Oocyte atresia in WT (HdrR) and P53 (-/-) medaka (Oryzias latipes) exposed to UVA
Keywords: UVA; Histology; Oocyte; Atresia; Medaka; p53;
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Computational design of small interfering RNAs and small hairpin RNAs to silence mutated P53 gene expressions
Keywords: Gene silencing; Interference; Motifs; P53; siRNA; shRNA;
Chitosan-coated doxorubicin nano-particles drug delivery system inhibits cell growth of liver cancer via p53/PRC1 pathway
Keywords: Chitosan; Doxorubicin; Nano-particles; FA-CS-DOX; p53;
Overexpression of GRIM-19 accelerates radiation-induced osteosarcoma cells apoptosis by p53 stabilization
Keywords: Osteosarcoma; Radiation; GRIM-19; MDM2; p53; Apoptosis;
ADC-histogram analysis in head and neck squamous cell carcinoma. Associations with different histopathological features including expression of EGFR, VEGF, HIF-1α, Her 2 and p53. A preliminary study
Keywords: ADC; apparent diffusion coefficient; DWI; diffusion-weighted imaging; DCE; dynamic-contrast enhanced MRI; HNSCC; head and neck squamous cell carcinoma; p53; tumor protein 53; Hif 1-alpha; hypoxia-inducible factor 1-alpha; VEGF; vascular endothelial growth
Regulation and biological roles of the multifaceted miRNA-23b (MIR23B)
Keywords: miRNAs; MicroRNAs; C9orf3; Chromosome 9 Open Reading Frame 3; pri-miRNAs; primary miRNA; pre-miRNAs; precursor miRNAs; miRISC; miRNA-induced silencing complex; ECs; endothelial cells; VSMCs; vascular smooth muscle cells; ACTA2; smooth muscle α-actin; MYH
Inhibition of CREPT restrains gastric cancer growth by regulation of cycle arrest, migration and apoptosis via ROS-regulated p53 pathway
Keywords: CREPT; Gastric cancer; Apoptosis; p53; ROS;
Cytotoxicity, molecular modeling, cell cycle arrest, and apoptotic induction induced by novel tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline chalcones
Keywords: Breast cancer; Modeling study; Apoptosis; Cell cycle arrest; Caspase-3; p53; Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline; Chalcones;
Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling
Keywords: Actein; Gastric cancer; TRAIL; Caspases; p53;
Nrf-2 transcriptionally activates P21Cip/WAF1 and promotes A549â¯cell survival against oxidative stress induced by H2O2
Keywords: Oxidative stress; Nrf-2; p21; p53; Transcriptional activation; Cancer;
Effects of Ginsenoside Rg3 on fatigue resistance and SIRT1 in aged rats
Keywords: Rg3; Ginsenoside Rg3; Rg3 group; Rg3-treated normal group; POFS; postoperative fatigue syndrome; POFS group; postoperative fatigue syndrome model group; POFSâ+âRg3 group; Rg3-treated postoperative fatigue syndrome model group; OFT; the open field test
Phosphatidylinositol 3 kinase (PI3K) modulates manganese homeostasis and manganese-induced cell signaling in a murine striatal cell line
Keywords: Manganese; STHdh; Neurotoxicity; Manganese transport; PI3K; p53; LY294002; NU7441; KU55933; KU60019;
MRI features predict p53 status in lower-grade gliomas via a machine-learning approach
Keywords: p53; Lower-grade gliomas; Radiogenomics; Prediction; Machine learning;
Acetylation of TIP60 at K104 is essential for metabolic stress-induced apoptosis in cells of hepatocellular cancer
Keywords: HAT; histone acetyltransferase; PTM; post translational modification; ROS; reactive oxygen species; PARP; poly ADP-ribose polymerase; Dox; doxycycline; TRRAP; transformation/transcription domain associated protein; p400; E1A binding protein p400; RUVBL1;
Friend or Foe: MicroRNAs in the p53 network
Keywords: microRNA; p53;
Hydroxyurea embryotoxicity is enhanced in P53-deficient mice
Keywords: Trp53; tumor suppressor related protein 53; GD; gestational day; DNA; deoxyribonucleic acid; HU; hydroxyurea; SAL; saline; CRL; crown-rump lengths; P53; Hydroxyurea; Organogenesis; Teratogen; Developmental toxicity; Birth defects;
PCL2 regulates p53 stability and functions as a tumor suppressor in breast cancer
Keywords: Polycomb repressive complexes; PCL2; p53; MDM2; Breast cancer;
Prognostic value of programmed death ligand 1, p53, and Ki-67 in patients with advanced-stage colorectal cancer
Keywords: Colorectal cancer; Prognosis; Biomarkers; PD-L1; p53; Ki-67 labeling index;
LQFM030 reduced Ehrlich ascites tumor cell proliferation and VEGF levels
Keywords: Ehrlich ascites tumor; Nutlins; p53; p21; VEGF; MDM2 inhibitors;
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis
Keywords: Tanshinone-1; S222; S439; Anticancer targets; DNA topoisomerases; P53;
HMGB1-mediated DNA bending: Distinct roles in increasing p53 binding to DNA and the transactivation of p53-responsive gene promoters
Keywords: HMG; high mobility group; WT; wild-type; oxiHMGB1; oxidized HMGB1; HMGB1ÎC; HMGB1 lacking the acidic C-terminal tail; EMSA; electrophoresis mobility shift assay; HMGB; p53; DNA bending; DNA-protein interaction; Promoter transactivation;
Design, synthesis and biological evaluation of 1, 4-dihydro indeno[1,2-c] pyrazole linked oxindole analogues as potential anticancer agents targeting tubulin and inducing p53 dependent apoptosis
Keywords: 1, 4-dihydroindeno-[1, 2-c] pyrazole; Oxindoles; Knoevenagel condensation; p53; Apoptosis;
Expression patterns and mutation analysis of p53 in fish Rita rita from polluted riverine environment
Keywords: Aquatic pollution; Gene expression patterns; Mutation; p53; Rita rita;
The IRF9-SIRT1-P53 axis is involved in the growth of human acute myeloid leukemia
Keywords: Acute myeloid leukemia; IRF9; SIRT1; p53;
Perturbations in the p53/miR-34a/SIRT1 pathway in the R6/2 Huntington's disease model
Keywords: Huntington's disease; miR-34a; SIRT1; p53;
Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells
Keywords: Fluoride; Apoptosis; Neurotoxicity; p53; SIRT1;
Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53
Keywords: Wogonin; Glycolysis; p53; HCT116 cells;
Phosphorylation of SET mediates apoptosis via P53 hyperactivation and NM23-H1 nuclear import
Keywords: SET; Apoptosis; p53; NM23-H1; Tau; Alzheimer's disease;
Lanthanide-doped nanoparticles conjugated with an anti-CD33 antibody and a p53-activating peptide for acute myeloid leukemia therapy
Keywords: Acute myeloid leukemia; Peptide delivery; CD33 antibody; p53; Lanthanide-doped theranostic nanoparticles;
Intraperitoneal nanotherapy for metastatic ovarian cancer based on siRNA-mediated suppression of DJ-1 protein combined with a low dose of cisplatin
Keywords: ovarian cancer; DJ-1; cisplatin; combinatorial therapy; siRNA; IV chemotherapy; intravenous chemotherapy; IP chemotherapy; intraperitoneal chemotherapy; PTEN; phosphatase and tensin homolog; p53; tumor suppressor protein 53; NRF2; nuclear factor (erythroi
Curcumin ameliorates the in vitro efficacy of carfilzomib in human multiple myeloma U266 cells targeting p53 and NF-κB pathways
Keywords: Myeloma; Curcumin; Carfilzomib; NF-κB; p53; Proteasome inhibitor;
Overexpression of p53 and Bax mediating apoptosis in cancer cell lines induced by a bioactive compound from Bacillus endophyticus JUPR15
Keywords: Anticancer; DNA fragmentation; Caspase; Cell cycle; p53; Bax;
High-throughput gene expression analysis identifies p53-dependent and -independent pathways contributing to the adrenocortical dysplasia (acd) phenotype
Keywords: TPP1; protein encoded by adrenocortical dysplasia gene; Acd; adrenocortical dysplasia gene; acd; adrenocortical dysplasia mutation; p53; transformation related protein 53; DNA; Deoxyribonucleic acid; DC; Dyskeratosis congenita; HHS; Hoyeraal-Hreidarsson s
Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner
Keywords: Quinacrine; Gold; Angiogenesis; p53; p21; Oral cancer; CSCs;
