The role of matrix metalloproteinases in acute coronary syndromes
Keywords: Acute coronary syndrome; Myocardial infarction; Matrix metalloproteinases; MMP
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A molecular modeling analysis of novel non-hydroxamate inhibitors of TACE
Keywords: TACE; TACE inhibitor; Modeling; Hydantoin; Barbiturate; Hydroxamate; MMP; Metalloprotease; Metalloproteinase; TNF; Non-hydroxamate
Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Keywords: TACE; TACE inhibitor; Non-hydroxamate; MMP; Matrix metalloprotease; Matrix metalloproteinase; TNF
Thiol supplementation inhibits metalloproteinase activity independent of glutathione status
Keywords: Antioxidant; Gelatinase; Metalloproteinase; MMP; Reactive oxygen species; Thiol
Differential biocompatibility of carbon nanotubes and nanodiamonds
Keywords: Carbon nanomaterials; Cell culture; Viability; MTT; MMP; ROS
Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)
Keywords: TACE; TACE inhibitor; TNF-α; MMP; Matrix metalloprotease; Non-hydroxamate
The effect of epidermal growth factor on matrix metalloproteinases and tissue inhibitors of metalloproteinase gene expression in cultured human gingival fibroblasts
Keywords: EGF; MMP; TIMP; Gingival fibroblast
Induction of matrix metalloproteinases (MMP3, MMP12 and MMP13) expression in the microglia by amyloid-β stimulation via the PI3K/Akt pathway
Keywords: Microglia; Alzheimer’s disease; Amyloid β; MMP; Akt
Pirfenidone inhibits TGF-β expression in malignant glioma cells
Keywords: boc-RVRR-amc; butoxycarbonyl-Arg-Val-Arg-Arg-7-amido-4-methylcoumarine; dec-RVKR-cmk; decanoyl-Arg-Val-Lys-Arg-chloromethylketone; DMEM; Dulbecco's modified Eagle's medium; FCS; fetal calf serum; LDH; lactate dehydrogenase; LAP; latency associated pro
Acetylcholine induces neurite outgrowth and modulates matrix metalloproteinase 2 and 9
Keywords: MMP; matrix metalloproteinase; ACh; acetylcholine; ChAT; choline acetyltransferase; CCh; carbachol; FCS; fetal calf serum; DMEM; Dulbecco's modified Eagle's medium; EDTA; ethylene-diaminetetraacetic acid; PBS; phosphate buffered saline; Matrix metallo
Increased mucosal matrix metalloproteinase-1, -2, -3 and -9 activity in patients with inflammatory bowel disease and the relation with Crohn's disease phenotype
Keywords: Fibrosis; Fistulae; IBD; MMP; TIMP
Highlights of the 2006 Scientific Sessions of the American Society of Nuclear Cardiology
Keywords: CAC; coronary artery calcium; CAD; coronary artery disease; CT; computed tomography; FDG; 18F-fluorodeoxyglucose; LV; left ventricular; MIBG; 123I-metaiodobenzylguanidine; MMP; matrix metalloproteinase; MRI; magnetic resonance imaging; PET; positron emiss
Tgat oncoprotein functions as a inhibitor of RECK by association of the unique C-terminal region
Keywords: Tgat, trio related transforming gene in ATL tumor cells; RECK, reversion-inducing cysteine-rich protein with Kazal motifs; MMP, matrix metalloproteinaseTgat; Rho-GEF; RECK; MMP; Cell invasion; HTLV-1; ATL
On the horizon: Can bisphosphonates prevent bone metastases?
