دانلود مقالات ISI درباره Pi3K + ترجمه فارسی

Efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 in a preclinical model of adrenocortical carcinoma

Keywords: ACC; adrenocortical carcinoma; IGF-1R; IGF-1 receptor; PI3K; PI3 kinase; mTOR; mammalian target of rapamycin; Adrenal; Cancer; Pharmacology; Signalling;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery and bioactivity of 4-(2-arylpyrido[3′,2′:3,4]pyrrolo[1,2-f][1,2,4]triazin-4-yl) morpholine derivatives as novel PI3K inhibitors

Keywords: PI3K; Cancer; PI-103 analogs;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Translational regulation of the serum- and glucocorticoid-inducible kinase-1 (SGK1) in platelets

Keywords: SGK1; Platelets; Translation; PI3K

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Dendritic spine plasticity as an underlying mechanism of neuropathic pain: Commentary on Tan et al.

Keywords: AMPA; 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid; aPKC; atypical protein kinase C; BDNF; brain derived neurotrophic factor; CCI; chronic constriction injury; DHPG; dihydroxyphenyglycine; FMRP; fragile X mental retardation protein; IL-6; inte

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1

Keywords: 3-Phosphoinositide-dependent kinase 1 (PDK1); PI3K; Akt; CDK2; 4-Aryl-purine

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Porcine reproductive and respiratory syndrome virus activates the transcription of interferon alpha/beta (IFN-α/β) in monocyte-derived dendritic cells (Mo-DC)

Keywords: PRRSV; Mo-DC; IFN-α/β; PI3K; Post-transcriptional mechanism

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Biological evaluation and docking studies of recently identified inhibitors of phosphoinositide-3-kinases

Keywords: PI3Ks; phosphatidylinositol 3-kinases; PIP3; phosphatidylinositol 3,4,5-triphosphate; QPLD; Quantum-Polarized Ligand Docking; PI3K; Docking; Pharmacophore modeling; Apoptosis; LY294002; GSK2126458;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Bone morphogenetic protein (BMP)-4 and BMP-7 suppress granulosa cell apoptosis via different pathways: BMP-4 via PI3K/PDK-1/Akt and BMP-7 via PI3K/PDK-1/PKC

Keywords: BMP; Apoptosis; PI3K; Akt; CAD; Granulosa cell;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

PI3K–ERK1/2 activation contributes to extracellular H2O2 generation in amyloid β toxicity

Keywords: Amyloid β peptide; Oxidative stress; NADPH oxidase; PI3K; ERK1/2

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Polysaccharides derived from Lycium barbarum suppress IGF-1-induced angiogenesis via PI3K/HIF-1α/VEGF signalling pathways in MCF-7 cells

Keywords: LBPs; Breast cancer; IGF-1; PI3K; HIF-1α; VEGF; Angiogenesis;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Chrysotoxine, a novel bibenzyl compound selectively antagonizes MPP+, but not rotenone, neurotoxicity in dopaminergic SH-SY5Y cells

Keywords: [Ca2+]i; intracellular calcium concentration; DAT; dopamine transporter; DBH; dopamine-β-hydroxylase; DCFH-DA; 2,7-dichlorofluorescein diacetate; DMEM/F-12; Dulbecco's modified eagle medium nutrient mixture F-12; DMSO; dimethyl sulfoxide; FBS; fetal bovi

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of 4-morpholino-pyrimidin-6-one and 4-morpholino-pyrimidin-2-one-containing Phosphoinositide 3-kinase (PI3K) p110β isoform inhibitors through structure-based fragment optimisation

Keywords: Fragment-based; Phosphoinositide 3-kinase; PI3K; p110β; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of phosphoinositide 3-kinases (PI3K) p110β isoform inhibitor 4-[2-hydroxyethyl(1-naphthylmethyl)amino]-6-[(2S)-2-methylmorpholin-4-yl]-1H-pyrimidin-2-one, an effective antithrombotic agent without associated bleeding and insulin resistance

Keywords: Fragment-based; Phosphoinositide 3-kinase; PI3K; p110β; Inhibitor; Thromboembolism; Anti-thrombotic agent; Insulin resistance;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Receptor for advanced glycation end products inhibits proliferation in osteoblast through suppression of Wnt, PI3K and ERK signaling

