PDGF-BB; platelet-derived growth factor-BB; bFGF; basic fibroblast growth factor; EGF; epidermal growth factor; STAT3; signal transducers and activators of transcription 3; JAK2; Janus-activated kinase 2;
The dawn of targeted therapy for primary myelofibrosis: Opportunities and challenges
Keywords: Primary myelofibrosis; Myeloproliferative disorders; PTK 787; VEGF; JAK2;
Janus kinase 2 V617F mutation is detectable in spleen of patients with chronic myeloproliferative diseases suggesting a malignant nature of splenic extramedullary hematopoiesis
Keywords: JAK2; Spleen; Extramedullary hematopoiesis; Chronic myeloproliferative disorders; Chronic myelomonocytic leukemia
JAK2, the JAK2 V617F mutant and cytokine receptors
Keywords: JAK2; Erythropoietin; Thrombopoietin; IGF1JAK2; Érythropoïétine; Thrombopoïétine; IGF1
Usefulness of JAK2V617F mutation in distinguishing idiopathic erythrocytosis from polycythemia vera
Keywords: JAK2; Idiopathic erythrocytosis; Polycythemia vera; Primary erythrocytosis; Chronic myeloproliferative disorders;
The suppressor of cytokine signalling-1 (SOCS-1) gene is overexpressed in Philadelphia chromosome negative chronic myeloproliferative disorders
Keywords: Chronic myeloproliferative disorders; SOCS-1; JAK2; Bone marrow cells; Real-time RT-PCR;
Evaluation of “Increased” Hemoglobin in the JAK2 Mutations Era: A Diagnostic Algorithm Based on Genetic Tests
Keywords: CP; congenital polycythemia; Epo; erythropoietin; EPOR; erythropoietin receptor; ET; essential thrombocythemia; HIF; hypoxia-inducible factor; JAK2; Janus kinase 2; MPD; myeloproliferative disorder; p50; oxygen tension at which hemoglobin is 50% saturated
Cytogénétique et génétique moléculaire dans la myélofibrose avec métaplasie myéloïde et dans la polyglobulie de Vaquez
Keywords: Syndromes myéloprolifératifs; Cytogénétique; JAK2; Polyglobuline du VaquezMyeloproliferative disorders; Polycythemia vera; Myelofibrosis with myeloid metaplasia; Cytogenetics; JAK2
The Third International Congress on Myeloproliferative and Myelodysplastic Syndromes
Keywords: Myelodysplastic syndrome; JAK2; Myeloproliferative; Leukemia
Tyk2 mutation homologous to V617F Jak2 is not found in essential thrombocythaemia, although it induces constitutive signaling and growth factor independence
Keywords: Myeloproliferative diseases; Jak2; Tyk2; Polycythaemia vera; Essential thrombocythaemia