Keywords: Antitumour; Bisphosphonates; Bone metastases; Skeletal-related events; FGF; fibroblast growth factor; FPP; farnesyl diphosphate; HCM; hypercalcaemia of malignancy; MMP; matrix metalloproteinases; NSCLC; non-small cell lung cancer; SREs; skeletal-related e
Tissue Inhibitor of Metalloproteinase 2 and Coronary Artery Lesions in Kawasaki Disease
Keywords: CAL; Coronary artery lesion; CI; Confidence interval; FBS; Fetal bovine serum; IVIG; Intravenous immunoglobulin; KD; Kawasaki disease; MMP; Matrix metalloproteinase; OR; Odds ratio; PBMNC; Peripheral blood mononuclear cell; RT-PCR; Real-time polymerase ch
Vitamin D and Parathyroid Hormone in Outpatients With Noncholestatic Chronic Liver Disease
Keywords: ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CLD; chronic liver disease; HBV; hepatitis B virus; HCV; hepatitis C virus; GGT; γ-glutamyltransferase; INR; international normalized ratio; MMP; matrix metallopro
Identification by surface plasmon resonance of the mycobacterial lipomannan and lipoarabinomannan domains involved in binding to CD14 and LPS-binding protein
Keywords: LM; lipomannan; LAM; lipoarabinomannan; LBP; LPS-binding protein; MMP; matrix metalloproteinase; LPS; lipopolysaccharide; MPI; mannosyl-phosphatidyl-myo-inositol; TLR; Toll-like receptor; PIM2; phosphatidyl-myo-inositol dimannoside; PIM; phosphatidyl-myo-
Cationized catalase-loaded hydrogel for growth inhibition of peritoneally disseminated tumor cells
Keywords: H2O2; hydrogen peroxide; ED-catalase; ethylenediamine-conjugated catalase; ROS; reactive oxygen species; IEP; isoelectric point; MMP; matrix metalloproteinase; ICAM-1; intercellular adhesion molecule-1; HBSS; Hank's-balanced salt solution; FBS; fetal bovi
Matrix Metalloproteinase-9 May Play a Role in Recanalization and Recurrence after Therapeutic Embolization of Aneurysms or Arteries
Keywords: EC; endothelial cell; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GSL-1; Griffonia simplicifolia lectin-1; MMP; matrix metalloproteinase; mRNA; messenger RNA; PCR; polymerase chain reaction; TIMP; tissue inhibitor of metalloproteinase;
Endogenous production of reactive oxygen species is required for stimulation of human articular chondrocyte matrix metalloproteinase production by fibronectin fragments
Keywords: OA; osteoarthritis; ROS; reactive oxygen species; MnTBAP; Mn(III) tetrakis(4-benzoic acid)porphyrin; MMP; matrix metalloproteinase; FN-f; 110-kDa fibronectin fragment; MAP kinases; mitogen-activated protein kinase; NF-κB; nuclear factor-κB; JNK; c-Jun N
Identification and characterization of matrix metalloproteinase-20 (MMP20; enamelysin) genes in reptile and amphibian
Keywords: MMP; matrix metalloproteinase; MMP20; matrix metalloproteinase-20 enamelysin; AMEL; amelogenin; PCR; polymerase chain reaction; RT-PCR; reverse transcription PCR; GAPDH; glycerol 3-phosphate dehydrogenase; Poly-A; polyadenylation; mRNA; messenger RNA.Xeno
A Complete Expression Profile of Matrix-Degrading Metalloproteinases in Dupuytren’s Disease
Keywords: ADAMTS; Dupuytren’s disease; gene expression; MMP; TIMP
Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties
Keywords: Cartilage; Degradation; Mechanical properties; Interleukin-1; Aggrecanase; MMP
TGF-β-induced transcriptional activation of MMP-2 is mediated by activating transcription factor (ATF)2 in human breast epithelial cells
Keywords: TGF-β; MMP; p38 MAPK; ATF2; AP-1; Breast epithelial cells
Protein kinase Cα mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonists
Keywords: DAG; diacylglycerol; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; HB-EGF; heparin-bound EGF-like growth factor; MMP; matrix metalloprotease; PDB; phorbo
Nonreceptor Tyrosine Kinases in Prostate
Keywords: Nonreceptor tyrosine kinase; prostate cancer; Src; FAK; ETK; Abl; v-Abl Abelson murine leukemia viral oncogene homolog; At; androgenindependent; Aid; v-akt murine thymoma viral oncogene homolog 1; AR; androgen receptor; ARG; Abelson-related gene; Bcr; bre
Intracerebroventricular administration of an endothelin ETB receptor agonist increases expression of tissue inhibitor of matrix metalloproteinase-1 and -3 in rat brain
Keywords: endothelin-1; MMP; glial cell; brain injuryECM, extracellular matrix; ET, endothelin; GFAP, glial fibrillary acidic protein; G3PDH, glyceraldehyde-3-phosphate dehydrogenase; MEM, minimum essential medium; MMP, matrix metalloproteinase; TIMP, tissue inhibi
Critical involvement of ILK in TGFβ1-stimulated invasion/migration of human ovarian cancer cells is associated with urokinase plasminogen activator system
Keywords: Integrin-linked kinase (ILK); Invasion; Migration; MMP; SKOV3 ovarian cancer cell line; uPA; PAI-1; TGFβ1
The development of cardiac fibrosis in low tissue factor mice is gender-dependent and is associated with differential regulation of urokinase plasminogen activator
Keywords: APMA; amino-phenyl mercuric acetate; COL1A1; collagen type I α1; COL3A1; collagen type III α1; CTGF; connective tissue growth factor; ECM; extracellular matrix; HO-1; heme oxygenase 1; MMP; matrix metalloproteinase; MT1-MMP; membrane type 1 matrix metal
Vascular injury and modulation of MAPKs: A targeted approach to therapy of restenosis
Keywords: Intimal hyperplasia; Vascular remodeling; Angioplasty; Signaling; Coronary artery bypass graft; Smooth muscle cells; Endothelial cells; Endothelium; Extracellular-regulated kinases; ERK; JNK; p38MAPK; FGF; TGF; MMP; Thrombin; Inflammation; Topical inhibit
Matrix Metalloproteinase-9 Regulates MUC-2 Expression Through Its Effect on Goblet Cell Differentiation
Keywords: AB; Alcian Blue; CA; carbonic anhydrase; ECM; extracellular matrix; MMP; matrix metalloproteinases; NICD; Notch intracellular domain; PAS; periodic acid-Schiff stain; WT; wild type;
CD147 immunoglobulin superfamily receptor function and role in pathology
Keywords: CD147; EMMPRIN; MMP; MCT; Immunoglobulin superfamily; Integrin; Tumor; Metastasis
Brefeldin A triggers apoptosis associated with mitochondrial breach and enhances HA14-1- and anti-Fas-mediated cell killing in follicular lymphoma cells
Keywords: ARF; ADP ribosylation factor; Bcl-2; B-cell lymphoma 2 protein; BFA; Brefeldin A; CLL; chronic lymphocytic leukaemia; DMSO; dimethyl sulfoxide; ER; endoplasmic reticulum; FL; follicular lymphoma; FLICA; fluorescently labelled inhibitors of caspases; HA14-
Protease inhibitors and their peptidomimetic derivatives as potential drugs
Keywords: α1-PI; alpha1-protease inhibitor; 3D-QSAR; three-dimensional quantitative structure-activity relationship; ACE; angiotensin-converting enzyme; AIDS; acquired immune deficiency syndrome; BBI; Bowman-Birk inhibitor; BBIC; Bowman-Birk inhibitor concentrat
Carvedilol, a pharmacological antioxidant, inhibits neointimal matrix metalloproteinase-2 and -9 in experimental atherosclerosis
Keywords: AP-1; activator protein; EMSA; electrophoretic mobility-shift assay; 8-OHdG; 8-hydroxy-2â²-deoxyguanosine; HC; high cholesterol; HASMCs; human aortic smooth muscle cells; MMP; matrix metalloproteinase; NF-κB; nuclear factor-κB; PCR; polymerase chain re
Significance and Therapeutic Potential of Endothelial Progenitor Cell Transplantation in a Cirrhotic Liver Rat Model