Keywords: RAGE; Cell proliferation; PI3K; Wnt; ERK;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress

Keywords: CoCl2; cobalt chloride; DIC; differential interference contrast; DiI; 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate; GSK-3; glycogen synthase kinase 3; HIF-1; hypoxia-inducible factor-1; LPS; lipopolysaccharide; Mal; MyD88 adapt

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Insulin-like growth factor 1 (IGF1) and its active peptide (1-3)IGF1 enhance the expression of synaptic markers in neuronal circuits through different cellular mechanisms

Keywords: IGF1; insulin-like growth factor 1; (1-3)IGF1; active peptide of IGF1 (aminoacids 1-3); IGF1R; insulin-like growth factor 1 receptor; MAPK; mitogen activated protein kinase; PI3K; phosphatidylinositol 3 kinase; Growth factors; Synaptic transmission; I

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Electroacupuncture inhibits phosphorylation of spinal phosphatidylinositol 3-kinase/Akt in a carrageenan-induced inflammatory rat model

Keywords: Electroacupuncture; PI3K; Akt; Neuron

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Immunoglobulin G1 immune complex upregulates interferon-γ-induced nitric oxide production via ERK1/2 activation in murine microglia

Keywords: CNS; central nervous system; EAE; experimental autoimmune encephalomyelitis; ERK; extracellular signal-regulated kinase; FcγR; Fcγ receptor; IC; immune complex; IgG; Immunoglobulin G; IL; interleukin; iNOS; inducible nitric oxide synthatase; L-NMMA; NG-

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

EGF receptor inhibitors increase ErbB3 mRNA and protein levels in breast cancer cells

Keywords: EGF; epidermal growth factor; EGFR; EGF receptor; Erk; extracellular signal-regulated kinase; FAS; (TNF receptor superfamily, member 6); FoxO3a; forkhead box O3a; Ki-67; (antigen KI-67); MEK-1; MAPK/Erk kinase 1; PI3K; phosphatidylinositol 3-kinase; EGFR

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues

Keywords: TPCK; N-alpha-tosyl-l-phenylalanyl chloromethyl ketone; PDK1; 3-phosphoinositide dependent protein kinase-1; AGC; related to protein kinase A, protein kinase G and protein kinase C; RSK; ribosomal S6 kinase; S6K; S6 kinase; PKA; protein kinase A; ERK; ext

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

IL-12 inhibits glucocorticoid-induced T cell apoptosis by inducing GMEB1 and activating PI3K/Akt pathway

Keywords: FITC; fluorescein isothiocyanate; GC; glucocorticoids; GMEB; glucocorticoid modulatory element binding protein; GR; glucocorticoid receptor; IFN; interferon; IL; interleukin; Jak; Janus kinase; MS; multiple sclerosis; NK; natural killer; PBMC; peripheral

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for type 2 diabetes

Keywords: HCC; hepatocellular carcinoma; BCAAs; branched-chain amino acids; PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; OGTT; oral glucose tolerance test; IRI; immunoreactive insulin; HOMA-IR; homeostasis model assessment of insulin re

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Preconditioning the hyperlipidemic myocardium: Fact or fantasy?

Keywords: I/R; ischemia-reperfusion; FWOP; first window of protection; SWOP; second window of protection; TWOP; third window of protection; BH4; tetrahydrobiopterin; eNOS; endothelial nitric oxide synthase; TNF-α; tumor necrosis factor-α; MAPK; mitogen-activate

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells

Keywords: GEF; guanine nucleotide exchange factor; GFP; green fluorescent protein; GST; glutathione S-transferase; HA; hemagglutinin; PI3K; phosphoinositide 3 kinase; siRNA; small interfering RNA; TRITC; tetramethylrhodamine isothiocyanate; Glucose uptake; GTPase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold

Keywords: Phosphoinositide 3-kinase; Mammalian target of rapamycin; PI3K; mTOR; Sulfonamide; Triazine; Oncology;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Functional significance of glycogen synthase kinase-3 regulation by serotonin

Keywords: FST; forced swim test; GSK3; glycogen synthase kinase-3; 5-HT1A; serotonin type 1A receptors; i.p.; intraperitoneal; KI; knock-in; PI3K; phosphoinositide 3-kinase; PKA; protein kinase A; PKC; protein kinase C; WT; wild type; Serotonin; 5-HT1A; Fluoxetine;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation

Keywords: PDE8; phosphodiesterase 8; PKA; protein kinase A; cAMP; cyclic-AMP; PI3K; phosphoinositide 3-kinase; DNAPK; DNA_dependent protein kinase; FSK; forskolin; EPAC; exchange protein directly activated by cAMP; cGMP; cyclic guanine monophosphate; PDE8; PKA; cAM

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

mTOR inhibitors in cancer therapy

Keywords: PI3K; phosphatidylinositol 3-kinase; mTOR; mammalian target of rapamycin; mTORC; mammalian target of rapamycin complex; Raptor; regulatory-associated protein of mTOR; S6K1; S6 kinase 1, 4E-BP1, 4E-binding protein 1; Rictor; rapamycin-insensitive companion

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

AKT1 induces caspase-mediated cleavage of the CDK inhibitor p27Kip1 during cell cycle progression in leukemia cells transformed by FLT3-ITD

Keywords: FLT-ITD; AKT1; PI3K; Caspase 3; p27Kip1; Cell cycle; AML;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Growth inhibition and mechanism of action of p-dodecylaminophenol against refractory human pancreatic cancer and cholangiocarcinoma

Keywords: 1; p-dodecylaminophenol, 4-(dodecylamino)phenol; 2; p-decylaminophenol, 4-(decylamino)phenol; 3; N-(4-hydroxyphenyl)retinamide, fenretinide; 4; N-(4-hydroxyphenyl)dodecananamide, p-dodecanoylaminophenol; 5; N-(4-hydroxyphenyl)decananamide, p-decanoylamino

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Human breast carcinoma cells are induced to apoptosis by samsum ant venom through an IGF-1-dependant pathway, PI3K/AKT and ERK signaling

Keywords: CFSE; carboxyfluorescein diacetate succinimidyl ester; ERK; extracellular signal-regulated kinase; IGF-1; insulin-like growth factor-1; PI3K; phosphatidylinositol-3 kinase; PKB or AKT; protein kinase B; SAV; samsum ant venom; Ant; Apoptosis; Breast cancer

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

c-Jun N-terminal kinase controls a negative loop in the regulation of glial fibrillary acidic protein expression by retinoic acid

Keywords: GFAP; c-Jun N-terminal kinase; retinoic acid; neural precursor cells; BMP-2; bone morphogenetic protein-2; DNA-PKcs; DNA-protein kinase catalytic subunit; ERK; extracelular-regulated kinase; GFAP; glial fibrillary acidic protein; GSK-β; glycogen synthase

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Detection of Ras GTPase protein radicals through immuno-spin trapping

Keywords: DEA/NO; 2-(N,N-diethylamino)diazenolate-2-oxide diethylammonium salt; DMPO; 5,5-dimethyl-1-pyrroline N-oxide; eNOS; endothelial nitric oxide synthase; FTICR; Fourier transform ion cyclotron resonance; IST; immuno-spin trapping; •NO; nitric oxide; •NO2

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Involvement of calmodulin and calmodulin kinase II in tumor necrosis factor alpha-induced survival of bone marrow derived macrophages

Keywords: CAM; calmodulin; CAMKII; calmodulin dependent kinase II; GSK3β; glycogen synthase kinase 3 beta; PI3K; phosphatidylinositol-3-kinase; NFκB; nuclear factor kappa B; M-CSF; macrophage-colony stimulating factor; TNFα; tumor necrosis factor alpha; TRPC; tr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Exploratory analysis of activation of PTEN–PI3K pathway and downstream proteins in malignant pleural mesothelioma (MPM)

Keywords: FOXO3; Malignant pleural mesothelioma; PI3K; pS6; Prognostic factor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Functional roles of the phosphatidylinositol 3-kinases (PI3Ks) signaling in the mammalian ovary

Keywords: PI3K; PTEN; Oogenesis; Folliculogenesis; Premature ovarian failure; Ovarian cancer

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Atrial natriuretic peptide prevents the mitochondrial permeability transition pore opening by inactivating glycogen synthase kinase 3β via PKG and PI3K in cardiac H9c2 cells

Keywords: ANP; GSK-3β; mPTP; PKG; PI3K; Reperfusion injury

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Receptor fusion proteins for the inhibition of cytokines

Keywords: Akt; a serine-threonine protein kinase; Bcr-Abl; fusion of the breakpoint cluster region (bcr) gene and a cellular Abelson murine leukemia viral oncogene homolog; CAPS; cryopyrin-associated periodic syndromes; CBM; cytokine binding module; CLC; cardiotr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Src/NF-κB-targeted inhibition of LPS-induced macrophage activation and dextran sodium sulphate-induced colitis by Archidendron clypearia methanol extract

Keywords: PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumor necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAPK; mitogen activated protein kinase; NF-κB; nuclear facto

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

The apoptotic effects of the flavonoid N101-2 in human cervical cancer cells

Keywords: HPV; human papillomavirus; PPAR; peroxisome proliferator-activated receptor; DMSO; dimethyl sulfoxide; N101-2; 5,7,4′-trihydroxy flavanone N-phenyl hydrazone; PARP; poly ADP-ribose polymerase; PBS; phosphate-buffered saline; PI; propidium iodide; PVDF;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Heme oxygenase-1 mediates the protective role of quercetin against ethanol-induced rat hepatocytes oxidative damage

Keywords: ALD; alcoholic liver disease; ARE; antioxidant response element; AST; aspartate transaminase; CAT; catalase; GSH; glutathione; CYP 2E1; cytochrome P450 2E1; ERK; extracellular signal-regulated kinase; HO-1; heme oxygenase-1; JNK; c-Jun N-terminal kinase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Ephedrine hydrochloride protects mice from LPS challenge by promoting IL-10 secretion and inhibiting proinflammatory cytokines

Keywords: EH; ephedrine hydrochloride; LPS; lipopolysaccharide; TLR; Toll-like receptor; DCs; dendritic cells; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinositol (PI) 3-kinase; IL-10; interleukin 10; ERK1/2; extracellular signal regulated kinase; JN

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Methanol extract of Osbeckia stellata suppresses lipopolysaccharide- and HCl/ethanol-induced inflammatory responses by inhibiting Src/Syk and IRAK1

Keywords: Os-ME; methanol extract of Osbeckia stellata; PGE2; prostaglandin E2; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; TNF-α; tumor necrosis factor-alpha; ERK; extracellular signal-related kinase; TLR; toll-like receptor; MAPK; mitogen

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Mechanisms of human smooth muscle cell proliferation and transplant vasculopathy induced by HLA class I antibodies: In vitro and in vivo studies

Keywords: TV; transplant vasculopathy; HLA; human leukocyte antigen; SMC; smooth muscle cells; EC; endothelial cells; MMP; matrix metalloproteinases; MMP-2; matrix metalloproteinase 2; FAK; focal adhesion kinase; mTOR; mammalian target of rapamycin; PI3K; phosphati

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Src and Syk are targeted to an anti-inflammatory ethanol extract of Aralia continentalis

Keywords: PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumour necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAPK; mitogen activated protein kinase; NF-κB; nuclear fact

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action

Keywords: PG; prostaglandin; NO; nitric oxide; COX; cyclooxygenase; iNOS; inducible NO synthase; (TNF)-α; tumor necrosis factor; ERK; extracellular signal-related kinase; TLR; Toll-like receptors (TLR); MAPK; mitogen activated protein kinase; NF-κB; nuclear facto

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Ursodeoxycholic acid suppresses mitochondria-dependent programmed cell death induced by sodium nitroprusside in SH-SY5Y cells

Keywords: UDCA; ursodeoxycholic acid; TUDCA; tauroursodeoxycholic acid; YS; Yoo's solution; SNP; sodium nitroprusside; ROS; reactive oygen species; RNS; reactive nitrogen species; NO; nitric oxide; PD; Parkinson's disease; PI3K; phosphatidylinositol-3-kinase; PKA;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

A novel imidazopyridine analogue as a phosphatidylinositol 3-kinase inhibitor against human breast cancer

Keywords: PI3K; mTOR; Apoptosis; Breast cancer

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

mTOR kinase inhibitor potentiates apoptosis of PI3K and MEK inhibitors in diagnostically defined subpopulations

Keywords: mTOR; PI3K; MAPK; GDC-0941

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

TOR signaling is involved in PTTH-stimulated ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori

Keywords: Bombyx mori; Prothoracic gland; PI3K; Akt; TOR signaling; PTTH; 4E-BP; S6K; ERK;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه