Phosphatase and tensin homologue deleted on chromosome 10: Extending its PTENtacles
Keywords: PTEN; AKT; PI3K; Tumor; Nucleus;
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CoA Synthase is in complex with p85αPI3K and affects PI3K signaling pathway
Keywords: Coenzyme A; CoASy; PI3K; p85αPI3K; Metabolism
NGF-induced Tyro3 and Axl function as survival factors for differentiating PC12 cells
Keywords: NGF; TrkA; PC12; Tyro3; Axl; Receptor interaction; PI3K; Neuron protection
The steady-state expression of connexin43 is maintained by the PI3K/Akt in osteoblasts
Keywords: Gap junction; Gap junctional intercellular communication; Connexin43; PI3K; Akt; mRNA stability;
Roles of ERK, PI3 kinase, and PLC-γ pathways induced by overexpression of translationally controlled tumor protein in HeLa cells
Keywords: EGFR; ERK; Na,K-ATPase; Ouabain; PI3K; PLC-γ; TCTP;
Silencing of secretory clusterin sensitizes NSCLC cells to V-ATPase inhibitors by downregulating survivin
Keywords: AKT; Clusterin; mTOR; PI3K; Survivin; V-ATPase;
In vivo expression of signaling proteins in reconstituted NK cells
Keywords: Natural Killer cells; IL2Rγc; PI3K;
LPS-stimulated MUC5AC production involves Rac1-dependent MMP-9 secretion and activation in NCI-H292 cells
Keywords: AG; AG1478; DPI; diphenyleneiodonium; EGFR; epidermal growth factor receptor; GM; GM6001; LPS; lipopolysaccharides; LY; LY294002; MMP; matrix metalloproteinase; MUC5AC; mucin 5AC; NAC; N-acetylcysteine; NADPH; nicotinamide adenine dinucleotide phosphate;
Epinephrine-induced hyperpolarization of pancreatic islet cells is sensitive to PI3K–PDK1 signaling
Keywords: PKB/Akt, protein kinase B; FCS, fetal calf serum; HEPES, N-2-hydroxyethylpiperazine-N′-2-ethanesulfonic acid; LY294002, PI3K inhibitor; PI3K, phosphatidylinositol 3-kinaseK+ channel; Cell membrane potential; PI3K; LY294002
EGF promotes invasion by PANC-1 cells through Rac1/ROS-dependent secretion and activation of MMP-2
Keywords: DPI; diphenyleneiodonium; EGF; epidermal growth factor; EGFR; EGF receptor; MMP; matrix metalloproteinase; NADPH; nicotinamide adenine dinucleotide phosphate; PI3K; phosphatidylinositol 3-kinase; PP2; pyrazolopyrimidine; ROS; reactive oxygen species; PANC
Exogenous insulin stimulates glycogen accumulation in Rhipicephalus (Boophilus) microplus embryo cell line BME26 via PI3K/AKT pathway
Keywords: PI3K; GSK3; BME26 cell line; Signal transduction; Tick; Embryogenesis; Glycogen; Insulin
Effects of PI3K catalytic subunit and Akt isoform deficiency on mTOR and p70S6K activation in myoblasts
Keywords: PI3K; Akt; mTOR; S6K; MyoblastPI3K, phosphoinositide 3-kinase; mTOR, mammalian target of rapamycin; p70S6K, 70 kDa ribosomal protein S6 kinase; IGF-I, insulin-like growth factor-I; PRAS40, proline-rich Akt substrate of 40 kDa
Phosphoinositide-3-kinase (PI3K) inhibitors: Identification of new scaffolds using virtual screening
Keywords: PI3K; Phosphoinositide-3-kinase; Virtual screening; Drug discovery
Inhibition of PI3K by ZSTK474 suppressed tumor growth not via apoptosis but G0/G1 arrest
Keywords: PI3K; PI3K inhibitor; G0/G1 arrest; Apoptosis
Ablation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation
Keywords: HCC, hepatocellular carcinoma; PI3K, phosphoinositide-3-kinase; PIK3C2α, phosphoinositide-3-kinase class 2 alphaHCC; Phosphoinositide-3-kinase; PI3K; Cell growth; Liver; Apoptosis; PIK3C2α
IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways
Keywords: IGF-1; Col2a1; MMP-13; Endplate chondrocyte; PI3K; ERK/MAPK
Pathological Effects of Prostate Cancer Correlate With Neuroendocrine Differentiation and PTEN Expression After Bicalutamide Monotherapy
Keywords: prostatic neoplasms; treatment failure; bicalutamide; PTEN phosphohydrolase; epidermal growth factor; ADT; androgen deprivation therapy; BCR; biochemical recurrence; CgA; chromogranin A; ECE; extracapsular extension; HER; human epidermal receptor; IHC; im
Original scientific articlePhosphatidylinositol 3-Kinase-Akt Signaling in Pulmonary Carcinoid Cells
Keywords: ASCL1; achaete-scute complex-like 1; CgA; chromogranin A; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NSCLC; non-small cell lung cancer; pAkt; phosphorylated Akt; PI3K; phosphatidylinositol 3-kinase; RNAi; RNA interference; SCLC; sm
Mycobacterium bovis Bacillus Calmette-Guérin (BCG)-induced activation of PI3K/Akt and NF-kB signaling pathways regulates expression of CXCL10 in epithelial cells
Keywords: Akt; CXCL10; Mycobacterium bovis; NF-kB; PI3K
A novel hypothesis regarding the possible involvement of cytosolic phospholipase 2 in insulin-stimulated proliferation of vascular smooth muscle cells
Keywords: Vascular smooth muscle cells; INS; Proliferation; cPLA2; ERK1/2; PI3K;
PKCδ survival signaling in cells containing an activated p21Ras protein requires PDK1
Keywords: PKCδ; PI3K; Akt; Protein kinase C; Apoptosis; Proliferation;
Macrophage inflammatory protein-1β induced cell adhesion with increased intracellular reactive oxygen species
Keywords: AngII; angiotensin II; CAMs; cell adhesion molecules; CVD; cardiovascular disease; DCFHDA; 2â²7â²-dichlorofluorescein-diacetate; DPI; diphenyleneiodonium; ECs; endothelial cells; FBS; fetal bovine serum; GTP; guanosine triphosphate; HIV; human immunodef
Soy phytoestrogens are neuroprotective against stroke-like injury in vitro
Keywords: AKT; Akt serine-threonine kinase; BSA; bovine serum albumin; B27; B-27 serum-free supplement; Calcein AM; calcein acetoxymethylester; DAPI; 4â²,6-diamidino-2-phenylindole; DIV; days in vitro; ER; estrogen receptor; E2; 17β-estradiol; GPR30; G-protein-co
Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes
Keywords: Nucleus; PI3K; PDK1; Cardiomyocyte; Akt; Phosphoinositide;
E6 variants of human papillomavirus 18 differentially modulate the protein kinase B/phosphatidylinositol 3-kinase (akt/PI3K) signaling pathway
Keywords: HPV variants; hDlg; E6; Akt/PKB; MAPK; PI3K;
A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms
Keywords: PI3K; phosphatidylinositol 3-kinase; AKT; protein kinase B; PDK; phosphoinositide-dependent kinase; MAPK; mitogen activated protein kinase; COX-2; cyclooxygenase 2; NSAIDs; non-steroidal anti-inflammatory drugs; PGE2; prostaglandin E2; Her2; human epiderm
Evidence for the involvement of FAM110C protein in cell spreading and migration
Keywords: MT; microtubule; ECM; extracellular matrix; PI3K; phosphoinoside 3-kinase; HGF; hepatocyte growth factor; FAM110C; Akt1; Migration; Adhesion; Microtubule;
SOCS3 expression induced by PIM2 requires PKC and PI3K signaling
Keywords: PIM2; TLR2; SOCS3; PI3K; PKC
Visualization of Ras-PI3K interaction in the endosome using BiFC
Keywords: Ras; PI3K; Endosome; BiFC
Ghrelin inhibits apoptosis induced by high glucose and sodium palmitate in adult rat cardiomyocytes through the PI3K-Akt signaling pathway
Keywords: Cardiomyocytes; Ghrelin; Oxidative stress; Apoptosis; PI3K
Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation
Keywords: Forkhead transcription factor; Foxo3; Ovary; Oocyte; Primordial follicle; PI3K; Kit; Imatinib
Melanocortin 5 receptor activates ERK1/2 through a PI3K-regulated signaling mechanism
Keywords: Melanocortin 5 receptor; PI3K; ERK1/2; α-MSH; GPCR; Akt/PKB
NMDA-mediated and self-induced bdnf exon IV transcriptions are differentially regulated in cultured cortical neurons
Keywords: NMDA; BDNF; Transcription; CaM KII/IV; PI3K; ERK; PLC
Ethanolic Hwaeumjeon induces mitochondrial dependent apoptosis partly via PI3K/AKT/HSP27/ERK pathways and inhibits PSA and AR in LNCaP cells
Keywords: Hwaeumjeon; PI3K; AKT; ERK; HSP27; Apoptosis; LNCaP
Brain derived neurotrophic factor and neurotrophin-4 employ different intracellular pathways to modulate norepinephrine uptake and release in rat hypothalamus
Keywords: Neurotrophins; Neurotransmission; PI3K; PLC; Hypothalamus; Trk receptors; NE uptake; NE release
VEGF secretion by macrophages is stimulated by lipid and protein components of OxLDL via PI3-kinase and PKCζ activation and is independent of OxLDL uptake
Keywords: OxLDL; Scavenger Receptor; Macrophage; Atherosclerosis; PKCζ; PI3K
Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells
Keywords: LDL; low density lipoproteins; SMC; smooth muscle cells; oxLDL; oxidized low density lipoprotein; FCS; fetal calf serum; PI3K; phosphoinositide 3 kinase; mTOR; mammalian target of rapamycin; Resveratrol; PDK1; Akt; Oxidized LDL; Smooth muscle cells; Proli
Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes
Keywords: Leishmania; Parasitic-protozoan; Intracellular parasitism; Signal transduction; Cytokines; IL-12; Protein kinases; PI3K; Akt
Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells
Keywords: Dendritic cells; Toll-like receptors; Cytokines; Signal transduction; JAK; STAT; PI3K; Akt; MAPK; NF-κB
Phosphatidylinositol-3-Kinase/Akt Signaling Pathway and Kidney Cancer, and the Therapeutic Potential of Phosphatidylinositol-3-Kinase/Akt Inhibitors
Keywords: kidney; carcinoma; renal cell; D 21266; 1-phosphatidylinositol 3-kinase; mTOR protein; 17-HWT; 17-hydroxy-wortmannin; APC; alkylphosphocholine; ERK; extracellular regulated kinase; GSK3; glycogen synthase kinase-3; HIF; hypoxia-inducible factor; IC50; hal
Insulin stimulates ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori
Keywords: Bombyx mori; Insulin; Insulin receptor; Ecdysteroidogenesis; Prothoracic gland; PI3K; Signal transduction; In vivo; Akt phosphorylation
Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells
Keywords: Akt; Erk; Erythropoietin; Gab1; Jak2; PI3K;
TIS21/BTG2/PC3 and cyclin D1 are key determinants of nuclear diacylglycerol kinase-ζ-dependent cell cycle arrest
Keywords: cdk; cyclin dependent kinase; DG; diacylglycerol; DGK; diacylglycerol kinase; ECL; enhanced chemiluminescence; GSK; glycogen synthase kinase; mTOR; mammalian Target Of Rapamycin; NLS; nuclear localization signal; p70S6K; p70S6 kinase; PA; phosphatidic aci
Density- and serum-dependent regulation of the Reck tumor suppressor in mouse embryo fibroblasts
Keywords: Mmp2; Fibroblasts; Src; PI3K; Collagen; Fibronectin;
Docosahexaenoic acid induces ERK1/2 activation and neuritogenesis via intracellular reactive oxygen species production in human neuroblastoma SH-SY5Y cells
Keywords: DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; ERK; extracellular-regulated kinase; GAP-43; growth-associated protein-43; H2DCF-DA; 2â²,7â²-dichlorofluorescin diacetate; PI3K; phosphatidyl inositol 3 kinase; PTPase; protein tyrosine phosphatase;
CCL5 increases lung cancer migration via PI3K, Akt and NF-κB pathways
Keywords: ECM, extracellular matrix; PI3K, phosphatidylinositol 3-kinase; IKK α/β, IκB kinase α/β; NF-κB, nuclear factor-κBCCL5; Lung cancer; Migration; Akt; PI3K
Regenerative pharmacology in the treatment of genetic diseases: The paradigm of muscular dystrophy
Keywords: MD; muscular dystrophies; DMD; duchenne muscular dystrophy; DAPC; dystrophin-associated protein complex; DGC; dystrophin-glycoprotein complex; DG; dystroglycans; SCG; sarcoglycans; nNOS; neuronal nitric oxide synthase; NO; nitric oxide; HDAC; histone deac
αvβ5/β6 integrin suppression leads to a stimulation of α2β1 dependent cell migration resistant to PI3K/Akt inhibition
Keywords: Integrins; Crosstalk; Cell migration; Colon adenocarcinoma; Integrin signaling; PI3K; PKC
Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways
Keywords: ADAM; a disintegrin and metalloproteinase; α-LA; α-lipoic acid; APC; activated protein C; APMA; 4-aminophenylmercuric acetate; BSA; bovine serum albumin; CV; crystal violet; DHLA; dihydrolipoic acid; DMSO; dimethyl sulfoxide; DPI; diphenylene iodonium;