Keywords: α-SMA; α-smooth muscle actin; BM; bone marrow; CCl4; carbon tetrachloride; ECM; extracellular matrix; EGF; epithelial growth factor; EPC; endothelium progenitor cell; Flk-1; fetal liver kinase-1; Flt-1; fms-like tyrosine kinase-1; HGF; hepatocyte growth
Expression of MMPs and TIMPs in liver fibrosis – a systematic review with special emphasis on anti-fibrotic strategies
Keywords: Liver; Fibrosis; MMP; TIMP; Matrix; Metalloproteinase; Tissue; Inhibitor; Therapy; Expression
Molecular effectors of multiple cell death pathways initiated by photodynamic therapy
Keywords: 1O2; singlet oxygen; ÎÏm; mitochondrial transmembrane potential; [Ca2+]cyt; cytosolic Ca2+-concentration; AlPc; aluminum phthalocyanine; ALA; 5-aminolevulinic acid; AIF; apoptosis inducing factor; ANT; adenine nucleotide translocator; Apaf-1; apoptosis
Syndecans in wound healing, inflammation and vascular biology
Keywords: Aβ; amyloid β protein; AD; Alzheimer's disease; AT-III; antithrombin-III; CAA; cerebral amyloid angiopathy; CS; chondroitin sulphate; EB; embryoid body; ECM; extracellular matrix; EGF; epidermal growth factor; ES cells; embryonic stem cells; FGF; fibrob
Oxidative mechanism and homeostasis of proteinase/antiproteinase in congestive heart failure
Keywords: Angiotensin II; MMP; TIMP; Endothelial myocyte coupling; ECM remodeling; Heart failure;
Synthesis of Collagen I in Collagenous Sprue
Keywords: CD; celiac disease; CS; collagenous sprue; ECM; extracellular matrix; IEL; intraepithelial lymphocyte; MMP; matrix metalloproteinase; TGF; transforming growth factor; TIMP; tissue inhibitor of matrix metalloproteinase.;
A cassette-dosing approach for improvement of oral bioavailability of dual TACE/MMP inhibitors
Keywords: TNFα; TACE; MMP; Metalloproteinase; Dual; Inhibitor; Pharmacokinetics; Cassette-dosing; Bioavailability; Oral; Clearance; Absorption; Rheumatoid arthritis; Trocade; TNF484; Claisen–Ireland rearrangement
N-Hydroxyurea—A versatile zinc binding function in the design of metalloenzyme inhibitors
Keywords: Zinc enzyme; Carbonic anhydrase; MMP; N-Hydroxyurea; X-ray crystallography; Enzyme–inhibitor
Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritis
Keywords: MMP; Inflammation; Joint; Bacteria
A Look Between the Cardiomyocytes: The Extracellular Matrix in Heart Failure
Keywords: ACE; angiotensin-converting enzyme; ECM; extracellular matrix; ET; endothelin; LV; left ventricular; MMP; matrix metalloproteinase; RALES; Randomized Aldactone Evaluation Study; TGF; transforming growth factor; TIMP; tissue inhibitors of MMP; TNF; tumor n
Induced secretion of tissue inhibitor of metalloproteinases-1 (TIMP-1) in vivo and in vitro by hepatotoxin rubratoxin B
Keywords: DMSO; dimethyl sulfoxide; IL-6; interleukin-6; IL-8; interleukin-8; JNK; c-Jun-N-terminal kinase; MMP; matrix metalloproteinase; RT-PCR; reverse transcription-polymerase chain reaction; SAPK; stress-activated MAP kinase; TIMP-1; tissue inhibitor of metall
Bcl-xL overexpression restricts γ-radiation-induced apoptosis
Keywords: Radiation; Apoptosis; Bcl-xL; Bax; ROS; MMP;
Calculation of minimum miscibility pressure for gas condensate reservoirs
Keywords: Gas condensate; MMP; ER EOS; CO2; NGL
Apoptotic cell death increases with senescence in normal human dermal fibroblast cultures
Keywords: Apoptosis; Human dermal fibroblasts; Senescence; FACScan; flow cytometry cell sorting; MMP; mitochondrial membrane potential; PI; propidium iodide; PT; permeability transition pore; ROS; reactive oxygen species; SA-β-gal; senescence-associated-β-galacto
Modulation of angiogenesis by tissue inhibitor of metalloproteinase-4
Keywords: MMP; Matrix metalloproteinase; TIMP; Tissue inhibitor of metalloproteinase; Angiogenesis; Endothelial cell