mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis
Keywords: mTORC1; Chondrocyte; Osteoarthritis; FGFR3; PPR;
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DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)
Keywords: 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia
ReviewThe Journey of the Autophagosome through Mammalian Cell Organelles and Membranes
Keywords: ER; endoplasmic reticulum; ATG; autophagy-related gene; mTORC1; mammalian target of rapamycin complex 1; PI3KC3; class III PI3 kinase; PI3P; phosphatidyl-inositol-3-phosphate; COPs; coating proteins; SNAREs; small Rab GTPases, membrane fusion proteins; MA
The activation of autophagy protects neurons and astrocytes against bilirubin-induced cytotoxicity
Keywords: UCB; unconjugated bilirubin; TFP; trifluoroperazine; Bf; free bilirubin; 4-PBA; 4-phenyl-butyric acid; 4EBP; eukaryotic initiation factor 4E-binding protein; mTORC1; mammalian target of rapamycin complex 1; SQSTM1/p62; sequestosome-1 or ubiquitin-binding
Importance of ROS-mediated autophagy in determining apoptotic cell death induced by physapubescin B
Keywords: GβL; G protein beta subunit-like; PRAS40; Proline-rich AKT1 substrate 40; Raptor; regulatory-associated protein of mTOR; Physapubescin B; Autophagy; ROS; MTORC1; Apoptotic cell death;
A 15-gene signature for prediction of colon cancer recurrence and prognosis based on SVM
Keywords: TCGA; The Cancer Genome Atlas; LIMMA; Linear Models for Microarray data; DEGs; differentially expressed genes; SVM; support vector machine; d-CEA; draining venous blood; GEO; Gene Expression Omnibus; RMA; Robust Multichip Average; RFE; recursive feature e
A new role of GCN2 in the nucleolus
Keywords: GCN2; Amino acid starvation; Nucleolus; p53; RNA polymerase III; ARPP P0; acidic ribosomal phosphoprotein P0; ATF4; activating transcription factor 4; BRF1; B-related factor 1; eIF2α; eukaryotic initiation factor 2 alpha subunit; FC; fibrillar center; GA
A novel mechanism of mTORC1-mediated serine/glycine metabolism in osteosarcoma development
Keywords: mTORC1; Serine/glycine; Proliferation; Antioxidant; Osteosarcoma;
Ginkgo biloba L. attenuates spontaneous recurrent seizures and associated neurological conditions in lithium-pilocarpine rat model of temporal lobe epilepsy through inhibition of mammalian target of rapamycin pathway hyperactivation
Keywords: CA; Cornu Ammonis; DAB; 3,3Ë-Diaminobenzidine; DG; Dentate gyrus; DPX; dibutyl phthalate xylene; GBbf; Ginkgo biloba butanol fraction; GBe; hydrolyzed ethyl acetate fraction; LiPc; lithium-pilocarpine; mTOR; mammalian target of rapamycin; mTORC1; mammali
Discrete signaling mechanisms of mTORC1 and mTORC2: Connected yet apart in cellular and molecular aspects
Keywords: mTOR; mTORC1; mTORC2; Akt; Stem cell;
PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling
Keywords: Autophagy; mTOR; mTORC1; PAQR3; Nutrient sensing;
Glucose-mediated inactivation of AMP-activated protein kinase reduces the levels of L-type amino acid transporter 1 mRNA in C2C12 cells
Keywords: LAT1; L-type amino acid transporter 1; SNAT2; sodium-dependent neutral amino acid transporter 2; 4F2hc; 4F2 heavy chain; AMPK; AMP-activated protein kinase; AICAR; 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside; BCAA; branched chain amino acid; mTOR
The roles of subcellularly located EGFR in autophagy
Keywords: AMPK; AMP-activated protein kinase; ATG; autophagy-related; BCL2; B-cell lymphoma 2; BCL2L1; BCL2 like 1; BNIP3; BCL2/Adenovirus E1B-binding protein Nip3; CME; clathrin-mediated endocytosis; cytoSTAT3; cytoplasmic STAT3; Dsbs; double strand breaks; ECD; e
Nudix-type motif 2 contributes to cancer proliferation through the regulation of Rag GTPase-mediated mammalian target of rapamycin complex 1 localization
