Keywords: فسفونیوییدید-3-کیناز; aBCC; advanced basal cell carcinoma; AE; adverse event; PI3K; phosphoinositide-3-kinase; PFS; progression free survival; SI; smoothened inhibitor;
مقالات ISI فسفونیوییدید-3-کیناز (ترجمه نشده)
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Keywords: فسفونیوییدید-3-کیناز; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; CLL; B-cell chronic lymphocytic leukemia; CML; chronic myelogenous leukemia; ERK; extracellular signal-regulated kinase; FN3; fibronectin type-III (domain); GBM; glioblastoma multiforme; JMML
Keywords: فسفونیوییدید-3-کیناز; Irisin; Growth hormone; Tilapia; Hepatocytes; Pituitary cells; GH; Growth hormone; UCP1; uncoupling protein 1; PI3K; Phosphoinositide-3-kinase; Akt; Akt/PKB Serine/threonine Kinase; MAPK; Mitogen-activated Protein Kinase; Erk; Extracellularly Regulated Ki
Keywords: فسفونیوییدید-3-کیناز; AHR; airway hyperresponsiveness; ACQ; Asthma Control Questionnaire; ACOS; asthma-COPD overlap syndrome; BAL; bronchoalveolar lavage; CLCA1; chloride channel regulator 1; COPD; chronic obstructive lung disease; CS; corticosteroids; CXCR; CXC chemokine rece
Keywords: فسفونیوییدید-3-کیناز; 8-OHdG; 8-oxo-2â²-deoxyguanosine; AMPK; AMP-activated protein kinase; ANT; adenine nucleotide translocator; Bad; Bcl2-associated agonist of cell death; BKA; bongkrekic acid; CAT; catalase; CsA; cyclosporine A; Cu/Zn-SOD; Cu/Zn-superoxide dismutase; DR4;
Keywords: فسفونیوییدید-3-کیناز; FLL cells; Fibroblast-like ligament cells; AS; Ankylosing spondylitis; HC; Healthy controls; IPA; Ingenuity pathway analysis; HADHB; Trifunctional enzyme subunit beta; ECHS1; Enoyl-CoA hydratase; ACSL4; Long-chain-fatty-acid-CoA ligase 4; ACADM; Medium-ch
Keywords: فسفونیوییدید-3-کیناز; Orexin; Hypocretin; Phospholipase; Endocannabinoid; Ion fluxes; 2-AG; 2-arachidonoylglycerol; AA; arachidonic acid; anandamide; N-arachidonoylethanolamine; CNS; central nervous system; cPLA2 and iPLA2; cytosolic (Ca2+-dependent) and intracellular (Ca2+-in
Keywords: فسفونیوییدید-3-کیناز; ACT; Asthma Control Test; AFU; arbitrary fluorescence units; AM; alveolar macrophage; BALF; BAL fluid; Feno; fraction of exhaled nitric oxide; HDAC; histone deacetylase; IP; immunoprecipitated; MDA; malondialdehyde; PI3K; phosphoinositide-3-kinase; PMA; p
Keywords: فسفونیوییدید-3-کیناز; Gal-1; galectin-1; PI3K; phosphoinositide-3-kinase; MEK; mitogen-activated protein kinase kinase (MAP2K); ERK; extracellular-signal-regulated kinase; ECM; extracellular matrix; MMP; matrix metalloproteinase; tPA; tissue plasminogen activator; CDC42; cell
Keywords: فسفونیوییدید-3-کیناز; AC; adenylate cyclase; Ace; acetophenone; 2-APB; 2-aminoethoxydiphenyl borate; Ben; benzaldehyde; [Ca2+]i; intracellular calcium; CC; chelerythrine chloride; cH; cis-4-heptenal; CNG; cyclic nucleotide-gated; DAG; diacylglycerol; DMSO; dimethyl sulfoxide;
Keywords: فسفونیوییدید-3-کیناز; Azithromycin; Macrolide antibiotic; Mechanisms of action; Pharmacokinetics; Immunomodulation; Clinical efficacy; AECOPD; acute exacerbations of COPD; AP-1; activator protein-1; ARDS; acute respiratory distress syndrome; AUC; area under the plasma concentr
Tranilast inhibits interleukin-33 production by macrophages
Keywords: فسفونیوییدید-3-کیناز; Tranilast (PubChem CID: 5282230); LY294002 (PubChem CID: 3973); Tranilast; Interleukin-33; Macrophages; Lipopolysaccharide; Phosphoinositide-3-kinase;
Insulin-like peptides and DNA/tRNA methyltransferases are involved in the nutritional regulation of female reproduction in Nilaparvata lugens (Stål)
Keywords: فسفونیوییدید-3-کیناز; bp; base pair; cDNA; DNA complementary to RNA; dNTP; deoxyribonucleoside triphosphate; kb; kilobase; kDa; kilodalton; ORF; open reading frame; UTR; untranslated region; RACE; rapid amplification of cDNA ends; qPCR; quantitative real time PCR; AAs; amino a
The expressional disorder of the renal RAS mediates nephrotic syndrome of male rat offspring induced by prenatal ethanol exposure
Keywords: فسفونیوییدید-3-کیناز; PEE; prenatal ethanol exposure; GD; gestational day; PW; postnatal week; PD; postnatal day; GDNF; glial-cell-line-derived neurotrophic factor; c-ret; c-ret tyrosine kinase receptor; Ang II; angiotensin II; ACE; angiotensin-converting enzyme; AT2R; angiote
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: فسفونیوییدید-3-کیناز; Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
STYK1 promotes cancer cell proliferation and malignant transformation by activating PI3K-AKT pathway in gallbladder carcinoma
Keywords: فسفونیوییدید-3-کیناز; GBC; gallbladder carcinoma; STYK1; serinethreoninetyrosinekinase1; EMT; epithelial-mesenchymal transition; H&E; hematoxylin and eosin; qRT-PCR; quantitative real-time PCR analysis; IHC; immunohistochemicalanalysis; CCK-8; Cell Counting Kit-8; PI3K; phosph
ER stress and cancer: The FOXO forkhead transcription factor link
Keywords: فسفونیوییدید-3-کیناز; Endoplasmic reticulum; ER stress; Cancer; FOXO; Forkhead transcription factors; Unfolded protein response; AKT; Protein Kinase B; AKT1; Protein Kinase B Alpha; AMPK; AMP-activated protein kinase; ASK1; Apoptosis Signal Regulated Kinase 1; ATF4; Activating
ROS signalling in the biology of cancer
Keywords: فسفونیوییدید-3-کیناز; AEJ; alternative end joining; ALL; acute lymphoblastic leukaemia; AML; acute myeloid leukaemia; Apaf-1; apoptotic protein activating factor 1; APL; acute promyelocytic leukaemia; ASK1; apoptosis signal regulating kinase 1; Bcr-Abl; breakpoint cluster-Abel
Activation of Nrf2 signaling by natural products-can it alleviate diabetes?
Keywords: فسفونیوییدید-3-کیناز; Nrf2; type 2 diabetes; natural products; hyperglycemia; cellular stress; insulin sensitivity; β-cell function; vascular complications; AGE; advanced glycation end products; AhR; arylhydrocarbon receptor; AMPK; AMP-activated kinase; ARE; antioxidant respo
Schisandrin rescues depressive-like behaviors induced by chronic unpredictable mild stress via GDNF/ERK1/2/ROS and PI3K/AKT/NOX signaling pathways in mice
Keywords: فسفونیوییدید-3-کیناز; CUMS; Chronic unpredictable mild stress; GDNF; Glial cell line-derived neurotrophic factor; TGF-β; Transforming growth factor-beta; ERK; Extracellular regulated protein kinases; PERK; Phosphorylase extracellular regulated protein kinases; NOX; NADPH oxid
Defining the Na+/H+ exchanger NHE1 interactome in triple-negative breast cancer cells
Keywords: فسفونیوییدید-3-کیناز; ACC1; acetyl-CoA carboxylase; AKT; protein kinase B, PKB; CAII; carbonic anhydrase II; CHP1; calcineurin B homologous protein 1; ER; estrogen receptor; ERK1/2; extracellular signal-regulated kinase 1/2; ERM; ezrin-radixin-moesin; FOXO3a; forkhead box O3a;
Fluid shear stress applied by orbital shaking induces MG-63 osteosarcoma cells to activate ERK in two phases through distinct signaling pathways
Keywords: فسفونیوییدید-3-کیناز; FSS; fluid shear stress; PI3-kinase; phosphoinositide-3-kinase; Rho kinase; Rho-associated kinase; Mechanoresponse; Fluid flow; Shear stress; Osteoblast; Orbital shaking;
The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells
Keywords: فسفونیوییدید-3-کیناز; G protein-coupled estrogen receptor (GPER); Melanoma; Antiestrogens; Proliferation; BCA; bicinchoninic acid; BrdU; 5-bromo-2â²-deoxyuridine; CYP; cytochrome P450; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; EC
Overcoming ABC transporter-mediated multidrug resistance: The dual role of tyrosine kinase inhibitors as multitargeting agents
Keywords: فسفونیوییدید-3-کیناز; MDR; BCR-ABL inhibitors; EGFR inhibitors; VEGFR inhibitors; Drug combinations; ABC; ATP binding cassette; ADME-tox; absorption, distribution, metabolism, excretion, toxicity; AKT; v-akt murine thymoma viral oncogene homolog; ALL; acute lymphoblastic leuke
MiR-1271 upregulated by saturated fatty acid palmitate provokes impaired insulin signaling by repressing INSR and IRS-1 expression in HepG2 cells
Keywords: فسفونیوییدید-3-کیناز; microRNA; miR-1271; Saturated fatty acid; Palmitate; Insulin resistance; INSR; IRS-1; Akt2; v-akt murine thymoma viral oncogene homolog 2; C/EBPα; CCAAT/enhancer binding protein alpha; ER; endoplasmic reticulum; FOXQ1; forkhead box Q1; GPC3; glypican 3;
Sophoraflavanone G from Sophora alopecuroides inhibits lipopolysaccharide-induced inflammation in RAW264.7 cells by targeting PI3K/Akt, JAK/STAT and Nrf2/HO-1 pathways
Keywords: فسفونیوییدید-3-کیناز; SG; Sophoraflavanone G; LPS; lipopolysaccharide; NO; nitric oxide; PGE2; prostaglandin E2; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; PI3K; phosphoinositi
A new steroidal saponin, furotrilliumoside from Trillium tschonoskii inhibits lipopolysaccharide-induced inflammation in Raw264.7 cells by targeting PI3K/Akt, MARK and Nrf2/HO-1 pathways
Keywords: فسفونیوییدید-3-کیناز; FT; furotrilliumoside; LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; PI3K; phosphoinositide-3-kinase; MARK; mitoge
Epigallocatechin gallate and mitochondria-A story of life and death
Keywords: فسفونیوییدید-3-کیناز; ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; ALT; alanine aminotransferase; AMP; adenosine monophosphate; AP-1; activator protein-1; ASK1; apoptosis signal-regulating kinase 1; ATP; adenosine triphosphate; Bax; BCL2-Associated X Protein; Bc
Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells
Keywords: فسفونیوییدید-3-کیناز; Akt; protein kinase B; Atg; autophagy-related gene; ECM; extracellular matrix; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; eIF4E; eukaryotic translation initiation factor 4E; Hsc70; heat shock cognate protein 70; LC3B; microtubule-associate
Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment
Keywords: فسفونیوییدید-3-کیناز; APRIL; a proliferation-inducing ligand; ATM; ataxia telangiectasia mutated; BAFF; B-cell activating factor; BAFFR; BAFF receptor; BAG6; BCL2-associated athanogene 6; BCMA; B-cell maturation antigen; BCL2; B-cell lymphoma 2; BCR; B cell receptor; bFGF; bas
Autocrine insulin increases plasma membrane KATP channel via PI3K-VAMP2 pathway in MIN6 cells
Keywords: فسفونیوییدید-3-کیناز; Insulin; KATP channel; Ca2+ signaling; Phosphoinositide-3-kinase; VAMP2; MIN6 cells;
Unfractionated heparin attenuates LPS-induced IL-8 secretion via PI3K/Akt/NF-κB signaling pathway in human endothelial cells
