Heterocyclic chalcone activators of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) with improved in vivo efficacy
Keywords: Chalcone; Nrf2; Keap1; Bioavailability; Solubility;
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Antioxidant and cytoprotective properties of partridgeberry polyphenols
Keywords: Partridgeberry; Lingonberry; Vaccinium vitis-idaea; Antioxidant; Polyphenol; Flavonoids; Fractionation; Cytoprotection; Nrf2; (â)-Epicatechin (PubChem CID: 72276); Caffeic acid (PubChem CID: 689043); Catechin (PubChem CID: 9064); Chlorogenic acid (PubCh
Nrf2-heme oxygenase-1 axis in mucoepidermoid carcinoma of the lung: Antitumoral effects associated with down-regulation of matrix metalloproteinases
Keywords: Mucoepidermoid carcinoma; Non-small cell lung cancer; Nrf2; Nuclear factor (erythroid-derived 2)-like 2; Heme oxygenase-1; Matrix metalloproteinases; MMP-1;
Copper exposure induces toxicity to the antioxidant system via the destruction of Nrf2/ARE signaling and caspase-3-regulated DNA damage in fish muscle: Amelioration by myo-inositol
Keywords: Muscle; Nrf2; Copper; myo-Inositol; DNA fragmentation; Carp;
Methamphetamine oxidative stress, neurotoxicity, and functional deficits are modulated by nuclear factor-E2-related factor 2
Keywords: Methamphetamine; Nrf2; Reactive oxygen species; DNA oxidation; Neurodegeneration; Behavioral abnormalities; Free radicals;
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
Keywords: AMC; 7-amino-4-methylcoumarin; CDDO-Me; methyl-2-cyano-3,12-dioxooleana-1, 9(11)dien-28-oate; DNCB; 2,4-dinitrochlorobenzene; Gclm; glutamate-cysteine ligase regulatory subunit; HIF-1α; hypoxia-inducible factor 1α; IAA; iodoacetamide; Keap1; Kelch-lik
Skin resistance to oxidative stress induced by resveratrol: From Nrf2 activation to GSH biosynthesis
Keywords: Resveratrol; Glutathione; Nrf2; Oxidative stress; Reconstructed human skin model; Normal human keratinocyte; Free radicals;
Characterization of skn-1/wdr-23 phenotypes in Caenorhabditis elegans; pleiotrophy, aging, glutathione, and interactions with other longevity pathways
Keywords: Detoxification; Nrf2; Dietary restriction;
The transcription factor Nrf2 is decreased after spontaneous term labour in human fetal membranes where it exerts anti-inflammatory properties
Keywords: Nrf2; Fetal membranes; Human labour; Inflammation;
Modulation of oxidized-LDL receptor-1 (LOX1) contributes to the antiatherosclerosis effect of oleanolic acid
Keywords: Ox-LDL; oxidized low density lipoprotein; HUVECs; human umbilical vein endothelial cells; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide; DCFDA; 2â²,7â²-dichlorofluorescein diacetate; ROS; reactive oxygen species; OA; oleanolic a
The role of Nrf2 in protection against Pb-induced oxidative stress and apoptosis in SH-SY5Y cells
Keywords: Lead; Neurotoxicity; Nrf2; Oxidative stress; Antioxidant gene; ARE; antioxidant response element; BSO; buthionine sulfoximine; DCFH-DA; 2â²7â²-dichlorodihydrofluorescein diacetate; DMSA; dimercaptosuccinic acid; DPI; diphenyliodonium chloride; EMSA; Ele
Erdosteine protects HEI-OC1 auditory cells from cisplatin toxicity through suppression of inflammatory cytokines and induction of Nrf2 target proteins
Keywords: AIF; apoptosis-inducing factor; Cisplatin; cis-diammine-dichloroplatinum II; Nrf2; NF-E2-related factor 2; OC; organ of Corti; PARP; poly ADP ribose polymerase; PUMA; p53-upregulated modulator of apoptosis;
Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy
Keywords: Nrf2; nuclear factor erythroid-2 related factor 2; Am. G; American ginseng; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; MCP-1; monocyte chemotactic protein-1; MIP-1β; macrophage inflammatory protein-1 beta; IL-1β; interleukin-1 beta;
