Keywords: AMD; Autophagy; βA3/A1-crystallin; Lysosome; mTORC1; Oxidative stress; RPE; V-ATPase
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Keywords: mTORC1; Raptor; Rapamycin; Lipodystrophy; Obesity; White Adipose Tissue (WAT)
The amino acid transporter PAT1 regulates mTORC1 in a nutrient-sensitive manner that requires its transport activity
Keywords: PAT1; mTORC1; Lysosome; Amino acids;
Loss of Leucyl-tRNA synthetase b leads to ILFS1-like symptoms in zebrafish
Keywords: ILFS1; Leucyl-tRNA synthetase b; Liver; mTORC1; Zebrafish; ILFS1; infantile liver failure syndromes type 1; LARS; leucyl-tRNA synthetase; larsb; leucyl-tRNA synthetase b; aaRSs; aminoacyl-tRNA synthetases; mTORC1; mechanistic target of rapamycin complex 1
Different concentrations of docosahexanoic acid supplement during lactation result in different outcomes in preterm Sprague-Dawley rats
Keywords: DHA; Docosahexanoic acid; LCPUFA; long chain polyunsaturated fatty acid; PKB; protein kinase B; mTORC1; mammalian target of rapamycin complex 1; Sug; sufficient DHA Group; Eng; enriched DHA Group; Exg; excess DHA Group; DeG; deficient DHA Group; PND; post
MTOR pathway in focal cortical dysplasia type 2: What do we know?
Keywords: FCD; focal cortical dysplasia; FCD II; focal cortical dysplasia type 2; FLE; frontal lobe epilepsy; GG; ganglioglioma; HME; hemimegalencephaly; ILAE; International League Against Epilepsy; MCD; malformation of cortical development; MPPH; megalencephaly-
Apoptosis and pro-death autophagy induced by a spirostanol saponin isolated from Rohdea chinensis (Baker) N. Tanaka (synonym Tupistra chinensis Baker) on HL-60 cells
Keywords: Spirostanol saponin; Autophagy; Apoptosis; Rohdea chinensis; Human acute promyelocytic leukemia; Akt; protein kinase B; AMPK; adenosine 5â²-monophosphate-activated protein kinase; Baf-A1; bafilomycin A1; FBS; fetal bovine serum; JC-1; 5,5´,6,6´-tetrach
Melanoma metabolism contributes to the cellular responses to MAPK/ERK pathway inhibitors
Keywords: MAPK; mitogen-activated protein kinase; BRAF; v-raf murine sarcoma viral oncogene homolog B1; MEK; mitogen-activated protein/extracellular signal- regulated kinase kinase; ERK; extracellular signal-regulated kinase; HIF-1α; hypoxia inducible factor 1 alp
Activation of mTORC1 in chondrocytes does not affect proliferation or differentiation, but causes the resting zone of the growth plate to become disordered
Keywords: Chondrocyte; Growth plate; mTORC1; Tsc1; Knockout mice; Col2-Cre; Cre;
mTORC1-dependent increase in oxidative metabolism in POMC neurons regulates food intake and action of leptin
Keywords: Hypothalamus; Reactive oxygen species; mTORC1; Leptin; Food intake; POMC;
Reciprocity in ROS and autophagic signaling
Keywords: ROS; Autophagy; Mitophagy; Pexophagy; Ferritinophagy; ULK1; AMPK; mTORC1; PIK3C3; ATG4; p62; NBR1; PEX2; PEX5; NCOA4; KEAP1; Nrf2;
A role for Glucagon-Like Peptide-1 in the regulation of β-cell autophagy
Keywords: Akt; protein kinase B; Ambra1; Autophagy And Beclin 1 Regulator 1; AMPK; 5â² AMP-activated protein kinase; Atg; autophagy related proteins; CAMKK; Ca2+/calmodulin-dependent protein kinase kinase; DFCP1; double FYVE-containing protein 1; DPP4; dipeptidyl
Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients
Keywords: mTORC1; Stat3; Inflammation; Drug target; Psychiatric disorders; Microglia; Phosphoflow;
The effects of L-type amino acid transporter 1 on milk protein synthesis in mammary glands of dairy cows
Keywords: mammary gland; LAT1; milk protein; mTORC1;
Hyperglycemia-induced Bcl-2/Bax-mediated apoptosis of Schwann cells via mTORC1/S6K1 inhibition in diabetic peripheral neuropathy