Keywords: فسفونیوییدید-3-کیناز; UFH, unfractionated heparin; HPMEC, human pulmonary microvascular endothelial cells; LPS, lipopolysaccharide; PI3K, phosphoinositide-3-kinase; NF-κB, nuclear factor-κB; IL, interleukinUnfractionated heparin; Lipopolysaccharide; Phosphoinositide-3-kinase;
Ferritin-stimulated lipid peroxidation, lysosomal leak, and macroautophagy promote lysosomal “metastability” in primary hepatocytes determining in vitro cell survival
Keywords: فسفونیوییدید-3-کیناز; ACD; accidental (necrotic) cell death; AO; acridine orange; CM; conditioned medium; DAPI; 4â²,6-diamidino-2-phenylindole; DFO; desferrioxamine mesylate; EGF; epidermal growth factor; ELC; endo-/lysosomal compartment; GFL; green AO fluorescence; GSH; glut
Photoactivation of Dok1/ERK/PPARγ signaling axis inhibits excessive lipolysis in insulin-resistant adipocytes
Keywords: فسفونیوییدید-3-کیناز; Akt; protein kinase B; Dex; dexamethasone; Dok1; downstream of tyrosine kinases-1; ERK1/2; extracellular signal-regulated kinase 1 and 2; ap2; fatty acid binding protein 4; IBMX; isobutylmethylxanthine; IRS; insulin receptor substrate; InsR; insulin recep
Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR
Keywords: فسفونیوییدید-3-کیناز; mgp96; uPAR; Liver cancer; MAPK; DFS; ADAMTS9; a disintegrin-like and metalloprotease domain with thrombospondin type 1 motifs 9; AIMP1; aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; AKT; v-akt murine thymoma viral oncogene homo
Epibrassinolide alters PI3K/MAPK signaling axis via activating Foxo3a-induced mitochondria-mediated apoptosis in colon cancer cells
Keywords: فسفونیوییدید-3-کیناز; AR; Androgen receptor; AZ; Antizyme; AZI; Antizyme inhibitor; AP-1; Activator protein 1; BR; Brassinosteroid; Bcl-2; B-cell lymphoma 2; DiOC6; 3,3â²-dihexyloxacarbocyanineiodide; CHENSpm; N1-ethyl-N11-((cycloheptyl)methy)-4,8-diazaundecane; DAPI; 4â²,6-
Redox-regulated fate of neural stem progenitor cells
Keywords: فسفونیوییدید-3-کیناز; ARE; antioxidant response element; bHLH; basic helix-loop-helix; BMI1; B lymphoma Mo-MLV insertion region 1 homolog; CtBPs; C-terminal binding proteins; DLL4; delta-like protein 4; DVL; disheveled; DOUX; dual oxidases; ES; embryonic stem cells; EGFR; epid
Methylseleninic acid promotes antitumour effects via nuclear FOXO3a translocation through Akt inhibition
Keywords: فسفونیوییدید-3-کیناز; Methylseleninic acid (PubChem CID: 161597); Sodium selenite (PubChem CID: 24934); Cisplatin (PubChem CID: 441203); LY294002 (PubChem CID: 3973); MSA; methylseleninic acid; Se; selenium; PPP; pentose phosphate pathway; TCA; tricarboxylic acid; ROS; reactiv
Peroxisome proliferator activated receptor gamma (PPARγ) as a therapeutic target for improvement of cognitive performance in Fragile-X
Keywords: فسفونیوییدید-3-کیناز; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; CNS; central nervous system; ECM; extra cellular matrix; FMR1 gene; Fragile X mental retardation 1 gene; FMRP; Fragile-X mental retardation protein; FXS; Fragile X syndrome; GLUT-3; gl
Research ReportSquamosamide derivative FLZ protected dopaminergic neuron by activating Akt signaling pathway in 6-OHDA-induced in vivo and in vitro Parkinson's disease models
Keywords: فسفونیوییدید-3-کیناز; PD; Parkinson's disease; PI3K; phosphoinositide-3-kinase; α-Syn; α-synuclein; 6-OHDA; 6-hydroxydopamine; TH; tyrosine hydroxylase; Co-IP; Co-Immunoprecipitation; FLZ; Parkinson's disease; Akt; α-synuclein; Tyrosine hydroxylase;
p70S6 kinase is a critical node that integrates HER-family and PI3 kinase signaling networks
Keywords: فسفونیوییدید-3-کیناز; p70S6K; p70S6 kinase; PI3K; phosphoinositide-3-kinase; RPPA; Reverse Phase Protein Array; mTOR; mammalian target of rapamycin; MAPK; mitogen activated protein kinase; EGFR; epidermal growth factor receptor; NSCLC; non-small cell lung cancer; RTK; receptor
The intricate interplay between RNA viruses and NF-κB
Keywords: فسفونیوییدید-3-کیناز; ss; single-stranded; ds; double-stranded; HTLV; human T cell leukemia virus; SARS; severe acute respiratory syndrome; IAVs; influenza A viruses; IFN; interferon; IRF3; interferon regulatory factor 3; NF-κB; nuclear factor κB; TLRs; toll-like receptors;
The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival
Keywords: فسفونیوییدید-3-کیناز; AIF; apoptosis inducing factor; Akt; v-Akt murine thymoma viral oncogene; AP-1; activator protein 1; ARE; antioxidant responsive element; ASK1; apoptosis signal-regulated kinase 1; ATM; ataxia telangiectasia mutated; Duox; Dual oxidase enzymes; DUSP3; dua
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway
Keywords: فسفونیوییدید-3-کیناز; AKT; v-akt murine thymoma viral oncogene; CRC; colorectal cancer; FDR; false discovery rate; HECT; homologous to E6AP C terminus; KEGG; Kyoto Encyclopedia of Genes and Genomes; mut; mutated; NCBI; National Center for Biotechnology Information; PBS; phosph
Tetramethylpyrazine attenuates TNF-α-induced iNOS expression in human endothelial cells: Involvement of Syk-mediated activation of PI3K-IKK-IκB signaling pathways
Keywords: فسفونیوییدید-3-کیناز; Tetramethylpyrazine; Spleen tyrosine kinase; Phosphoinositide-3-kinase; Inducible NO synthase; Endothelial cells;
Research ArticleAdiponectin and resistin protect steatotic livers undergoing transplantation
Keywords: فسفونیوییدید-3-کیناز; I/R; ischemia-reperfusion; PC; ischemic preconditioning; Ob; obese; Ln; lean; TR; transplantation; UW; University of Wisconsin; AMPK; AMP-activated protein kinase; AICAR; aminoimidazole-4-carboxamide ribonucleoside; PI3K; phosphoinositide-3-kinase; ALT; a
Azathioprine desensitizes liver cancer cells to insulin-like growth factor 1 and causes apoptosis when it is combined with bafilomycin A1
Keywords: فسفونیوییدید-3-کیناز; ERK; extracellular signal-regulated kinase; TSC-2; tuberous sclerosis 2 protein; mTOR; mammalian target of rapamycin; IRS; insulin receptor substrate; PI3K; phosphoinositide-3-kinase; AKT; protein kinase B; MAPK; mitogen-activated protein kinase; FOXO1; f
Switching from MAPK-dependent to MAPK-independent repression of the sodium-iodide symporter in 2D and 3D cultured normal thyroid cells
Keywords: فسفونیوییدید-3-کیناز; EGF; epidermal growth factor; EMT; epithelial to mesenchymal transition; ERK1/2; extracellular-signal regulated kinase 1/2; FBS; fetal bovine serum; IGF-1; insulin-like growth factor-1; LY294002; PI3K inhibitor; MAPK; mitogen-activated protein kinase; MEK
G protein-coupled estrogen receptor is required for the neuritogenic mechanism of 17β-estradiol in developing hippocampal neurons
Keywords: فسفونیوییدید-3-کیناز; Akt; G1; G15; GPR30; Neurogenin 3; Phosphoinositide-3-kinase
The Importance of Molecular Profiling in Predicting Response to Epidermal Growth Factor Receptor Family Inhibitors in Non–Small-Cell Lung Cancer: Focus on Clinical Trial Results
Keywords: فسفونیوییدید-3-کیناز; Epidermal growth factor receptor tyrosine kinase inhibitor; Gene amplification; Hepatocyte growth factor receptor; Kirsten rat sarcoma viral oncogene homolog; Phosphoinositide-3-kinase