Keywords: هدف پستانداران رپامایسین; Aβ; amyloid β protein; NFT; neurofibrillary tangles; APP; amyloid precursor protein; PSs; presenilins; NICD; Notch intracellular domain; mTOR; mammalian Target of Rapamycin; PP2A; protein phosphatase 2; GSK-3; glycogen synthase kinase-3; CTFS; cytosol-s
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Keywords: هدف پستانداران رپامایسین; ALDH2; aldehyde dehydrogenase 2; ANT; adenine nucleotide transportor; AR; aldose reductase; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; ATG; AuTophaGy; ATM; ataxia-telangiectasia mutate; COPD; chronic obstructive pulmonary
Keywords: هدف پستانداران رپامایسین; AIF; apoptosis-inducing factor; AMPK; AMP kinase; Apaf-1; apoptotic protease activating factor; BMM; bone marrow-derived macrophages; cFLIP; cellular FLICE-like inhibitory protein; cIAP; cellular inhibitor of apoptosis protein; COX; cyclooxygenase; CTL; c
Keywords: هدف پستانداران رپامایسین; ESFT; Ewing's sarcoma family tumors; ES; Ewing's sarcoma; MCTS; multicellular tumor spheroids; 3D; three-dimensional; PCL; poly(ε-caprolactone); ECM; extracellular matrix; PDX; patient-derived tumor explants; MSC; mesenchymal stem cells; EC; endothelial
Keywords: هدف پستانداران رپامایسین; VEGF; vascular endothelial growth factor; CRC; colorectal cancer; VEGFR; VEGF receptors; PLGF; placental growth factor; HGF; hepatocyte growth factor; Il; Interleukin; Del-1; developmentally-regulated endothelial cell locus 1 protein; FGF; fibroblast grow
Keywords: هدف پستانداران رپامایسین; Aβ; amyloid-β; AD; Alzheimer's disease; ALP; autophagy-lysosome pathway; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ApoER2; apolipoprotein E receptor 2; APP; Aβ precursor protein; BDNF; brain-derived neurotrophic factor; CSF; cere
Keywords: هدف پستانداران رپامایسین; AA; arachidonic acid; ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPK; AMP-activated protein kinase; ANT; adenine nucleotide translocase; Apaf-1; apoptotic protease activating factor-1; ATP; adenosine triphosphate; ATP-ase; ATP synthase;
Keywords: هدف پستانداران رپامایسین; 5FU; 5-fluorouracile; ABC; ATP-binding cassette; AUC; area under the curve; BCRP; breast cancer resistance protein; Cmax; maximum (peak) plasma concentration; CYP; cytochrome p450 enzymes; DDI; drug-drug interactions; EIAEDS; enzyme-inducing antiepilept
Keywords: هدف پستانداران رپامایسین; AL; ad libitum; BAP; Biomarkers of Aging Program; CR; caloric restriction; EM; Emory-Morse; GSH; glutathione; GSSG; glutathione disulfide; mTOR; mammalian target of rapamycin; NCTR; National Center for Toxicological Research; NIA; National Institute on Ag
Keywords: هدف پستانداران رپامایسین; Senolytic; an agent that targets senescent cells; ADME; absorption, distribution, metabolism, and excretion of a drug; SASP; senescence-associated secretory phenotype; mTOR; mammalian target of rapamycin; JAK; Janus-activated kinase; GLP; good laboratory
Keywords: هدف پستانداران رپامایسین; cAMP; cyclic adenosine monophosphate; mTOR; mammalian target of rapamycin; EGFR; epidermal growth factor receptor; ERK; extracellular-signal-regulated kinases; ADPKD; Berberine; Cell proliferation; ERK and p70-S6 signaling; Apoptosis;
Keywords: هدف پستانداران رپامایسین; BMI; body mass index; CRP; C-reactive protein; db/db; diabetic; ER; endoplasmic reticulum; HSP; heat shock proteins; JAK; janus kinase; ob/ob; obese; LEPR; leptin receptor; MAPK; mitogen-activated protein kinase; mTOR; mammalian target of rapamycin; NK; n
Keywords: هدف پستانداران رپامایسین; AKT; a serine/threonine-specific protein kinase, also known as Protein Kinase B (PKB); CCS; charcoal-stripped fetal-calf serum; CSC; cancer stem cell; E2; 17β-estradiol; E2:ER; E2-bound estrogen receptor; EGFR; epidermal growth factor receptor; ER; estro
Keywords: هدف پستانداران رپامایسین; BM; basement membrane; ECM; extracellular membrane; EMT; epithelial mesenchymal transition; FAK; focal adhesion kinase; MAPK; mitogen-activated protein kinase; LOH; loss of heterozygosity; NCOR1; nuclear receptor co-repressor 1; MMP; matrix metalloprotein
Keywords: هدف پستانداران رپامایسین; FOXO; forkhead box O; GC; glucocorticoids; MuRF-1; muscle RING-finger protein-1; mTOR; mammalian target of rapamycin; IGF-I; Insulin-like Growth Factor-I; eIF4E; eukaryotic translation initiation factor 4E; S6K1; ribosomal protein kinase 1; 4E-BP1; eukary
Keywords: هدف پستانداران رپامایسین; Anti-angiogenesis; Resistance; Targeted therapies; Predictive markers; Autophagy; AKT/PKB; protein kinaseB; BMDCs; bone marrow-derived cells; BVZ; bevacizumab/Avastin; CSC; cancer stem-like cells; EGF; epidermal growth factor; EPC; endothelial progenitor
Keywords: هدف پستانداران رپامایسین; Carotid stenosis; Cell adhesion; Cell surface markers; Gene expression; Immunophenotyping; Mononuclear cells; Thrombosis; ATF; atrial fibrillation; BP; blood pressure; BMI; body mass index; CV; cardiovascular; CEA; carotid endarterectomy; CDP; carotid dis
Keywords: هدف پستانداران رپامایسین; 15-F2t-IsoP; 15-F2t-isoprostane; ADP; adenosine 5ʹ-diphosphate; Arg-1; arginase-1; BCAAs; branched-chain amino acids; BME; basal Eagle's medium; IGF-1; insulin-like growth factor-1; IL; interleukin; iNOS; inducible nitric oxide synthase; KPBS; potassium-
Keywords: هدف پستانداران رپامایسین; IGFs; insulin-like growth factors; SHBG; sex hormone binding globulin; BMI; body mass index; IGFBPs; IGF binding proteins; IGF-1R; insulin-like growth factor-1 receptor; CLS; crown-like structure; NFκB; nuclear factor kappa-B; STAT3; signal transducer an
Keywords: هدف پستانداران رپامایسین; 3â²UTR; 3â² untranslated region; Ago2; Argonaute 2; CCN5; cysteine-rich 61/connective tissue growth factor/nephroblastoma overexpressed 5; ChIP; chromatin immunoprecipitation; CUL2; cullin2; DGCR8; Di George syndrome critical region 8; DMNT; DNA methylt
Keywords: هدف پستانداران رپامایسین; ECM; extracellular matrix; NF-κB; nuclear factor kappa B; Akt; protein kinase B; tPA; tissue plasminogen activator; TSRs; thrombospondin type 1 repeats; PDGF; platelet-derived growth factor; PCR; polymerase chain reaction; MCA; middle cerebral artery; CB
Keywords: هدف پستانداران رپامایسین; ALP; alkylphospholipid; ASK1; apoptosis signal-regulating kinase 1; CT; CTP:phosphocholine cytidylyltransferase; DISC; death-inducing signaling complex; EGF; epidermal growth factor; ER; endoplasmic reticulum; ERK; extracellular-signal-regulated kinase; J
Keywords: هدف پستانداران رپامایسین; 4E-BP1; 4E-binding protein-1; AA; amino acid; ALS; autophagy-lysosomal system; AMPK; adenosine monophosphate-activated protein kinase; COPD; chronic obstructive pulmonary disease; CRP; C-reactive protein; ERK; extracellular signal regulated kinase; FFM; f
Keywords: هدف پستانداران رپامایسین; HCC; hepatocellular carcinoma; K; keratin; IF; intermediate filament; G6P; glucose-6-phosphate; HK; hexokinase; GK; glucokinase; VDAC; voltage-dependent anion channel; GS; glycogen synthase; PI3K; phosphatidylinositol-3 kinase; GSK-3β; glycogen synthase
Keywords: هدف پستانداران رپامایسین; ACTRIIB; activin receptor type-2B; APC; adenomatosis polyposis coli; APPR; acute phase protein response; ARC; arcuate nucleus; ATP; adenosine-5â²-triphosphate; C-26; colon-26 adenocarcinoma mouse model; CHO; Chinese hamster ovary; COPD; chronic obstructi
Keywords: هدف پستانداران رپامایسین; DRG; dorsal root ganglion; EM; electron microscopy; EMG; electromyographic; ER; endoplasmic reticulum; HRP; horseradish peroxidase; IM; intramuscular; mTOR; mammalian target of rapamycin; RER; rough endoplasmic reticulum; RSE; relative standard error of t
Keywords: هدف پستانداران رپامایسین; mPFC; medial prefrontal cortex; ACC; anterior cingulate cortex; DG; dentate gyrus; NAc; nucleus accumbens; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor; NMDAR; N-methyl-d-aspartic acid receptor; VDCC; voltage-dependent calcium ch
Keywords: هدف پستانداران رپامایسین; Inositol; Insulin resistance; Diabetes; Polycystic ovary syndrome; Metabolic syndrome; Diabetic neuropathy; AC; adenylyl cyclase; ACC; acetyl-coenzyme A carboxylase; AGEs; advanced glycation end products; AMP; adenosine monophosphate; cAMP; cyclic AMP; AM
Keywords: هدف پستانداران رپامایسین; ATF-4; activating transcription factor-4; ARNT; aryl hydrocarbon receptor nuclear translocator; bHLH; basic helix-loop-helix; BBB; Basso, Beattie, and Bresnahan; cFLIP; cellular FLICE-inhibitory protein; cyt C; cytochrome C; Cygb; cytoglobin; CYP2B6; cyto
Keywords: هدف پستانداران رپامایسین; ATP5C1; ATP synthase, HÂ + transporting, mitochondrial F1 complex, gamma polypeptide; ATP5O; ATP synthase, HÂ + transporting, mitochondrial F1 complex, O subunit; ATP5B; ATP synthase, HÂ + transporting, mitochondrial F1 complex, beta polypeptide; ATP5A1;
Keywords: هدف پستانداران رپامایسین; ARE; antioxidant response element; APAP; acetaminophen; EGF; epidermal growth factor; ERK; Extracellular signal-regulated kinase; ECM; extracellular matrix; HO-1; heme oxygenase-1; HSC; hepatic stellate cells; HCC; hepatocellular carcinoma; ITC; isothiocy
Keywords: هدف پستانداران رپامایسین; ADME; absorption, distribution, metabolism and excretion; ADMET; absorption, distribution, metabolism, excretion and toxicity; FDA; USA Food and Drug Administration; GWAS; genome-wide association study; mTOR; mammalian target of rapamycin; NME; new molecu
The mechanisms and clinical significance of PDCD4 in colorectal cancer
Keywords: هدف پستانداران رپامایسین; Abbreviations; Full name in English; 3â²-UTR; 3â²-untranslated region; AA; asiatic acid; AOM; azoxymethane; AP-1; activating protein 1; AR; aldose reductase; ATF; activating transcription factor; Bcl-2; B-cell lymphoma 2; CAC; colitis-associated CRC; CD
Early intrathecal infusion of everolimus restores cognitive function and mood in a murine model of Alzheimer's disease
Keywords: هدف پستانداران رپامایسین; Intrathecal administration; Everolimus; Mammalian target of rapamycin; Alzheimer's disease; Depression; Learning and memory; 3â¯Ãâ¯Tg-AD mice;
Ketamine promotes rapid and transient activation of AMPA receptor-mediated synaptic transmission in the dorsal raphe nucleus
Keywords: هدف پستانداران رپامایسین; ACSF; Artificial cerebrospinal fluid; D-AP5; [D-(-)-2-Amino-5-phosphonopentanoic acid]; DMSO; Dimethyl sulfoxide; DNQX; [6,7-Dinitroquinoxaline-2,3-dione]; DR; Dorsal raphe nucleus; MK-801; [(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5
Aggressive neuroendocrine tumor of the ovary with multiple metastases treated with everolimus: A case report
Keywords: هدف پستانداران رپامایسین; Carcinoid; Everolimus; Multiple metastases; Neuroendocrine tumor; Ovary; NETs; neuroendocrine tumors; FIGO; International Federation of Gynecology and Obstetrics; mTOR; mammalian target of rapamycin; MRI; magnetic resonance imaging; CT; computed tomograph
Giant angiomyolipoma in a tuberous sclerosis patient and review of the literature
Keywords: هدف پستانداران رپامایسین; Renal angiomyolipoma; Giant renal angiomyolipoma; Tuberous sclerosis complex; Nephrectomy; Mammalian target of rapamycin;
MTOR pathway in focal cortical dysplasia type 2: What do we know?
Keywords: هدف پستانداران رپامایسین; FCD; focal cortical dysplasia; FCD II; focal cortical dysplasia type 2; FLE; frontal lobe epilepsy; GG; ganglioglioma; HME; hemimegalencephaly; ILAE; International League Against Epilepsy; MCD; malformation of cortical development; MPPH; megalencephaly-
Deciphering the pathways that protect from IL-13-mediated potentiation of oxidative stress-induced dopaminergic nerve cell death
Keywords: هدف پستانداران رپامایسین; Parkinson's disease; mTOR; Jak; Akt; 4E-BP1; Oxidative stress; BSA; bovine serum albumin; CM-H2DCFDA; 5-(and-6)-chloromethyl-2â²,7â²-dichlorofluorescein diacetate; mTOR; mammalian target of rapamycin; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetr
Aspirin induces Beclin-1-dependent autophagy of human hepatocellular carcinoma cell
Keywords: هدف پستانداران رپامایسین; aspirin; autophagy; hepatocellular carcinoma cells; Beclin-1; AMP-activated protein kinase; mammalian target of rapamycin;
Apoptosis and pro-death autophagy induced by a spirostanol saponin isolated from Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) on HL-60 cells
Keywords: هدف پستانداران رپامایسین; Spirostanol saponin; Autophagy; Apoptosis; Rohdea chinensis; Human acute promyelocytic leukemia; Akt; protein kinase B; AMPK; adenosine 5â²-monophosphate-activated protein kinase; Baf-A1; bafilomycin A1; FBS; fetal bovine serum; JC-1; 5,5´,6,6´-tetrach
SRT1720, a potential sensitizer for radiotherapy and cytotoxicity effects of NVB-BEZ235 in metastatic breast cancer cells
Keywords: هدف پستانداران رپامایسین; TNBC; triple negative breast cancer; IL-6; interleukin 6; BC; breast cancer; PI3K; phosphatidylinositol 3-kinase; mTOR; Mammalian target of rapamycin; CSC; cancer stem cell; CRT; chemo-radio therapy; Breast cancer; Chemo-radiotherapy; Cancer stem cells; I
Inhibition of mTOR ameliorates bleomycin-induced pulmonary fibrosis by regulating epithelial-mesenchymal transition
Keywords: هدف پستانداران رپامایسین; Mammalian target of rapamycin; Epithelial-mesenchymal transition; Pulmonary fibrosis;
Protective effect and mechanism of Muntingia calabura Linn. fruit ethanolic extract against vascular endothelial growth factor production in nickel-stimulated hepatocellular carcinoma cells
Keywords: هدف پستانداران رپامایسین; MFEE; M. calabura Linn. fruit ethanolic extract; Ni; nickel; VEGF; vascular endothelial growth factor; RAF1; Raf-1 proto-oncogene, serine/threonine kinase; MEK1/2; mitogen-activated protein kinase 1/2; ERK1/2; extracellular-signal-regulated kinase1/2; JAK
4â²-hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling
Keywords: هدف پستانداران رپامایسین; 4â²-hydroxywogonin; Colorectal cancer; Vascular endothelial growth factor-A; PI3K; AKT; Angiogenesis; 4â²-HW; 4â²-hydroxywogonin; PI3K; phosphatidylinositol 3 kinase; VEGF-A; vascular endothelial growth factor-A; GAPDH; glyceraldehyde-3-phosphate dehyd
A gene expression profile associated with perineural invasion identifies a subset of HNSCC at risk of post-surgical recurrence
Keywords: هدف پستانداران رپامایسین; Head and neck squamous cell carcinoma; Perineural invasion; The Cancer Genome Atlas (TCGA); Gene expression; ALI; angiolymphatic invasion; CPE; consensus purity estimation score; DFS; disease free survival; ECS; extracapsular spread; FDR; false discovery
Activation of mammalian target of rapamycin induces lipid accumulation in the diaphragm of ventilated rats and hypoxia-treated C2C12 cells
Keywords: هدف پستانداران رپامایسین; Diaphragm; Lipopolysaccharide; Mammalian target of rapamycin; Mechanical ventilation; Low-density lipoprotein receptor pathway; Hypoxia;
Roles of microRNA in prostate cancer cell metabolism
Keywords: هدف پستانداران رپامایسین; AMPK; adenosine monophosphate-activated protein kinase; HIF-1α; hypoxia-inducible factor 1-alpha; mTOR; mammalian target of rapamycin; PI3K/AKT; phosphatidylinositol 3-kinase; ATP; adenosine triphosphate; TCA cycle; tricarboxylic acid cycle; GLUTs; gluco
Silent Information Regulator 1 Negatively Regulates Atherosclerotic Angiogenesis via Mammalian Target of Rapamycin Complex 1 Signaling Pathway
Keywords: هدف پستانداران رپامایسین; Angiogenesis; Atherosclerosis; Silent information regulator 1; Mammalian target of rapamycin; Hypoxia-inducible factor-1α;
Compound C enhances tau phosphorylation at Serine396 via PI3K activation in an AMPK and rapamycin independent way in differentiated SH-SY5Y cells
Keywords: هدف پستانداران رپامایسین; Compound C; Mammalian target of rapamycin; Phosphoinositide 3 kinase; Adenosine monophosphate kinase protein kinase; Rapamycin; Tau (Ser396) phosphorylation; Akt;