دانلود مقالات ISI درباره هدف پستانداران رپامایسین + ترجمه فارسی

Design and synthesis of alkyl substituted pyridino[2,3-D]pyrimidine compounds as PI3Kα/mTOR dual inhibitors with improved pharmacokinetic properties and potent in vivo antitumor activity

Keywords: هدف پستانداران رپامایسین; PI3K; phosphoinositide 3-kinase; mTOR; mammalian target of rapamycin; TSC; tuberous sclerosis; DDQ; 2,3-dicyano-5,6-dichlorobenzoquinone; THF; tetrahydrofuran; DIPEA; N,N-diisopropylethylamine; DMF; N,N-dimethylformamide; MRT; mean retention time; PI3Kα/

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Gallotannin derivatives from mango (Mangifera indica L.) suppress adipogenesis and increase thermogenesis in 3T3-L1 adipocytes in part through the AMPK pathway

Keywords: هدف پستانداران رپامایسین; ATCC; American Type Culture Collection; AMPK; AMP-activated protein kinase; BAT; brown adipose tissue; C/EBPα; CCAAT/enhancer binding protein α; CPT1; carnitine palmitoyltransferase I; DCFH-DA; 2′,7′-dichlorofluorescein diacetate; DMEM; Dulbecco's

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Compound C enhances tau phosphorylation at Serine396 via PI3K activation in an AMPK and rapamycin independent way in differentiated SH-SY5Y cells

Keywords: هدف پستانداران رپامایسین; Compound C; Mammalian target of rapamycin; Phosphoinositide 3 kinase; Adenosine monophosphate kinase protein kinase; Rapamycin; Tau (Ser396) phosphorylation; Akt;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Silent Information Regulator 1 Negatively Regulates Atherosclerotic Angiogenesis via Mammalian Target of Rapamycin Complex 1 Signaling Pathway

Keywords: هدف پستانداران رپامایسین; Angiogenesis; Atherosclerosis; Silent information regulator 1; Mammalian target of rapamycin; Hypoxia-inducible factor-1α;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Exosomes as a liquid biopsy for lung cancer

Keywords: هدف پستانداران رپامایسین; Alix; ALG 2 interacting protein X; ALK; anaplastic lymphoma kinase; AREG; Amphiregulin; Atg2; autophagy related protein 2; AUC; area under the curve; BAL; bronchoalveolar lavage; circRNA; circular RNA; CSE; cigarette smoke extract; CTC; circulating tumor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Alpha, 2'-dihydroxy-4,4'-dimethoxydihydrochalcone inhibits cell proliferation, invasion, and migration in gastric cancer in part via autophagy

Keywords: هدف پستانداران رپامایسین; TEM; transmission electron microscope; DCFDA; dihydrodichlorofluorescein diacetate; MEK; mitogen activated protein kinase kinase; ERK; extracellular signal-regulated kinase; mTOR; mammalian target of rapamycin; ROS; reactive oxygen species; PDX; patient

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Radiation-Induced Endothelial Vascular Injury

Keywords: هدف پستانداران رپامایسین; angiogenesis; apoptosis; cytokines; senescence; ATM; ataxia telangiectasia mutated; CD; cluster of differentiation; EC; endothelial cell; HUVEC; human umbilical vein endothelial cell; IGF; insulin-like growth factor; IGFBP; insulin-like growth factor bind

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

The metaplastic effects of NMDA receptors blockade on reactivation of instrumental memories in rats

Keywords: هدف پستانداران رپامایسین; Akt; protein kinase B; ALP; active lever presses; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; Amy; amygdala; ANOVA; analysis of variance; BLA; basolateral complex of amygdala; CeA; central nucleus of amygdala; Cx; context; DAB;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

eIF4E Phosphorylation in Prostate Cancer

Keywords: هدف پستانداران رپامایسین; eIF4E; eukaryotic translation initiation factor 4E; mTOR; mammalian target of rapamycin; PCa; prostate cancer; Mnk; mitogen activated protein kinase interacting protein kinase; ADT; androgen deprivation therapy; MAPK; mitogen-activated protein kinase; CRP

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Immunosuppression, Race, and Donor-Related Risk Factors Affect De novo Cancer Incidence Across Solid Organ Transplant Recipients

Keywords: هدف پستانداران رپامایسین; BMI; body mass index; CNI; calcineurin inhibitor; HR; hazard ratio; mTOR; mammalian target of rapamycin; SRTR; Scientific Registry of Transplant Recipients; SOT; solid organ transplant;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

Tsc1-dependent transcriptional programming of dendritic cell homeostasis and function

Keywords: هدف پستانداران رپامایسین; Dendritic cells; Tuberous sclerosis complex 1; Mammalian target of rapamycin; Transcriptional regulation;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2018 سفارش ترجمه

KRAS-Mutant non-small cell lung cancer: From biology to therapy

Keywords: هدف پستانداران رپامایسین; BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Plk2 Loss Commonly Occurs in Colorectal Carcinomas but not Adenomas: Relationship to mTOR Signaling

Keywords: هدف پستانداران رپامایسین; Plk2; Polo-like kinase 2; TSC; tuberous sclerosis complex; mTOR; mammalian target of rapamycin; p70S6K/S6K; S6: Ribosomal protein S6 kinase; AMPK; AMP-responsive protein kinase; REDD 1; regulated in DNA damage and development 1; 4EBP1; eukaryotic translat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Possible use of Punica granatum (Pomegranate) in cancer therapy

Keywords: هدف پستانداران رپامایسین; 27HC; 27-hydroxycholesterol; 8-OHdG; 8-hydroxy-2′ -deoxyguanosine; 8-oxodG; 8-oxo-7,8-dihydro-2′-deoxyguanosine; APC; adenomatous polyposis coli; AR; androgen receptors; AOM; azoxymethane; ATP; adenosine triphosphate; B(a)P; benzo(a)pyrene; Bad; Bcl-2

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats

Keywords: هدف پستانداران رپامایسین; CB1; cannabinoid receptor type-1; PFC; prefrontal cortex; DH; dorsal hippocampus; PND; postnatal day; AM251; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide; CORT; corticosterone; GAD67; glutamic acid decarboxyla

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

5-HT 2 receptor mediates high-fat diet-induced hepatic steatosis and very low density lipoprotein overproduction in rats

Keywords: هدف پستانداران رپامایسین; 5-HT 2 receptor; 5-HT synthesis; Hepatic lipid abnormality; Mammalian target of rapamycin;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Resistance to EGFR inhibitors in non-small cell lung cancer: Clinical management and future perspectives

Keywords: هدف پستانداران رپامایسین; NNSCLC; non-small cell lung cancer; OS; overall survival; EGFR; epidermal growth factor receptor; TKI; tyrosine kinase inhibitor; ALK; Anaplastic lymphoma kinase; MET; mesenchymal epithelial transition factor; PFS; progression free survival; HER2; human e

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Autophagy in endometriosis: Friend or foe?

Keywords: هدف پستانداران رپامایسین; Autophagy; Endometriosis; Friend; Foe; Mechanism; 3-MA; 3-methyladenine; ERK; extracellular signal-regulated kinase; MIS; Mullerian inhibiting substance; mTOR; Mammalian target of rapamycin; NF-κB; nuclear factor-k-gene binding κ; OH-1; heme oxygenase-1

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

The Transcription Factor ETV5 Mediates BRAFV600E-Induced Proliferation and TWIST1 Expression in Papillary Thyroid Cancer Cells

Keywords: هدف پستانداران رپامایسین; AKT; protein kinase B (or PKB); ATC; anaplastic thyroid carcinoma; BRAF; v-Raf murine sarcoma viral oncogene homolog B (or B-RAF); EMT; epithelial-mesenchymal transition; ERK; extracellular signal-regulated kinase (or mitogen-activated protein kinase 1);

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Lycium barbarum polysaccharide protects diabetic peripheral neuropathy by enhancing autophagy via mTOR/p70S6K inhibition in Streptozotocin-induced diabetic rats

Keywords: هدف پستانداران رپامایسین; LBP; Lycium barbarum polysaccharide; DM; diabetes mellitus; DPN; diabetic peripheral neuropathy; LC3-II; microtubule-associated protein 1 light chain 3-II; HDL; high density lipoprotein; SC; Schwarm cell; STZ; streptozotocin; LA; lipoic acid; PWT; paw wit

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2018 سفارش ترجمه

Reduced NGF in Gastric Endothelial Cells Is One of the Main Causes of Impaired Angiogenesis in Aging Gastric Mucosa

Keywords: هدف پستانداران رپامایسین; Nerve Growth Factor; Angiogenesis; Endothelial Cells; Aging; Gene Therapy; Ulcer Healing; Akt; serine threonine kinase signaling protein; BrdU; bromodeoxyuridine; EC; endothelial cell; FITC; fluorescein isothiocyanate; GEC; gastric mucosal microvascular e

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

Correlation between telomerase and mTOR pathway in cancer stem cells

Keywords: هدف پستانداران رپامایسین; CSCs; cancer stem cells; mTOR; mammalian target of rapamycin; PI3K; phosphoinositide 3-kinase; AKT; serine/threonine kinase 1; hTERT; human telomerase reverse transcriptase; TERC; telomerase RNA component; GBM; glioblastoma multiforme; TRF1; telomeric rep

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

MicroRNAs link chronic inflammation in childhood to growth impairment and insulin-resistance

Keywords: هدف پستانداران رپامایسین; ALS; acid-labile subunit; APC; antigen-presenting cell; CXCL2; chemokine (C-X-C motif) ligand 2; ESR; erythrocyte sedimentation rate; FGFR1; fibroblast growth factor receptor 1; FOXO1; Forkhed box O1; FOXP3; forkhead box P3; GH; growth hormone; GHR; growt

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacological disruption of the MID1/α4 interaction reduces mutant Huntingtin levels in primary neuronal cultures

Keywords: هدف پستانداران رپامایسین; HTT; Huntingtin; HD; Huntington's Disease; MID1; Midline 1; PP2A; Protein Phosphatase 2A; mHTT; Mutant Huntingtin; wtHTT; Wild type Huntingtin; S6K; 40S ribosomal S6 kinase; mTOR; Mammalian target of rapamycin; CGN; Cerebellar granule neurons; MAP2; Mic

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2018 سفارش ترجمه

Binge-like ethanol treatment in adolescence impairs autophagy and hinders synaptic maturation: Role of TLR4

Keywords: هدف پستانداران رپامایسین; TLR4; toll-like receptor 4; PFC; prefrontal cortex; PND; postnatal day; mTOR; mammalian target of rapamycin; LC3-II; light chain 3-II; PSD; postsynaptic density; SHANK3; SH3 and multiple ankyrin repeat domains 3; p62/SQSTM1; protein 62/sequestosome 1; ULK

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

Xanthone-rich extract from Gentiana dinarica transformed roots and its active component norswertianin induce autophagy and ROS-dependent differentiation of human glioblastoma cell line

Keywords: هدف پستانداران رپامایسین; Gentiana dinarica transformed roots; Xanthone; Norswertianin; Glioblastoma; Cell differentiation; Autophagy; GBM; Glioblastoma multiforme; Atg; autophagy-related proteins; mTOR; mammalian target of rapamycin; PI3K; phosphoinositide 3-kinase; AMPK; AMP-act

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

The unknown face of IRE1α - Beyond ER stress

Keywords: هدف پستانداران رپامایسین; ER; endoplasmic reticulum; UPR; unfolded protein response; IRE1; inositol requiring kinase enzyme 1; XBP1; x-box binding protein 1; bZIP; basic leucine zipper domain; HAC1; histone acetyl transferase 1; ATF; activating transcription factor; RIDD; regulate

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

T-Track-CMV and QuantiFERON-CMV assays for prediction of protection from CMV reactivation in kidney transplant recipients

Keywords: هدف پستانداران رپامایسین; ATG; anti-thymocyte globulin; AUC; area under curve; CI; confidence interval; CMI; cell-mediated immunity; CMV; cytomegalovirus; CNI; calcineurin inhibitor; D; donor; GCV; Ganciclovir; HLA; human leukocyte antigens; KTx; kidney transplant; M; Month; MMF;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

A cardiac glycoside HTF-1 isolated from Helleborus thibetanus Franch displays potent in vitro anti-cancer activity via caspase-9, MAPK and PI3K-Akt-mTOR pathways

Keywords: هدف پستانداران رپامایسین; Cardiac glycoside; Anti-Cancer; Helleborus thibetanus Franch.; Apoptosis; ERK and JNK pathways; PI3K-Akt-mTOR pathway; CGs; cardiac glycosides; FEN1; flap endonuclease 1; PARP; (poly (ADP-ribose) polymerase; MAPK; mitogen-activated protein kinase; ERK1/2;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2018 سفارش ترجمه

PKM2, a potential target for regulating cancer

Keywords: هدف پستانداران رپامایسین; PK; pyruvate kinase; HCC; hepatocellular carcinoma; FBP; fructose 1,6-bisphosphate; SAICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-50-phosphate; hnRNPs; heterogeneous nuclear ribonucleoproteins; PTB; polypyrimidine tract-binding protein; NEK2; n