Remote Ischemic Preconditioning for Kidney Protection: GSK3β-Centric Insights Into the Mechanism of Action
Keywords: Acute kidney injury (AKI); remote ischemic preconditioning (IPC); limb IPC; ischemia/reperfusion; glycogen synthase kinase 3β (GSK3β); NFκB; Nrf2; inflammation; mitochondria permeability transition (MPT); lithium; renal protection; review;
Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells
Keywords: Carnosic acid; Methylglyoxal; Oxidative stress; Akt; Nrf2
Manganese deficiency or excess caused the depression of intestinal immunity, induction of inflammation and dysfunction of the intestinal physical barrier, as regulated by NF-κB, TOR and Nrf2 signalling, in grass carp (Ctenopharyngodon idella)
Keywords: Manganese; Cytokine; Tight junction; Antioxidant status; TOR; Nrf2
Blockage of ROS and NF-κB-mediated inflammation by a new chalcone L6H9 protects cardiomyocytes from hyperglycemia-induced injuries
Keywords: DCM; diabetic cardiomyopathy; L6H9; (E)-2,6-difluoro-4â²-methoxychalcone; Cur; curcumin; DHE; dihydroethidium; HG; high glucose; ARE; antioxidant-responsive element; NQO-1; NADPH quinine oxidoreductase-1; ROS; reactive oxygen species; HO-1; heme oxygenas
The molecular mechanism underlying the hepatoprotective potential of Moringa oleifera leaves extract against acetaminophen induced hepatotoxicity in mice
Keywords: Antioxidant enzyme; Antioxidant response element (ARE); Cytochrome P450 2E1/1A2/2A6; Inflammatory cytokines; Nuclear factor erythroid 2-related factor 2 (Nrf2); MO; Moringa oleifera; APAP; acetaminophen; GSH; glutathione; Nrf2; nuclear factor-erythroid 2
Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene
Keywords: Nrf2; Histone; Epigenetic; Arsenic; HO-1; Antioxidant response element
Redox-regulated fate of neural stem progenitor cells
Keywords: ARE; antioxidant response element; bHLH; basic helix-loop-helix; BMI1; B lymphoma Mo-MLV insertion region 1 homolog; CtBPs; C-terminal binding proteins; DLL4; delta-like protein 4; DVL; disheveled; DOUX; dual oxidases; ES; embryonic stem cells; EGFR; epid
ReviewThe relation between α-synuclein and microglia in Parkinson's disease: Recent developments
Keywords: CSF; cerebrospinal fluid; FcgR; Fc gamma receptors; HO-1; heme oxygenase-1; IgG; immunoglobulin G; LPS; lipopolysaccharide; Nrf2; NF-E2-related factor 2; PD; Parkinson's disease; PET; positron emission tomography; rAAV; recombinant adeno-associated vira
Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a, and preserved endothelial function
Keywords: BP; blood pressure; CO; cardiac output; DP; developed pressure; DT; deceleration time; FMD; flow-mediated dilation; GC; guanylyl cyclase; IVRT; isovolumic relaxation time; KO; knock out; LV; left ventricular; MVET; mitral valve ejection time; Nrf2; nuclea
Nitroxide delivery system for Nrf2 activation and skin protection
Keywords: ME; microemulsion; SOD1; superoxide dismutase; TPO; tempo (2,2,6,6-tetramethyl-piperidine-1-oxyl); TPL, 4-OH-TPO; tempol (4-hydroxy-TEMPO, 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl); Nrf2; nuclear factor (erythroid derived 2)-like 2, NF-E2 related fac
Keap1–Nrf2 pathway: A promising target towards lung cancer prevention and therapeutics
Keywords: Cancer prevention; Keap1; Lung cancer; Nrf2
Transcriptomics hit the target: Monitoring of ligand-activated and stress response pathways for chemical testing
Keywords: AD; adefovir dipivoxil; AhR; aryl hydrocarbon receptor; AMIO; amiodarone; APAP; acetaminophen; ATF4; activating transcription factor 4; CAA; chloroacetaldehyde; CdCl2; cadmium chloride; ChIP-seq; chromatin immunoprecipitation followed by DNA sequencing; C
Recovery of redox homeostasis altered by CuNPs in H4IIE liver cells does not reduce the cytotoxic effects of these NPs: An investigation using aryl hydrocarbon receptor (AhR) dependent antioxidant activity
Keywords: CuNP; copper nanoparticle; ROS; reactive oxygen species; AhR; aryl hydrocarbon receptor; ÃNF; Ã-Naphthoflavone; αNF; α-Naphthoflavone; GST; glutathione-S-transferase; GSH; glutathione; GSSG; oxidised glutathione; Nrf2; nuclear factor erythroid-2-relat
Alterations in the Nrf2–Keap1 signaling pathway and its downstream target genes in rat brain under stress
Keywords: Behavior; Hippocampus; Prefrontal cortex; Oxidative stress; Nrf2; Keap1; NFkB
Nrf2 facilitates repair of radiation induced DNA damage through homologous recombination repair pathway in a ROS independent manner in cancer cells
Keywords: Nrf2; DNA repair; Ionizing radiation; DNA damage; RAD51; Radiosensitivity;
Youngia denticulata attenuates diet-induced obesity-related metabolic dysfunctions by activating AMP-activated protein kinase and regulating lipid metabolism
Keywords: Youngia denticulata; Obesity; Fatty liver; Lipid accumulation; AMP-activated protein kinase; YDE; Youngia denticulata extract; ACC; acetyl-CoA carboxylase; AMPK; AMP activated protein kinase; SREBP1-c; sterol regulatory element-binding transcription facto
Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway
Keywords: AREs; Antioxidant response elements; CI; Combination index; DRI; Dose reduction index; EGFR; Epidermal growth factor receptor; EMT; Epithelial-to-mesenchymal transition; GSK3β; Glycogen synthase kinase 3β; HDACi; Histone deacetylase inhibitor; HK1; Hexo
Research ReportDiallyl trisufide protects against oxygen glucose deprivation -induced apoptosis by scavenging free radicals via the PI3K/Akt -mediated Nrf2/HO-1 signaling pathway in B35 neural cells
Keywords: DATS; diallyl trisulfide; OGD; oxygen glucose deprivation; Nrf2; nuclear factor E2-related factor 2; HO-1; Heme oxygenase-1; PI3K; phosphatidylinositol 3 kinase; Akt; protein kinase B; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide; DC
On the role of 4-hydroxynonenal in health and disease
Keywords: AD; Alzheimer's disease; ALDH; aldehyde dehydrogenase; AMI; acute myocardial infarction; ARE; antioxidant response element; CDK; cyclin-dependent kinase; CHF; chronic heart failure; DHLA; dihydrolipoic acid; ER; endoplasmic reticulum; GSH; glutathione; HL
Respiratory syncytial virus infection down-regulates antioxidant enzyme expression by triggering deacetylation-proteasomal degradation of Nrf2
Keywords: AEC; Airway epithelial cell; AOE; Antioxidant enzyme; ARE; Antioxidant response element; BHA; Butylated hydroxyanisole; ChIP; Chromatin immunoprecipitation; GCLC; Glutamyl cysteine ligase-catalytic; GPX1; Glutathione peroxidase 1; HDAC; Histone deacetylas
Integrated transcriptomic and proteomic analyses uncover regulatory roles of Nrf2 in the kidney
Keywords: iTRAQ; Keap1; Nrf2; oxidative stress; ROS;
Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity
Keywords: Treadmill exercise; Nrf2; γGCLC; HO-1; Parkinson's disease; Dopaminergic neurons; MPP+;
Anti-angiogenic properties of coenzyme Q0 through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling in TNF-α-activated human endothelial cells
Keywords: Coenzyme Q0; Endothelial cells; Inflammation; Heme oxigenase-1; NF-κB; Nrf2
Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling
Keywords: Pancreatic β cell survival; Nck1; PERK; Autophagy; Nrf2; Akt;
Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response element signaling pathway
Keywords: 6-OHDA; 6-hydroxydopamine; ARE; antioxidant response element; BSA; bovine serum albumin; Cyt C; cytochrome c; DA; dopamine; DAPI; 4â²,6-diamidino-2-phenylindole; DCFH-DA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DMSO; dimethylsulfoxide; DOPAC; dih
Beyond antioxidant genes in the ancient Nrf2 regulatory network
Keywords: Nrf2; Keap1; ARE; Drosophila; Human; Genomics; Transcriptional regulation; Enhancer; Free radicals;
Quantitative in vitro to in vivo extrapolation of tissues toxicity
Keywords: ADME; absorption, distribution, metabolism, and excretion; ARE; antioxidant responses elements; BBB; blood brain barrier; CsA; cyclosporine A; CYP; cytochrome P450; EPA; Environmental Protection Agency; GCL; glutamate cysteine ligase; GCLC; glutamate cyst
Platinum-induced kidney damage: Unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury
Keywords: ApG; adenine-guanine; ATM; Ataxia telangiectasia mutated; ATR; ATM and Rad3 related kinase; Bax; Bcl2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; EdU; 5-ethynyl-2â²-deoxyuridine; CarboPt; carboplatin; CENP-F; centromere protein F; Chk1; checkpoint
Multiple binding modes of a small molecule to human Keap1 revealed by X-ray crystallography and molecular dynamics simulation
Keywords: DTT; dithiothreitol; Keap1; Kelch-like ECH-associated protein 1; MD; molecular dynamics; Nrf2; Nuclear factor erythroid 2-related factor 2; PDB; Protein Data Bank; Oxidative stress; Antioxidant response; β-Propeller; Crystal packing; Fragment-based drug
Nrf2 and Nrf2-related proteins in development and developmental toxicity: Insights from studies in zebrafish (Danio rerio)
Keywords: Oxidative stress; Nrf2; NFE2L2; Embryo; Zebrafish; Development;
Novel oxime-bearing coumarin derivatives act as potent Nrf2/ARE activators in vitro and in mouse model
Keywords: Nrf2/ARE activators; Oxime-bearing coumarins; Antioxidant activity; Cytoprotection; ABCC3; ATP-binding cassette, subfamily C, member 1; AKR1C1; aldo-keto reductase 1 subunit C-1; AKR1C2; aldo-keto reductase 1 subunit C-2; AKR1C3; aldo-keto reductase 1 sub
Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability
Keywords: Resin monomer; HEMA; Reactive oxygen species; Nrf2; Antioxidant protein; Apoptosis;
Regulation of Ahr signaling by Nrf2 during development: Effects of Nrf2a deficiency on PCB126 embryotoxicity in zebrafish (Danio rerio)
Keywords: Ahr; aryl hydrocarbon receptor; Ahrr; aryl hydrocarbon receptor repressor; ARE; antioxidant response element; Cyp1a; cytochrome P540 1a; DLC; dioxin-like compound; DMSO; dimethyl sulfoxide; dpf; days post fertilization; hpf; hours post fertilization; Keap
Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome
Keywords: Arthritis; ES-62; IL-1β; Inflammasome; NRF2; Parasitic worm;
Epigallocatechin gallate exacerbates fluoride-induced oxidative stress mediated testicular toxicity in rats through the activation of Nrf2 signaling pathway
Keywords: Fluoride; EGCG; Testes; Oxidative stress; Inflammation; Apoptosis; Nrf2
The dermato-protective effects of lucidone from Lindera erythrocarpa through the induction of Nrf2-mediated antioxidant genes in UVA-irradiated human skin keratinocytes
Keywords: Lucidone; Lindera erythrocarpa; UVA; ROS; Nrf2
The miR-200 family differentially regulates sensitivity to paclitaxel and carboplatin in human ovarian carcinoma OVCAR-3 and MES-OV cells
Keywords: Carboplatin; Drug resistance; Epithelial mesenchymal transition; miRNA-200; Paclitaxel; ALDH1A3; aldehyde dehydrogenase 1A3; AKR1C1 and AKRIC4; aldo-keto reductase family 1 and 4; CDH6; cadherin 6; COL5A1; collagen type V alpha 1; COL6A1; collagen type VI