Keywords: Diabetic peripheral neuropathy; Schwann cell; Apoptosis; mTORC1; S6K1; Bcl-2; Bax;
Vacuolar ATPase in phago(lyso)some biology
Keywords: DAMP; 3 (2,4-dinitroanilino)-30-amino-N-methyldipropylamine; mTORC1; mechanistic target of rapamycin complex 1; SNARE; soluble N-ethylmaleimide sensitive factor attachment protein receptors; V-ATPase; vacuolar ATPase; Intracellular pathogen; pH quantifica
Enhanced Repair of UV-Induced DNA Damage by 1,25-Dihydroxyvitamin D3 in Skin Is Linked to Pathways that Control Cellular Energy
Keywords: 1,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 2-dG; 2-deoxy-d-glucose; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; Akt; acutely transforming retrovirus AKT8 in rodent T-cell lymphoma; CPD; cyclobutane pyrimidine dimer; ÎÏm; mitochondrial membrane potential; ECAR; e
microRNA-181a downregulates deptor for TGFβ-induced glomerular mesangial cell hypertrophy and matrix protein expression
Keywords: Glomerulosclerosis; miR-181a; Deptor; mTORC1;
Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia
Keywords: COPD; Chronic obstructive pulmonary disease; extensor digitorum longus; EDL; fl; fiber lengths; gastrocnemius; Gastroc; IFN-β; interferon-beta; mTORC1; mechanistic target of rapamycin complex 1; mN; milliNewton; MuRF-1; Muscle ring finger-1; MyHC; Myosin
Takeda G Protein-Coupled Receptor 5-Mechanistic Target of Rapamycin Complex 1 Signaling Contributes to the Increment of Glucagon-Like Peptide-1 Production after Roux-en-Y Gastric Bypass
Keywords: BAs; Bile acids; Cyp7a1; Cytochrome P450 family 7 subfamily A member 1; DCA; Deoxycholic acid; FXR; Farnesoid X receptor; GLP-1; Glucagon-like peptide-1; ip; Intraperitoneal; mTOR; mechanistic target of rapamycin; mTORC1; mechanistic target of rapamycin c
Anti-tumor effect of AZD8055 against neuroblastoma cells in vitro and in vivo
Keywords: NB; Neuroblastoma; IGF; Insulin and insulin-like growth factors; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; mTORC2; mTOR complex 2; p70S6K; p70 ribosomal protein S6 kinase; 4E-BP1; eukaryotic translat
PKM2, a potential target for regulating cancer
Keywords: PK; pyruvate kinase; HCC; hepatocellular carcinoma; FBP; fructose 1,6-bisphosphate; SAICAR; Succinyl-5-aminoimidazole-4-carboxamide-1-ribose-50-phosphate; hnRNPs; heterogeneous nuclear ribonucleoproteins; PTB; polypyrimidine tract-binding protein; NEK2; n
Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFα signaling
Keywords: Akt; AKT serine/threonine kinase 1; BCA; bicinchoninic acid; BRAF; B-Raf proto-oncogene, serine/threonine kinas; COX-2; cyclooxygenase-2; CUR; curcumin; CYP3A4; cytochrome P450 3A4; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; eEF2; eukaryotic translati
Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice
Keywords: Fatty Liver; Gene Regulation; Hepatic Protection; Mouse Model; Ad; adenovirus; AH; alcoholic hepatitis; ALD; alcoholic liver disease; ALT; alanine aminotransferase; ATP6V0E1; ATPase H+ transporting V0 subunit E1; ATP6V1D; ATPase H+ transporting V1 subunit
In situ analysis of mTORC1/2 and cellular metabolism-related proteins in human Lymphangioleiomyomatosis
Keywords: ACSS2; acyl-coenzyme A synthetase short-chain family member 2; ATPB; β-F1-ATPase; BSM; bronchial smooth muscle; CPT1A; carnitine palmitoyltransferase 1A; ER; estrogen receptor; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GLS; glutaminase; GLUT1; glu
Small molecules bind human mTOR protein and inhibit mTORC1 specifically
Keywords: mTOR; mTORC1; mTORC2; Piperazine; Cinnarizine; Hydroxyzine; Cancer;
Antileukemic effect of paclitaxel in combination with metformin in HL-60 cell line
