دانلود مقالات ISI درباره Mtorc1 + ترجمه فارسی

Targeting respiratory complex I to prevent the Warburg effect

Keywords: OXPHOS; oxidative phosphorylation; CI; complex I; ROS; reactive oxygen species; TCA; tricarboxylic acid; PARP1; poly (ADP ribose) polymerase 1; AMPK; AMP activated kinase; mTORC1; mammalian target of rapamycin complex 1; HIF1α; hypoxia inducible factor 1

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer

Keywords: PRAS40; PI3K/AKT; mTORC1; Cancer therapeutics;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1

Keywords: PF-4708671; p70 ribosomal S6 kinase 1 (S6K1); p62; Autophagy; Nuclear factor erythroid 2-related factor 2 (Nrf2); Kelch-like ECH-associated protein 1 (Keap1); GSTA1; glutathione S-transferase A1; Keap1; Kelch-like ECH-associated protein 1; MEF; mouse embr

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

The PI3K/AKT/mTOR pathway as a therapeutic target in ovarian cancer

Keywords: CCC; clear cell carcinoma; SAC; serous adenocarcinoma; mTOR; mammalian target of rapamycin; mTORC; mTOR complex; S6K-1; ribosomal S6 kinase-1; 4E-BP1; elF4E binding protein 1; PI3K; phosphatidylinositol 3-kinase; cisplatin; cis-diaminodichloroplatinum; PT

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

mTORC1 signaling in Agrp neurons mediates circadian expression of Agrp and NPY but is dispensable for regulation of feeding behavior

Keywords: mTORC1; Raptor; Hypothalamus; Agrp; NPY; Metabolism;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways

Keywords: mTOR; Rapamycin; Rb; TGF-β; eIF4E; 4E-BP1; eIF4E-binding protein-1; CDK; cyclin-dependent kinase; eIF4E; eukaryotic initiation factor 4E; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; S6K; S6 kinase; TGF-β; transforming growth factor-β;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Sphingosylphosphorylcholine protects cardiomyocytes against ischemic apoptosis via lipid raft/PTEN/Akt1/mTOR mediated autophagy

Keywords: SPC; sphingosylphosphorylcholine; I/R; ischemia/reperfusion; MTOR; mammalian target of rapamycin; MTORC1; mTOR complex 1; MTORC2; mTOR complex 2; MI; myocardial infarction; PI3K; phosphatidylinositol 3-kinase; TSC2; tuberous sclerosis complex 2; HUVECs; h

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Docosahexaenoic acid inhibits proteolytic processing of sterol regulatory element-binding protein-1c (SREBP-1c) via activation of AMP-activated kinase

Keywords: SREBP; Sterol regulatory element binding protein; AMPK; AMPK-activated kinase; DHA; Docosahexaenoic Acid; PUFA; Polyunsaturated fatty acids; Akt; Akt/Protein Kinase B; mTORC1; Mammalian target of rapamycin complex 1; p70S6K; p70S6Kinase; T2DM; Type II Dia

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

A phosphoproteomic study reveals shp-1 cleavage reprograms LPS signaling via a PI-3K/NF-κB and mTORC1 related mechanism

Keywords: Shp-1; PI-3K; mTORC1; MODS; Phosphoproteome;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

A structural insight into the inhibitory mechanism of an orally active PI3K/mTOR dual inhibitor, PKI-179 using computational approaches

Keywords: PI3K; phosphatidylinositide 3-kinase; PIP2; phosphatidylinositol-4,5-bisphosphate; PIP3; phosphatidylinositol-3,4,5-trisphosphate; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; ASA; accessible surface area; ΔASA; lo

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The amelioration of metabolic disorders in early stage diabetic rats by resveratrol is associated with mTORC1 regulation

Keywords: Resveratrol; mTORC1; Diabetic rats;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Noncoding RNAs as regulators of cardiomyocyte proliferation and death

