کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8716123 | 1587878 | 2018 | 37 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Indoleamine 2,3-Dioxygenase Expression in Primary Cutaneous Melanoma Correlates with Breslow Thickness and Is of Significant Prognostic Value for Progression-Free Survival
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
mAbAPCIDOPFs - PF هاMonoclonal antibody - آنتی بادی مونوکلونالantigen-presenting cell - آنتیژن ارائه سلولindoleamine 2,3-dioxygenase - ایندولامین 2،3-دیوکسژیگنازprogression-free survival - بقا بدون پیشرفتoverall survival - بقای کلTIL - بهDendritic cell - سلول دندریتیکtumor-infiltrating lymphocyte - لنفوسیت نفوذی تومور
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
امراض پوستی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The enzyme indoleamine 2,3-dioxygenase (IDO) is emerging as a facilitator of cancer development through its effects on cancer-associated inflammation. Recent studies report a significant improvement of the response rates in melanoma patients to PD-1 antibodies when IDO inhibitors were added to the regimen. Data on IDO expression in primary human melanomas are, however, incomplete and conflicting. Here, we show that the level of IDO expression in primary human melanoma cells significantly correlates with Breslow thickness (PÂ =Â 0.003), the presence of tumor-infiltrating lymphocytes (PÂ = 0.029), and the intensity of the peritumoral inflammatory infiltrate (PÂ = 0.001). The expression of IDO in melanoma cells predicted independently of Breslow thickness and tumor stage (PÂ = 0.04). We further show that CD11c+ dendritic cells and CD68+ macrophages in the microenvironment of melanomas express IDO. The level of IDO expression in antigen-presenting cells correlated positively to peritumoral inflammation (PÂ = 0.001) but not to tumor-infiltrating lymphocytes. Significant negative correlation with progression-free survival was found for patients for whom antigen-presenting cells were very strongly IDO positive. These results suggest that IDO induction within melanoma cells may directly reflect tumor progression, whereas IDO in antigen-presenting cells may determine immune surveillance with impact on local and systemic tolerance.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Investigative Dermatology - Volume 138, Issue 3, March 2018, Pages 679-687
Journal: Journal of Investigative Dermatology - Volume 138, Issue 3, March 2018, Pages 679-687
نویسندگان
Felicia Rubel, Johannes S. Kern, Kristin Technau-Hafsi, Sibylle Uhrich, Kaethe Thoma, Georg Häcker, Nikolas von Bubnoff, Frank Meiss, Dagmar von Bubnoff,