Keywords: APL; acute promyelocytic leukemia; AML; acute myeloid leukemia; PML/RARα; promyelocytic leukemia/retinoic acid receptor α; ATRA; all-trans retinoic acid; ATO; arsenic trioxide; T2DM; Type 2 Diabetes Mellitus; mTORC1; rapamycin complex 1; AMPK; AMP-activ
Cardiac natriuretic peptides promote adipose 'browning' through mTOR complex-1
Keywords: Thermogenesis; UCP1; Kinases; βAR; β-adrenergic receptor; 8-Br-cAMP; 8-Bromoadenosine 3â²,5â²-cyclic monophosphate; 8-Br-cGMP; 8-Bromoguanosine 3â²,5â²-cyclic monophosphate; Akt; protein kinase B; ANP; Atrial natriuretic peptide; BNP; B-type natriur
Systemic L-buthionine-S-R-sulfoximine administration modulates glutathione homeostasis via NGF/TrkA and mTOR signaling in the cerebellum
Keywords: GSH; Cysteine transport; NGF; mTOR; Redox; Cerebellum; 4F2hc; 4F2 cell surface antigen; BBB; blood-brain barrier; BSO; L-buthionine-S-R-sulfoximine; CNS; central nervous system; DAPI; 4â²,6-diamidino-2-phenylindole DTPA; diethylenetriamine penta-acetic a
Hydroxychloroquine efficiently suppresses inflammatory responses of human class-switched memory B cells via Toll-like receptor 9 inhibition
Keywords: Hydroxychloroquine; Toll-like receptor 9; Human B cell; Plasmablast; CFSE; carboxyfluorescein succinimidyl ester; CD; Cluster of differentiation; CpG; cytosine-phosphate-guanine; dsDNA; double-stranded DNA; IFN; interferon; Ig; immunoglobulin; LPS; lipopo
ZBTB38, a novel regulator of autophagy initiation targeted by RB1CC1/FIP200 in spinal cord injury
Keywords: ATG2; autophagy-related protein 2; ATG13; autophagy-related protein 13; ATG14; autophagy-related protein 14; ATG101; autophagy-related protein 101; ATM; ataxia telangiectasia-mutated gene; BECN1; the homologue of yeast autophagy-related protein 6; CCK-8;
Neural progenitors derived from Tuberous Sclerosis Complex patients exhibit attenuated PI3K/AKT signaling and delayed neuronal differentiation
Keywords: TSC; Tuberous Sclerosis Complex; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; LOH; loss of heterozygosity; iPSCs; induced pluripotent stem cells; NPCs; neural progenitor cells; PI3K; phosphoinositide 3-kinase; SENs; subependymal nodules; S
α1A-Adrenoceptors activate mTOR signalling and glucose uptake in cardiomyocytes
Keywords: AMPK; 5â² adenosine monophosphate-activated protein kinase; AR; adrenoceptor; CaMKK; calmodulin-dependent protein kinase kinase; CHO; Chinese hamster ovary; Comp C; compound C; DAG; diacylglycerol; IP3; inositol 1,4,5-trisphosphate; mTOR; mechanistic tar
ROS signalling in the biology of cancer
Keywords: AEJ; alternative end joining; ALL; acute lymphoblastic leukaemia; AML; acute myeloid leukaemia; Apaf-1; apoptotic protein activating factor 1; APL; acute promyelocytic leukaemia; ASK1; apoptosis signal regulating kinase 1; Bcr-Abl; breakpoint cluster-Abel
Agmatine potentiates neuroprotective effects of subthreshold concentrations of ketamine via mTOR/S6 kinase signaling pathway
Keywords: Agmatine; Akt; HT22; Ketamine; Neuroprotection; p70S6 kinase; PSD95; 4E-BPs; 4E binding proteins; ANOVA; analysis of variance; DMEM; Dulbecco's Modified Eagle Medium; ECT; electroconvulsive therapy; CUS; chronic unpredictable stress; FST; forced swim test
Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin
Keywords: Nrf2 activation; Pyridone; Enone; Aldol condensation; Nrf2; nuclear factor erythroid 2 related factor 2; CNS; central nervous system; Keap1; Kelch-like ECH associated protein 1; NF-κB; nuclear factor kappa-light-chain enhancer of activated B cells; Maf;
Multifunctional molecule ERp57: From cancer to neurodegenerative diseases
Keywords: 1α,25(OH)2D3; 1,25-dihydroxyvitamin D3; ADAM10; a disintegrin and metalloproteinase 10; AIF; apoptosis-inducing factor; AP-1; activator protein 1; ATRA; all-trans retinoic acid; BMP-2; bone morphogenic protein 2; CLNX; calnexin; CRT; calreticulin; ECM; e
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
Keywords: Vascular smooth muscle; Vasoproliferative disease; Vascular smooth muscle cell; Phenotype switching; Signalling pathways; AJ; adherens junction; ApoE; apolipoprotein E; BMP; bone morphogenetic protein; CAD; coronary artery diseases; CADASIL; cerebral auto
Modulating autophagy in cancer therapy: Advancements and challenges for cancer cell death sensitization
Keywords: 3-MA; 3-Methyl Adenine; Akt; Protein kinase B; AMP; Adenosine monophosphate; AMPK; AMP-activated protein kinase; Atg; Autophagy related genes; ATP; Adenosine triphosphate; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; BCL-2; B-
Autophagy in ischemic stroke
Keywords: 3-MA; 3-methyladenine; Aβ; amyloid β; AIF; apoptosis-inducing factor; Akt; protein kinase B; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; Atg; autophagy-related genes; ATP; adenosine 5â²-triphosphate; BBB; blood-brain ba
Bacterial Autophagy: Offense and Defense at the Host-Pathogen Interface
Keywords: Autophagy; Xenophagy; Salmonella; FAK; Akt; Interferon; DAG; diacylglycerol; FAK; focal adhesion kinase; IFN; interferon; LC3; microtubule-associated light chain 3; mTORC1; mechanistic target of rapamycin 1; SCV; Salmonella-containing vacuole; TLR; Toll-l
Mini-reviewmTOR signaling in immune cells and its implications for cancer immunotherapy
Keywords: mTOR-mediated metabolism; mTORC1; mTORC2; Goldilocks mTOR; Cancer immunotherapy;
Characterization of overexpression of the alternatively spliced isoform of the protein phosphatase 2A catalytic subunit in cells
Keywords: Protein phosphatase 2A; Splicing isoform; Autophagy; mTORC1; Anchorage-independent growth;
Original ArticleRepletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution
Keywords: BCAA; Dietary protein; FGF21; mTORC1; Diabetes; PD; protein dilution; AA; amino acid; BCAA; branched chain amino acid; AAD; amino acid diluted; mTORC1; mammalian target of rapamycin complex 1; ISR; integrated stress response; HF; high fat; NZB; New Zealan
Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase
Keywords: AMPK; mTORC1; eEF2K; eEF2; Compound 991; Translation;
Mosaic Disorders of the PI3K/PTEN/AKT/TSC/mTORC1 Signaling Pathway
Keywords: Mosaicism; mTORC1; PIK3CA-related overgrowth spectrum; Proteus syndrome; Tuberous sclerosis complex; PTEN hamartoma tumor syndrome; Next-generation sequencing; Sirolimus;
Phosphorylation of Tudor-SN, a novel substrate of JNK, is involved in the efficient recruitment of Tudor-SN into stress granules
Keywords: SG; stress granule; Tudor-SN; Tudor staphylococcal nuclease; JNK; c-Jun N-terminal kinase; PKR; protein kinase R; PERK; PKR-like endoplasmic reticulum kinase; GCN2; general control nonderepressible 2; HRI; heme-regulated inhibitor kinase; eIF2α; eukaryot
Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish
Keywords: Ribosome biogenesis protein; Urb1; Digestive organ development; mTORC1; Zebrafish;
Electric field-induced suppression of PTEN drives epithelial-to-mesenchymal transition via mTORC1 activation
Keywords: Electric fields; Epithelial-to-mesenchymal transition; Keratinocyte; Migration; PTEN; mTORC1;
Original ArticleAspirin disrupts the mTOR-Raptor complex and potentiates the anti-cancer activities of sorafenib via mTORC1 inhibition
Keywords: Aspirin; mTORC1; AMPK; Sorafenib; Proliferation; AMPK; Adenosine 5'-monophosphate (AMP)-activated protein kinase; mTOR; mammalian target of rapamycin; MEF; mouse embryonic fibroblast; TSC2; Tuberous sclerosis 1; NSAID; non-steroidal anti-inflammatory dr