Requirement for lysosomal localization of mTOR for its activation differs between leucine and other amino acids
Keywords: mTORC1; Rags; Lysosome; Amino acids; Leucine;
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
AMPK activation prevents excess nutrient-induced hepatic lipid accumulation by inhibiting mTORC1 signaling and endoplasmic reticulum stress response
Keywords: AMPK; ER stress; mTORC1; SREBP; Lipid accumulation;
Influence of mTOR in energy and metabolic homeostasis
Keywords: mTORC1; mTORC2; Hypothalamus; Energy balance; Leptin; Hormone
SQSTM1 mutations - Bridging Paget disease of bone and ALS/FTLD
Keywords: ALS; amyotrophic lateral sclerosis; aPKC; atypical protein kinase C; C9orf72; chromosome 9 open reading frame 72; FTD; frontotemporal dementia; FTLD; frontotemporal lobar degeneration; FUS/TLS; fused in sarcoma/translocated in liposarcoma; GWAS; genome-wi
Growing knowledge of the mTOR signaling network
Keywords: mTOR; mTORC1; mTORC2; Insulin; Amino acids; Energy;
Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes
Keywords: AMPK; AMP-activated protein kinase; CHOP; C/EBP homologous protein; 4E-BP1; eukaryotic initiation factor 4E (eIF4E) binding protein 1; EPA; eicosapentaenoic acid; ER; endoplasmic reticulum; FFA; free fatty acid; HEK293; human embryonic kidney cell line 29
Energy adaptive response during parthanatos is enhanced by PD98059 and involves mitochondrial function but not autophagy induction
Keywords: 3AB; 3-aminobenzamide; 7AAD; 7-aminoactinomycin D; AIF; apoptosis-inducing factor; AMPK; AMP-activated protein kinase; DPI; diphenyliodonium; DXR; doxorubicin; FACS; fluorescence-activated cell sorting; FCCP; trifluorocarbonylcyanide phenylhydrazone; LC3;
mTOR signaling in tumorigenesis
Keywords: mTOR; the mechanistic target of rapamycin or the mammalian target of rapamycin; PIKK; phosphoinositide 3-kinase related protein kinase; ATM; ataxia-telangiectasia mutated; ATR; ataxia-telangiectasia and rad3-related; DNAPK; DNA-dependent protein kinase; R
TNF-α upregulates macroautophagic processing of APP/β-amyloid in a human rhabdomyosarcoma cell line
Keywords: sIBM; sporadic inclusion body myositis; APP; amyloid precursor protein; 3MA; 3-methyladenine; CQ; chloroquine; FKBP12; FK-binding protein 12; mTORC1; mammalian target of rapamycin complex1; BACE1; β-site APP-cleaving enzyme 1; AD; Alzheimer's dementia; M
Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)
Keywords: Mnk; mTORC1; Rapamycin; eIF4E;
Jurkat cell proliferation is suppressed by Chlamydia (Chlamydophila) pneumoniae infection accompanied with attenuation of phosphorylation at Thr389 of host cellular p70S6K
Keywords: PBMC; peripheral blood mononuclear cell; FCS; fetal calf serum; FITC; fluorescein isothiocyanate; LPS; lipopolysaccharide; HBSS; Hank's balanced salt solution; PI3K; mammalian target of rapamycin; mTOR; phosphoinositide 3-kinase; mTORC1; multi-component m
The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action
Keywords: ATF-4; activating transcription factor 4; CB1; cannabinoid type-1 receptor; CB2; cannabinoid type-2 receptor; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; MEF; mouse embryonic fibroblast; mTORC1; mammalian target of rapamycin complex 1; mTOR
Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
Keywords: P70S6K; ribosomal protein S6 kinase; mTOR; the mammalian target of rapamycin; SIRT; silent information regulator; Tsc; tuberous sclerosis complex; mTORC1; the mammalian target of rapamycin complex 1; POF; premature ovarian failure; PTEN; phosphatase and t
Vasopressin activates Akt/mTOR pathway in smooth muscle cells cultured in high glucose concentration
Keywords: AVP; arginine vasopressin; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; PI3K; phosphatidyl inositol-3 kinase; AMPK; AMP-activated protein kinase; PKC; protein kinase C, Akt or protein kinase B; TSC1/TSC2; tubero sclerosis protein 1 and 2;
Prion formation correlates with activation of translation-regulating protein 4E-BP and neuronal transcription factor Elk1
Keywords: PrPC; normal cellular prion protein; PrPSc; disease-associated prion protein; GT1-1 cells; immortalized hypothalamic gonadotropin-releasing hormone neurons; BDNF; brain-derived neurotrophic factor; MEK; mitogen-activated protein kinase kinase; ERK; extrac
Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; ATF4; activating transcription factor 4; ca; constitutively active; dn; dominant negative; ERK; extracellular signal-related protein kinase; FBS; fetal bovine serum; GCN2; general control non-dere
Fisetin regulates obesity by targeting mTORC1 signaling
Keywords: mTORC1; mammalian target of rapamycin complex 1; S6K1; 70-kDa ribosomal protein S6 kinase 1; TSC2; tuberous sclerosis protein 2; HFD; high-fat diet; PPAR-γ; peroxisome proliferator-activated receptor γ; SREBP-1; sterol regulatory element-binding protein
TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: A cautionary tale of the use of this cell line in studies on dioxin toxicity
Keywords: AhR; aryl hydrocarbon receptor; AKT1S1; proline-rich AKT1 substrate 1; CYP1A1; cytochrome P450 1A1; 4E-BP1; eukaryotic translation initiation factor 4E-binding protein 1; ERK; extracellular signal-regulated protein kinase; GSK3; glycogen synthase kinase 3
Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling
Keywords: AMPK; AMP-activated protein kinase; AgRP; agouti-related protein; CAMKK2; calmodulin-dependent kinase kinase 2; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; GHS-R1a; growth hormone secretagogue receptor type 1a; ICV; intracerebroventricular; mTORC1;
Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway
Keywords: HLJDD; Huang-Lian-Jie-Du-Decotion; MCAO; middle cerebral artery occlusion; TTC; 2,3,5-triphenyltetrazolium chloride; HE; hematoxylin-eosin; NO; nitric oxide; MDA; malondialdehyde; GSH; glutathione; GSSG; glutathione disulfide; T-SOD; total superoxide di
Renal tumours in a Tsc1+/- mouse model show epigenetic suppression of organic cation transporters Slc22a1, Slc22a2 and Slc22a3, and do not respond to metformin
Keywords: Tuberous sclerosis; Mouse model; Kidney; mTORC1; Metformin; AMPK;
mTORC1-dependent protein synthesis underlying rapid antidepressant effect requires GABABR signaling
Keywords: GABAB receptors; NMDA receptors; Protein synthesis; Rapid antidepressant; Hippocampal neurons; Prefrontal cortex; mTORC1; L-type calcium channels; Calcium imaging;
Bidirectional regulation of NF-κB by reactive oxygen species: A role of unfolded protein response
Keywords: NF-κB; nuclear factor-κB; UV; ultraviolet; IκB; inhibitor of NF-κB; IKK; IκB kinase; NEMO; NF-κB essential modulator; TNFR; tumor necrosis factor receptor; IL-1R; interleukin-1 receptor; NIK; NF-κB inducing kinase; LPS; lipopolysaccharide; PKD; pro
Long-term effects of cocaine experience on neuroplasticity in the nucleus accumbens core of addiction-prone rats
Keywords: AcbC; nucleus accumbens, core subregion; bHR; selectively bred high-responder rats; bLR; selectively bred low-responder rats; DiI; 1,1â²-dioctadecyl-3,3,3â²,3â²-tetramethylindocarbocyanine perchlorate (lipophilic dye); MSN; medium spiny neuron; mTORC1;
Autophagy, polyphenols and healthy ageing
Keywords: AD; Alzheimer's disease; AMP; adenosine monophosphate; AMPK; adenosine monophosphate activated protein kinase; APP; amyloid beta precursor protein; Atg; autophagy (related gene); ATP; adenosine triphosphate; AV; autophagic vacuoles; Aβ; amyloid beta; Bcl
Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation
Keywords: Cell commitment; Cell survival; Endocannabinoids; Membrane receptors; Niche cues; Protein kinases; Transcription factors; 2-AG; 2-arachidonoylglycerol; AEA; N-arachidonoylethanolamine; BDNF; brain derived neurotrophic factor; CBD; cannabidiol; CBG; cannab
Polymorphisms in mTORC1 Genes Modulate Risk of Esophageal Squamous Cell Carcinoma in Eastern Chinese Populations
Keywords: mTORC1; Genetic polymorphisms; Risk; Esophageal cancer; Gene–environment interaction
Post-translational regulation of mTOR complex 1 in hypoxia and reoxygenation
Keywords: mTORC1; Hypoxia; Reoxygenation; HIF-1α; REDD1; Prolyl hydroxylases;
Akt and mTORC1 Have Different Roles During Liver Tumorigenesis in Mice
Keywords: Liver Cancer; Mouse Model; Signal Transduction; Gene Disruption; Akt; v-akt murine thymoma viral oncogene homolog 1; Alb; albumin; DKO; double knock-out; DMEM; Dulbecco's modified Eagle medium; EGF; epidermal growth factor; FBS; fetal bovine serum; FGFR1;
β-Arrestin signal complex plays a critical role in adipose differentiation
Keywords: GHSR1a; growth hormone secretagogue receptor type 1a; PPARγ; peroxisome proliferator-activated receptor; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT/enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; PI3K; phosphatidy
Amino acid sensing and regulation of mTORC1
Keywords: Amino acid; Sensing; Regulation; mTORC1;
Autophagy and cancer cell metabolism
Keywords: mTORC1; mammalian target of rapamycin complex 1; ULK1; Unc-51-like kinase complex; Atg; autophagy-related protein; TSC; tuberous sclerosis complex; AMP; adenosine monophosphate; AMPK; AMP kinase; HIF; hypoxia-inducible factor; MAP1LC3B or LC3; microtubule
The late endosome/lysosome-anchored p18-mTORC1 pathway controls terminal maturation of lysosomes
Keywords: Endosome; Late endosome; Lysosome; p18; LAMTOR1; mTORC1
p62: a versatile multitasker takes on cancer
Keywords: p62; sequestosome1; NF-κB; NRF2; mTORC1; atypical PKCs; cancer; autophagy
Proline-rich Akt substrate of 40Â kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway
Keywords: PRAS40; PI3k/Akt; mTORC1; Insulin resistance; Tumorigenesis;
Mitochondrial Ca2+ signals in autophagy
Keywords: mTOR; mammalian target of rapamycin; InsP3R; inositol 1,4,5-trisphosphate receptor; AMPK; adenosine monophosphate activated protein kinase; mTORC1; mammalian target of rapamycin complex 1; GAP; GTPase activating protein; TSC1/TSC2; tuberous sclerosis comp
Impaired social interactions and motor learning skills in tuberous sclerosis complex model mice expressing a dominant/negative form of tuberin
Keywords: ADHD; attention deficit hyperactivity disorder; ASD; autism spectrum disorders; GAP; GTPase-activating protein; TSC; tuberous sclerosis complex; TSC2-DN; TSC2-dominant/negative; Tuberous sclerosis complex; Autism; TSC2; GAP domain; mTORC1; Social interact
Perifosine sensitizes UVB-induced apoptosis in skin cells: New implication of skin cancer prevention?
Keywords: UVB; Ultraviolet B; NAC; N-acetyl-L-cysteine; ROS; reactive oxygen species; JNK; c-Jun-NH2-kinase; PDMP; 1-Phenyl-2-decanoylamino-3-morpholino-1-propanol; AMPK; AMP-activated protein kinas; ACC; Acetyl-CoA carboxylase; mTOR; Mammalian target of rapamycin;
Hydrophobic statins induce autophagy and cell death in human rhabdomyosarcoma cells by depleting geranylgeranyl diphosphate
Keywords: Statin; Autophagy; Rhabdomyolysis; Geranylgeranyl diphosphate; mTORC1;
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling
Keywords: mTORC1; mTORC2; endoplasmic reticulum stress; unfolded protein response; anabolism; apoptosis
Metabotropic glutamate receptor-dependent long-term depression is impaired due to elevated ERK signaling in the ÎRG mouse model of tuberous sclerosis complex
Keywords: 4E-BP; eIF4E binding protein; ACSF; artificial cerebrospinal fluid; CMV; cytomegalovirus; FXS; fragile X syndrome; GAP; GTPase-activating protein; GDP; guanosine diphosphate; GTP; guanosine triphosphate; mTORC1; mammalian target of rapamycin complex 1; Rh
The regulation of cancer cell death and metabolism by extracellular matrix attachment
Keywords: ECM; extra cellular matrix; ROS; reactive oxygen species; PPP; pentose phosphate pathway; TCA; tricarboxylic acid; PDH; pyruvate dehydrogenase; PDK4; pyruvate dehydrogenase kinase 4; ANGPTL4; angiopoietin-like 4; PK; pyruvate kinase; TIGAR; TP53-induced g
mTOR inhibition with rapamycin causes impaired insulin signalling and glucose uptake in human subcutaneous and omental adipocytes
Keywords: BCA; bicinchoninic acid protein; ECL; enhanced chemiluminescence; IR; insulin receptor; mTOR; mammalian target of rapamycin; mTORC1; mammalian target of rapamycin complex 1; mTORC2; mammalian target of rapamycin complex 2; NODAT; new onset diabetes after
Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners
Keywords: AMPK; AMP-activated protein kinase; ARF; ADP-ribosylation factor; CDK5; cyclin-dependent kinase 5; CEM; caveolin-enriched membrane; CRMP-2; collapsin response mediator protein-2; EGF; epidermal growth factor; EGFR; EGF receptor; GAP; GTPase-activating pro
K-Ras mutation-mediated IGF-1-induced feedback ERK activation contributes to the rapalog resistance in pancreatic ductal adenocarcinomas
Keywords: K-Ras; mTORC1; Rapalog; ERK; Pancreatic cancer
Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin
Keywords: Cortical development; mTOR; mTORC1; mTORC2; Neural progenitor cell; Radial glia;
Rapid induction of REDD1 expression by endurance exercise in rat skeletal muscle
Keywords: mTORC1; 4E-BP1; Protein synthesis
Sindbis virus replication, is insensitive to rapamycin and torin1, and suppresses Akt/mTOR pathway late during infection in HEK cells
Keywords: PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex1; mTORC2; mTOR complex2; S6K1; p70 S6 kinase1; S6; ribosomal protein S6; 4E-BP1; eIF4E1 binding protein1; eIF2α; eukaryotic initiation factor 2α; PKR; ds RNA
Imidazo[1,5-a]pyrazines: Orally efficacious inhibitors of mTORC1 and mTORC2
Keywords: mTOR; mTORC1; mTORC2; Imidazo[1,5-a]pyrazine; Oral inhibitor
CCCP induces autophagy in an AMPK-independent manner
Keywords: AMPK; CCCP; Autophagy; Mitophagy; mTORC1;