Bombyx mori homolog of tumor suppressor p53 is involved in apoptosis-mediated antiviral immunity of B. mori cells infected with nucleopolyhedrovirus
Keywords: Apoptosis; p53; Bombyx mori; Baculovirus; Nucleopolyhedrovirus; Cell culture;
Bioactive compound 1,8-Cineole selectively induces G2/M arrest in A431 cells through the upregulation of the p53 signaling pathway and molecular docking studies
Keywords: 1,8-Cineole; Mitochondria; Cell cycle arrest; Apoptosis; p53; Caspase; A431; skin carcinoma; AB; alamar blue; ADT; autodock tools; ATG; autophagy-related genes; Bax; Bcl-2 associated X-protein; Bcl-2; B-cell lymphoma 2; Beclin-1; Bcl-2 interacting protein
The critical role of p16/Rb pathway in the inhibition of GH3 cell cycle induced by T-2 toxin
Keywords: Cell cycle; G1 phase arrest; T-2 toxin; p16/Rb pathway; Reactive oxygen species; p53;
MDM2 controls NRF2 antioxidant activity in prevention of diabetic kidney disease
Keywords: Diabetes; Diabetic nephropathy; Nrf2; Oxidative stress; P53;
Transcriptome analysis reveals novel insights into the response of low-dose benzo(a)pyrene exposure in male tilapia
Keywords: TGFi; TGF induced factor homeobox; TGF; transforming growth factor; IL1; interleukin 1; IL1i; IL1 inhibitors; IL1RL1; interleukin 1 receptor like 1; TNF; tumor necrosis factor; Nogo; reticulon 4 (RTN4/Nogo); NGF; nerve growth factor; STC; stanniocalcin 1;
p53 mediated transcriptional regulation of long non-coding RNA by 1-hydroxy-1-norresistomycin triggers intrinsic apoptosis in adenocarcinoma lung cancer
Keywords: Lung cancer; ROS; p53; Long non-coding RNAs; ChIP assay; Apoptosis;
Arsenic-induced apoptosis in the p53-proficient and p53-deficient cells through differential modulation of NFkB pathway
Keywords: Arsenite; p53; NFκB; Gene expression profiling; Apoptosis and transcription factors;
Multifunctional molecule ERp57: From cancer to neurodegenerative diseases
Keywords: 1α,25(OH)2D3; 1,25-dihydroxyvitamin D3; ADAM10; a disintegrin and metalloproteinase 10; AIF; apoptosis-inducing factor; AP-1; activator protein 1; ATRA; all-trans retinoic acid; BMP-2; bone morphogenic protein 2; CLNX; calnexin; CRT; calreticulin; ECM; e
Designing anticancer copper(II) complexes by optimizing 2-pyridine-thiosemicarbazone ligands
Keywords: Cu(II) complexes; Thiosemicarbazone; Anticancer; p53; Telomerase;
Neuroprotective effect of zolpidem against glutamate-induced toxicity is mediated via the PI3K/Akt pathway and inhibited by PK11195
Keywords: ANC; adenine nucleotide carrier; H2O2; hydrogen peroxide; LDH; lactate dehydrogenase; mPTP; mitochondrial permeability transition pore; PI3K; phosphatidylinositol-3-kinase; PK11195; 1-(-2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
p53 and glucose metabolism: an orchestra to be directed in cancer therapy
Keywords: Anticancer therapy; Cancer; Glycolysis; OXPHOS; p53;
How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance
Keywords: p53; Tumor suppressor; DNA binding; Targeted therapy; Drug resistance;
Role of p53 circuitry in tumorigenesis: A brief review
Keywords: p53; miRNA; Mdm2; Pirh2; COP1; Ubiquitin; Proteasome; Modulators; Pharmacophore;
Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells
Keywords: Thymoquinone; Senescence; Par-4; β-galactosidase; p53;
Abnormal nuclear morphology is independent of longevity in a zmpste24-deficient fish model of Hutchinson-Gilford progeria syndrome (HGPS)
Keywords: CMV; cytomegalovirus; DDR; DNA damage response; GFP; green fluorescent protein; Gy; gray; H2B; histone H2B; n.s.; not significant; qPCR; quantitative polymerase chain reaction; s.d.; standard deviation; zmpste24; zinc metallopeptidase, STE24 homolog; Lami
Enhanced anticancer effects of Scutellaria barbata D. Don in combination with traditional Chinese medicine components on non-small cell lung cancer cells
Keywords: Scutellaria barbata D. Don; TCM; NSCLC; EGFR; p53;