Keywords: miRNAs; microRNAs; lncRNA; long non-coding RNA; LAD; left anterior descending coronary artery; hCMPCs; human Cardiomyocyte Progenitor Cells; CSCs; Cardiac Stem Cells; MI; Myocardial Infarction; MFN1; Mitofusin 1; I/R; Ischemia/Reperfusion; BNIP3; BCL2/ade

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status

Keywords: dormant; quiescent; intestinal stem cells; PTEN; fasting; MTORC1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

TNF compromises lysosome acidification and reduces α-synuclein degradation via autophagy in dopaminergic cells

Keywords: TNF; tumor necrosis factor-α; PD; Parkinson's disease; α-SYN; α-synuclein; DA; dopamine; CQ; chloroquine; CM; conditioned medium; LPS; lipopolysaccharide; CHX; cycloheximide; 3-MA; 3-methyladenine; tf-LC3; RFP-GFP-tandem fluorescent LC3; TFEB; transcri

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling

Keywords: 4-HNE; mTORC1; Protein synthesis; Cardiac myocytes; Erk1/2; Free radicals;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Quercetin inhibits the mTORC1/p70S6K signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in diabetic nephropathy

Keywords: mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; DN; diabetic nephropathy; EMT; epithelial-mesenchymal transition; ECM; extracellular matrix; GBM; glomerular basement membrane; STZ; streptozotocin; Diabetic nephropathy; Epithelial-mesenchy

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Interleukin-10 inhibits chronic angiotensin II-induced pathological autophagy

Keywords: NRVM; neonatal rat ventricular cardiomyocytes; Class I PI3K; class I phosphoinositide 3-kinase; 4EBP1; 4E binding protein 1; CHOP; C/EBP homologous protein; EF; ejection fraction; FS; fractional shortening; LY02; LY2940002; WT; wild-type; Autophagy; Signa

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Distinct signaling mechanisms of mTORC1 and mTORC2 in glioblastoma multiforme: A tale of two complexes

Keywords: mTOR; mTORC1; mTORC2; S6K; 4E-BP1; GBM;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Insulin upregulates the expression of epithelial sodium channel in vitro and in a mouse model of acute lung injury: Role of mTORC2/SGK1 pathway

Keywords: AFC; alveolar fluid clearance; AGC; protein kinase A, protein kinase G and protein kinase C; AKT; protein kinase B; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; AT II; type II alveolar epithelial cell; ENaC; epithelial sodium channel

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Independent role of PP2A and mTORc1 in palmitate induced podocyte death

Keywords: Insulin resistance; Podocyte death; Protein phosphatase 2A; mTORc1; ApoptosisIR, insulin resistance; CKD, chronic kidney disease; PP2A, protein phosphatase 2A; BSA, bovine serum albumin; OA, okadaic acid; RAPA, rapamycin; Ins, insulin; Pal, palmitate; GR,

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex

Keywords: T-cell activation; T-cell tolerance; TCR signaling; NF-κB; mTORC1; CARMA1; Glutamine

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functions

Keywords: Raptor; regulatory associated protein of mTOR; Rictor; rapamycin-insensitive companion of mTOR; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; m-TORC2; mTOR complex 2; Sp1; specific protein 1; MTH; mithramycin; RAPA; rapamycin; ChIP; chromat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Dehydroepiandrosterone prevents linoleic acid-induced endothelial cell senescence by increasing autophagy

Keywords: ANOVA; one-way analysis of variance; AMPK; AMP-activated protein kinase; ATG; autophagy related genes; CVD; cardiovascular disease; DHEA; dehydroepiandrosterone; DHEA-S; dehydroepiandrosterone sulfate; DMSO; dimethyl sulfoxide; eNOS; endothelial nitric ox

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

The integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory

Keywords: 4E-BPs; 4E binding proteins; ACh; acetylcholine; AD; Alzheimer's Disease; APP; amyloid precursor protein; CaMKII; Ca2+/calmodulin-dependent protein kinase II; CREB; cAMP response element-binding protein; DG; dentate gyrus; eEF1A; eukaryotic Elongation F

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1

Keywords: Sesn; sestrin; ROS; reactive oxygen species; Prx; peroxiredoxin; Srx; sulfiredoxin; ERK; extracellular signal-regulated kinase; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH-associated protein 1; mTORC1; mechanistic target of ra

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice

Keywords: GSH; Glutathione; HPRT; Hypoxanthine-guanine phosphoribosyltransferase; IR; Insulin receptor; MR; Methionine restriction; mTORC1; Mechanistic target of rapamycin complex 1; NAFLD; Non-alcoholic fatty liver disease; p70S6K; p70 ribosomal S6 kinase; PIP3; P

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2015 سفارش ترجمه

Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation

Keywords: Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; APP; amyloid precursor protein; ATP; adenosine triphosphate; Bci3; Bax cannel inhibitor 3; cAMP; cyclic adenosine monophosphate; CMA; chaperone-mediated autophagy; DLB; dement

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2015 سفارش ترجمه

Genetic ablation of PRAS40 improves glucose homeostasis via linking the AKT and mTOR pathways

Keywords: GTT; glucose tolerance test; ITT; insulin tolerance test; shRNA; short-hairpin RNA; STZ; streptozotocin; PRAS40; proline-rich AKT substrate of 40 kDa; HbA1C; hemoglobin A1; PRAS40; AKT; mTORC1; GLUT4; Diabetes; Insulin;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2015 سفارش ترجمه

MYC and metabolism on the path to cancer

Keywords: 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance

Keywords: Diabetes; ER stress; mTORC1; IRS1;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

The novel mTORC1/2 dual inhibitor INK-128 suppresses survival and proliferation of primary and transformed human pancreatic cancer cells

Keywords: MTT; 3-[4,5-Dimethylthylthiazol-2-yl]-2,5 diphenyltetrazolium bromide; FACS; fluorescence-activated cell sorting; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; 4E-BP1; 4E-binding protein; OD; optical density; IP; imm

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Cycloheximide inhibits starvation-induced autophagy through mTORC1 activation

Keywords: Autophagy; Cycloheximide; mTORC1; Protein synthesis; Protein degradation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells

Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; 5′-AMP-activated protein kinase; APC; adenomatous polyposis coli; CK1; casein kinase 1; CM; conditioned medium; eIF4E; eukaryotic initiation factor 4E; GSK3β; glycogen synthase kinase-3β

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Phenotypes associated with inherited and developmental somatic mutations in genes encoding mTOR pathway components

Keywords: mTOR; Mamalian target of rapamycin; PI3K; phosphoinositide 3-kinase related kinase; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; AMP; Adenosine monophosphate; ATP; Adenosine triphosphate; S6K; ribosomal S6 Kinase; 4E-BP1; eukaryotic initiation factor 4

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

mTOR Signaling in Autophagy Regulation in the Kidney

Keywords: Autophagy; rapamycin; mTOR; mTORC1; AMPK; renal proximal tubular cell; podocyte;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Dramatic suppression of colorectal cancer cell growth by the dual mTORC1 and mTORC2 inhibitor AZD-2014

Keywords: 3-MA; 3-methyaldenine; 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; mTOR; mammalian target or rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; S6K; p70-S6 Kinase 1; LC3B; light chain 3B; Colorectal cancer; AZD-2014; mTOR complexes;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Increasing leucine concentration stimulates mechanistic target of rapamycin signaling and cell growth in C2C12 skeletal muscle cells

Keywords: Amino acids; Anabolic signaling; C2C12; Skeletal muscle; mTOR; Protein synthesis; ANOVA; analysis of variance; 4E-BP1; eukaryotic initiation factor 4E-binding protein 1; FBS; fetal bovine serum; mTOR; mechanistic target of rapamycin; mTORC1; mechanistic t

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

mTORC1 signaling controls multiple steps in ribosome biogenesis

Keywords: 4E-BP; eIF4E-binding protein; 5′-TOP; 5′-terminal oligopyrimidine tract; BOP1; block of proliferation 1; eEF2; eukaryotic elongation factor; eEF2K; eEF2 kinase; eIF; eukaryotic initiation factor; ERK; extracellular ligand-regulated kinase; MEK; MAP an

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

MicroRNA-451 regulates AMPK/mTORC1 signaling and fascin1 expression in HT-29 colorectal cancer

Keywords: AMPK; AMP-activated protein kinase; ACC; Acetyl-CoA Carboxylase; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; CAB39; calcium-binding protein 39; FSCN1; fascin1, mammalian target of rapamycin (mTOR); mTORC1; mTOR complex 1; Raptor; regulato

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Deficiency of cardiac Acyl-CoA synthetase-1 induces diastolic dysfunction, but pathologic hypertrophy is reversed by rapamycin

Keywords: Acsl; long-chain acyl-CoA synthetase; FA; fatty acid; mTOR; mechanistic target of rapamycin; mTORC1; mTOR complex-1; MPI; mean performance index; Fatty acid oxidation; mTOR; Insulin resistance; Gene expression; Ventricular function; Substrate switching;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1

Keywords: Cardiac hypertrophy; Autophagy; AMPK; mTORC1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Autophagy: Emerging Therapeutic Target for Diabetic Nephropathy

Keywords: Autophagy; diabetic nephropathy; mTORC1; AMPK; proteinuria;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Parkin ubiquitinates mTOR to regulate mTORC1 activity under mitochondrial stress

Keywords: mTOR; mTORC1; Parkin; Ubiquitination; Mitochondrial stress;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

G protein-coupled receptors and the regulation of autophagy

Keywords: autophagy; amino acid sensing GPCRs; muscarinic receptor; β-adrenergic receptor; GLP-1 receptor; mTORC1; AMPK

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

mTOR and autophagy: A dynamic relationship governed by nutrients and energy

Keywords: Akt1; v-akt murine thymoma viral oncogene homolog 1; AMBRA; Autophagy/Beclin-1 regulator 1; AMPK; AMP-dependent protein kinase; ATG; autophagy-related; BECN1; beclin 1; DEPTOR; DEP domain containing mTOR-interacting protein; EGFR; epidermal growth factor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Post-transcriptional regulation of autophagy in C2C12 myotubes following starvation and nutrient restoration

Keywords: ACC; acetyl-CoA carboxylase; Akt/PKB; protein kinase B; AMPK; AMP-activated protein kinase; ANOVA; analysis of variance; Atg; autophagy-related gene; Bnip3; B-cell lymphoma 2 interacting protein 3; DMEM; Dulbecco's modified Eagle medium; DPBS; Dulbecco's

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Nicotinamide phosphoribosyltransferase can affect metastatic activity and cell adhesive functions by regulating integrins in breast cancer

Keywords: AMP; adenosine monophosphate; ATP; adenosine triphosphate; BRCA1; breast cancer 1; BRCA2; breast cancer 2; eNAMPT; extracellular nicotinamide phosphoribosyltransferase; ERK; extracellular signal-regulated kinases; iNAMPT; intracellular nicotinamide phosph

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Benzofuran derivatives as a novel class of inhibitors of mTOR signaling

Keywords: Benzofuran; Cytotoxicity; mTOR; mTORC1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of mTOR down-regulates scavenger receptor, class B, type I (SR-BI) expression, reduces endothelial cell migration and impairs nitric oxide production

Keywords: ABCG1; ATP binding cassette transporter G1; BP-C; Bodipy-cholesterol; BP-CE; Bodipy-cholesteryl oleate; CETP; cholesteryl ester transfer protein; DAF-2 DA; 4,5-diaminofluorescein diacetate; DiI; 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling

Keywords: ACC; acetyl-CoA carboxylase; AMPK; AMP-activated protein kinase; AMD; age-related macular degeneration; HO-1; heme oxygenase-1; mTORC1; mammalian target of rapamycin complex 1; Nrf2; NF-E2-related factor 2; ROS; reactive oxygen species; RPE; retinal pigme

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه