Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Nrf2; Hepatotoxicity; Natural products; Curcumin; Sulforaphane; Antioxidant response element; (ARE); Kelch-like ECH-associated protein 1; (Keap1); Glutathione S-transferase; (GST); NAD(P)H:quinone oxidoreductase 1; (NQO1); Nuclear factor erythroid 2 (NFE2
مقالات ISI NAD (P) H: کینون اکسیدوردوکتاز 1 (ترجمه نشده)
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Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Menadione; Pregnancy; Carbon monoxide; Mouse placenta; Pre-eclampsia; AdsFlt-1; adenovirus soluble fms-like tyrosine kinase-1; CO; carbon monoxide; COHb; carboxyhemoglobin; CPR; cytochrome p450 reductase; EGD; early gestational demise; LGD; late gestation
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; ACS; Acyl-CoA synthetase; ARE/EpRE; Antioxidant/electrophile response element; Bcl-2; B-cell lymphoma 2; BMI; Body mass index; BSP; Broccoli sprout powder; CAT; Catalase; C/EBP; CCAAT/enhancer-binding protein; CD36; CD36 molecule/thrombospondin receptor;
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Cancer; Target therapy; Prodrug; MDR; Multidrug resistance; ROS; Reactive oxygen species; GSH; Glutathione; ADCs; Antibody-drug conjugates; ADEPT; Antibody-directed enzyme prodrug therapy; GDEPT; Gene-directed enzyme prodrug therapy; HIF; Hypoxia-inducibl
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Q3G; quercetin 3-O-β-glucoside; Q4â²G; quercetin 4â²-O-β-glucoside; OPAC; 3-hydroxyphenylacetic acid; DOPAC; 3,4-dihydroxyphenylacetic acid; PCA; protocatechuic acid (3,4-dihydroxybenzoic acid); HPA; hippuric acid; DPPH; 1,1-diphenyl-2-picrylhydrazyl;
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; NO2-FA; Nitro-fatty acids; SOD1; Cu/Zn superoxide dismutase; ALS; Amyotrophic Lateral Sclerosis; NO2-OA; Nitro-oleic acid; NO2-AA; Nitro-arachidonic acid; Nrf2; Nuclear factor-erythroid 2-related factor 2; ARE; Antioxidant Response Element; Keap1; Kelch-l
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; PAPS; 3â²-Phosphoadenosine 5â²-phosphosulfate; DTNB; 5,5â²-Dithiobis(2-nitrobenzoic acid); APAP; Acetaminophen; ALT; Alanine aminotrasferase; BSA; Bovine serum albumin; CCl4; Carbon tetrachloride; Ccr2; C-C chemokine receptor 2; CFB; Clofibrate; CD;
Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; AhR; aryl hydrocarbon receptor; AP1; activating protein 1; ARE; antioxidant-response element; CAR; constitutive androstane receptor; CYP; cytochrome P450; DREs; dioxin-responsive elements; EMSA; electromobility gel shift assay; FBS; fetal bovine serum; GS
Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; AhR; aryl hydrocarbon receptor; BaP; benzo[a]pyrene; BPDE; benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; COMT; catechol-O-methyltransferase; CYP; cytochrome P450; EE2; 17α-ethinylestradiol; DMSO; dimethylsulfoxide; ED; endocrine disruptor; dG-N2-BPDE; 10-
Moringa oleifera and their phytonanoparticles: Potential antiproliferative agents against cancer
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; ARE; antioxidant response element; CPT1; carnitine palmitoyltransferase I; CPTII; carnitine palmitoyltransferase II; associated 9 (Cas9); clustered regulatory interspaced short palindromic repeat (CRISPR); DEN; diethyl nitrosamine; DMBA; 7, 12 dimethylben
Facilitation of 9,10-phenanthrenequinone-elicited neuroblastoma cell apoptosis by NAD(P)H:quinone oxidoreductase 1
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; 9,10-Phenanthrenequinone; Neuroblastoma cell; Apoptosis; Reactive oxygen species; Antioxidant property; NAD(P)H:quinone oxidoreductase 1; AKR; aldo-keto reductase; AMC; 7-amido-4-methylcoumarin; ATM; ataxia telangiectasia mutated kinase; BSO; dl-buthionin
MicroRNA-494 inhibition alleviates acute lung injury through Nrf2 signaling pathway via NQO1 in sepsis-associated acute respiratory distress syndrome
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; MicroRNA-494; Sepsis-associated acute respiratory distress syndrome; NAD(P)H:quinone oxidoreductase 1; Nuclear factor E2 p45-related factor 2; Acute lung injury;
NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; NRF2; Alcohol; Hepatic injury; Pancreatic injury; Alcoholism; ADH1; alcohol dehydrogenase 1; ALD; alcoholic liver disease; ALDH; aldehyde dehydrogenase; AMS; amylase; ALT; alanine transaminase; ARE; antioxidant response element; AST; aspartate aminotransf
Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; NASH; Nrf2; TBE-31; ACACA; acetyl-CoA carboxylase alpha; ACLY; ATP citrate lyase; ACOT7; acetyl-CoA thioesterase 7; ACOX2; acetyl-CoA oxidase 2; ADRP; adipose differentiation-related protein; AP-1; activator protein 1; ApoB; apolipoprotein B; ATF4; activa
Toralactone glycoside in Cassia obtusifolia mediates hepatoprotection via an Nrf2-dependent anti-oxidative mechanism
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; LC-MS; liquid chromatography-mass spectrometry; NMR; nuclear magnetic resonance; DMSO; dimethyl sulfoxide; HPLC; high-performance liquid chromatography; Nrf2; nuclear factor erythroid-2-related factor 2; NQO1; NAD(P)H:quinone oxidoreductase 1; HO-1; heme
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Oxadiazole-substituted naphtho[2,3-b]thiophene-4,9-diones as potent inhibitors of keratinocyte hyperproliferation. Structureâactivity relationships of the tricyclic quinone skeleton and the oxadiazole substituent
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Antiproliferative activity; HaCaT cells; Quinone; Redox activation; Superoxide radical; 7-AAD; 7-aminoactinomycin D; CPR; NADPH-cytochrome P450 oxidoreductase; DCC; N,N'-dicyclohexylcarbodiimide; DHE; dihydroethidium; DMAP; 4-(dimethylamino)pyridine; DTPA
RelB attenuates cigarette smoke extract-induced apoptosis in association with transcriptional regulation of the aryl hydrocarbon receptor
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; bHLH/PAS; basic helix-loop-helix/PER-ARNT-Sim; COPD; chronic obstructive pulmonary disease; ChiP; chromatin immunoprecipitation; CYP; cytochrome P450; NQO1; NAD(P)H:quinone oxidoreductase 1; SOD; supe
β-Lapachone enhances Mre11-Rad50-Nbs1 complex expression in cisplatin-induced nephrotoxicity
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; β-Lapachone; NAD(P)H:quinone oxidoreductase 1; DNA damage; Nephrotoxicity; SIRTuin1;
Deletion of NAD(P)H:quinone oxidoreductase 1 represses Mre11-Rad50-Nbs1 complex protein expression in cisplatin-induced nephrotoxicity
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; AKI; acute kidney injury; ATM; ataxia telangiectasia mutated; DSBs; double-strand breaks; MRN; Mre11, Rad50, and Nbs1; NQO1; NAD(P)H:quinone oxidoreductase 1; NAD; nicotinamide adenine dinucleotide; NQO1; NAD(P)H:quinone oxidoreductase 1; PARP1; poly[ADP-
8-Halo-substituted naphtho[2,3-b]thiophene-4,9-diones as redox-active inhibitors of keratinocyte hyperproliferation with reduced membrane-damaging properties
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Antiproliferative activity; HaCaT cells; Naphtho[2,3-b]thiophene-4,9-diones; Quinone; Redox activation; Superoxide radical; CPR; NADPH-cytochrome P450 oxidoreductase; DCC; N,Nâ²-dicyclohexylcarbodiimide; DHE; dihydroethidium; DMAP; 4-dimethylaminopyridin
The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; FLU; flutamide; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; CYP; cytochrome P450; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; 3-MC; 3-methylcholanthrene; ABCC4; ATP-binding cassette sub-family C member 4; MRP4; mul
Epigallocatechin-3-gallate enhances key enzymatic activities of hepatic thioredoxin and glutathione systems in selenium-optimal mice but activates hepatic Nrf2 responses in selenium-deficient mice
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BSO; buthionine sulfoximine; CDNB; 1-chloro-2, 4-dinitrobenzene; ECL; enhanced chemiluminescense; EDTA; ethylene diamine tetraacetic acid; EGCG; epigallocatechin-3-gallate; FoxO; Forkhead box
Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; ARE; antioxidant response elements; A1AT; α-1-antitrypsin; COPD; chronic obstructive pulmonary disease; CR; coding region; FL; firefly luciferase; GRB; growth factor receptor-bound protein; IP; immunoprecipitation; Keap1; Kelch-like ECH-associated protei
Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; ARE; antioxidant response element; ATP; adenosine triphosphate; 5-hmC; hydroxymethylcytosine; ATG; AuTophaGy related; BNIP; Bcl-2/adenovirus E18 19-kDa-interacting protein; Drp1; dynamin related protein 1; EpRE; electrophile response element; eNOS; endoth
Associate Editor: P. MolenaarActivation of endogenous antioxidants as a common therapeutic strategy against cancer, neurodegeneration and cardiovascular diseases: A lesson learnt from DJ-1
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; DJ-1; Endogenous antioxidant; Mechanism-oriented therapy; Disease-oriented therapy; ASK1; apoptosis signal regulating kinase; JNK; Jun N-terminal kinase; NQO1; NAD(P)H:quinone oxidoreductase 1; Nrf2; nuclear factor erythroid 2-related factor; p53; tumor p
Regular ArticleTwo enzymes catalyze vitamin K 2,3-epoxide reductase activity in mouse: VKORC1 is highly expressed in exocrine tissues while VKORC1L1 is highly expressed in brain
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; DTT; dithiothreitol; Gas6; Growth arrest-specific protein 6; GGCX; γ-glutamyl carboxylase; Gla; γ-glutamyl dicarboxylic acid; MGP; matrix Gla-protein; NQO1; NAD(P)H:quinone oxidoreductase 1; VKD; vitamin K-dependent; VKOR; vitamin K 2,3-epoxide reductas
Selective antagonization of activated Nrf2 and inhibition of cancer cell proliferation by procyanidins from Cinnamomi Cortex extract
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Nrf2; Cinnamomi Cortex; Cancer cells; Antiproliferation; Procyanidin; Suppression; ARE; antioxidant response element; CCE; Cinnamomi Cortex extract; GST; glutathione S-transferase; Keap1; Kelch-like ECH-associated protein 1; NQO1; NAD(P)H:quinone oxidored
The role of Nrf2 in protection against Pb-induced oxidative stress and apoptosis in SH-SY5Y cells
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Lead; Neurotoxicity; Nrf2; Oxidative stress; Antioxidant gene; ARE; antioxidant response element; BSO; buthionine sulfoximine; DCFH-DA; 2â²7â²-dichlorodihydrofluorescein diacetate; DMSA; dimercaptosuccinic acid; DPI; diphenyliodonium chloride; EMSA; Ele
The molecular mechanism underlying the hepatoprotective potential of Moringa oleifera leaves extract against acetaminophen induced hepatotoxicity in mice
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Antioxidant enzyme; Antioxidant response element (ARE); Cytochrome P450 2E1/1A2/2A6; Inflammatory cytokines; Nuclear factor erythroid 2-related factor 2 (Nrf2); MO; Moringa oleifera; APAP; acetaminophen; GSH; glutathione; Nrf2; nuclear factor-erythroid 2
Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; AEC; Airway epithelial cell; AOE; Antioxidant enzyme; ARE; Antioxidant response element; BHA; Butylated hydroxyanisole; ChIP; Chromatin immunoprecipitation; GCLC; Glutamyl cysteine ligase-catalytic; GPX1; Glutathione peroxidase 1; HDAC; Histone deacetylas
Functional polymorphisms in Nrf2: implications for human disease
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; AAO; age at onset; ALI; acute lung injury; AMD; age-related macular degeneration; ARE; antioxidant response element; BPD; bronchopulmonary dysplasia; β-TrCP; β-transducin repeats-containing proteins; CCA; cholangiocarcinoma; Cns; non-synonymous coding;
PPARγ activation rescues mitochondrial function from inhibition of complex I and loss of PINK1
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; PD; Parkinson's disease; PPARγ; peroxisome proliferator-activated receptor gamma; TZDs; thiazolidinediones; RGS; Rosiglitazone; ÎΨm; Mitochondrial membrane potential; ROS; reactive oxygen species; PI; propidium Iodide; TMRM; Tetramethylrhodamine methyl
Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; OC; osteoclast; M-CSF; macrophage colony-stimulating factor; NF-κB; nuclear factor-κB; RANKL; receptor activator of NF-κB ligand; TNF; tumor necrosis factor; TRAF; TNF receptor-associated factor; MAPK; mitogen-activated protein kinase; JNK; c-Jun N-ter
Seaweed extracts and unsaturated fatty acid constituents from the green alga Ulva lactuca as activators of the cytoprotective Nrf2-ARE pathway
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; ARE; antioxidant-response element; AP-1; activator protein-1; DEM; diethyl maleate; GCLC; glutamate-cysteine ligase, catalytic subunit; GCLM; glutamate-cysteine ligase, modifier subunit; GSH; glutathione; GSTA4; glutathione S-transferase Alpha 4; HMOX
Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Hepatitis B virus X protein; NAD(P)H:quinone oxidoreductase 1; Hepatocellular carcinoma; Epigenetic modification; Mitochondrial injury; Redox status; Free radicals;
ReviewBlack cohosh: Coming full circle?
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; CE; catecholestrogen; CYP; cytochrome P450; GST; glutathione-S-transferase; NMS; N-Ï-methylserotonin; NE; norepinephrine; PMS; premenstrual syndrome; NQO1; NAD(P)H:quinone oxidoreductase 1; TRPV; transient receptor potential vanilloid; Analgesic; Antinoc
The effects of idebenone on mitochondrial bioenergetics
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; CRC; calcium retention capacity; Cs; cyclosporin; DMEM; Dulbecco's modified Eagle's medium; ÎÏm; mitochondrial membrane potential difference; DTT; dithiothreitol; FCCP; carbonylcyanide-p-trifluoromethoxyphenyl hydrazone; LHON; Leber's hereditary optic n
Dual effects of N-acetyl-l-cysteine dependent on NQO1 activity: Suppressive or promotive of 9,10-phenanthrenequinone-induced toxicity
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; BSFGE; biased sinusoidal field gel electrophoresis; DCFH-DA; 6-carboxy-2, 7â²-diclorodihydrofluorescein diacetate, di(acetoxymethyl ester); DCPIP; 2,6-dichlorophenol-indophenol; DSBs; double strand breaks; DTT; dithiothreitol; GSH; glutathione; γ-H2AX;
Effect of oxidative stress on UDP-glucuronosyltransferases in rat astrocytes
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; UDP-glucuronosyltransferase; Astrocytes; Oxidative stress; NADPH:cytochrome P450 reductase; NAD(P)H:quinone oxidoreductase 1; 1-NP; 1-naphthol; ARE; antioxidant response element; DMSO; dimethyl sulfoxyde; FeHQ; FeCl3/8-hydroxyquinoline; FITC; fluorescein
Research ArticleBak deficiency inhibits liver carcinogenesis: A causal link between apoptosis and carcinogenesis
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; HCC; hepatocellular carcinoma; ALT; alanine aminotransferase; RT-PCR; reverse-transcription PCR; HO-1; heme oxygenase-1; NQO1; NAD(P)H:quinone oxidoreductase 1; 8-OHdG; 8-hydroxy-2â²-deoxyguanosine; TUNEL; terminal deoxynucleotidyl transferase-mediated d
Role of GSTM1 in resistance to lung inflammation
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; GSTM1; glutathione S-transferase Mu 1; IL-8; interleukin 8; ROS; reactive oxygen species; NF-κB; nuclear factor κB; COPD; chronic obstructive pulmonary disease; GSH; glutathione; JNK; c-Jun N-terminal kinase; ASK; apoptosis-signal regulating kinase; ARE
Validation of the multiple sensor mechanism of the Keap1-Nrf2 system
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; tBHQ; tert-butylhydroquinone; BTB; broad complex-tramtrack-bric a brad; CDDO-Im; 2-cyano-3,12 dioxooleana-1,9 diene-28-imidazolide; CDNB; 1-chloro-2,4-dinitrobenzene; DEM; diethylmaleate; DMF; dimethylfumarate; Gclc; glutamate-cysteine ligase catalytic su
NRF2 inhibition represses ErbB2 signaling in ovarian carcinoma cells: Implications for tumor growth retardation and docetaxel sensitivity
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; NRF2; NF-E2-related factor-2; ARE; antioxidant-response element; ROS; reactive oxygen species; GSH; glutathione; GCLC; catalytic subunit of γ-glutamate-cysteine ligase; NQO1; NAD(P)H:quinone oxidoreductase 1; UGT1A6; UDP-glucuronosyl transferase 1A6; A
The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; ARE; antioxidant response element; CNS; central nervous system; EDSS; Expanded Disability Status System; MS; multiple sclerosis; NQO1; NAD(P)H:quinone oxidoreductase 1; PCR; polymerase chain reaction; PP; primary progressive; RFLP; restriction fragment le
Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; AITC; allyl isothiocyanate; ARE; antioxidant response element; BITC; butyl isothiocyanate; CpG; cytosine-phospho-guanine; ERK; extracellular signal-regulated kinase; FCS; fetal calf serum; γGCS; γ-glutamyl cysteine synthetase; HO-1; heme oxygenase-1; IT
Characterization of the threshold for NAD(P)H:quinone oxidoreductase activity in intact sulforaphane-treated pulmonary arterial endothelial cells
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Lung; Pulmonary endothelium; Quinone; Pyridine nucleotides; NAD(P)H:quinone oxidoreductase 1; Mathematical model; Glucose-6-phosphate dehydrogenase; Sulforaphane; Free radicals
Nrf2-dependent induction of NQO1 in mouse aortic endothelial cells overexpressing catalase
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Endothelial cell; Catalase; NAD(P)H:quinone oxidoreductase 1; Aryl hydrocarbon receptor; Nuclear factor erythroid 2-related factor-2; Free radicals;
Cooperation of NAD(P)H:quinone oxidoreductase 1 and UDP-glucuronosyltransferases reduces menadione cytotoxicity in HEK293 cells
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; UDP-glucuronosyltransferase; NAD(P)H:quinone oxidoreductase 1; UGT1A6; UGT1A10; MenadioneCDNB, 1-chloro-2,4-dinitrobenzene; DCIP, 2,6-dichloroindophenol; Dox, doxycycline hydrochloride; Fp2, NADPH-cytochrome P450 reductase; GPx, glutathione peroxidase; GS
Functionalized aurones as inducers of NAD(P)H:quinone oxidoreductase 1 that activate AhR/XRE and Nrf2/ARE signaling pathways: Synthesis, evaluation and SAR
Keywords: NAD (P) H: کینون اکسیدوردوکتاز 1; Aurones; Chemoprevention; NAD(P)H:quinone oxidoreductase 1; Phase II enzyme inducers