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Critical role of mammalian target of rapamycin for IL-10 dendritic cell induction by a flagellin A conjugate in preventing allergic sensitization

Keywords: هدف پستانداران رپامایسین; Vaccine; Bet v 1; flagellin; rFlaA; fusion protein; birch pollen allergy; IL-10 dendritic cell; mammalian target of rapamycin; metabolism; alum; Aluminum hydroxide; APC; Antigen-presenting cell; B/A; Bet v 1/alum; DC; Dendritic cell; 2-DO; 2-Deoxyglucose;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology

Keywords: هدف پستانداران رپامایسین; AMPK; 5′AMP-activated protein kinase; LRRK2; Leucine rich repeat kinase; LAMP1; Lysosomal associated membrane protein 1; iPD; idiopathic PD; mTOR; mammalian target of rapamycin; LC3; microtubule-associated protein1A/1B light chain 3; PD; Parkinson's d

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Anti-tumor effect of AZD8055 against neuroblastoma cells in vitro and in vivo

Keywords: هدف پستانداران رپامایسین; NB; Neuroblastoma; IGF; Insulin and insulin-like growth factors; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; p70S6K; p70 ribosomal protein S6 kinase; 4E-BP1; eukaryotic translat

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

mTOR/AMPK signaling in the brain: Cell metabolism, proteostasis and survival

Keywords: هدف پستانداران رپامایسین; Mammalian target of rapamycin; Adenosine monophosphate-activated protein kinase; Autophagy; Mitochondria; Glycolysis; Cell death; Nutrient deprivation; Energy failure;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2018 سفارش ترجمه

IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease

Keywords: هدف پستانداران رپامایسین; Asthma; house dust mite; glycolysis; IL-1; inhibitor of κB kinase ε; lactate; lactate dehydrogenase A; AHR; Airways hyperresponsiveness; BAL; Bronchoalveolar lavage; BMI; Body mass index; DC; Dendritic cell; 2-DG; 2-Deoxyglucose; ECAR; Extracellular aci

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

Jianpi Jiedu decoction, a traditional Chinese medicine formula, inhibits tumorigenesis, metastasis, and angiogenesis through the mTOR/HIF-1α/VEGF pathway

Keywords: هدف پستانداران رپامایسین; JPJD; Jianpi Jiedu decoction; CRC; colorectal cancer; TUNEL; Terminal deoxynucleotidyl transferase dUTP nick end labeling; IHC; immunohistochemistry; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; mTOR; mammalian target of rapamyc

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2018 سفارش ترجمه

A novel selenonucleoside suppresses tumor growth by targeting Skp2 degradation in paclitaxel-resistant prostate cancer

Keywords: هدف پستانداران رپامایسین; CRPC; castration-resistant prostate cancer; PI3K; Phosphatidylinositol-4,5-bisphosphate 3 kinase; PTEN; Phosphatase and tensin homolog; mTOR; mammalian target of rapamycin; BrdU; bromodeoxy-uridine; FITC; Fluorescein isothiocyanate; Skp2; S phase kinase-a

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Low-functional programming of the CREB/BDNF/TrkB pathway mediates cognitive impairment in male offspring after prenatal dexamethasone exposure

Keywords: هدف پستانداران رپامایسین; Akt; protein kinase B; Bax; Bcl-2 associated x protein; Bcl-2; B-cell lymphoma 2; BDNF; brain-derived neurotrophic factor; CaMKII; calmodulin-dependent protein kinase II; Caspase-3; cysteine aspartic protease 3; CDK2; cyclin-dependent kinase-2; CDC42; cel

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis

Keywords: هدف پستانداران رپامایسین; ACSS2; acyl-coenzyme A synthetase short-chain family member 2; ATPB; β-F1-ATPase; BSM; bronchial smooth muscle; CPT1A; carnitine palmitoyltransferase 1A; ER; estrogen receptor; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GLS; glutaminase; GLUT1; glu

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

High glucose up-regulates Semaphorin 3A expression via the mTOR signaling pathway in keratinocytes: A potential mechanism and therapeutic target for diabetic small fiber neuropathy

Keywords: هدف پستانداران رپامایسین; Semaphorin 3A; Diabetic small fiber neuropathy; Keratinocyte; mTOR; 4E-BP1; Eukaryotic initiation factor 4E-binding protein 1; AD; atopic dermatitis; CPT; cold perception threshold; DPN; diabetic peripheral neuropathy; DRG; dorsal nerve root ganglia; FPG;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Platycodon grandiflorum-derived saponin enhances exercise function, skeletal muscle protein synthesis, and mitochondrial function

Keywords: هدف پستانداران رپامایسین; Platycodon grandiflorum; Saponin; Exercise function; Skeletal muscle synthesis and breakdown; Oxidative phosphorylation; CPT-1; carnitine palmitoyltranserase; ERK; extracellular-signal-regulated kinases; mTOR; mammalian target of rapamycin; MHC; myosin he

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

The feedback loop of “EMMPRIN/NF-κB” worsens atherosclerotic plaque via suppressing autophagy in macrophage

Keywords: هدف پستانداران رپامایسین; Atherosclerosis; Extracellular matrix metalloproteinase inducer; Macrophage autophagy; Nuclear factor kappa B; Vulnerable plaque; AMPK; Adenosine Monophosphate Activated Protein Kinase; ApoE −/−;  Apolipoprotein E-deficient; AS; atherosclerosis; CQ;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia

Keywords: هدف پستانداران رپامایسین; mTOR; mammalian target of rapamycin; AD; Alzheimer Disease; DS; Down Syndrome; NTF; Neurofibrillary tangles; Aβ; β-amyloid; Chr21; Chromosome 21; AMPK; 5' AMP-activated protein kinase; GSK-3β; Glycogen synthase kinase 3β; KIN; Kinase catalytic domain;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

FKBP8 protects the heart from hemodynamic stress by preventing the accumulation of misfolded proteins and endoplasmic reticulum-associated apoptosis in mice

Keywords: هدف پستانداران رپامایسین; αMHC-Cre; α-myosin heavy chain promoter-driven Cre recombinase; BCL2L13; Bcl-2-like protein 13; CCCP; mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone; ER; endoplasmic reticulum; FKBP8; FK506-binding protein 8; GRP78; glucose-regulated p

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Hypericin inhibits hepatitis C virus replication via deacetylation and down-regulation of heme oxygenase-1

Keywords: هدف پستانداران رپامایسین; Hepatitis C virus (HCV); Hypericin; Epigenetic; Deacetylation; HCV; Hepatitis C virus; NS5A; non-structure protein 5A; NS3; non-structure protein 3; HO-1; heme oxygenase 1; 5-Aza-dC; 5-aza-2′-deoxycytidine; DAAs; direct acting antivirals; PCR; polymeras

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell Carcinomas

Keywords: هدف پستانداران رپامایسین; 4E-BP; 4E binding protein; AKT; v-akt murine thymoma viral oncogene homolog; BCC; basal cell carcinoma; BCNS; basal cell nevus syndrome; CCND1; cyclin D1; GLI; glioma-associated oncogene homolog; HEK; human embryonic kidney; ITRA; itraconazole; mTOR; mamm

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer

Keywords: هدف پستانداران رپامایسین; 7-AAD; 7-amino-actinomycin D; ABC; ATP-binding cassette; AEC; 3-amino-9-ethyl carbazole; ATD; acute toxicity determination; Atg5; autophagy protein 5; ATP; adenosine-5′-triphosphate; BCL-2; B-cell lymphoma 2; Bip/GRP78; binding immunoglobulin protein/78

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Evolution, regulation, and function of porcine selenogenome

Keywords: هدف پستانداران رپامایسین; ACC; acetyl CoA carboxylase; AKT; protein kinase B; Cys; cysteine; DIO1; type 1 iodothyronine deiodinase; ER; endoplasmic reticulum; FAS; fatty acid synthase; FOXO1; forkhead box protein O1; GPX; glutathione peroxidase; INSR; insulin receptor; MIEN; migra

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Emerging roles of microRNAs in the metabolic control of immune cells

Keywords: هدف پستانداران رپامایسین; Non-coding RNAs; Immunometabolism; T cells; Macrophages; Metabolic reprogramming; ATP; adenosine triphosphate; TCA; tricarboxylic acid cycle; PPP; pentose phosphate pathway; FAO; fatty acid oxidation; PEP; phosphoenolpyruvate; α-KG; alpha-ketoglutarate;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

LncRNA UCA1 attenuates autophagy-dependent cell death through blocking autophagic flux under arsenic stress

Keywords: هدف پستانداران رپامایسین; AKT; protein kinase B (PKB); AMPK; protein kinase AMP-activated catalytic subunit alpha 1 (PRKAA1); HOTAIR; HOX transcript antisense RNA; Keap1; kelch like ECH associated protein 1; mTOR; mammalian target of rapamycin; NBR2; neighbor of BRCA1 gene 2; Nrf2

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه