Production and characterization of a novel HPV anti-L2 monoclonal antibody panel
Keywords: HPV; Antibody; mAb; L2; Minor capsid protein; Epitope; Fab;
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Specific intron-dependent loading of DAZAP1 onto the cox6c transcript suppresses pre-mRNA splicing efficacy and induces cell growth retardation
Keywords: GST; glutathione S-transferase; Mab; monoclonal antibody; RNA binding protein; mRNA splicing; Posttranscriptional regulation; Cell growth; Mitochondria;
Gene signatures and expression of miRNAs associated with efficacy of panitumumab in a head and neck cancer phase II trial
Keywords: Head and neck cancer; Recurrent/metastatic; Anti-EGFR; Second line treatment; Progression-free survival; Gene expression signatures; Hypoxia signature; Microenvironment score; miRNA; EGFR; epidermal growth factor receptor; mAb; monoclonal antibody; RM; re
Detailed genetic analyses of the HN gene in human respirovirus 3 detected in children with acute respiratory illness in the Iwate Prefecture, Japan
Keywords: AICM; Akaike's information criterion through MCMC; ARI; acute respiratory infection; BSP; Bayesian skyline plot; ESS; effective sample size; FEL; fixed effects likelihood; GTR; general time reversible; HN; hemagglutinin-neuraminidase; HPD; highest posteri
Transitioning from first- to second-generation biosimilars: An appraisal of regulatory and post-marketing challenges
Keywords: ACR; American College of Rheumatology; ADAb; anti-drug antibody; ADCC; antibody-dependent cell-mediated cytotoxicity; AIFA; Italian Medicines Agency; CDC; complement-dependent cytotoxicity; CHMP; Committee for Medicinal Products for Human Use; DAS28; 28-j
Mycobacterium tuberculosis protein Rv2220 induces maturation and activation of dendritic cells
Keywords: Ab; antibody; BMDCs; bone marrow-derived dendritic cells; DCs; dendritic cells; FITC; fluorescein isothiocyanate; GM-CSF; granulocyte-macrophage colony-stimulating factor; GS; glutamine synthetase; HRP; horseradish peroxidase; IFN; interferon; LPS; lipo
Loggerhead turtles are good ocean-observers in stratified mid-latitude regions
Keywords: Satellite telemetry; Cold pool; Northwest Atlantic Ocean; Temperature; Depth; MAB; United States Mid-Atlantic Bight; NES LME; Northeast U.S. Continental Shelf Large Marine Ecosystem; MLD; Mixed-Layer Depth; CPW; Cold Pool Water; MARACOOS; Mid-Atlantic Reg
p-Cresyl sulfate decreases peripheral B cells in mice with adenine-induced renal dysfunction
Keywords: Bone marrow; Cell cycle; Chronic kidney disease; p-Cresol; STAT5; Uremic toxin; APC; allophycocyanin; BUN; blood urea nitrogen; BV; Brilliant⢠Violet; CKD; chronic kidney disease; FITC; fluorescein isothiocyanate; FMO; fluorescence minus one; HPLC; high
Phylogeny and expression patterns of two apolipoprotein E genes in the flatfish Senegalese sole
Keywords: ai; anterior intestine; b; brain; ABCA1; ATP Binding Cassette Subfamily A Member 1; BCIP; bromo-chloro-indolyl-phosphate; CNS; central nervous system; DMSO; dimehtylsulfoxide; dph; days post-hatch; e; eye; HDL; high-density lipoproteins; hb; hindbrain; h;
Monomeric amyloid-β reduced amyloid-β oligomer-induced synapse damage in neuronal cultures
Keywords: AD; Alzheimer's disease; APP; amyloid precursor protein; Aβ; amyloid-β; PrPC; cellular prion protein; cPLA2; cytoplasmic phospholipase A2; CSP; cysteine-string protein; ELISA; enzyme-linked immunoassay; Fab; fragment antigen-binding; GPI; glycosylphosph
Honokiol enhances temozolomide-induced apoptotic insults to malignant glioma cells via an intrinsic mitochondrion-dependent pathway
Keywords: Malignant glioma; Honokiol; Temozolomide; Apoptosis; Intrinsic pathway; ANOVA; analysis of variance; Bax; Bcl-2-associated X protein; BrdU; bromodeoxyuridine; CI; combination index; DEVD; Asp-Glu-Val-Asp; DiOC6; 3,3â²-dihexyloxacarbocyanine; DAPI; 4â²-6
Peptide Tk-PQ induces immunosuppression in skin allogeneic transplantation via increasing Foxp3+ Treg and impeding nuclear translocation of NF-κB
Keywords: CM; culture medium; CFA; complete Freund's adjuvant; FACS; flow cytometry; HLA; human leukocyte antigens; HIV; human immunodeficiency virus; H&E staining; hematoxylin-eosin staining; i.m.; intramuscular injection; LNMCs; lymph node mononuclear cells; LD
Targeting phosphatases of regenerating liver (PRLs) in cancer
Keywords: Protein tyrosine phosphatase; Metastasis; Theinopyridone; Structure; CBS; cystathionine-beta-synthase; CHO; Chinese hamster ovary; CNNM; magnesium transporters of cyclin M; EMT; epithelial-mesenchymal transition; HMVEC; human microvascular endothelial c
Heterogeneity of auto-antibodies against nAChR in myasthenic serum and their pathogenic roles in experimental autoimmune myasthenia gravis
Keywords: Ab; antibody; α-Btx; alpha-Bungarotoxin; CDC; complement dependent cytotoxicity; cpm; count per minute; Cmax; maximum plasma concentration; EAMG; experimental autoimmune myasthenia gravis; EDL; extensor digitorum longus; Fab; Fab fragment of monoclonal a
The avidity of cross-reactive virus-specific T cells for their viral and allogeneic epitopes is variable and depends on epitope expression
Keywords: Allo-HLA; allogeneic HLA; CMV; cytomegalovirus; CRA; 51chromium-release assay; EBV-LCL; Epstein-Barr Virus transformed lymphoblastoid cell line; ELISA; enzyme-linked immunosorbent assay; FACS; fluorescence-activated cell sorting; FCS; fetal calf serum; FI
A Randomized Phase 2 Study of an Anti-Amyloid β Monoclonal Antibody in Geographic Atrophy Secondary to Age-Related Macular Degeneration
Keywords: AE; adverse event; AMD; age-related macular degeneration; BCVA; best-corrected visual acuity; CFI; complement factor I; EDTA; ethylenediaminetetraacetic acid; FP; fundus photography; GA; geographic atrophy; LLVA; low-luminance visual acuity; mAb; monoclon
The spatial molecular pattern of integrin recognition sites and their immobilization to colloidal nanobeads determine α2β1 integrin-dependent platelet activation
Keywords: Platelet signaling; Platelet activation; Integrin α2β1 cluster; Nanopatterning; Biofunctionalized nanobeads and nano-sized membrane protein clusters; BCECF-AM; 2â²,7â²-Bis-(2-carboxyethyl)-5-(and-6)-carboxyfluorescein-acetoxymethyl ester; BSA; bovine
Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide
Keywords: Autophagy; Lysosomal dysfunction; MRL/lpr mice; P140 peptide; Salivary glands; Sjögren's syndrome; ATG; autophagy related; CMA; chaperone-mediated autophagy; B6; C57BL/6; ELISA; enzyme-linked immunosorbent assay; H&E; hematoxylin and eosin; HSPA8/HSC70;
Molecular adjuvants that modulate regulatory T cell function in vaccination: A critical appraisal
Keywords: ADCC; antibody dependent cell cytotoxicity; CD; cluster of differentiation; mAb; monoclonal antibody; CsA; cyclosporine; CTLA-4; T-lymphocyte antigen 4; GITR; glucocorticoid-induced tumor necrosis factor receptor (TNFR) family related gene; CCR4; C-C chem
Dysregulated Response of Follicular Helper T Cells to Hepatitis B Surface Antigen Promotes HBV Persistence in Mice and Associates With Outcomes of Patients
Keywords: Viral Hepatitis; Immune Regulation; Neutralizing Antibody Response; Immunotherapy; ADCC; antibody-dependent cell-mediated cytotoxicity; anti-HBs; antibodies specific for hepatitis B surface antigen; ASC; antibody-secreting cell; CHB; chronic hepatitis B;
Metal-based BODIPY derivatives as multimodal tools for life sciences
Keywords: acac; acetylacetonate; BMDC; bone marrow derived dendritic cell; BODIPY; boron dipyrromethene, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene; bpy; 2,2â²-dipyridyl; BSA; bovine serum albumin; cat; catechol; CLSM; confocal laser scanning microscopy; CT; compu
Paradoxical development of polymyositis-like autoimmunity through augmented expression of autoimmune regulator (AIRE)
Keywords: Medullary thymic epithelial cell (mTEC); AIRE; Muscle; Tolerance; Ab; antibody; APC; antigen-presenting cell; BM; bone marrow; Crp; C-reactive protein; cTEC; cortical thymic epithelial cell; DC; dendritic cell; EpCAM; epithelial cell adhesion molecule 1;
PD-1 pathway and its clinical application: A 20Â year journey after discovery of the complete human PD-1 gene
Keywords: hPD-1; Human Programmed Cell Death 1; PD-L; program death ligand; TILs; tumor-infiltrating lymphocytes; mAb; monoclonal antibody; NSCLC; non-small-cell lung cancer; RCC; renal-cell carcinoma; UBC; urothelial bladder cancer; TTF; time-to-treatment failure;
Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution
Keywords: BSA; bovine serum albumin; DIC; differential interference contrast; ER; endoplasmic reticulum; FAD; flavin adenine dinucleotide; GFP; green fluorescent protein; HEK; human embryonic kidney; mAb; monoclonal antibody; MOPS; 3-(N-morpholino)propanesulfonic a
Confocal microscopic dual-laser dual-polarization FRET (2polFRET) at the acceptor side for correlating rotations at different distances on the cell surface
Keywords: FRET; fluorescence resonance energy transfer; FCET; flow cytometric energy transfer method, MHCI/MHCII, Class I/Class II Major Histocompatibility Complex protein; β2m; beta-2 microglobulin, the light chain (l.c.) component of MHCI; mAb; monoclonal antibo
Mass spectrometry characterization of DOTA-Nimotuzumab conjugate as precursor of an innovative βâ tracer suitable in radio-guided surgery
Keywords: NIM; Nimotuzumab; p-SCN-Bn-DOTA or DOTA; S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraaza cyclododecanetetraacetic acid; RGS; radio-guided surgery; RGS-βâ; RGS able to detect βâ radiation; mAb; monoclonal antibody; EGFr; Epidermal Growth Factor recept
3D mesoscopic fluorescence tomography for imaging micro-distribution of antibody-photon absorber conjugates during near infrared photoimmunotherapy in vivo
Keywords: Fluorescence laminar optical tomography (FLOT); Photoimmunotherapy (PIT); Enhanced permeability and retention effect; Two-photon microscopy (TPM); PIT; photo-immunotherapy; mAb; monoclonal antibody; NIR; near-infrared; NIR-PIT; near-infrared photoimmunoth
Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation
Keywords: Polyethylene glycol; Anti-IL-17A; Anti-IL-13; Lung periphery; Central airways; Residence time; Mucus; Lung inflammation; BAL; bronchoalveolar lavage; DMEM; Dulbecco's Modified Eagle Medium; EDTA; ethylenediaminetetraacetic acid; ELISA; enzyme-linked immun
Human CD4+ CD25+ CD127hi cells and the Th1/Th2 phenotype
Keywords: T cell subsets; CD25+Â CD127hi cells; Cytokines; Chemokine receptors; Th1 and Th2; PBMC; peripheral blood mononuclear cells; IRB; Institutional Review Board; mAb; monoclonal antibody; CM; central memory; EM; effector memory; T1D; type 1 diabetes; Treg; Fo
Glyco-Mapper: A Chinese hamster ovary (CHO) genome-specific glycosylation prediction tool
Keywords: CCM; central carbon metabolism; CHO; Chinese hamster ovary; DReaM-zyP; Discretized Reaction Network Modeling using Fuzzy Parameters; EPO; erythropoietin; mAb; monoclonal antibody; SEAP; secreted alkaline phosphatase; siRNA; short interfering RNA; Chinese
An improved method to quantify human NK cell-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) per IgG FcR-positive NK cell without purification of NK cells
Keywords: ADCC; antibody-dependent cell-mediated cytotoxicity; CD16A; cluster of differentiation designation for the Fc-gamma type III low affinity receptor for IgG, found on NK cells; CD20; cluster of differentiation designation for a B cell surface protein; CX1:1
Human Vδ3+ γδ T cells induce maturation and IgM secretion by B cells
Keywords: APC; antigen presenting cell; DC; dendritic cell; ELISA; enzyme-linked immunosorbent assay; HMB-PP; (E)-4-hydroxy-3-methyl-but-2 enyl pyrophosphate; ICOS; inducible co-stimulatory molecule; IFN; γinterferon-γ; Ig; immunoglobulin; IL; interkeukin; iNKT c
Unexplored benefits of controlled ice nucleation: Lyophilization of a highly concentrated monoclonal antibody solution
Keywords: Lyophilization; mAb; Controlled ice nucleation; Glass fogging; Shaking stress;
Core-shell nanoparticles for targeted and combination antiretroviral activity in gut-homing T cells
Keywords: Targeted drug delivery; Lipid-polymer hybrid nanoparticles; α4β7 Monoclonal antibody; GALT; Gut-homing T cell; HIV-1; α4β7 mAb; monoclonal antibody against α4β7 integrin; A4B7-LCNP; LCNP surface conjugated with α4β7 mAb; APC anti-α4β7; α4β7 mA
The scavenger activity of the human P2X7 receptor differs from P2X7 pore function by insensitivity to antagonists, genetic variation and sodium concentration: Relevance to inflammatory brain diseases
Keywords: ATP; adenosine triphosphate; APC; allophycocyanin; CNS; central nervous system; FITC; fluorescein isothiocyanate; IL; interleukin; mAb; monoclonal antibody; oxATP; oxidised ATP; PBMC; peripheral blood mononuclear cells; YG; yellow-green; P2X7 receptor; Ph
Conservation and variation of the hepatitis E virus ORF2 capsid protein
Keywords: HEV; hepatitis E virus; ORF; open reading frames; AA; amino acid; ICTV; International Committee on Taxonomy of Virus; PDB; Protein Data Bank; RMSD; root mean square deviation; VLP; virus-like particles; mAb; monoclonal antibody; MW; molecular weight; NCBI
Identification of another primordial CD80/86 molecule in rainbow trout: Insights into the origin and evolution of CD80 and CD86 in vertebrates
Keywords: CD80/86; Duplication; Evolution; Rainbow trout; APC; antigen presenting cell; DN; double negative; EF-1a; elongation factor 1a; HKL; head kidney leukocyte; mAb; monoclonal antibody; Mya; million years ago; Mye; myeloid; ORF; open reading frame; qPCR; quan
Immune-modulation via IgD B-cell receptor suppresses allergic skin inflammation in experimental contact hypersensitivity models despite of a Th2-favoured humoral response
Keywords: ACD; allergic contact dermatitis; AD; atopic dermatitis; BAFF; B-cell activating factor; BCR; B-cell receptor; Breg; regulatory B cells; CD40L; CD40 ligand; CHS; contact hypersensitivity; DNCB; 2,4 dinitrochlorobenzene; FcRs; Fc receptors; FcγRβII; Fc g
Spatial and temporal expression of bmp8a and its role in regulation of lipid metabolism in zebrafish Danio rerio
Keywords: a.m.; ante meridiem; BCA; bicinchonininc acid; BMP; bone morphogenetic protein; cDNA; DNA complementary to RNA; DNA; deoxyribonucleic acid; dpf; days post fertilization; h; hour; hpf; hours post fertilization; IPTG; isopropyl β-d-thiogalactoside; KDa; ki
Generating a recombinant phosphothreonine-binding domain for a phosphopeptide of the human transcription factor, c-Myc
Keywords: CaMKII; calmodulin-dependent protein kinase II; CDK; cyclin-dependent kinase; ERK; extracellular signal-regulated kinase; FBXW7; F-box/WD repeat containing protein 7; FN3; fibronectin type III domain; FHA1; forkhead-associated 1 domain; GSK3β; glycogen s
Characterisation of the intestinal microbial communities of rainbow trout (Oncorhynchus mykiss) fed with Hermetia illucens (black soldier fly) partially defatted larva meal as partial dietary protein source
Keywords: DAB; digesta-associated bacterial community; DISAFA; Department of Agricultural, Forest and Food Sciences; DISPAA; Department of Agri-Food Production and Environmental Sciences; EFSA; European Food and Safety Authority; Hi; Hermetia illucens; LAB; lactic
Indoleamine 2,3-Dioxygenase Expression in Primary Cutaneous Melanoma Correlates with Breslow Thickness and Is of Significant Prognostic Value for Progression-Free Survival
Keywords: APC; antigen-presenting cell; DC; dendritic cell; IDO; indoleamine 2,3-dioxygenase; mAb; monoclonal antibody; OS; overall survival; PFS; progression-free survival; TIL; tumor-infiltrating lymphocyte;
Intrinsic structural versatility of the highly conserved 412-423 epitope of the Hepatitis C Virus E2 protein
Keywords: HCV; Hepatitis C Virus; E2; envelope glycoprotein 2; CD81; Cluster of Differentiation 81; ThT; Thioflavin T; PDB; Protein Data Bank; mAb; monoclonal Antibodies; Fab; antigen-binding fragment; MD; molecular dynamics; RMSD; root mean square deviation; RMSIP
Evaluation of targeted curcumin (CUR) loaded PLGA nanoparticles for in vitro photodynamic therapy on human glioblastoma cell line
Keywords: CUR; Curcumin; NPs; Nanoparticles; PLGA NPs; Poly (D, l-lactic-co-glycolic acid) Nanoparticles; CUR-PLGA NPs; Curcumin loaded PLGA Nanoparticles; PEMA; Poly(ethylene-alt-maleic anhydride); PVA; Polyvinyl alcohol; FITC; Fluorescein isothiocyanate; Blank PL
Double-enhanced lateral flow immunoassay for potato virus X based on a combination of magnetic and gold nanoparticles
Keywords: Gold nanoparticles; Magnetic nanoparticles; Lateral flow immunoassay; Potato virus X; Signal amplification; BSA; bovine serum albumin; conjugate-TB; 10â¯mM Tris buffer, pH 7.4, containing 0.25% BSA, 0.25% detergent Tween 20, and 1% sucrose; CI; test line
Dermal fibroblast-to-myofibroblast transition sustained by αvÃ3 integrin-ILK-Snail1/Slug signaling is a common feature for hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorders
Keywords: Ab; polyclonal antibody; α-SMA; α-smooth muscle actin; CE; cellular extract; cEDS; classical Ehlers-Danlos syndrome; CID; chronic inflammatory systemic diseases; CM; conditioned medium; COLLs; collagens; COLLIII; type III collagen; COLLV; type V collage
Autoimmunity in multiple sclerosis: role of sphingolipids, invariant NKT cells and other immune elements in control of inflammation and neurodegeneration
Keywords: Ag; antigen; APC; antigen presenting cell; BBB; blood brain barrier; BCR; B cell receptor; BDNF; brain-derived neurotrophic factor; CIS; clinically isolated syndrome; CLR; C-type lectin receptor; CNS; central nervous system; CSF; cerebrospinal fluid; DAMP
Sequence defined antibodies improve the detection of cadherin 2 (N-cadherin) during zebrafish development
Keywords: mAb; monoclonal antibody; Cdh2; cadherin-2; zCdh2; zebrafish Cadherin-2; ECD; extracellular domain; Ig; immunoglobulin; CNS; central nervous system; crybb1; crystallin Beta B1; pac; parachute; Tg; transgenic; BAC; bacterial artificial chromosome; GFP; gre
Evidence of a role for spinal HMGB1 in ischemic stress-induced mechanical allodynia in mice
Keywords: CPSP; central post-stroke pain; HMGB1; high-mobility group box-1; BCAO; bilateral carotid artery occlusion; mAb; monoclonal antibody; LMWH; low-molecular-weight heparin; LPS-RS; lipopolysaccharides from the photosynthetic bacterium Rhodobacter sphaeroides
A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines
Keywords: Alprenolol (Pubchem CID: 2119); CGP 12177 (Pubchem CID: 2687); CGP 20712A (Pubchem CID: 2685); Cimaterol (Pubchem CID: 2755); Furimazine (Pubchem CID: 219083); Hoechst 33342 (Pubchem CID: 1464); IBMX (Pubchem CID: 3758); ICI 118551 (Pubchem CID: 5484725);