Keywords: mTORC1; mammalian target of rapamycin complex 1; NUDT2; Nudix-type motif 2; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; Ap4A; 5â², 5â³-p1,p4-tetraphosphate; DCIS; ductal cell in situ; IDC; invasive ductal carcinoma cell;
IRE1α links Nck1 deficiency to attenuated PTP1B expression in HepG2 cells
Keywords: ATF6; activating transcription factor 6; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; HNF4α; hepatocyte nuclear factor 4α; GAP; GTPase-activating protein; HFD; high fat diet; IL-4; interleukin-4; IRE1α; inositol-requiring enzyme 1
The cochaperone BAG3 coordinates protein synthesis and autophagy under mechanical strain through spatial regulation of mTORC1
Keywords: BAG3; BCL2-associated athanogene; mTOR; mammalian target of rapamycin; mTORC1; mammalian target of rapamycin complex 1; TSC; tuberous sclerosis; CASA; chaperone-assisted selective autophagy; CMA; chaperone-mediated autophagy; RE; maximal eccentric resista
Protein and exercise in the prevention of sarcopenia and aging
Keywords: Sarcopenia; Protein; Aerobic exercise; Resistance exercise; Aging; Supplement; 1-RM; 1 repetition maximum; 4E-BP1; eukaryotic initiation factor 4E-binding protein-1; aLM; appendicular lean mass; BIA; bioelectrical impedance analysis; CSA; cross-sectiona
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease
Keywords: AD; Alzheimer's disease; AGC; protein kinase A/protein kinase G/protein kinase C; Akt; protein kinase B; ATG13; autophagy-related gene 13; Aβ; amyloid-beta; BDNF; brain-derived neurotrophic factor; CaMKII; Ca2+/calmodulin-dependent kinase II; cAMP; cyc
Sulforaphane inhibits platelet-derived growth factor-induced vascular smooth muscle cell proliferation by targeting mTOR/p70S6kinase signaling independent of Nrf2 activation
Keywords: Sulforaphane (PubChem CID: 5350); Dimethyl Sulfoxide (PubChem CID: 679); ARE; antioxidant response element; CREB; cAMP-response element-binding protein; DAB; diaminobenzidine; DMSO; dimethyl sulfoxide; 4E-BP1; eukaryotic translation initiation factor 4E-b
Regulation of autophagy by mitochondrial phospholipids in health and diseases
Keywords: ALCAT1; lysocardiolipin acyltransferase 1; ALE1; lysophospholipid acyltransferase (yeast); AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATGL; adipose triglyceride lipase; AVT1; amino acid vacuolar transport; BNIP3; BCL2/adenovirus E1B
Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells
Keywords: F6P; fructose 6-phosphate; HBP; Hexosamine Biosynthetic Pathway; GlcN6P; glucosamine-6-phosphate; GFAT; glutamine-fructose-6-phosphate amidotransferase; UDP-GlcNAc; UDP-N-acetylglucosamine; O-GlcNAc; O-GlcNAcylation; GAM; Glucosamine; VEGF; vascular endot
ALS-FTLD associated mutations of SQSTM1 impact on Keap1-Nrf2 signalling
Keywords: ALS; Amyotrophic lateral sclerosis; ARE; Antioxidant response element; FTLD; Frontotemporal lobar degeneration; IKKβ; Inhibitor of nuclear factor kappa-B kinase subunit beta; Keap1; Kelch-like ECH-associated protein 1; KIR; Keap1-interacting region; LIR;
SLC7 family transporters control the establishment of left-right asymmetry during organogenesis in medaka by activating mTOR signaling
Keywords: Left-right asymmetry; mTOR signaling; SLC7 transporter; Ciliogenesis; Nodal flow; Medaka; spaw; southpaw; KV; Kupffer's vesicle; LPM; lateral plate mesoderm; mTORC1; mTOR complex1; S6K1; S6 kinase 1; HAT; heteromeric amino acid transporter;
Panaxatriol derived from ginseng augments resistance exercised-induced protein synthesis via mTORC1 signaling in rat skeletal muscle
Keywords: Ginseng; Intracellular signaling; Skeletal muscle; Rat; Resistance exercise; ERK1/2; extracellular signal-regulated kinase 1/2; IGF-1; insulin-like growth factor-1; mTORC1; mammalian target of rapamycin complex 1; TSC; tuberous sclerosis complex; PT; pa
Orientin protects myocardial cells against hypoxia-reoxygenation injury through induction of autophagy
Keywords: Orientin (PubChem CID: 5281675); Wortmannin (PubChem CID: 312145)Orientin; Hypoxia/reoxygenation; Autophagy; AMPK; mTORC1; Beclin 1
Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells
Keywords: Tg, thapsigargin; UPR, unfolded protein response; GRP78, glucose-regulated peptide 78ER stress; Unfolded protein response; mTORC1; Glucose-regulated peptide 78; siRNA interference; Apoptosis
TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy
Keywords: ARD1; arrest defective type 1; Atg; autophagy related; CHX; cycloheximide; GAP; GTPase activating protein; LC3B; microtubule-associated protein 1 light chain 3 beta; mTORC1; mammalian/mechanistic target of rapamycin complex 1; NAD; nicotinamide adenine di
Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells
Keywords: Arsenic trioxide; Apoptotic cell death; Melatonin; mTORC1; Redd1;
mTORC1 Inhibition Corrects Neurodevelopmental and Synaptic Alterations in a Human Stem Cell Model of Tuberous Sclerosis
Keywords: mTORC1; tuberous sclerosis; human pluripotent stem cells; neuronal differentiation; autism spectrum disorder; synaptogenesis
Recent progress in the identification of adenosine monophosphate-activated protein kinase (AMPK) activators
Keywords: ACC; acetyl-CoA carboxylase; ADaM; allosteric drug and metabolite; AID; auto-inhibitory domain; α-RIM; α-regulatory interacting motif; AMPK; adenosine monophosphate-activated protein kinase; ASMS; affinity selection mass spectrometry; CamKKβ; Ca2+/calm
Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells
Keywords: ACC; acetyl-CoA carboxylase; Akt; protein kinase B; AMPK; AMP-activated protein kinase; apoB; apolipoprotein B; apoE; apolipoprotein E; CPT1α; carnitine palmitoyltransferase 1α; DGAT1; diacylglycerol O-acyltransferase 1; DGAT2; diacylglycerol O-acyltran
High mTORC1 signaling is maintained, while protein degradation pathways are perturbed in old murine skeletal muscles in the fasted state
Keywords: Aging; Muscle; mTORC1; Autophagy; p62; Protein degradation;
Aryl hydrocarbon receptor-dependent up-regulation of the heterodimeric amino acid transporter LAT1 (SLC7A5)/CD98hc (SLC3A2) by diesel exhaust particle extract in human bronchial epithelial cells
Keywords: AhR; aryl hydrocarbon receptor; BCH; 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid; CYP; cytochrome P-450; DEP; diesel exhaust particle; DEPe; diesel exhaust particle extract; DMSO; dimethyl sulfoxide; EGR1; early growth response 1; ERK; extracellular
mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances
Keywords: mTORC1; Rapamycin; Proteomics; KPNA2; HIF1α; Glycolysis;
Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy
Keywords: Apoptosis; Autophagy; Endoplasmic reticulum; IP3 receptor; Lysosomes; Mitochondria; AMBRA1; autophagy/Beclin 1 regulator 1; AMPK; AMP-activated kinase; ATF4; activating transcription factor-4; Atg; autophagy-related; BIRD-2; Bcl-2/IP3R disruptor-2; CREB;
Paeonia japonica root extract protects hepatocytes against oxidative stress through inhibition of AMPK-mediated GSK3β
Keywords: AA; arachidonic acid; ACC; acetyl-CoA carboxylase; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; AST; aspartate aminotransferase; DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; 4EBP-1; eIF-4E binding protein 1; FACS; fluorescence-a
Hepatitis B virus (HBV) X protein-mediated regulation of hepatocyte metabolic pathways affects viral replication
Keywords: HBV; Hepatitis B virus; HCC; Hepatocellular carcinoma; HBx; HBV X protein; cccDNA; Covalently closed circular DNA; ORF; Open reading frame; mTORC1; Mammalian target of rapamycin (mTOR) complex 1; TSC2; Tuberous-sclerosis complex-2; AMPK; AMP-activated pro
Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
Keywords: 4E-BP1; 4E binding protein; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; ATP; adenosine triphosphate; DEPTOR; DEP domain containing mTOR-interacting protein; CI; complexes I; CII; complex II; CIII; complex III; CIV; complex
Uroguanylin modulates (Na+Â +Â K+)ATPase in a proximal tubule cell line: Interactions among the cGMP/protein kinase G, cAMP/protein kinase A, and mTOR pathways
Keywords: UGN; uroguanylin; PT; proximal tubule; GFR; glomerular flow rate; NHE3; Na+/H+ exchanger isoform 3; PKA; protein kinase A; PKG; protein kinase G; Gi; inhibitory G protein; PKB; protein kinase B; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1;
Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1
Keywords: Autophagy; Cell viability; Human telomerase reverse transcriptase (hTERT); Mammalian target of rapamycin complex 1 (mTORC1); Telomerase; AMPK; AMP-activated protein kinase; DMEM; Dulbecco's Modified Eagle's medium; EBSS; Earle's balanced salt solution; ER
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
Keywords: AMPK; 5â² AMP-activated protein kinase; Atg13; autophagy-related protein 13; CDK; cyclin-dependent kinase; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified eagle's medium; DMSO; dimethyl sulfoxide; FDA; US Food and Drug Administration; GF
Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation
Keywords: NPRL2; nitrogen permease regulator-like 2; mTORC1; mammalian target of rapamycin complex 1; DEPDC5; DEP domain containing 5; GATOR1; GAP activity toward Rag 1; LAMP2; lysosome-associated membrane protein 2; NPRL2; mTOR complex 1 (mTORC1); Rag GTPases; Rap
Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation
Keywords: mTOR; mammalian target of rapamycin; UVB; ultraviolet-B; NMSC; non-melanoma skin cancer; mTORC1; mTOR complex 1; mTOC2; mTOR complex 2; AKT/PKB; protein kinase B; SCC; squamous cell carcinoma; ERK; extracellular-signal-regulated kinases; MEK; mitogen-acti
Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling
Keywords: Endothelial dysfunction; AICAR; Mitochondrial biogenesis; eNOS; Nitric oxide; mTORC1; AMPK; Rapamycin;
Class I PI3-kinase or Akt inhibition do not impair axonal polarization, but slow down axonal elongation
Keywords: Akt; PI3K; mTORC1; Signalling; Axon establishment; Polarity;
Everolimus (RAD001) ameliorates vascular cognitive impairment by regulating microglial function via the mTORC1 signaling pathway
Keywords: VaD; vascular dementia; mTORC1; mammalian target of rapamycin complex 1; AD; Alzheimer's disease; ROS; reactive oxygen species; GWAS; genome-wide association study; IFN; interferon; TNF-α; tumor necrosis factor alpha; IL; interleukin; Arg-1; arginase-1;
Autophagy: A double-edged sword in intervertebral disk degeneration
Keywords: IVD; intervertebral disk; NP; nucleus pulposus; AF; annulus fibrosus; CEPs; cartilaginous endplates; ECM; extracellular matrix; Col II; type II collagen; Col I; type I collagen; IDD; intervertebral disk degeneration; LBP; low back pain; miRNAs; microRNAs;
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis
Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH associated protein 1; TUNEL; terminal deoxynucleotidyl transferase dUTP nick end labeling; MTT; 3-(4,5-di
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; AMP-activated protein kinase; Atg13; autophagy-related 13; FIP200; 200Â kilodalton focal adhesion kinase family kinase-interacting protein; GAP; GTPase activator protein; GATOR; GAP activity
Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle
Keywords: AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5â²AMP activated protein kinase; ANOVA; Analysis of Variance; ATG; autophagy related gene; ATP; adenosine triphosphate; BCA; bicinchoninic acid; BSA; bovine serum albumin